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BR9811252A - Processo para preparação de compostos farmacêuticos - Google Patents

Processo para preparação de compostos farmacêuticos

Info

Publication number
BR9811252A
BR9811252A BR9811252-0A BR9811252A BR9811252A BR 9811252 A BR9811252 A BR 9811252A BR 9811252 A BR9811252 A BR 9811252A BR 9811252 A BR9811252 A BR 9811252A
Authority
BR
Brazil
Prior art keywords
preparing pharmaceutical
pharmaceutical compounds
early
compounds
epoxidation
Prior art date
Application number
BR9811252-0A
Other languages
English (en)
Inventor
David W Hoard
Eric D Moher
Vinod F Patel
Original Assignee
Lilly Co Eli
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ Hawaii, Univ Wayne State filed Critical Lilly Co Eli
Publication of BR9811252A publication Critical patent/BR9811252A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção:<B>"PROCESSO PARA PREPARAçãO DE COMPOSTOS FARMACêUTICOS"<D>. Podem ser preparados compostos de Criptoficina utilizando uma etapa de epoxidação precoce no processo sintético sob as condições estipuladas neste relatório. Esta invenção também refere-se a novos intermediários produzidos através deste processo de epoxidação precoce.
BR9811252-0A 1997-02-26 1998-02-25 Processo para preparação de compostos farmacêuticos BR9811252A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3911697P 1997-02-26 1997-02-26
US3911497P 1997-02-26 1997-02-26
PCT/US1998/003655 WO1998038158A1 (en) 1997-02-26 1998-02-25 Process for preparing pharmaceutical compounds

Publications (1)

Publication Number Publication Date
BR9811252A true BR9811252A (pt) 2000-09-26

Family

ID=26715826

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9811252-0A BR9811252A (pt) 1997-02-26 1998-02-25 Processo para preparação de compostos farmacêuticos
BR9807265-0A BR9807265A (pt) 1997-02-26 1998-02-25 Processo de epoxidação seletiva para preparação de compostos farmacêuticos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR9807265-0A BR9807265A (pt) 1997-02-26 1998-02-25 Processo de epoxidação seletiva para preparação de compostos farmacêuticos

Country Status (17)

Country Link
US (1) US6143909A (pt)
EP (2) EP0861839A1 (pt)
JP (2) JP2002513403A (pt)
KR (2) KR20000075671A (pt)
CN (2) CN1255121A (pt)
AU (2) AU738999B2 (pt)
BR (2) BR9811252A (pt)
CA (2) CA2281108A1 (pt)
CZ (1) CZ9902998A3 (pt)
EA (2) EA002547B1 (pt)
ID (2) ID22984A (pt)
IL (2) IL131162A0 (pt)
NO (2) NO994049D0 (pt)
NZ (1) NZ336918A (pt)
PL (2) PL335347A1 (pt)
TR (2) TR199902064T2 (pt)
WO (2) WO1998038158A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0932601A4 (en) * 1996-08-30 2000-02-02 Lilly Co Eli METHOD FOR PRODUCING PHARMACEUTICALS
CA2264557A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
JP2002527509A (ja) * 1998-10-16 2002-08-27 イーライ・リリー・アンド・カンパニー 抗腫瘍剤を製造するための立体選択的な方法
WO2000034252A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Process for the preparation of cryptophycin derivatives
WO2000034253A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Intermediates and reaction sequence to produce said intermediates useful for the preparation of antineoplastic and antifungal cryptophycin derivatives
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
EP1751279A4 (en) * 2004-05-05 2008-03-19 Univ Minnesota NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN
CN101962323B (zh) * 2010-07-16 2013-06-05 中国人民解放军第二军医大学 2-丙烯酰x基-3-取代苯基丙酸类化合物及其用途
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
JPH04504416A (ja) * 1989-02-17 1992-08-06 コセルコ・ミモトープス・ピィ・ティ・ワイ．エル・ティ・ディ． ペプチドの使用方法と合成方法
US5256802A (en) * 1990-04-03 1993-10-26 Miles Inc. Process for the production of oxiranes
CA2148591A1 (en) * 1992-11-06 1994-05-26 H. Mario Geysen Support for the synthesis of modular polymers
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
CA2179490A1 (en) * 1993-12-21 1995-06-29 Trimurtulu Golakoti New cryptophycins
DE69516415T2 (de) * 1994-10-14 2000-09-14 Stratagene, La Jolla Porphyrin-markierung von polynukleotiden
RO118931B1 (ro) * 1995-03-07 2004-01-30 University Of Hawaii Derivaţi de criptoficine, procedeu de preparare a acestora, compoziţie farmaceutică şi utilizarea lor
CA2217051C (en) * 1995-03-31 2006-05-30 Nippon Chemiphar Co., Ltd. Epoxysuccinic acid derivatives
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
EP0850316A4 (en) * 1995-08-30 2000-08-23 Univ Hawaii CRYPTOPHYCINS OBTAINED FROM AN ABERRANT BIOSYNTHESIS
AU1469097A (en) * 1995-12-22 1997-07-17 Eli Lilly And Company Pharmaceutical compounds
CZ233698A3 (cs) * 1996-02-07 1998-12-16 Buckman Laboratories International, Inc. Synergicky antimikrobiální prostředky obsahující ionenový polymer a sůl dodecylaminu a způsoby jeho použití
DE69704731D1 (de) * 1996-02-27 2001-06-13 Lilly Co Eli Cryptophycinderivate und ihre Verwendung als antimikrotubuli Mittel
WO1998008505A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Pharmaceutical compounds
WO1998008829A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Pharmaceutical compounds
JP2001502297A (ja) * 1996-08-30 2001-02-20 イーライ・リリー・アンド・カンパニー 医薬用化合物
US6025506A (en) * 1997-02-21 2000-02-15 Dsm N.V. Process for preparing an optically active phenylglycidyl acid derivative
IL123352A0 (en) * 1997-02-27 1998-09-24 Tanabe Seiyaku Co Process for preparing an optically active trans-3-substituted glycidic acid ester

Also Published As

Publication number Publication date
JP2002512603A (ja) 2002-04-23
TR199902065T2 (xx) 2000-02-21
JP2002513403A (ja) 2002-05-08
WO1998038164A1 (en) 1998-09-03
CZ9902998A3 (cs) 2002-10-16
ID24527A (id) 2000-07-20
EP0861839A1 (en) 1998-09-02
CN1255121A (zh) 2000-05-31
EA002547B1 (ru) 2002-06-27
KR20000075623A (ko) 2000-12-26
WO1998038158A1 (en) 1998-09-03
EA199900770A1 (ru) 2000-04-24
CN1252788A (zh) 2000-05-10
PL335478A1 (en) 2000-04-25
ID22984A (id) 1999-12-23
NO994083L (no) 1999-10-25
CA2281104A1 (en) 1998-09-03
NO994083D0 (no) 1999-08-24
TR199902064T2 (xx) 2001-10-22
AU6667198A (en) 1998-09-18
BR9807265A (pt) 2000-05-23
AU6667298A (en) 1998-09-18
CA2281108A1 (en) 1998-09-03
NO994049L (no) 1999-08-23
IL131205A0 (en) 2001-01-28
US6143909A (en) 2000-11-07
NO994049D0 (no) 1999-08-23
AU738999B2 (en) 2001-10-04
KR20000075671A (ko) 2000-12-26
NZ336918A (en) 2001-11-30
EP0861838A2 (en) 1998-09-02
EP0861838A3 (en) 1998-12-09
EA199900772A1 (ru) 2000-04-24
PL335347A1 (en) 2000-04-25
IL131162A0 (en) 2001-01-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.