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BR9811348A - Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas. - Google Patents

Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas.

Info

Publication number
BR9811348A
BR9811348A BR9811348-8A BR9811348A BR9811348A BR 9811348 A BR9811348 A BR 9811348A BR 9811348 A BR9811348 A BR 9811348A BR 9811348 A BR9811348 A BR 9811348A
Authority
BR
Brazil
Prior art keywords
preparing
indole
pharmaceutical compositions
compounds derived
compounds
Prior art date
Application number
BR9811348-8A
Other languages
English (en)
Inventor
Michel Perez
Serge Halazy
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR9811348A publication Critical patent/BR9811348A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"COMPOSTOS, PROCESSO PARA PREPARAçãO DOS MESMOS, E, COMPOSIçõES FARMACêUTICAS". A presente invenção refere-se a derivados inéditos de piperazinas indólicas de fórmula (I). A presente invenção também tem por objeto um processo de preparação destes compostos, bem como sua utilização como substâncias terapeuticamente ativas, principalmente para o tratamento ou a prevenção das doenças ligadas à disfunção dos receptores 5-HT~ 1-like~.
BR9811348-8A 1997-08-25 1998-08-20 Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas. BR9811348A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710606A FR2767527B1 (fr) 1997-08-25 1997-08-25 Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
PCT/FR1998/001826 WO1999010344A1 (fr) 1997-08-25 1998-08-20 Derives d'indole comme agonistes de 5-ht1b et 5-ht1d

Publications (1)

Publication Number Publication Date
BR9811348A true BR9811348A (pt) 2000-09-12

Family

ID=9510463

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811348-8A BR9811348A (pt) 1997-08-25 1998-08-20 Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas.

Country Status (11)

Country Link
US (2) US6277853B1 (pt)
EP (1) EP1007524B1 (pt)
JP (1) JP2001514180A (pt)
CN (1) CN1272108A (pt)
AT (1) ATE254122T1 (pt)
AU (1) AU736074B2 (pt)
BR (1) BR9811348A (pt)
CA (1) CA2301750A1 (pt)
DE (1) DE69819742D1 (pt)
FR (1) FR2767527B1 (pt)
WO (1) WO1999010344A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026811A1 (en) * 2003-05-20 2005-02-03 Mjalli Adnan M. M. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
ATE529110T1 (de) * 2002-03-05 2011-11-15 Transtech Pharma Inc Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
PT1988397E (pt) * 2002-12-19 2011-12-02 Scripps Research Inst Composições e utilizações para estabilização da transtirretina e inibição do enrolamento
AU2004210711B2 (en) * 2003-02-12 2010-07-08 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ，インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
AU2005244999A1 (en) * 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
CA2636929A1 (en) * 2005-12-21 2007-07-12 Decode Genetics, Ehf Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
AU2007211319B9 (en) * 2006-01-30 2012-05-31 Vtv Therapeutics Llc Substituted imidazole derivatives and their use as PTPase inhibitors
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
WO2011002067A1 (ja) * 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
US8580833B2 (en) 2009-09-30 2013-11-12 Transtech Pharma, Inc. Substituted imidazole derivatives and methods of use thereof
EP2755961A1 (en) 2011-09-16 2014-07-23 Pfizer Inc Solid forms of a transthyretin dissociation inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699918B1 (fr) * 1992-12-30 1995-03-17 Pf Medicament Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments.
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.

Also Published As

Publication number Publication date
US6589953B2 (en) 2003-07-08
EP1007524A1 (fr) 2000-06-14
WO1999010344A1 (fr) 1999-03-04
JP2001514180A (ja) 2001-09-11
US6277853B1 (en) 2001-08-21
ATE254122T1 (de) 2003-11-15
CN1272108A (zh) 2000-11-01
AU9077498A (en) 1999-03-16
CA2301750A1 (fr) 1999-03-04
AU736074B2 (en) 2001-07-26
FR2767527A1 (fr) 1999-02-26
EP1007524B1 (fr) 2003-11-12
US20020061891A1 (en) 2002-05-23
FR2767527B1 (fr) 1999-11-12
DE69819742D1 (de) 2003-12-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.