BRPI0910232A2 - formas de sais inibidores do mtor - Google Patents

formas de sais inibidores do mtor

Info

Publication number: BRPI0910232A2
Authority: BR; Brazil
Prior art keywords: salt forms; inhibitor salt; inhibitor; forms; salt
Prior art date: 2008-03-19

Application number

BRPI0910232A

Other languages

English (en)

Inventor

Arlindo L Castelhano

Gary C Visor

Josef A Rechka

Kristen Michelle Mulvihill

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-19

Filing date

2009-03-18

Publication date

2015-09-29

2009-03-18 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2015-09-29 Publication of BRPI0910232A2 publication Critical patent/BRPI0910232A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0910232A 2008-03-19 2009-03-18 formas de sais inibidores do mtor BRPI0910232A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7006208P	2008-03-19	2008-03-19
PCT/US2009/037505 WO2009117482A1 (en)	2008-03-19	2009-03-18	Mtor inhibitor salt forms

Publications (1)

Publication Number	Publication Date
BRPI0910232A2 true BRPI0910232A2 (pt)	2015-09-29

Family

ID=40597405

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0910232A BRPI0910232A2 (pt)	2008-03-19	2009-03-18	formas de sais inibidores do mtor

Country Status (12)

Country	Link
US (1)	US8557814B2 (pt)
EP (1)	EP2276763A1 (pt)
JP (1)	JP2011515410A (pt)
KR (1)	KR20110017845A (pt)
CN (1)	CN101977912A (pt)
AU (1)	AU2009225614A1 (pt)
BR (1)	BRPI0910232A2 (pt)
CA (1)	CA2716924A1 (pt)
EA (1)	EA018144B1 (pt)
MX (1)	MX2010010300A (pt)
WO (1)	WO2009117482A1 (pt)
ZA (1)	ZA201006641B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7700594B2 (en) *	2005-11-17	2010-04-20	Osi Pharmaceuticals, Inc.	Fused bicyclic mTOR inhibitors
JP2010532756A (ja) *	2007-07-06	2010-10-14	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	ｍＴＯＲＣ１及びｍＴＯＲＣ２の両方の阻害剤を含む組み合わせ抗癌療法
BRPI0910232A2 (pt)	2008-03-19	2015-09-29	Osi Pharm Inc	formas de sais inibidores do mtor
WO2011049625A1 (en)	2009-10-20	2011-04-28	Mansour Samadpour	Method for aflatoxin screening of products
EP2496567B1 (en)	2009-11-05	2017-07-12	Rhizen Pharmaceuticals S.A.	Novel benzopyran kinase modulators
WO2011112666A1 (en)	2010-03-09	2011-09-15	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
EA022586B1 (ru)	2011-02-23	2016-01-29	Пфайзер Инк.	ИМИДАЗО[5,1-f][1,2,4]ТРИАЗИНЫ ДЛЯ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ РАССТРОЙСТВ
LT2705029T (lt)	2011-05-04	2019-02-11	Rhizen Pharmaceuticals S.A.	Naujieji junginiai, kaip baltymų kinazės moduliatoriai
WO2013152342A1 (en)	2012-04-06	2013-10-10	OSI Pharmaceuticals, LLC	Anti-cancer mtor inhibitor and anti-androgen combination
SI3260455T1 (sl)	2012-07-04	2019-07-31	Rhizen Pharmaceuticals S.A.	Selektivni inhibitorji PI3K-delta
EP3021849B1 (en) *	2013-07-16	2019-10-09	Dr. Reddy's Laboratories Ltd.	Novel crystalline forms of pemetrexed tromethamine salts
WO2015134711A1 (en)	2014-03-06	2015-09-11	Ptc Therapeutics, Inc.	Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
US9987241B2 (en)	2014-09-25	2018-06-05	The Board Of Regents Of The University Of Oklahoma	Enzyme conjugate and prodrug cancer therapy
EP3209664B1 (en)	2014-10-22	2020-06-03	Bristol-Myers Squibb Company	Bicyclic heteroaryl amine compounds as pi3k inhibitors
WO2016064958A1 (en)	2014-10-22	2016-04-28	Bristol-Myers Squibb Company	Heteroaryl substituted pyrrolotriazine amine compounds as pi3k inhibitors
WO2017156350A1 (en)	2016-03-09	2017-09-14	K-Gen, Inc.	Methods of cancer treatment
EP4321513A3 (en)	2016-03-28	2024-05-08	Incyte Corporation	Pyrrolotriazine compounds as tam inhibitors
WO2020032951A1 (en)	2018-08-09	2020-02-13	The Board Of Regents Of The University Of Oklahoma	Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same
FR3075794A1 (fr)	2017-12-21	2019-06-28	Galderma Research & Development	Nouveaux composes inhibiteurs de mtor
FR3075795A1 (fr)	2017-12-21	2019-06-28	Galderma Research & Development	Nouveaux composes inhibiteurs de mtor

