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BR9811747A - Inibidores de metaloproteinase de matriz à base de ácido malÈnico - Google Patents

Inibidores de metaloproteinase de matriz à base de ácido malÈnico

Info

Publication number
BR9811747A
BR9811747A BR9811747-5A BR9811747A BR9811747A BR 9811747 A BR9811747 A BR 9811747A BR 9811747 A BR9811747 A BR 9811747A BR 9811747 A BR9811747 A BR 9811747A
Authority
BR
Brazil
Prior art keywords
malonic acid
matrix metalloproteinase
metalloproteinase inhibitors
inhibitors based
inhibitors
Prior art date
Application number
BR9811747-5A
Other languages
English (en)
Inventor
Frank Grams
Luis Moroder
Erich Graf Von Roedern
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of BR9811747A publication Critical patent/BR9811747A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Patente de Invenção: <B>"INIBIDORES DE METALOPROTEINASE DE MATRIZ à BASE DE áCIDO MALÈNICO"<D>. A invenção refere-se a compostos os quais são representados pela fórmula geral (I) em que o significado dos substituintes é dado nas reivindicações, seu processo de produção e sua aplicação como inibidores de MMP.
BR9811747-5A 1997-09-01 1998-08-27 Inibidores de metaloproteinase de matriz à base de ácido malÈnico BR9811747A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97115086A EP0911319A1 (en) 1997-09-01 1997-09-01 Malonic acid based matrix metalloproteinase inhibitors
PCT/EP1998/005441 WO1999011608A1 (en) 1997-09-01 1998-08-27 Malonic acid based matrix metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
BR9811747A true BR9811747A (pt) 2000-09-26

Family

ID=8227298

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811747-5A BR9811747A (pt) 1997-09-01 1998-08-27 Inibidores de metaloproteinase de matriz à base de ácido malÈnico

Country Status (11)

Country Link
EP (2) EP0911319A1 (pt)
JP (1) JP2001514247A (pt)
KR (1) KR20010023299A (pt)
CN (1) CN1278245A (pt)
AR (1) AR020044A1 (pt)
AU (1) AU9739398A (pt)
BR (1) BR9811747A (pt)
CA (1) CA2302037A1 (pt)
TR (1) TR200000555T2 (pt)
WO (1) WO1999011608A1 (pt)
ZA (1) ZA987896B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004359546A (ja) * 2001-03-15 2004-12-24 Ono Pharmaceut Co Ltd ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および／または治療剤
JPWO2002074298A1 (ja) * 2001-03-21 2004-07-08 小野薬品工業株式会社 Ｉｌ−６産生阻害剤
AU2002256505B2 (en) 2001-05-11 2008-06-26 Eisai Inc. Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
WO2003082190A2 (en) 2002-03-26 2003-10-09 Merck & Co., Inc. Spirocyclic amides as cannabinoid receptor modulators
KR20190140654A (ko) * 2018-06-12 2019-12-20 주식회사 비알팜 Dna 단편 혼합물 및 매트릭스 메탈로프로테아제 생성 억제제를 포함하는 관절염 예방 및 치료용 조성물
CA3191078A1 (en) * 2020-08-25 2022-03-03 Christian Ducho Inhibitors of pseudomonas aeruginosa virulence factor lasb

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
JPH0539266A (ja) * 1990-12-26 1993-02-19 Yamanouchi Pharmaceut Co Ltd 新規なトリプトフアン誘導体
JPH06145143A (ja) * 1992-11-06 1994-05-24 Yamanouchi Pharmaceut Co Ltd 新規なトリプトファン誘導体
DK0796257T3 (da) * 1994-12-09 2000-03-20 Roche Diagnostics Gmbh Malonsyrebaserede matrixmetalloproteinase-inhibitorer

Also Published As

Publication number Publication date
AU9739398A (en) 1999-03-22
EP0911319A1 (en) 1999-04-28
KR20010023299A (ko) 2001-03-26
AR020044A1 (es) 2002-04-10
JP2001514247A (ja) 2001-09-11
WO1999011608A1 (en) 1999-03-11
CN1278245A (zh) 2000-12-27
EP1009736A1 (en) 2000-06-21
ZA987896B (en) 2000-02-28
TR200000555T2 (tr) 2000-11-21
CA2302037A1 (en) 1999-03-11

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.