BRPI0912928A2 - "composto, e, composição isenta de pirogênio" - Google Patents

"composto, e, composição isenta de pirogênio"

Info

Publication number: BRPI0912928A2
Authority: BR; Brazil
Prior art keywords: compound; free composition; pyrogen free; pyrogen; composition
Prior art date: 2008-08-29

Application number

BRPI0912928-6A

Other languages

English (en)

Inventor

Scott Harbeson

Original Assignee

Concert Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-08-29

Filing date

2009-08-28

Publication date

2015-08-04

2009-08-28 Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc

2015-08-04 Publication of BRPI0912928A2 publication Critical patent/BRPI0912928A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0912928-6A 2008-08-29 2009-08-28 "composto, e, composição isenta de pirogênio" BRPI0912928A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9329308P	2008-08-29	2008-08-29
PCT/US2009/055427 WO2010025407A1 (en)	2008-08-29	2009-08-28	Substituted triazolo-pyridazine derivatives

Publications (1)

Publication Number	Publication Date
BRPI0912928A2 true BRPI0912928A2 (pt)	2015-08-04

Family

ID=41721962

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0912928-6A BRPI0912928A2 (pt)	2008-08-29	2009-08-28	"composto, e, composição isenta de pirogênio"

Country Status (17)

Country	Link
US (4)	US8003646B2 (pt)
EP (2)	EP2328414B1 (pt)
JP (3)	JP5183808B2 (pt)
KR (1)	KR20110063479A (pt)
CN (2)	CN104098578A (pt)
AU (1)	AU2009285533B2 (pt)
BR (1)	BRPI0912928A2 (pt)
CA (1)	CA2735549A1 (pt)
DK (1)	DK2328414T3 (pt)
EA (1)	EA020071B1 (pt)
ES (1)	ES2451542T3 (pt)
HR (1)	HRP20140195T1 (pt)
MX (1)	MX2011002278A (pt)
PL (1)	PL2328414T3 (pt)
PT (1)	PT2328414E (pt)
WO (1)	WO2010025407A1 (pt)
ZA (1)	ZA201102123B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20110063479A (ko)	2008-08-29	2011-06-10	콘서트 파마슈티컬즈, 인크.	치환된 트리아졸로-피리다진 유도체
US20110177468A1 (en)	2008-10-03	2011-07-21	Fabiola Barbosa Ormiga Galvao	Method and device for removing metallic fragments and metallic elements from dental root canals
WO2011005520A1 (en) *	2009-06-23	2011-01-13	Concert Pharmaceuticals, Inc.	Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
US20140249147A1 (en) *	2011-10-20	2014-09-04	GlaxoSmithKline, LLC	Substituted Bicyclic Aza-Heterocycles and Analogues as Sirtuin Modulators
CN104394869A (zh)	2011-10-20	2015-03-04	葛兰素史密斯克莱有限责任公司	用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物
WO2013104705A1 (de)	2012-01-11	2013-07-18	Bayer Intellectual Property Gmbh	Tetrazol-5-yl- und triazol-5-yl-arylverbindungen und ihre verwendung als herbizide
WO2013170241A1 (en)	2012-05-11	2013-11-14	Concert Pharmaceuticals, Inc.	Polymorphs of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolol[4,3b]pyridazine
US20150099753A1 (en)	2012-05-11	2015-04-09	Concert Pharmaceuticals Inc.	Form 5 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
JP2015516440A (ja)	2012-05-11	2015-06-11	コンサートファーマシューティカルズインコーポレイテッド	７−（ｔｅｒｔ−ブチル−ｄ９）−３−（２，５−ジフルオロフェニル）−６−（（１−メチル−１Ｈ−１，２，４−トリアゾール−５−イル）メトキシ）−［１，２，４］トリアゾロ［４，３−ｂ］ピリダジンの２型多形
WO2015052173A1 (en)	2013-10-10	2015-04-16	Basf Se	Tetrazole and triazole compounds and their use as herbicides
WO2015052178A1 (en)	2013-10-10	2015-04-16	Basf Se	1,2,5-oxadiazole compounds and their use as herbicides
WO2015095549A1 (en) *	2013-12-18	2015-06-25	Concert Pharmaceuticals, Inc.	Dosage regimen for gabaa receptor subtype selective drug
US10166183B2 (en)	2014-02-07	2019-01-01	Auspex Pharmaceuticals, Inc.	Pharmaceutical formulations
CN104474549A (zh) *	2014-11-24	2015-04-01	王寿世	异丙酚和gabaa受体拮抗剂在制备麻醉药物中的用途
CN104353078B (zh) *	2014-11-24	2017-10-24	王寿世	一种麻醉用药物组合物
US10026332B1 (en)	2017-04-10	2018-07-17	Jasmine Gupta	Method to deliver contextual educational information utilizing smart wearables
US20220152037A1 (en) *	2019-03-18	2022-05-19	Neurocycle Therapeutic, Inc.	Use of gabaa receptor modulators for treatment of pain
WO2023205722A1 (en) *	2022-04-20	2023-10-26	Engrail Therapeutics, Inc.	Gabaa receptor modulator salts, particles, and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9321162D0 (en)	1993-10-13	1993-12-01	Boots Co Plc	Therapeutic agents
EP0751926B1 (en)	1994-03-25	2007-09-12	Isotechnika,Inc.	Enhancement of the efficacy of drugs by deuteration
US6221335B1 (en) *	1994-03-25	2001-04-24	Isotechnika, Inc.	Method of using deuterated calcium channel blockers
KR20000029548A (ko) *	1996-07-25	2000-05-25	더블유. 지. 콜	가바수용체에대한리간드로서의치환된트리아졸로-피리다진유도체
MXPA00007135A (es) *	1998-01-21	2002-11-07	Merck Sharp & Dohme	Derivados de triazolo-piridazina como ligandos para receptores gaba.
US6440710B1 (en) *	1998-12-10	2002-08-27	The Scripps Research Institute	Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
DE60016566T2 (de) *	1999-01-27	2005-12-15	Merck Sharp & Dohme Ltd., Hoddesdon	Triazolopyridazinderivate als liganden für gaba-rezeptoren
EP1104760B1 (en) *	1999-12-03	2003-03-12	Pfizer Products Inc.	Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
US20020165217A1 (en) *	2001-05-01	2002-11-07	Pfizer Inc.	Combination treatment for anxiety and depression
TW200413273A (en) *	2002-11-15	2004-08-01	Wako Pure Chem Ind Ltd	Heavy hydrogenation method of heterocyclic rings
WO2004048980A1 (en) *	2002-11-28	2004-06-10	Neurosearch A/S	Method for screening for compounds as potential sedatives or anxiolytics
WO2006061428A2 (en)	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
CA2624179A1 (en) *	2005-10-06	2007-04-12	Auspex Pharmaceuticals, Inc.	Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
US7750168B2 (en) *	2006-02-10	2010-07-06	Sigma-Aldrich Co.	Stabilized deuteroborane-tetrahydrofuran complex
JO2630B1 (en)	2006-04-13	2012-06-17	نوفارتيس ايه جي	Organic compounds
CN101594870A (zh) *	2006-08-22	2009-12-02	康塞特医药品有限公司	4-氨基喹唑啉衍生物及其使用方法
JP2010502702A (ja) *	2006-09-05	2010-01-28	シェーリングコーポレイション	脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物
US20080242687A1 (en) *	2007-04-02	2008-10-02	Auspex Pharmaceuticals, Inc.	Substituted pyrimidines
KR20110063479A (ko) *	2008-08-29	2011-06-10	콘서트 파마슈티컬즈, 인크.	치환된 트리아졸로-피리다진 유도체

