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BR9814656A - Composições farmacêuticas na forma de pós, e, processo para a preparação das composições farmacêuticas - Google Patents

Composições farmacêuticas na forma de pós, e, processo para a preparação das composições farmacêuticas

Info

Publication number
BR9814656A
BR9814656A BR9814656-4A BR9814656A BR9814656A BR 9814656 A BR9814656 A BR 9814656A BR 9814656 A BR9814656 A BR 9814656A BR 9814656 A BR9814656 A BR 9814656A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
drug
polymer
preparation
supercritical fluid
Prior art date
Application number
BR9814656-4A
Other languages
English (en)
Inventor
Fabio Carli
Italo Colombo
Paolo Alessi
Ireneo Kikic
Angelo Cortesi
Original Assignee
Eurand Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Int filed Critical Eurand Int
Publication of BR9814656A publication Critical patent/BR9814656A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DAS COMPOSIçõES FARMACêUTICAS, E, COMPOSIçãO FARMACêUTICA". Composições farmacêuticas em forma de pó são preparadas através do carregamento das drogas solubilizadas em fluidos supercríticos sobre polímeros reticulados. O processo de carga é executado por meio de duas etapas. Na primeira etapa o fluido supercrítico é saturado com a droga em condições adequadas de temperatura e pressão. Na segunda etapa o fluido supercrítico contendo a droga é contatado com o polímero reticulado. Devido a suas propriedades particulares o fluido supercrítico penetra no polímero e permite a droga impregnar o polímero propriamente dito. Após a remoção do fluido a droga permanece no polímero propriamente dito.
BR9814656-4A 1997-11-19 1998-11-16 Composições farmacêuticas na forma de pós, e, processo para a preparação das composições farmacêuticas BR9814656A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI002571A IT1296464B1 (it) 1997-11-19 1997-11-19 Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
PCT/EP1998/007311 WO1999025322A2 (en) 1997-11-19 1998-11-16 Pharmaceutical compositions having the shape of powders of cross-linked polymers loaded with drugs and related preparation process by supercritical fluids

Publications (1)

Publication Number Publication Date
BR9814656A true BR9814656A (pt) 2000-10-03

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814656-4A BR9814656A (pt) 1997-11-19 1998-11-16 Composições farmacêuticas na forma de pós, e, processo para a preparação das composições farmacêuticas

Country Status (9)

Country Link
EP (1) EP1033977A2 (pt)
JP (1) JP2001522873A (pt)
KR (1) KR20010032251A (pt)
AU (1) AU738748B2 (pt)
BR (1) BR9814656A (pt)
CA (1) CA2310423A1 (pt)
IT (1) IT1296464B1 (pt)
NZ (1) NZ505290A (pt)
WO (1) WO1999025322A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
AU2001240515A1 (en) * 2000-01-17 2001-07-31 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Method for modifying the surfaces of fine-porous adsorbents
IT1318404B1 (it) * 2000-03-17 2003-08-25 Eurand Int Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi.
EP1258241A1 (en) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Method of increasing the bioavailability of nimesulide
DE10296849T5 (de) 2001-05-30 2004-04-29 Csir Corporate Building Scientia Verfahren zur Einkapselung eines Wirkstoffes
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (de) * 2001-07-04 2003-01-30 Degussa Verfahren zur physikalischen Behandlung von Stärke(-Derivaten)
FR2830760B1 (fr) 2001-10-12 2004-06-04 Pf Medicament Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
WO2003074028A1 (en) * 2002-03-07 2003-09-12 Eurand Pharmaceuticals Ltd. Process for loading and thermodynamically activating drugs on polymers by means of supercritical fluids
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
FR2854079B1 (fr) 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (en) 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
CA2626802A1 (en) * 2005-11-09 2007-09-20 Novartis Ag Process for making pharmaceutical compositions with a transient plasticizer
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (fr) * 2009-05-15 2012-10-05 Pf Medicament Procede d'impregnation par co2 supercritique
CN105687141A (zh) * 2016-03-04 2016-06-22 中国药科大学 超临界抗溶剂法制备尼美舒利-左旋聚乳酸(Nim-PLLA)复合微球的工艺研究
CN112812355B (zh) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 一种具有缓释挥发性中草药有效成分的功能高分子发泡材料、制备方法和用途
CN113425895A (zh) * 2021-07-12 2021-09-24 大连大学 一种载药骨修复内固定材料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
FR2635043B1 (fr) * 1988-08-05 1990-09-28 Michelin & Cie Appareil de fabrication d'un renforcement pour pneumatiques, ledit renforcement etant constitue a partir d'un seul fil
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
IT1252867B (it) * 1991-12-31 1995-06-28 Gentili Ist Spa Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita'
DE4202320A1 (de) * 1992-01-29 1993-08-05 Dierk Dr Knittel Verfahren zum impraegnieren von substraten
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Also Published As

Publication number Publication date
AU738748B2 (en) 2001-09-27
IT1296464B1 (it) 1999-06-25
CA2310423A1 (en) 1999-05-27
ITMI972571A1 (it) 1999-05-19
WO1999025322A3 (en) 1999-08-19
EP1033977A2 (en) 2000-09-13
WO1999025322A2 (en) 1999-05-27
KR20010032251A (ko) 2001-04-16
NZ505290A (en) 2002-08-28
AU2153199A (en) 1999-06-07
JP2001522873A (ja) 2001-11-20

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1912 DE 28/08/2007.