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BRPI0511037A - derivados de camptotecinas conjugados na posição 20 com antagonistas de integrina - Google Patents

derivados de camptotecinas conjugados na posição 20 com antagonistas de integrina

Info

Publication number
BRPI0511037A
BRPI0511037A BRPI0511037-8A BRPI0511037A BRPI0511037A BR PI0511037 A BRPI0511037 A BR PI0511037A BR PI0511037 A BRPI0511037 A BR PI0511037A BR PI0511037 A BRPI0511037 A BR PI0511037A
Authority
BR
Brazil
Prior art keywords
camptothecin derivatives
integrin antagonists
conjugated
compounds
antagonists
Prior art date
Application number
BRPI0511037-8A
Other languages
English (en)
Inventor
Alma Dal Pozzo
Sergio Penco
Lucio Merlini
Giuseppe Giannini
Maria Ornella Tinti
Claudio Pisano
Franco Zunino
Domenico Alloatti
Loredana Vesci
Sabrina Dallavalle
Ming Hong Ni
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of BRPI0511037A publication Critical patent/BRPI0511037A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE CAMPTOTECINAS CONJUGADOS NA POSIçãO 20 COM ANTAGONISTAS DE INTEGRINA. A presente invenção descreve compostos da Fórmula (1), nos quais os grupos R e R~ 1~ são como aqui definidos abaixo, e incluem a condensação da molécula de camptotecina na posição 20 com um ciclopeptídeo que contém a seqüência RGD. Os ditos compostos são dotados de alta afinidade pelos receptores de integrinas <244>~ V~<225>~ 3~ e <244>~ V~<225>~ 5~ e atividade citotóxica seletiva sobre linhagens de células humanas tumorosas em concentrações micromolares.
BRPI0511037-8A 2004-05-13 2005-05-04 derivados de camptotecinas conjugados na posição 20 com antagonistas de integrina BRPI0511037A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000241A ITRM20040241A1 (it) 2004-05-13 2004-05-13 Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
PCT/IT2005/000261 WO2005110487A2 (en) 2004-05-13 2005-05-04 Camptothecin derivatives conjugated in position 20 with integrin antagonists

Publications (1)

Publication Number Publication Date
BRPI0511037A true BRPI0511037A (pt) 2007-11-27

Family

ID=35124307

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511037-8A BRPI0511037A (pt) 2004-05-13 2005-05-04 derivados de camptotecinas conjugados na posição 20 com antagonistas de integrina

Country Status (12)

Country Link
US (1) US20070232639A1 (pt)
EP (1) EP1747019A2 (pt)
JP (1) JP2007537244A (pt)
CN (1) CN101010103A (pt)
AR (1) AR049275A1 (pt)
AU (1) AU2005243834A1 (pt)
BR (1) BRPI0511037A (pt)
CA (1) CA2562572A1 (pt)
IT (1) ITRM20040241A1 (pt)
MX (1) MXPA06012886A (pt)
TW (1) TW200538125A (pt)
WO (1) WO2005110487A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008098788A2 (en) * 2007-02-16 2008-08-21 Ktb Tumorforschungsgesellschaft Mbh Receptor and antigen targeted prodrug
KR20150009952A (ko) * 2012-01-27 2015-01-27 에프. 호프만-라 로슈 아게 알파-v-베타-3 발현 세포로의 표적화 전달을 위한 인테그린 안타고니스트 접합체
CN105399757A (zh) * 2015-12-29 2016-03-16 遵义医学院 酸敏感型喜树碱-20位去甲斑蝥酸酯衍生物及其抗肿瘤应用
CN111068068A (zh) * 2019-12-04 2020-04-28 云南民族大学 一种rgd多肽-喜树碱多肽药物偶联物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
EP1044977B1 (en) * 1999-03-09 2002-05-02 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
ES2330079T3 (es) * 1999-09-08 2009-12-04 Bayer Schering Pharma Aktiengesellschaft Direccionamiento de farmaco mediado par la integrina.

Also Published As

Publication number Publication date
AR049275A1 (es) 2006-07-12
CN101010103A (zh) 2007-08-01
ITRM20040241A1 (it) 2004-08-13
TW200538125A (en) 2005-12-01
WO2005110487A2 (en) 2005-11-24
EP1747019A2 (en) 2007-01-31
CA2562572A1 (en) 2005-11-24
AU2005243834A1 (en) 2005-11-24
MXPA06012886A (es) 2007-02-15
WO2005110487A3 (en) 2007-02-15
US20070232639A1 (en) 2007-10-04
JP2007537244A (ja) 2007-12-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.

B15K Others concerning applications: alteration of classification

Ipc: A61K 47/64 (2017.01), A61P 35/00 (2006.01), A61P 3