2009
- 2009-08-28 KR KR20117006632A patent/KR20110063479A/ko not_active Application Discontinuation
- 2009-08-28 PL PL09810685T patent/PL2328414T3/pl unknown
- 2009-08-28 DK DK09810685.9T patent/DK2328414T3/en active
- 2009-08-28 WO PCT/US2009/055427 patent/WO2010025407A1/en active Application Filing
- 2009-08-28 AU AU2009285533A patent/AU2009285533B2/en not_active Ceased
- 2009-08-28 EP EP20090810685 patent/EP2328414B1/en active Active
- 2009-08-28 EA EA201100409A patent/EA020071B1/ru not_active IP Right Cessation
- 2009-08-28 MX MX2011002278A patent/MX2011002278A/es active IP Right Grant
- 2009-08-28 CA CA 2735549 patent/CA2735549A1/en not_active Abandoned
- 2009-08-28 ES ES09810685T patent/ES2451542T3/es active Active
- 2009-08-28 CN CN201410346402.7A patent/CN104098578A/zh active Pending
- 2009-08-28 CN CN200980140350.5A patent/CN102176826B/zh not_active Expired - Fee Related
- 2009-08-28 PT PT98106859T patent/PT2328414E/pt unknown
- 2009-08-28 EP EP20130196185 patent/EP2716158A1/en not_active Withdrawn
- 2009-08-28 JP JP2011525250A patent/JP5183808B2/ja not_active Expired - Fee Related
- 2009-08-28 BR BRPI0912928-6A patent/BRPI0912928A2/pt not_active IP Right Cessation
- 2009-08-28 US US12/550,346 patent/US8003646B2/en active Active
2011
- 2011-03-22 ZA ZA2011/02123A patent/ZA201102123B/en unknown
- 2011-06-30 US US13/174,662 patent/US8399467B2/en active Active
2013
- 2013-01-15 JP JP2013004449A patent/JP5373982B2/ja not_active Expired - Fee Related
- 2013-03-18 US US13/846,119 patent/US8921366B2/en active Active
- 2013-09-19 JP JP2013194060A patent/JP2014058518A/ja active Pending
2014
- 2014-03-03 HR HRP20140195AT patent/HRP20140195T1/hr unknown
- 2014-12-23 US US14/581,843 patent/US20150111895A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2014058518A (ja)	2014-04-03
US20100056529A1 (en)	2010-03-04
ES2451542T3 (es)	2014-03-27
US20120004236A1 (en)	2012-01-05
HRP20140195T1 (hr)	2014-04-11
PT2328414E (pt)	2014-03-17
EA020071B1 (ru)	2014-08-29
CN102176826A (zh)	2011-09-07
KR20110063479A (ko)	2011-06-10
CA2735549A1 (en)	2010-03-04
AU2009285533A2 (en)	2011-04-21
EP2328414A1 (en)	2011-06-08
EA201100409A1 (ru)	2011-10-31
ZA201102123B (en)	2011-12-28
JP2013100322A (ja)	2013-05-23
US8003646B2 (en)	2011-08-23
EP2328414B1 (en)	2013-12-11
PL2328414T3 (pl)	2014-05-30
EP2716158A1 (en)	2014-04-09
US8399467B2 (en)	2013-03-19
JP5183808B2 (ja)	2013-04-17
JP5373982B2 (ja)	2013-12-18
AU2009285533A1 (en)	2010-03-04
US20130225590A1 (en)	2013-08-29
MX2011002278A (es)	2011-04-14
US20150111895A1 (en)	2015-04-23
JP2012501346A (ja)	2012-01-19
EP2328414A4 (en)	2011-11-16
DK2328414T3 (en)	2014-03-10
AU2009285533B2 (en)	2014-02-13
CN104098578A (zh)	2014-10-15
US8921366B2 (en)	2014-12-30
CN102176826B (zh)	2014-08-20
WO2010025407A1 (en)	2010-03-04

