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BRPI0413413A - feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada - Google Patents

feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada

Info

Publication number
BRPI0413413A
BRPI0413413A BRPI0413413-3A BRPI0413413A BRPI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A
Authority
BR
Brazil
Prior art keywords
piperidine
improved
vivo efficacy
antimicrobial activity
derivatives
Prior art date
Application number
BRPI0413413-3A
Other languages
English (en)
Inventor
Prasad Keshav Deshpande
Sachin Subhash Bhagwat
Milind Chintaman Shukla
Noel John De Souza
Mahesh Vithalbhai Patel
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of BRPI0413413A publication Critical patent/BRPI0413413A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"FENILOXAZOLIDINONAS DE PIPERIDINO SUBSTITUìDO TENDO ATIVIDADE ANTIMICROBIANA COM EFICáCIA IN VIVO MELHORADA". A presente invenção fornece agentes tendo atividade antimicrobiana para prevenir e tratar doenças infecciosas. Desse modo, a presente invenção fornece novos derivados de feniloxazolidinona de piperidino substituído, processos para preparar compostos, bem como composições antimicrobianas contendo os referidos derivados como ingredientes ativos e métodos de tratar infecções bacterianas com os referidos derivados.
BRPI0413413-3A 2003-09-08 2004-09-08 feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada BRPI0413413A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN924MU2003 2003-09-08
PCT/IN2004/000276 WO2005054234A2 (en) 2003-09-08 2004-09-08 Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy

Publications (1)

Publication Number Publication Date
BRPI0413413A true BRPI0413413A (pt) 2007-01-09

Family

ID=34640331

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413413-3A BRPI0413413A (pt) 2003-09-08 2004-09-08 feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada

Country Status (8)

Country Link
US (2) US7687627B2 (pt)
EP (1) EP1664038A2 (pt)
JP (1) JP4917432B2 (pt)
AU (1) AU2004295208A1 (pt)
BR (1) BRPI0413413A (pt)
CA (1) CA2537559C (pt)
EA (1) EA200600374A1 (pt)
WO (1) WO2005054234A2 (pt)

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US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
WO2007004049A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinones containing azetidine as antibacterial agents
RU2008148319A (ru) * 2006-05-09 2010-06-20 Вокхардт Лтд (In) Замещенные пиперидинофенилоксазолидиноны
EP2069339B1 (en) * 2006-09-25 2011-05-18 Wockhardt Research Centre Substituted piperidinophenyl oxazolidinones
WO2009037542A2 (en) * 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Spirocyclic compounds as stearoyl coa desaturase inhibitors
EP2072513A1 (en) * 2007-12-17 2009-06-24 Ferrer Internacional, S.A. A cyano piperidinyl-phenil-oxazolidinone and use thereof
CA2712613C (en) 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
EP2141161A1 (en) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-cyanopyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
JP5738268B2 (ja) * 2009-03-27 2015-06-24 カウンシル・オヴ・サイエンティフィック・アンド・インダストリアル・リサーチ 殺真菌薬として有用な置換１，４−ジオキサ−８−アザスピロ［４，５］デカン類およびその調製方法
KR20130102614A (ko) * 2010-11-03 2013-09-17 욱크하르트 리미티드 인산 모노-(1-[4-[(s)-5-(아세틸아미노메틸)-2-옥소-옥사졸리딘-3-일]-2,6-디플루오로페닐]-4-메톡시메틸피페리딘-4-일) 에스테르의 제조 방법
JP5796134B2 (ja) 2011-09-29 2015-10-21 山東軒竹医薬科技有限公司 ビアリールヘテロ環で置換されたオキサゾリドン抗菌薬
WO2015066413A1 (en) * 2013-11-01 2015-05-07 Novartis Ag Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
BR112020005370A2 (pt) * 2017-10-27 2020-09-24 Huntsman International Llc método para a produção de compostos de oxazolidinona, e, uso de compostos.
US12109203B2 (en) * 2018-07-25 2024-10-08 Zydus Lifesciences Limited Substituted oxazolidinones for the treatment of mammalian infections
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

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US3344145A (en) * 1963-10-21 1967-09-26 Geschickter Fund Med Res N-substituted phenoxyalkyl or phenylthioalkyl-mono azaspiroalkanes
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
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NZ293741A (en) * 1994-10-26 1998-06-26 Upjohn Co 3-[4-(azetidin-1-yl or pyrrolidin-1-yl)phenyl]-5-aminomethyloxazolidin-2-one amide derivatives
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GB9821938D0 (en) * 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
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JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
BR0012742A (pt) * 1999-07-28 2002-06-11 Upjohn Co Oxazolidinonas e seus usos como antibiótico
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AU2002360238B2 (en) * 2001-04-17 2007-11-15 Kyorin Pharmaceutical Co., Ltd. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7405228B2 (en) * 2002-07-11 2008-07-29 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites
AU2003274676A1 (en) * 2002-07-11 2004-02-02 Yati Chugh Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
AU2003272071A1 (en) * 2002-07-11 2004-02-02 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
KR100490643B1 (ko) * 2002-10-29 2005-05-19 한국과학기술연구원 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
RU2008148319A (ru) * 2006-05-09 2010-06-20 Вокхардт Лтд (In) Замещенные пиперидинофенилоксазолидиноны

Also Published As

Publication number Publication date
US20100144735A1 (en) 2010-06-10
AU2004295208A1 (en) 2005-06-16
WO2005054234A8 (en) 2006-11-23
WO2005054234A3 (en) 2005-09-29
CA2537559C (en) 2012-11-20
US8729269B2 (en) 2014-05-20
EA200600374A1 (ru) 2006-08-25
CA2537559A1 (en) 2005-06-16
EP1664038A2 (en) 2006-06-07
US7687627B2 (en) 2010-03-30
WO2005054234A2 (en) 2005-06-16
JP4917432B2 (ja) 2012-04-18
US20050143421A1 (en) 2005-06-30
JP2007505102A (ja) 2007-03-08

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 3A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.