BRPI0211899B8 - processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona - Google Patents
processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfonaInfo
- Publication number
- BRPI0211899B8 BRPI0211899B8 BRPI0211899A BR0211899A BRPI0211899B8 BR PI0211899 B8 BRPI0211899 B8 BR PI0211899B8 BR PI0211899 A BRPI0211899 A BR PI0211899A BR 0211899 A BR0211899 A BR 0211899A BR PI0211899 B8 BRPI0211899 B8 BR PI0211899B8
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- noroxymorphone
- production
- hydroxynormorphinone
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01203187.8 | 2001-08-23 | ||
EP01203187 | 2001-08-23 | ||
PCT/EP2002/009280 WO2003018588A2 (en) | 2001-08-23 | 2002-08-15 | Process for the preparation of a 14-hydroxynormorphinone derivative |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0211899A BR0211899A (pt) | 2004-09-21 |
BR0211899B1 BR0211899B1 (pt) | 2014-01-21 |
BRPI0211899B8 true BRPI0211899B8 (pt) | 2021-05-25 |
Family
ID=8180821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0211899A BRPI0211899B8 (pt) | 2001-08-23 | 2002-08-15 | processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona |
Country Status (26)
Country | Link |
---|---|
US (1) | US7435817B2 (pt) |
EP (1) | EP1421085B1 (pt) |
JP (1) | JP4559730B2 (pt) |
KR (1) | KR100901402B1 (pt) |
CN (1) | CN1271072C (pt) |
AR (1) | AR035289A1 (pt) |
AT (1) | ATE466016T1 (pt) |
AU (1) | AU2002331163B2 (pt) |
BR (1) | BRPI0211899B8 (pt) |
CA (1) | CA2457671C (pt) |
DE (1) | DE60236171D1 (pt) |
EC (1) | ECSP044984A (pt) |
ES (1) | ES2345327T3 (pt) |
HK (1) | HK1063803A1 (pt) |
HR (1) | HRP20040161A2 (pt) |
HU (1) | HUP0401600A3 (pt) |
IL (1) | IL160193A0 (pt) |
IS (1) | IS7153A (pt) |
MX (1) | MXPA04001647A (pt) |
NO (1) | NO328655B1 (pt) |
NZ (1) | NZ531152A (pt) |
PE (1) | PE20030460A1 (pt) |
PL (1) | PL368732A1 (pt) |
RU (1) | RU2297419C2 (pt) |
WO (1) | WO2003018588A2 (pt) |
ZA (1) | ZA200401016B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8067597B2 (en) | 2005-06-16 | 2011-11-29 | Mallinckrodt Llc | Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
WO2008118654A1 (en) * | 2007-03-23 | 2008-10-02 | Mallinckrodt Inc. | Improved preparation of oxymorphone from oripavine |
CN101033228B (zh) * | 2007-04-04 | 2010-05-19 | 复旦大学 | 14-羟基-7,8-二氢降吗啡酮的制备方法 |
MX2009010931A (es) | 2007-04-16 | 2009-10-29 | Mallinckrodt Inc | Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno. |
WO2009078988A1 (en) * | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | Sinomenine derivatives and processes for their synthesis |
WO2009078990A1 (en) | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | N-demethylation of n-methyl morphinans |
US8252808B2 (en) * | 2007-12-17 | 2012-08-28 | Mallinckrodt Llc | Process and compounds for the production of (+)opiates |
WO2011141488A2 (en) | 2010-05-10 | 2011-11-17 | Euro-Celtique S.A. | Pharmaceutical compositions comprising hydromorphone and naloxone |
EP2568968B1 (en) | 2010-05-10 | 2017-07-12 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
US9901540B2 (en) | 2010-05-10 | 2018-02-27 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
ES2645725T3 (es) | 2010-06-11 | 2017-12-07 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
AU2011263416B2 (en) | 2010-06-11 | 2014-04-10 | Rhodes Technologies | Process for N-dealkylation of tertiary amines |
WO2013036729A1 (en) | 2011-09-08 | 2013-03-14 | Mallinckrodt Llc | Production of alkaloids without the isolation of intermediates |
CN105452253A (zh) * | 2013-08-02 | 2016-03-30 | 庄信万丰股份有限公司 | 用于制备氢羟吗啡酮的方法 |
KR20160060768A (ko) | 2013-11-13 | 2016-05-30 | 유로-셀티큐 에스.에이. | 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2562072B1 (fr) | 1984-03-27 | 1989-07-07 | Mallinckrodt Inc | Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede |
US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
WO2000066588A1 (en) | 1999-05-05 | 2000-11-09 | The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services | Direct c-14 oxidation of opioids |
-
2002
- 2002-08-15 ES ES02767405T patent/ES2345327T3/es not_active Expired - Lifetime
- 2002-08-15 WO PCT/EP2002/009280 patent/WO2003018588A2/en active IP Right Grant
- 2002-08-15 US US10/487,884 patent/US7435817B2/en not_active Expired - Lifetime
- 2002-08-15 EP EP02767405A patent/EP1421085B1/en not_active Expired - Lifetime
- 2002-08-15 PL PL02368732A patent/PL368732A1/xx not_active Application Discontinuation
- 2002-08-15 KR KR1020047002513A patent/KR100901402B1/ko not_active IP Right Cessation
- 2002-08-15 MX MXPA04001647A patent/MXPA04001647A/es active IP Right Grant
- 2002-08-15 AT AT02767405T patent/ATE466016T1/de active
- 2002-08-15 IL IL16019302A patent/IL160193A0/xx unknown
- 2002-08-15 DE DE60236171T patent/DE60236171D1/de not_active Expired - Lifetime
- 2002-08-15 JP JP2003523248A patent/JP4559730B2/ja not_active Expired - Lifetime
- 2002-08-15 CA CA2457671A patent/CA2457671C/en not_active Expired - Lifetime
- 2002-08-15 CN CNB028163524A patent/CN1271072C/zh not_active Expired - Lifetime
- 2002-08-15 NZ NZ531152A patent/NZ531152A/en not_active IP Right Cessation
- 2002-08-15 HU HU0401600A patent/HUP0401600A3/hu unknown
- 2002-08-15 BR BRPI0211899A patent/BRPI0211899B8/pt not_active IP Right Cessation
- 2002-08-15 AU AU2002331163A patent/AU2002331163B2/en not_active Expired
- 2002-08-15 RU RU2004108210/04A patent/RU2297419C2/ru active
- 2002-08-21 AR ARP020103130A patent/AR035289A1/es active IP Right Grant
- 2002-08-21 PE PE2002000800A patent/PE20030460A1/es not_active Application Discontinuation
-
2004
- 2004-02-06 ZA ZA200401016A patent/ZA200401016B/en unknown
- 2004-02-13 IS IS7153A patent/IS7153A/is unknown
- 2004-02-19 EC EC2004004984A patent/ECSP044984A/es unknown
- 2004-02-19 NO NO20040724A patent/NO328655B1/no not_active IP Right Cessation
- 2004-02-19 HR HR20040161A patent/HRP20040161A2/xx not_active Application Discontinuation
- 2004-09-06 HK HK04106705.9A patent/HK1063803A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INTE.CL: C07D 489/08 Ipc: C07D 489/08 (2011.01), A61P 29/00 (2011.01) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: MSD OSS B.V. (NL) |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/01/2014, OBSERVADAS AS CONDICOES LEGAIS. |
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B25A | Requested transfer of rights approved | ||
B25A | Requested transfer of rights approved | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/08/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B15V | Prolongation of time limit allowed | ||
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 15/08/2022 |