BR9809143A - Processo para sintetizar composto - Google Patents
Processo para sintetizar compostoInfo
- Publication number
- BR9809143A BR9809143A BR9809143-3A BR9809143A BR9809143A BR 9809143 A BR9809143 A BR 9809143A BR 9809143 A BR9809143 A BR 9809143A BR 9809143 A BR9809143 A BR 9809143A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- synthesizing compound
- mdri
- intermediates
- synthesis
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002194 synthesizing effect Effects 0.000 title 1
- INBURRUOTJXJKO-UHFFFAOYSA-N 1-(2-phenylethyl)isoquinolin-3-amine Chemical compound N=1C(N)=CC2=CC=CC=C2C=1CCC1=CC=CC=C1 INBURRUOTJXJKO-UHFFFAOYSA-N 0.000 abstract 1
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSO PARA SINTETIZAR COMPOSTO". Síntese do MDRI de fórmula (I) a partir dos intermediários ácido acridona de fórmula (II) e aminofenetil isoquinolina de fórmula (III), por meio de etapas que incluem acoplamento e conversão para produzir o MDRI de fórmula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710612.4A GB9710612D0 (en) | 1997-05-23 | 1997-05-23 | Synthesis of acridine derivatives |
| PCT/EP1998/002991 WO1998052923A1 (en) | 1997-05-23 | 1998-05-22 | Synthesis of acridine derivative multidrug-resistant inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809143A true BR9809143A (pt) | 2000-08-01 |
Family
ID=10812906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809143-3A BR9809143A (pt) | 1997-05-23 | 1998-05-22 | Processo para sintetizar composto |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6248891B1 (pt) |
| EP (1) | EP0983246B1 (pt) |
| JP (1) | JP4390861B2 (pt) |
| KR (1) | KR100536155B1 (pt) |
| CN (1) | CN1178918C (pt) |
| AT (1) | ATE228506T1 (pt) |
| AU (1) | AU744402B2 (pt) |
| BR (1) | BR9809143A (pt) |
| CA (1) | CA2289492C (pt) |
| DE (1) | DE69809733T2 (pt) |
| DK (1) | DK0983246T3 (pt) |
| ES (1) | ES2187984T3 (pt) |
| GB (1) | GB9710612D0 (pt) |
| HK (1) | HK1023995A1 (pt) |
| HU (1) | HUP0002083A3 (pt) |
| IL (1) | IL132593A (pt) |
| PL (1) | PL190109B1 (pt) |
| PT (1) | PT983246E (pt) |
| WO (1) | WO1998052923A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| CN1329609A (zh) | 1998-10-08 | 2002-01-02 | 史密丝克莱恩比彻姆有限公司 | 用作多巴胺d3受体调制剂(精神抑制药)的四氢苯并氮杂䓬衍生物 |
| EP1749540B1 (en) * | 1999-05-17 | 2010-10-13 | Cancer Research Ventures Limited | Compositions for improving bioavailability of orally administered drugs |
| SI21507A (sl) | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| US7829578B1 (en) | 2005-12-12 | 2010-11-09 | Oregon Health & Science University | Aromatic ketones and uses thereof |
| US8592447B2 (en) | 2006-11-13 | 2013-11-26 | Oregon Health & Science University | Acridone compounds |
| US8598354B2 (en) | 2008-12-05 | 2013-12-03 | University Of South Florida | Compounds having antiparasitic or anti-infectious activity |
| CN111867577A (zh) * | 2018-03-21 | 2020-10-30 | 艾祖米科技有限公司 | 依克立达的氘化类似物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ283038B6 (cs) * | 1991-01-11 | 1997-12-17 | Laboratoires Glaxo Sa | Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem |
| JPH10507177A (ja) * | 1994-10-05 | 1998-07-14 | グラクソ、ウェルカム、インコーポレーテッド | Ｇｆ１２０９１８ａを含む非経口医薬組成物 |
-
1997
- 1997-05-23 GB GBGB9710612.4A patent/GB9710612D0/en active Pending
-
1998
- 1998-05-22 ES ES98934892T patent/ES2187984T3/es not_active Expired - Lifetime
- 1998-05-22 KR KR10-1999-7010781A patent/KR100536155B1/ko not_active IP Right Cessation
- 1998-05-22 CN CNB988051265A patent/CN1178918C/zh not_active Expired - Fee Related
- 1998-05-22 PL PL98336937A patent/PL190109B1/pl not_active IP Right Cessation
- 1998-05-22 AT AT98934892T patent/ATE228506T1/de not_active IP Right Cessation
- 1998-05-22 DE DE69809733T patent/DE69809733T2/de not_active Expired - Lifetime
- 1998-05-22 JP JP54995998A patent/JP4390861B2/ja not_active Expired - Fee Related
- 1998-05-22 CA CA002289492A patent/CA2289492C/en not_active Expired - Fee Related
- 1998-05-22 BR BR9809143-3A patent/BR9809143A/pt not_active Application Discontinuation
- 1998-05-22 IL IL13259398A patent/IL132593A/en not_active IP Right Cessation
- 1998-05-22 AU AU84344/98A patent/AU744402B2/en not_active Ceased
- 1998-05-22 WO PCT/EP1998/002991 patent/WO1998052923A1/en active IP Right Grant
- 1998-05-22 US US09/403,158 patent/US6248891B1/en not_active Expired - Fee Related
- 1998-05-22 HU HU0002083A patent/HUP0002083A3/hu unknown
- 1998-05-22 DK DK98934892T patent/DK0983246T3/da active
- 1998-05-22 PT PT98934892T patent/PT983246E/pt unknown
- 1998-05-22 EP EP98934892A patent/EP0983246B1/en not_active Expired - Lifetime
-
2000
- 2000-05-25 HK HK00103130A patent/HK1023995A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU8434498A (en) | 1998-12-11 |
| EP0983246A1 (en) | 2000-03-08 |
| IL132593A (en) | 2004-07-25 |
| JP4390861B2 (ja) | 2009-12-24 |
| PL190109B1 (pl) | 2005-10-31 |
| CA2289492C (en) | 2009-03-24 |
| AU744402B2 (en) | 2002-02-21 |
| HUP0002083A3 (en) | 2002-03-28 |
| CA2289492A1 (en) | 1998-11-26 |
| KR100536155B1 (ko) | 2005-12-14 |
| CN1178918C (zh) | 2004-12-08 |
| GB9710612D0 (en) | 1997-07-16 |
| KR20010012817A (ko) | 2001-02-26 |
| HUP0002083A2 (hu) | 2001-04-28 |
| US6248891B1 (en) | 2001-06-19 |
| JP2002502371A (ja) | 2002-01-22 |
| WO1998052923A1 (en) | 1998-11-26 |
| DK0983246T3 (da) | 2003-03-24 |
| DE69809733T2 (de) | 2003-09-18 |
| CN1255918A (zh) | 2000-06-07 |
| IL132593A0 (en) | 2001-03-19 |
| EP0983246B1 (en) | 2002-11-27 |
| PL336937A1 (en) | 2000-07-17 |
| PT983246E (pt) | 2003-04-30 |
| ES2187984T3 (es) | 2003-06-16 |
| ATE228506T1 (de) | 2002-12-15 |
| DE69809733D1 (de) | 2003-01-09 |
| HK1023995A1 (en) | 2000-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DE ACORDO COM ART. 8O DA LPI. |