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BRPI0211899B8 - processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona - Google Patents

processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona

Info

Publication number
BRPI0211899B8
BRPI0211899B8 BRPI0211899A BR0211899A BRPI0211899B8 BR PI0211899 B8 BRPI0211899 B8 BR PI0211899B8 BR PI0211899 A BRPI0211899 A BR PI0211899A BR 0211899 A BR0211899 A BR 0211899A BR PI0211899 B8 BRPI0211899 B8 BR PI0211899B8
Authority
BR
Brazil
Prior art keywords
preparation
noroxymorphone
production
hydroxynormorphinone
derivative
Prior art date
Application number
BRPI0211899A
Other languages
English (en)
Other versions
BR0211899A (pt
BR0211899B1 (pt
Inventor
Theodorus Maria Linders Joannes
Vrijhof Pieter
Original Assignee
Akzo Nobel Nv
Merck Sharp & Dohme
Msd Oss Bv
N V Organon
Organon Biosciences Nederland B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Merck Sharp & Dohme, Msd Oss Bv, N V Organon, Organon Biosciences Nederland B V filed Critical Akzo Nobel Nv
Publication of BR0211899A publication Critical patent/BR0211899A/pt
Publication of BR0211899B1 publication Critical patent/BR0211899B1/pt
Publication of BRPI0211899B8 publication Critical patent/BRPI0211899B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

"processo para a preparação de um derivado de 14-hidroxinormorfinona, derivados de 14-hidroxinormorfinona e de morfinona, processo para a preparação de um composto, derivado de morfina, e, processo para a produção de noroximorfona". a presente invenção refere-se a processo para a preparação de um derivado de 14-hidroxinormorfinona de fórmula iv compreendendo reagir o composto de fórmula iii com um oxidante de cobalto (ii) na presença de uma base suave e ar ou oxigênio como o co-oxidante; em que r~ 1~ é alquila (1c-7c) opcionalmente substituída com um ou mais dentre cloros, butenila, vinila, benzila, fenila ou naftila; e r~ 2~ é benzila ou benzila substituída com um ou mais dentre grupo alcóxi (1c-6c) ou benzila substituído com um ou mais halogênio. o processo é muito apropriado na produção de noroximorfona.
BRPI0211899A 2001-08-23 2002-08-15 processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona BRPI0211899B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203187.8 2001-08-23
EP01203187 2001-08-23
PCT/EP2002/009280 WO2003018588A2 (en) 2001-08-23 2002-08-15 Process for the preparation of a 14-hydroxynormorphinone derivative

Publications (3)

Publication Number Publication Date
BR0211899A BR0211899A (pt) 2004-09-21
BR0211899B1 BR0211899B1 (pt) 2014-01-21
BRPI0211899B8 true BRPI0211899B8 (pt) 2021-05-25

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0211899A BRPI0211899B8 (pt) 2001-08-23 2002-08-15 processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona

Country Status (26)

Country Link
US (1) US7435817B2 (pt)
EP (1) EP1421085B1 (pt)
JP (1) JP4559730B2 (pt)
KR (1) KR100901402B1 (pt)
CN (1) CN1271072C (pt)
AR (1) AR035289A1 (pt)
AT (1) ATE466016T1 (pt)
AU (1) AU2002331163B2 (pt)
BR (1) BRPI0211899B8 (pt)
CA (1) CA2457671C (pt)
DE (1) DE60236171D1 (pt)
EC (1) ECSP044984A (pt)
ES (1) ES2345327T3 (pt)
HK (1) HK1063803A1 (pt)
HR (1) HRP20040161A2 (pt)
HU (1) HUP0401600A3 (pt)
IL (1) IL160193A0 (pt)
IS (1) IS7153A (pt)
MX (1) MXPA04001647A (pt)
NO (1) NO328655B1 (pt)
NZ (1) NZ531152A (pt)
PE (1) PE20030460A1 (pt)
PL (1) PL368732A1 (pt)
RU (1) RU2297419C2 (pt)
WO (1) WO2003018588A2 (pt)
ZA (1) ZA200401016B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067597B2 (en) 2005-06-16 2011-11-29 Mallinckrodt Llc Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
WO2008118654A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
MX2009010931A (es) 2007-04-16 2009-10-29 Mallinckrodt Inc Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
WO2009078988A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Sinomenine derivatives and processes for their synthesis
WO2009078990A1 (en) 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of n-methyl morphinans
US8252808B2 (en) * 2007-12-17 2012-08-28 Mallinckrodt Llc Process and compounds for the production of (+)opiates
WO2011141488A2 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
EP2568968B1 (en) 2010-05-10 2017-07-12 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
US9901540B2 (en) 2010-05-10 2018-02-27 Euro-Celtique S.A. Combination of active loaded granules with additional actives
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
WO2013036729A1 (en) 2011-09-08 2013-03-14 Mallinckrodt Llc Production of alkaloids without the isolation of intermediates
CN105452253A (zh) * 2013-08-02 2016-03-30 庄信万丰股份有限公司 用于制备氢羟吗啡酮的方法
KR20160060768A (ko) 2013-11-13 2016-05-30 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2562072B1 (fr) 1984-03-27 1989-07-07 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
WO2000066588A1 (en) 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
BR0211899A (pt) 2004-09-21
KR100901402B1 (ko) 2009-06-05
MXPA04001647A (es) 2004-05-31
NO20040724L (no) 2004-02-19
KR20040027950A (ko) 2004-04-01
CN1545517A (zh) 2004-11-10
US20050038250A1 (en) 2005-02-17
BR0211899B1 (pt) 2014-01-21
PE20030460A1 (es) 2003-05-15
WO2003018588A2 (en) 2003-03-06
ZA200401016B (en) 2004-10-19
ATE466016T1 (de) 2010-05-15
CN1271072C (zh) 2006-08-23
JP4559730B2 (ja) 2010-10-13
US7435817B2 (en) 2008-10-14
AR035289A1 (es) 2004-05-05
RU2004108210A (ru) 2005-04-10
HUP0401600A3 (en) 2008-05-28
PL368732A1 (en) 2005-04-04
RU2297419C2 (ru) 2007-04-20
DE60236171D1 (de) 2010-06-10
EP1421085A2 (en) 2004-05-26
ECSP044984A (es) 2004-04-28
NO328655B1 (no) 2010-04-19
WO2003018588B1 (en) 2004-02-26
ES2345327T3 (es) 2010-09-21
CA2457671A1 (en) 2003-03-06
IL160193A0 (en) 2004-07-25
WO2003018588A3 (en) 2003-11-27
CA2457671C (en) 2011-02-15
NZ531152A (en) 2005-11-25
EP1421085B1 (en) 2010-04-28
HK1063803A1 (en) 2005-01-14
AU2002331163B2 (en) 2008-02-21
HUP0401600A2 (hu) 2004-11-29
JP2005502670A (ja) 2005-01-27
HRP20040161A2 (en) 2004-06-30
IS7153A (is) 2004-02-13

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INTE.CL: C07D 489/08

Ipc: C07D 489/08 (2011.01), A61P 29/00 (2011.01)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: MSD OSS B.V. (NL)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/01/2014, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved
B25A Requested transfer of rights approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/08/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B15V Prolongation of time limit allowed
B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 15/08/2022