BRPI0503201B8 - stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis - Google Patents
stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióisInfo
- Publication number
- BRPI0503201B8 BRPI0503201B8 BRPI0503201A BRPI0503201A BRPI0503201B8 BR PI0503201 B8 BRPI0503201 B8 BR PI0503201B8 BR PI0503201 A BRPI0503201 A BR PI0503201A BR PI0503201 A BRPI0503201 A BR PI0503201A BR PI0503201 B8 BRPI0503201 B8 BR PI0503201B8
- Authority
- BR
- Brazil
- Prior art keywords
- poly
- nitrosothiols
- stents
- nitric oxide
- hydrophilic polymers
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 6
- 229920001477 hydrophilic polymer Polymers 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- -1 poly(vinyl alcohol) Polymers 0.000 abstract 18
- 238000000034 method Methods 0.000 abstract 4
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 4
- 238000000576 coating method Methods 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 2
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000007887 coronary angioplasty Methods 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/114—Nitric oxide, i.e. NO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
Abstract
"stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis". a presente invenção se refere a um dispositivo para implante intracoronário, introduzindo novos stents eluidores de s-nitrosotióis revestidos com multicamadas de polímeros hidrofílicos, utilizado em procedimentos médicos e se refere aos processos de revestimento de stents com polímeros hidrofílicos contendo s-nitrosotióis incorporados. os stents revestidos com polímeros hidrofílicos contendo s-nitrosotióis são capazes de liberar localmente tanto o óxido nítrico como os próprios s-nitrosotióis, por difusão para aplicações em angioplastia coronária, com o objetivo de inibir a reestenose aguda e crônica. os polímeros hidrofílicos utilizados nos revestimentos são poli (álcool vinílico), poli(vinil pirrolidona) blendas de poli(álcool vinílico)/poli(vinil pirrolidona), poli(álcool vinílico)/poli(etileno glicol), poli(vinil pirrolidona)/poli(etileno glicol) e poli(álcool vinílico)/poli(vinil pirrolidona)/poli(etileno glicol). os processos de revestimento incluem processos de imersão dos stents nas soluções poliméricas contendo os s-nitrosotióis e processos de nebulização das soluções poliméricas contendo os s-nitrosotióis sobre a superfície dos stents.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0503201A BRPI0503201B8 (pt) | 2005-07-28 | 2005-07-28 | stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis |
US11/997,087 US20100112033A1 (en) | 2005-07-28 | 2006-04-19 | Stents coated with no- and s-nitrosothiol-eluting hydrophlic polymeric blends |
PCT/BR2006/000073 WO2007012165A1 (en) | 2005-07-28 | 2006-04-19 | Stents coated with no- and s-nitrosothiol-eluting hydrophilic polymeric blends |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0503201A BRPI0503201B8 (pt) | 2005-07-28 | 2005-07-28 | stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0503201A BRPI0503201A (pt) | 2007-03-13 |
BRPI0503201B1 BRPI0503201B1 (pt) | 2020-12-22 |
BRPI0503201B8 true BRPI0503201B8 (pt) | 2021-05-25 |
Family
ID=37682944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0503201A BRPI0503201B8 (pt) | 2005-07-28 | 2005-07-28 | stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis |
Country Status (3)
Country | Link |
---|---|
US (1) | US20100112033A1 (pt) |
BR (1) | BRPI0503201B8 (pt) |
WO (1) | WO2007012165A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2912259C (en) | 2005-05-27 | 2020-04-28 | Mark H. Schoenfisch | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
CA2599082A1 (en) * | 2007-08-27 | 2009-02-27 | Ping I. Lee | Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds |
CA2671595A1 (en) * | 2009-07-09 | 2011-01-09 | Ping I. Lee | Controlled nitric oxide delivery from aqueous s-nitrosothiol conjugated polymers and their complexes |
US9526738B2 (en) | 2009-08-21 | 2016-12-27 | Novan, Inc. | Topical gels and methods of using the same |
DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
EP2681286B1 (en) | 2011-02-28 | 2018-08-15 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
US20130018448A1 (en) * | 2011-07-12 | 2013-01-17 | Boston Scientific Scimed, Inc. | Drug elution medical device |
EP3673928B1 (en) * | 2013-02-07 | 2021-06-30 | The Regents Of The University Of Michigan | Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability |
WO2018136845A1 (en) | 2017-01-21 | 2018-07-26 | Biocrede Inc. | Medical products and methods configured for controlled release of nitrous oxide |
