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BR9812229A - Processo para a purificação de antitrombina iii - Google Patents

Processo para a purificação de antitrombina iii

Info

Publication number
BR9812229A
BR9812229A BR9812229-0A BR9812229A BR9812229A BR 9812229 A BR9812229 A BR 9812229A BR 9812229 A BR9812229 A BR 9812229A BR 9812229 A BR9812229 A BR 9812229A
Authority
BR
Brazil
Prior art keywords
iii
purification
antithrombin iii
complex
antithrombin
Prior art date
Application number
BR9812229-0A
Other languages
English (en)
Inventor
Yendra Linnau
Ernst Hetzl
H Peter Matthiessen
Silvia Neppl
Wolfgang Sch Nhofer
Hans-Peter Schwarz
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Publication of BR9812229A publication Critical patent/BR9812229A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA A PURIFICAçãO DE ANTITROMBINA III". Descreve-se um processo para a purificação de antitrombina III a partir de um material inicial contendo um complexo AT III/heparina ou AT III/heparinóide, caracterizado pelo fato de que o complexo é adsorvido sobre um material trocador de ânions, com o que o complexo é clivado por meio de eluição de AT III.
BR9812229-0A 1997-09-19 1998-09-17 Processo para a purificação de antitrombina iii BR9812229A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0159497A AT405739B (de) 1997-09-19 1997-09-19 Verfahren zur reinigung von antithrombin iii
PCT/AT1998/000223 WO1999015562A1 (de) 1997-09-19 1998-09-17 Verfahren zur reinigung von antithrombin iii

Publications (1)

Publication Number Publication Date
BR9812229A true BR9812229A (pt) 2000-07-18

Family

ID=3516803

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812229-0A BR9812229A (pt) 1997-09-19 1998-09-17 Processo para a purificação de antitrombina iii

Country Status (11)

Country Link
US (1) US6395880B1 (pt)
EP (1) EP1015491A1 (pt)
JP (1) JP2001517679A (pt)
AT (1) AT405739B (pt)
AU (1) AU742861B2 (pt)
BR (1) BR9812229A (pt)
CA (1) CA2303924A1 (pt)
HU (1) HUP0003671A1 (pt)
NO (1) NO20001414L (pt)
SK (1) SK4012000A3 (pt)
WO (1) WO1999015562A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070123251A1 (en) * 1996-10-23 2007-05-31 Riparius Ventures, Llc Remote internet telephony device
EP3708581A3 (en) 2009-05-27 2021-10-20 Takeda Pharmaceutical Company Limited A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
IN2012DN03219A (pt) 2009-09-17 2015-10-23 Baxter Healthcare Sa
DE102016009442A1 (de) * 2016-08-03 2018-02-08 Fresenius Medical Care Deutschland Gmbh Verfahren zur Überwachung des Bicarbonat-Gehalts und des Natrium-Gehalts einer Dialyselösung
ES2906118T3 (es) 2016-12-22 2022-04-13 Km Biologics Co Ltd Método cromatográfico para recolectar factor VII de coagulación sanguínea con alto rendimiento
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392038B (sv) 1971-09-08 1977-03-14 Kabi Ab Forfarande for isolering av antitrombin ur blod eller blodprodukter
US4286056A (en) * 1980-01-28 1981-08-25 Baxter Travenol Laboratories, Inc. Method for making therapeutic enzyme compositions
AT379310B (de) * 1983-05-20 1985-12-27 Immuno Ag Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
AT389815B (de) 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
AT402891B (de) 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
US5319072A (en) * 1992-01-10 1994-06-07 Alpha Therapeutic Corporation Human antithrombin-III preparation
WO1994013329A1 (de) 1992-12-16 1994-06-23 Immuno Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
DE4434538C2 (de) 1993-10-06 2000-08-10 Immuno Ag Verfahren zur Virusinaktivierung in Gegenwart eines Polyethers und eines chaotropen Agens

Also Published As

Publication number Publication date
EP1015491A1 (de) 2000-07-05
JP2001517679A (ja) 2001-10-09
SK4012000A3 (en) 2000-10-09
NO20001414L (no) 2000-05-18
AT405739B (de) 1999-11-25
HUP0003671A1 (hu) 2001-02-28
ATA159497A (de) 1999-03-15
US6395880B1 (en) 2002-05-28
WO1999015562A1 (de) 1999-04-01
NO20001414D0 (no) 2000-03-17
AU742861B2 (en) 2002-01-17
CA2303924A1 (en) 1999-04-01
AU9244898A (en) 1999-04-12

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]