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BRPI0510769A - process for preparing an anthraquinone, process for methylating a hydroxy substituted anthraquinone to produce a dimethoxy substituted anthraquinone, method for inhibiting a filarial parasite, anthraquinone, and use of anthraquinone - Google Patents

process for preparing an anthraquinone, process for methylating a hydroxy substituted anthraquinone to produce a dimethoxy substituted anthraquinone, method for inhibiting a filarial parasite, anthraquinone, and use of anthraquinone

Info

Publication number
BRPI0510769A
BRPI0510769A BRPI0510769-5A BRPI0510769A BRPI0510769A BR PI0510769 A BRPI0510769 A BR PI0510769A BR PI0510769 A BRPI0510769 A BR PI0510769A BR PI0510769 A BRPI0510769 A BR PI0510769A
Authority
BR
Brazil
Prior art keywords
anthraquinone
substituted
inhibiting
preparing
produce
Prior art date
Application number
BRPI0510769-5A
Other languages
Portuguese (pt)
Inventor
Muraleedharan G Nair
Mugunthu R Dhananjeyan
Youli Milev
Michael A Kron
Original Assignee
Univ Michigan State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan State filed Critical Univ Michigan State
Publication of BRPI0510769A publication Critical patent/BRPI0510769A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/34—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCESSO PARA A PREPARAçãO DE UMA ANTRAQUINONA, PROCESSO PARA METILAR UMA ANTRAQUINONA HIDRóXI-SUBSTITUìDA PARA PRODUZIR UMA ANTRAQUINONA DIMETóXI-SUBSTITUìDA, MéTODO PARA INIBIR UM PARASITA FILARIAL, ANTRAQUINONA, E USO DA ANTRAQUINONA é descrito um processo para a preparação de antraquinonas hidroxil-substituídas. O processo acopla um anidrido ftálico (substituido ou não substituído) à fração anel benzeno substituída com pelo menos dois grupos hidroxila. Os grupos hidroxila remanescentes foram convertidos a grupos metoxila em algumas antraquinonas. Os compostos são particularmente úteis para o tratamento de doenças parasitárias. Também é apresentado um método para o tratamento ou a prevenção da malária, filariase do esquistossomose e outras doenças parasitárias usando antraquinonas.PROCEDURE FOR PREPARING AN ANCHRONONE, PROCESS TO METHYL A HYDROXY-SUBSTITUTED ANTRAKINONE TO PRODUCE A DIMETOXY-ANCHARKIN, METHOD FOR INHIBITING AN ANCHYCHRONIZED ANTIQUINON PROCESS The process couples a (substituted or unsubstituted) phthalic anhydride to the benzene ring moiety substituted with at least two hydroxyl groups. The remaining hydroxyl groups were converted to methoxyl groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also disclosed is a method for treating or preventing malaria, schistosomiasis filariasis and other parasitic diseases using anthraquinones.

BRPI0510769-5A 2004-05-11 2005-05-11 process for preparing an anthraquinone, process for methylating a hydroxy substituted anthraquinone to produce a dimethoxy substituted anthraquinone, method for inhibiting a filarial parasite, anthraquinone, and use of anthraquinone BRPI0510769A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57010904P 2004-05-11 2004-05-11
US65055205P 2005-02-07 2005-02-07
US11/074,227 US7658937B2 (en) 2004-05-11 2005-03-07 Anthraquinones and process for the preparation and method of use thereof
PCT/US2005/016501 WO2005113478A2 (en) 2004-05-11 2005-05-11 Novel anthraquinones and process for the preparation and method of use thereof

Publications (1)

Publication Number Publication Date
BRPI0510769A true BRPI0510769A (en) 2007-11-20

Family

ID=35426276

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510769-5A BRPI0510769A (en) 2004-05-11 2005-05-11 process for preparing an anthraquinone, process for methylating a hydroxy substituted anthraquinone to produce a dimethoxy substituted anthraquinone, method for inhibiting a filarial parasite, anthraquinone, and use of anthraquinone

Country Status (4)

Country Link
US (1) US7658937B2 (en)
EP (1) EP1745000A4 (en)
BR (1) BRPI0510769A (en)
WO (1) WO2005113478A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300810B6 (en) * 2007-11-02 2009-08-12 Mikrobiologický ústav AV CR, v.v.i. Deep cultivation strains Geosmithia species MK385B (CCM 8366) and Geosmithia species MK583B (CCM 8365), mixture of anthraquinone dyes produced by them and process for preparing such mixture
AP2012006601A0 (en) 2010-05-18 2012-12-31 Premananda Das Herbal composition for treatment of filariasis
CN103554188B (en) * 2013-11-19 2016-03-02 辽宁大学 6-(nitrogen heterocyclic replacement) anthraquinone platinum dichloride title complex and its preparation method and application
EP3564205A1 (en) 2018-04-30 2019-11-06 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Diels-alder ring-opening process
CN112441925B (en) * 2020-11-13 2022-04-01 宁波大学 Anthraquinone compound and preparation method thereof from ranunculus spinosus
CN114736110B (en) * 2022-05-10 2023-07-14 云南中烟工业有限责任公司 Anthraquinone compound, preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5024305B2 (en) * 1972-01-31 1975-08-14
FR2496097A1 (en) * 1980-12-16 1982-06-18 Ugine Kuhlmann PROCESS FOR THE PREPARATION OF ANTHRAQUINONE AND ITS SUBSTITUTED DERIVATIVES
JPS61100543A (en) 1984-10-22 1986-05-19 Nippon Shokubai Kagaku Kogyo Co Ltd Production of anthraquinone
DE3934934A1 (en) * 1989-10-20 1991-04-25 Basf Ag METHOD FOR PRODUCING HYDROXYANTHRACHINONES
JP3524424B2 (en) * 1999-04-01 2004-05-10 キヤノン株式会社 Mold or mold master for microstructure array, and method of manufacturing the same
US6800615B2 (en) * 2002-04-15 2004-10-05 Board Of Trustees Of Michigan State University Antihelminthic anthraquinones and method of use thereof

Also Published As

Publication number Publication date
WO2005113478A9 (en) 2009-02-05
WO2005113478A2 (en) 2005-12-01
EP1745000A4 (en) 2010-05-26
US20050267307A1 (en) 2005-12-01
WO2005113478A3 (en) 2008-12-18
US7658937B2 (en) 2010-02-09
EP1745000A2 (en) 2007-01-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6 ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.