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BRPI0614480A2 - composto, composição farmacêutica, uso do composto, e, métodos para tratamento de distúrbios mediados por mglur5 e para inibição da ativação de receptores de mglur5 - Google Patents

composto, composição farmacêutica, uso do composto, e, métodos para tratamento de distúrbios mediados por mglur5 e para inibição da ativação de receptores de mglur5

Info

Publication number
BRPI0614480A2
BRPI0614480A2 BRPI0614480A BRPI0614480A BRPI0614480A2 BR PI0614480 A2 BRPI0614480 A2 BR PI0614480A2 BR PI0614480 A BRPI0614480 A BR PI0614480A BR PI0614480 A BRPI0614480 A BR PI0614480A BR PI0614480 A2 BRPI0614480 A2 BR PI0614480A2
Authority
BR
Brazil
Prior art keywords
compound
mglur5
methods
pharmaceutical composition
treating
Prior art date
Application number
BRPI0614480A
Other languages
English (en)
Inventor
Slassi Abdelmalik
Minidis Alexander
Sun Guang-Ri
Edwards Louise
Isaac Methvin
Dove Peter
Xin Tao
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0614480A2 publication Critical patent/BRPI0614480A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0614480A 2005-08-15 2006-08-04 composto, composição farmacêutica, uso do composto, e, métodos para tratamento de distúrbios mediados por mglur5 e para inibição da ativação de receptores de mglur5 BRPI0614480A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70794505P 2005-08-15 2005-08-15
PCT/US2006/030393 WO2007021574A1 (en) 2005-08-15 2006-08-04 Bicyclic piperazines as metabotropic glutamate receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0614480A2 true BRPI0614480A2 (pt) 2017-06-06

Family

ID=37451264

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0614480A BRPI0614480A2 (pt) 2005-08-15 2006-08-04 composto, composição farmacêutica, uso do composto, e, métodos para tratamento de distúrbios mediados por mglur5 e para inibição da ativação de receptores de mglur5

Country Status (16)

Country Link
US (2) US20080312240A1 (pt)
EP (1) EP1919911A1 (pt)
JP (1) JP2009504735A (pt)
KR (1) KR20080050392A (pt)
CN (1) CN101248071A (pt)
AR (1) AR055367A1 (pt)
AU (1) AU2006280232A1 (pt)
BR (1) BRPI0614480A2 (pt)
CA (1) CA2616308A1 (pt)
IL (1) IL188808A0 (pt)
MX (1) MX2008001607A (pt)
NO (1) NO20080671L (pt)
TW (1) TW200800204A (pt)
UY (1) UY29734A1 (pt)
WO (1) WO2007021574A1 (pt)
ZA (1) ZA200801034B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2414340A1 (en) * 2009-04-03 2012-02-08 Dainippon Sumitomo Pharma Co., Ltd. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
FR2974365B1 (fr) 2011-04-20 2017-08-25 Centre Nat De La Rech Scient (C N R S) 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques
JP6465803B2 (ja) * 2012-10-22 2019-02-06 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ Ｅｔｐ誘導体
BR112019002659A2 (pt) 2016-08-10 2019-05-21 Bayer Cropscience Aktiengesellschaft 2-heterociclilimidazolilcarboxamidas substituídas como pesticidas
US10822353B2 (en) 2016-09-15 2020-11-03 City Of Hope Dithio ETP derivatives
CN114907258B (zh) * 2021-02-09 2023-04-11 中国科学院化学研究所 一种钯与氮杂环卡宾协同催化制备炔丙基酮类化合物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001592A (es) * 2002-08-09 2005-05-05 Astrazeneca Ab Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
DE602004012083T2 (de) * 2003-04-15 2009-04-23 Astrazeneca Ab Neue Verbindungen, die als Verstärker von Glutamatrezeptoren dienen
WO2005077373A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)

Also Published As

Publication number Publication date
US20080312240A1 (en) 2008-12-18
NO20080671L (no) 2008-03-04
WO2007021574A1 (en) 2007-02-22
IL188808A0 (en) 2008-08-07
CA2616308A1 (en) 2007-02-22
JP2009504735A (ja) 2009-02-05
UY29734A1 (es) 2007-02-28
KR20080050392A (ko) 2008-06-05
MX2008001607A (es) 2008-04-14
AU2006280232A1 (en) 2007-02-22
AR055367A1 (es) 2007-08-22
TW200800204A (en) 2008-01-01
US20070037816A1 (en) 2007-02-15
EP1919911A1 (en) 2008-05-14
CN101248071A (zh) 2008-08-20
ZA200801034B (en) 2008-12-31

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Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.

B11Z Dismissal: petition dismissal - article 216, par 2 of industrial property law

Free format text: REFERENTE A PETICAO NO 20080015979/RJ DE 31/01/2008.

B11M Decision cancelled [chapter 11.13 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]