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT783505E (pt) *	1994-09-29	2001-08-30	Novartis Ag	Pirrolo¬2,3-d\|pirimidinas e sua utilizacao
KR20000076426A (ko) *	1997-03-19	2000-12-26	스타르크, 카르크	피롤로[2,3-ｄ]피리미딘 및 티로신 키나제 저해제로서의 그의 용도
US7863444B2 (en) *	1997-03-19	2011-01-04	Abbott Laboratories	4-aminopyrrolopyrimidines as kinase inhibitors
US6383790B1 (en) *	1999-01-11	2002-05-07	Princeton University	High affinity protein kinase inhibitors
US6921763B2 (en) *	1999-09-17	2005-07-26	Abbott Laboratories	Pyrazolopyrimidines as therapeutic agents
AU2002333524A1 (en) *	2001-09-11	2003-03-24	Glaxosmithkline K.K.	Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
KR100872204B1 (ko) *	2003-10-15	2008-12-09	오에스아이 파마슈티컬스, 인코포레이티드	이미다조피라진 티로신 키나제 억제제
WO2005054268A1 (en) *	2003-10-27	2005-06-16	Genelabs Technologies, Inc.	Nucleoside compounds for treating viral infections
BRPI0416656A (pt) *	2003-11-17	2007-01-16	Pfizer Prod Inc	compostos de pirrolopirimidina úteis no tratamento do cáncer
MY143225A (en) *	2004-04-02	2011-03-31	Osi Pharm Inc	6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
AR053090A1 (es) *	2004-07-20	2007-04-25	Osi Pharm Inc	Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
JP2008520744A (ja) *	2004-11-19	2008-06-19	ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア	抗炎症性ピラゾロピリミジン
US7700594B2 (en) *	2005-11-17	2010-04-20	Osi Pharmaceuticals, Inc.	Fused bicyclic mTOR inhibitors
AR057960A1 (es) *	2005-12-02	2007-12-26	Osi Pharm Inc	Inhibidores de proteina quinasa biciclicos
TW200801008A (en) *	2005-12-29	2008-01-01	Abbott Lab	Protein kinase inhibitors
JP5156644B2 (ja) *	2006-01-25	2013-03-06	オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー	不飽和ｍＴＯＲ阻害剤
US7651687B2 (en) *	2006-03-13	2010-01-26	Osi Pharmaceuticals, Inc.	Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors
JP2009531443A (ja)	2006-03-29	2009-09-03	フォールドアールエックスファーマシューティカルズインコーポレーティッド	α−シヌクレイン毒性の抑制
KR20090017498A (ko) *	2006-04-04	2009-02-18	더 리젠트스 오브 더 유니이버시티 오브 캘리포니아	Ｐｉ３ 키나제 길항물질
DE102006016426A1 (de)	2006-04-07	2007-10-11	Merck Patent Gmbh	Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren
US20090263397A1 (en) *	2007-07-06	2009-10-22	Buck Elizabeth A	Combination anti-cancer therapy
JP2010532756A (ja) *	2007-07-06	2010-10-14	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	ｍＴＯＲＣ１及びｍＴＯＲＣ２の両方の阻害剤を含む組み合わせ抗癌療法
BRPI0818426A2 (pt) *	2007-10-15	2017-06-13	Astrazeneca Ab	produto de combinação, uso de um produto de combinação, e, método para tratar câncer
BRPI0910232A2 (pt)	2008-03-19	2015-09-29	Osi Pharm Inc	formas de sais inibidores do mtor
KR20120047256A (ko)	2009-07-09	2012-05-11	오에스아이 파마슈티컬스, 엘엘씨	치환된 3-아미노-5-옥소-4,5-다이하이드로-［1,2,4］트라이아진에 대한 방법
US20120128670A1 (en)	2009-07-31	2012-05-24	OSI Pharmaceuticals, LLC	mTOR INHIBITOR AND ANGIOGENESIS INHIBITOR COMBINATION THERAPY