CN115089773A (zh) * | 2022-07-19 | 2022-09-23 | 中国科学院长春应用化学研究所 | 一种血管支架仿生涂层和血管支架及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221425B1 (en) * | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
BRPI0004238B8 (pt) * | 2000-09-06 | 2021-05-25 | Univ Estadual Campinas Unicamp | formulações de s-nitrosotióis doadores de óxido nítrico incorporados em matrizes de poli (etileno glicol)/etileno glicol, e metodologia para incorporação de s-nitrosotióis em matrizes de poli (etileno glicol)/etileno glicol |
US6706274B2 (en) * | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
BR0201168B1 (pt) * | 2002-03-26 | 2011-10-04 | formulações de s-nitrosotióis doadores de óxido nìtrico incorporados em géis aquosos térmicamente reversìveis de copolìmero tribloco de poli(óxido de etileno) - poli(óxido de propileno) - poli(óxido de etileno) e metodologia de incorporação de s-nitrosotióis em matrizes de géis aquosos de copolìmero tribloco de poli(óxido de etileno) - poli(óxido de propileno) - poli(óxido de etileno). | |
BR0201167A (pt) * | 2002-03-26 | 2003-11-18 | Unicamp | Filmes poliméricos sólidos de poli(álcool vinìlico) e poli(álcool vinìlico) - poli (vinil pirrolidona), contendo s-nitrosotióis doadores de óxido nìtrico, bem como os métodos para sua preparação |
WO2005018697A2 (en) * | 2003-08-13 | 2005-03-03 | Medtronic, Inc. | Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods |
US7229471B2 (en) * | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
-
2005
- 2005-07-28 BR BRPI0503201A patent/BRPI0503201B8/pt active IP Right Grant
-
2006
- 2006-04-19 US US11/997,087 patent/US20100112033A1/en not_active Abandoned
- 2006-04-19 WO PCT/BR2006/000073 patent/WO2007012165A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
BRPI0503201B1 (pt) | 2020-12-22 |
WO2007012165A1 (en) | 2007-02-01 |
BRPI0503201A (pt) | 2007-03-13 |
US20100112033A1 (en) | 2010-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10314912B2 (en) | Polymer coating compositions and coated products | |
BRPI0503201B8 (pt) | stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis | |
DE602004012597D1 (de) | Beschichtungen für implantierbare vorrichtungen enthaltend blockcopolymeren aus milchsäure und ethylenglykol | |
WO2007111925A3 (en) | Zotarolimus-containing drug delivery systems for implantation into a body lumen of a subject | |
ES2692150T3 (es) | Revestimiento para sustrato | |
ES2526806T3 (es) | Recubrimientos de estents que comprenden aditivos hidrófilos | |
DK1937328T3 (da) | Polymercoating til medicinske indretninger | |
EP1832301A3 (en) | Coatings for implantable medical devices | |
DK1957130T3 (da) | Hydrofilt overtræk omfattende en polyelektrolyt | |
ATE467650T1 (de) | Biologisch aktive blockcopolymere und damit beschichtete artikel | |
WO2009014696A3 (en) | Medical devices with coatings for delivery of a therapeutic agent | |
WO2007046935A3 (en) | Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices | |
WO2008144130A3 (en) | Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties | |
ATE491481T1 (de) | Schicht für kontrollierte freigabe eines therapeutischen wirkstoffes | |
WO2007126768A3 (en) | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents | |
WO2008063319A3 (en) | Methods of administering rapamycin analogs with anti-inflammatories using medical devices | |
WO2007084361A3 (en) | Coated medical devices and methods of making the same | |
US10729820B2 (en) | Methods and processes for application of drug delivery polymeric coatings | |
WO2007032777A3 (en) | Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy | |
DE602006012437D1 (de) | Dreiarmige biologisch aktive Copolymere und beschichtete implantierbare Artikel | |
WO2006017245A3 (en) | Sulfonated styrene polymers for medical articles | |
Domingues et al. | Future directions for ureteral stent technology: from bench to the market | |
Yao et al. | Asymmetric wettable, waterproof, and breathable nanofibrous membranes for wound dressings | |
US20240277906A1 (en) | Lubricious coatings for medical devices with enhanced durability | |
EP4382144A1 (en) | Drug-eluting medical device and production method therefor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B15K | Others concerning applications: alteration of classification |
Ipc: A61L 27/54 (2010.01), A61F 2/82 (2010.01) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Ipc: A61L 27/54 (2006.01), A61F 2/82 (2013.01) |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/07/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |