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BRPI1013677A2 - método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. - Google Patents

método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Info

Publication number
BRPI1013677A2
BRPI1013677A2 BRPI1013677A BRPI1013677A BRPI1013677A2 BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2 BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2
Authority
BR
Brazil
Prior art keywords
hyperpolarized
pyruvate
infection
imaging medium
detecting inflammation
Prior art date
Application number
BRPI1013677A
Other languages
English (en)
Inventor
Daniel M Spielman
Dirk Mayer
John D Mackenzie
Yi-Fen Yen
Original Assignee
Ge Healthcare Ltd
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Univ Leland Stanford Junior filed Critical Ge Healthcare Ltd
Publication of BRPI1013677A2 publication Critical patent/BRPI1013677A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI1013677A 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. BRPI1013677A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157152 2009-04-02
PCT/EP2010/053912 WO2010112397A1 (en) 2009-04-02 2010-03-25 Use of a magnetic resonance imaging medium comprising hyperpolarized 13c pyruvate for the detection of inflammation or infection

Publications (1)

Publication Number Publication Date
BRPI1013677A2 true BRPI1013677A2 (pt) 2016-04-26

Family

ID=42128552

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013677A BRPI1013677A2 (pt) 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Country Status (11)

Country Link
US (1) US20120128593A1 (pt)
EP (1) EP2414854A1 (pt)
JP (1) JP5868311B2 (pt)
KR (1) KR101666239B1 (pt)
CN (1) CN102388317B (pt)
AU (1) AU2010230330B2 (pt)
BR (1) BRPI1013677A2 (pt)
CA (1) CA2757227A1 (pt)
MX (1) MX2011010294A (pt)
RU (1) RU2543704C2 (pt)
WO (1) WO2010112397A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011010294A (es) * 2009-04-02 2012-01-27 Ge Healthcare Ltd Uso de un medio de formacion de imagenes de resonancia magnetica que comprende 13c piruvato hiperpolarizado para la deteccion de inflamacion o infeccion.
DE102014112924A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
DE102014112923A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
KR101939454B1 (ko) * 2017-03-21 2019-01-16 전남대학교산학협력단 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030918A1 (en) 1997-01-08 1998-07-16 Nycomed Imaging As Method of magnetic resonance imaging
CN1269015A (zh) 1997-06-19 2000-10-04 耐克麦德英梅金公司 使用体外极化磁共振成像剂的奥氏磁共振成像方法
AU1047399A (en) 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6232497B1 (en) 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
WO2001089584A2 (en) 2000-05-23 2001-11-29 Amersham Health As Contrast agents
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
NO20004561D0 (no) 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
JP4061192B2 (ja) 2000-11-03 2008-03-12 ジーイー・ヘルスケア・アクスイェ・セルスカプ 分極ｎｍｒ試料用のデバイス及び方法
IL155475A0 (en) 2000-11-03 2003-11-23 Amersham Health As Methods and devices for polarised nmr samples
DE60238677D1 (de) * 2001-06-15 2011-02-03 Uv Solutions Llc Verfahren zur Bestimmung der Durchlässigkeit eines Verbands
ES2372058T3 (es) 2004-07-30 2012-01-13 Ge Healthcare As Procedimiento de visualización de imágenes rm para la discriminación entre tejido sano y tumoral.
ES2545260T3 (es) 2004-07-30 2015-09-09 Ge Healthcare As Composición que comprende radical triarilmetilo, útil en diagnóstico por IRM
CA2581222A1 (en) 2004-10-01 2006-04-13 Ge Healthcare As Method for producing pyruvic acid
RU2391047C2 (ru) * 2004-11-19 2010-06-10 Джи-И Хелткер АС Способ визуализации сердца с использованием гиперполяризованного 13c-пирувата
WO2007044867A2 (en) * 2005-10-11 2007-04-19 Huntington Medical Research Institutes Imaging agents and methods of use thereof
EP1954321B1 (en) 2005-12-01 2011-11-23 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
PL1962912T3 (pl) 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
US20100233096A1 (en) 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
WO2008020765A2 (en) * 2006-08-18 2008-02-21 Ge Healthcare As Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
ES2381380T3 (es) * 2006-08-18 2012-05-25 Ge Healthcare As Formación de imagenes de 13C-RM o de espectroscopia de muerte celular
US20100196283A1 (en) * 2007-07-26 2010-08-05 Lerche Matilde H Method and imaging medium for use in the method
US20090060841A1 (en) * 2007-08-27 2009-03-05 Yi-Fen Yen Apparatus and method for combined use of variable flip angles and centric phase encoding in hyperpolarized 13c imaging
US20110038802A1 (en) * 2008-05-02 2011-02-17 Zhong-Min Hu Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
MX2011010294A (es) * 2009-04-02 2012-01-27 Ge Healthcare Ltd Uso de un medio de formacion de imagenes de resonancia magnetica que comprende 13c piruvato hiperpolarizado para la deteccion de inflamacion o infeccion.

Also Published As

Publication number Publication date
AU2010230330B2 (en) 2015-06-25
KR20120016047A (ko) 2012-02-22
CN102388317A (zh) 2012-03-21
KR101666239B1 (ko) 2016-10-13
JP5868311B2 (ja) 2016-02-24
AU2010230330A1 (en) 2011-10-13
RU2543704C2 (ru) 2015-03-10
US20120128593A1 (en) 2012-05-24
EP2414854A1 (en) 2012-02-08
WO2010112397A1 (en) 2010-10-07
CA2757227A1 (en) 2010-10-07
MX2011010294A (es) 2012-01-27
CN102388317B (zh) 2015-11-25
JP2012522549A (ja) 2012-09-27
RU2011139218A (ru) 2013-05-10

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal: dismissal of application maintained