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BRPI0816519A2 - Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio - Google Patents

Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio

Info

Publication number
BRPI0816519A2
BRPI0816519A2 BRPI0816519A BRPI0816519A2 BR PI0816519 A2 BRPI0816519 A2 BR PI0816519A2 BR PI0816519 A BRPI0816519 A BR PI0816519A BR PI0816519 A2 BRPI0816519 A2 BR PI0816519A2
Authority
BR
Brazil
Prior art keywords
atracurium salt
preparing
atracurium
salt
isomerically enriched
Prior art date
Application number
Other languages
English (en)
Inventor
Oded Arad
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Publication of BRPI0816519A2 publication Critical patent/BRPI0816519A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0816519 2007-10-29 2008-10-07 Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio BRPI0816519A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98344007P 2007-10-29 2007-10-29
PCT/IL2008/001329 WO2009057086A1 (en) 2007-10-29 2008-10-07 Novel r,r'-atracurium salts

Publications (1)

Publication Number Publication Date
BRPI0816519A2 true BRPI0816519A2 (pt) 2015-03-24

Family

ID=40259082

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816519 BRPI0816519A2 (pt) 2007-10-29 2008-10-07 Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio

Country Status (6)

Country Link
US (1) US8354537B2 (pt)
EP (1) EP2197848A1 (pt)
AU (1) AU2008320380A1 (pt)
BR (1) BRPI0816519A2 (pt)
CA (1) CA2702535A1 (pt)
WO (1) WO2009057086A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
WO2008132748A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
BRPI0809892A2 (pt) 2007-05-01 2014-09-30 Chemagis Ltd Composto de isoquinolínio, forma cristalina, composto cristalino (vii) e método para preparar cis-atracúrio
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
EP2176227A1 (en) * 2007-07-09 2010-04-21 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
CN104292161B (zh) * 2014-09-19 2016-06-22 大道隆达（北京）医药科技发展有限公司 一种顺苯磺阿曲库铵的精制方法
CN111548306B (zh) * 2020-06-22 2021-04-16 连云港贵科药业有限公司 一种顺苯磺阿曲库铵的提纯方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
JPS62265266A (ja) * 1986-05-13 1987-11-18 Takasago Corp Ｎ−アシル−テトラヒドロイソキノリン類の製造法
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
GB9015473D0 (en) 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
EA002224B1 (ru) * 1997-03-25 2002-02-28 Глаксо Груп Лимитед Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия
CN1241576C (zh) * 1999-08-13 2006-02-15 阿克佐诺贝尔公司 化学螯合剂用于制备逆转临床使用的神经肌肉传导阻滞剂药物诱发的神经肌肉传导阻滞的药物的用途
EP1346214A2 (en) * 2000-12-29 2003-09-24 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
JP2009515895A (ja) * 2005-11-14 2009-04-16 ピーター ディー． ウインチ 注射用薬物および薬学的に許容されるその塩の着色溶液
KR20070080108A (ko) 2006-02-06 2007-08-09 주식회사종근당 질소의 알파 위치에 비대칭탄소가 있는 라세믹 유도체의광학 이성질체 분리 방법
US8148398B2 (en) * 2006-12-06 2012-04-03 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
BRPI0808272A2 (pt) 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
CN100531734C (zh) 2007-03-13 2009-08-26 黄乐群 阿曲库铵冷冻干燥组合物
AU2008231470A1 (en) 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
BRPI0809892A2 (pt) * 2007-05-01 2014-09-30 Chemagis Ltd Composto de isoquinolínio, forma cristalina, composto cristalino (vii) e método para preparar cis-atracúrio
WO2008132748A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
CN101337935B (zh) 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CN101337936B (zh) 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
EP2176227A1 (en) 2007-07-09 2010-04-21 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
ITMI20080319A1 (it) * 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
IT1396543B1 (it) * 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
CN101475530A (zh) 2009-01-16 2009-07-08 东英（江苏）药业有限公司 通过制备液相色谱法分离纯化顺苯磺酸阿曲库铵的方法
CN101845017A (zh) 2009-03-24 2010-09-29 天津市炜杰科技有限公司 苯磺酸阿曲库铵类中间体的制备方法
WO2010128519A1 (en) 2009-05-04 2010-11-11 Kumar C Jairaj A method for detecting neuropathy and predicting foot ulcer development in human beings with health conditions like diabetes mellitus
WO2010128518A2 (en) 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate

Also Published As

Publication number Publication date
WO2009057086A1 (en) 2009-05-07
EP2197848A1 (en) 2010-06-23
US20100234602A1 (en) 2010-09-16
CA2702535A1 (en) 2009-05-07
AU2008320380A1 (en) 2009-05-07
US8354537B2 (en) 2013-01-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.