Publication	Publication Date	Title
BRPI0912928A2 (pt)	2015-08-04	"composto, e, composição isenta de pirogênio"
LTPA2018014I1 (lt)	2018-12-10	Farmacinė kompozicija 514
BRPI0913806A2 (pt)	2015-10-20	"composição"
BRPI0916123A2 (pt)	2015-11-03	"composição de xampu concentrada"
BRPI0910229A2 (pt)	2015-09-01	Tetramatos de 4';4'-dioxaspiro espirociclicamente substituídos
BRPI0906962A2 (pt)	2015-07-14	Composto, e, composição farmacêutica
BRPI0906556A2 (pt)	2015-07-07	Composto, e, composição farmacêutica
BRPI0716325A2 (pt)	2014-03-04	Composição antimicrobianas
FR2899479B1 (fr)	2009-07-24	Composition cicatrisante
BRPI0810928A2 (pt)	2019-09-24	"composição farmacêutica"
BRPI0914375A2 (pt)	2015-10-20	''composições antiperspirantes''
BRPI0719626A2 (pt)	2014-06-24	'' composto ''
BRPI0922904A2 (pt)	2018-05-29	"compostos"
BRPI0923047A2 (pt)	2015-12-08	"conjugados de proteínas-oligossacarídeos".
BRPI0917681A2 (pt)	2015-08-04	Composto, e, composição farmacêutica
BRPI0716046A2 (pt)	2013-09-17	composiÇÕes de nanopartÍcula.
BRPI0716458A2 (pt)	2014-03-04	Composição de vulcanizado
BRPI0819383A2 (pt)	2014-10-14	"composição de limpeza"
BRPI0914383A2 (pt)	2015-10-20	"composição de shampoo condicionador"
BRPI0914503A2 (pt)	2016-01-12	"composição de shampoo concentrado"
BRPI0914063A2 (pt)	2015-11-03	composição de xampu concentrado
DK1686160T3 (da)	2009-07-06	Forbedret coatingsammensætning
BRPI0718141A2 (pt)	2013-11-05	Composições de frangrâncias
BRPI0715173A2 (pt)	2015-02-18	Composições de perfume
BRPI0814748A2 (pt)	2015-03-03	Compostos de alditóis substituídos, composições e métodos

Legal Events

Date	Code	Title	Description
2017-07-04	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-10-31	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]