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CA2007935A1 - Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these - Google Patents

Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these

Info

Publication number
CA2007935A1
CA2007935A1 CA2007935A CA2007935A CA2007935A1 CA 2007935 A1 CA2007935 A1 CA 2007935A1 CA 2007935 A CA2007935 A CA 2007935A CA 2007935 A CA2007935 A CA 2007935A CA 2007935 A1 CA2007935 A1 CA 2007935A1
Authority
CA
Canada
Prior art keywords
hydrogen
alkyl
substituted
nitrogen
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2007935A
Other languages
French (fr)
Other versions
CA2007935C (en
Inventor
Hans-Heiner Wuest
Bernd Janssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of CA2007935A1 publication Critical patent/CA2007935A1/en
Application granted granted Critical
Publication of CA2007935C publication Critical patent/CA2007935C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/12—Ketones containing more than one keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the general formula I

(see formula I) where A is ethylene or methylene which can be substituted by methyl, hydroxyl or oxo, L is one of the following (see formula II) R1 and R2 are hydrogen or methyl, R3 is hydrogen, hydroxyl ar C1-C6-alkoxy, R4 ; is hydrogen, C1-C4-alkyl, halogen or methoxy, R5 is hydrogen or methoxy, and R6 is hydrogen, methyl, cyano, a C2-C10 group of the formula (see formula III) where R',R" and R'" are each alkyl of 1 to 9 carbons, the total of carbons in R',R",R'" is 2 to 10, and R' can also be hydrogen, or the following -CHR7-OR8, -CHR7-NR9R10, -COR11, (see formula IV) or -SO2R11 where R7 is hydrogen or C1-C4-alkyl, R8 is hydrogen, C1-C4-alkyl, C1-C20-alkanoyl, or benzoyl which can be substituted, R9 and R10 are hydrogen, C1-C4-alkyl, C1-C6-alkanoyl, or benzoyl which can be substituted, or form, together with the nitrogen to which they are bonded, a 5- or 6-membered saturated heterocyclic radical which can also contain an oxygen in addition to the nitrogen, R11 is hydrogen, C1-C4-alkyl, or -OR13 or -NR14R15 where R13 is hydrogen, C1-C8-alkyl which can be substituted by 1 or 2 hydroxyls, or aryl or aralkyl each of which can be substituted in the aryl moiety, and where R14 and R15 are hydrogen, or aralkyl or aryl which can be substituted, or R14 and R15 form, together with the nitrogen to which they are banded, a 5- or 6-membered saturated heterocyclic radical which can also contain an oxygen in addition to the nitrogen, and R12 is C1-C4-alkyl, and the physiologically tolerated salts thexeof, processes far the preparation thereof, and drugs and cosmetics prepared therefrom are described.
CA002007935A 1989-02-10 1990-01-17 Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these Expired - Lifetime CA2007935C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3903992.7 1989-02-10
DE3903992A DE3903992A1 (en) 1989-02-10 1989-02-10 AROMATIC KETO COMPOUNDS, THEIR PRODUCTION AND MEDICINAL PRODUCTS AND COSMETICS THEREOF

Publications (2)

Publication Number Publication Date
CA2007935A1 true CA2007935A1 (en) 1990-08-10
CA2007935C CA2007935C (en) 2000-03-07

Family

ID=6373813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002007935A Expired - Lifetime CA2007935C (en) 1989-02-10 1990-01-17 Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these

Country Status (6)

Country Link
EP (1) EP0382078B1 (en)
JP (1) JP2924972B2 (en)
KR (1) KR900012878A (en)
AT (1) ATE94864T1 (en)
CA (1) CA2007935C (en)
DE (2) DE3903992A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194664A (en) * 1989-02-10 1993-03-16 Basf Aktiengesellschaft Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these
DE4033568A1 (en) * 1990-10-22 1992-04-23 Henkel Kgaa BICYCLIC COMPOUNDS WITH ANTISEBORRHOIC EFFECT
FR2753091B1 (en) * 1996-09-09 2001-03-16 Oreal USE OF AN RXR-TYPE RETINOID RECEPTOR AGONIST TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE LOSS
DE102005049225A1 (en) * 2005-10-14 2007-04-19 P + L Gmbh & Co. Kg Device for clamping tool to spindle shaft of machine tool, comprises sleeve accommodated in cylindrical outer end of spindle shaft

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62215581A (en) * 1986-03-18 1987-09-22 Koichi Shiyudo Flavone carboxylic acid derivative
FR2601670B1 (en) * 1986-07-17 1988-10-07 Cird NOVEL AROMATIC BICYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND IN COSMETICS
JPH07121890B2 (en) * 1989-03-15 1995-12-25 紘一 首藤 Carboxylic acid derivative

Also Published As

Publication number Publication date
DE59002774D1 (en) 1993-10-28
KR900012878A (en) 1990-09-03
EP0382078B1 (en) 1993-09-22
CA2007935C (en) 2000-03-07
DE3903992A1 (en) 1990-08-16
ATE94864T1 (en) 1993-10-15
JPH02235838A (en) 1990-09-18
JP2924972B2 (en) 1999-07-26
EP0382078A1 (en) 1990-08-16

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Legal Events

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