2009
- 2009-03-18 BR BRPI0910232A patent/BRPI0910232A2/pt not_active IP Right Cessation
- 2009-03-18 US US12/922,928 patent/US8557814B2/en not_active Expired - Fee Related
- 2009-03-18 KR KR1020107021794A patent/KR20110017845A/ko not_active Application Discontinuation
- 2009-03-18 EP EP09722933A patent/EP2276763A1/en not_active Withdrawn
- 2009-03-18 AU AU2009225614A patent/AU2009225614A1/en not_active Abandoned
- 2009-03-18 JP JP2011500920A patent/JP2011515410A/ja active Pending
- 2009-03-18 WO PCT/US2009/037505 patent/WO2009117482A1/en active Application Filing
- 2009-03-18 MX MX2010010300A patent/MX2010010300A/es not_active Application Discontinuation
- 2009-03-18 CN CN2009801096507A patent/CN101977912A/zh active Pending
- 2009-03-18 CA CA2716924A patent/CA2716924A1/en not_active Abandoned
- 2009-03-18 EA EA201071099A patent/EA018144B1/ru not_active IP Right Cessation
2010
- 2010-09-16 ZA ZA2010/06641A patent/ZA201006641B/en unknown

Also Published As

Publication number	Publication date
WO2009117482A1 (en)	2009-09-24
EP2276763A1 (en)	2011-01-26
ZA201006641B (en)	2011-05-25
MX2010010300A (es)	2010-10-26
US20110015197A1 (en)	2011-01-20
JP2011515410A (ja)	2011-05-19
KR20110017845A (ko)	2011-02-22
WO2009117482A8 (en)	2010-04-08
EA201071099A1 (ru)	2011-02-28
AU2009225614A1 (en)	2009-09-24
CA2716924A1 (en)	2009-09-24
US8557814B2 (en)	2013-10-15
EA018144B1 (ru)	2013-05-30
CN101977912A (zh)	2011-02-16

Publication	Publication Date	Title
BRPI0910232A2 (pt)	2015-09-29	formas de sais inibidores do mtor
CY2020024I2 (el)	2020-11-25	Αναστολεiς βητα-λακταμασων
BRPI0922466A2 (pt)	2018-10-23	sais
BRPI0917808A2 (pt)	2019-09-24	inibidores de cmet
BRPI0906764A2 (pt)	2015-08-18	Processos
BRPI0821868A2 (pt)	2015-07-28	Grânulo
BRPI0911175A2 (pt)	2015-10-13	conjuntos de válvula
BRPI0908115A2 (pt)	2015-10-06	torneira
BRPI0919591A2 (pt)	2015-12-08	válvula magnética
BRPI0914781A2 (pt)	2015-08-04	Microbiocidas
BRPI0924163A2 (pt)	2016-02-10	kit de limpeza de arma de fogo
BRPI0918564A2 (pt)	2015-12-01	inibidores
BRPI0908513A2 (pt)	2016-07-05	válvula
BRPI0911625A2 (pt)	2015-08-04	Métodos
FR2914943B1 (fr)	2011-04-01	Aube de soufflante
BRPI0911199A2 (pt)	2016-04-26	microbiocidas
BRPI0821901A2 (pt)	2014-10-14	Válvula homogeneizadora
BRPI0909106A2 (pt)	2015-07-28	Método herbicida
BRPI0918966A2 (pt)	2015-12-01	inibidores de protease
BRPI0912564A2 (pt)	2019-09-24	inibidores de jnk
DE602007002163D1 (de)	2009-10-08	Weichspülmittel
IT1394067B1 (it)	2012-05-25	Valvola
BRPI0914616A2 (pt)	2019-09-24	herbicidas
BRPI0919073A2 (pt)	2016-03-15	inibidores de protease
BRPI0919801A2 (pt)	2019-09-24	revestimento ii

Legal Events

Date	Code	Title	Description
2015-12-08	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.