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BR9807312B1 - Derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos, composição farmacêutica e processo para a preparação dos referidos derivados - Google Patents

Derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos, composição farmacêutica e processo para a preparação dos referidos derivados

Info

Publication number
BR9807312B1
BR9807312B1 BRPI9807312-5B1A BR9807312A BR9807312B1 BR 9807312 B1 BR9807312 B1 BR 9807312B1 BR 9807312 A BR9807312 A BR 9807312A BR 9807312 B1 BR9807312 B1 BR 9807312B1
Authority
BR
Brazil
Prior art keywords
derivatives
antipsycotic
piperidinyl
agents
preparation
Prior art date
Application number
BRPI9807312-5B1A
Other languages
English (en)
Other versions
BRPI9807312B8 (pt
BR9807312A (pt
Inventor
Joseph T Strupczewski
Kenneth J Bordeau
Shelley L Pavlek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9807312A publication Critical patent/BR9807312A/pt
Publication of BR9807312B1 publication Critical patent/BR9807312B1/pt
Publication of BRPI9807312B8 publication Critical patent/BRPI9807312B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BRPI9807312A 1997-02-07 1998-01-20 derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos, composição farmacêutica e processo para a preparação dos referidos derivados BRPI9807312B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79710797A 1997-02-07 1997-02-07
PCT/US1998/000979 WO1998034933A1 (en) 1997-02-07 1998-01-20 (4-piperidinyl)-1h-2-benzopyran derivatives useful as antipsychotic agents

Publications (3)

Publication Number Publication Date
BR9807312A BR9807312A (pt) 2000-05-02
BR9807312B1 true BR9807312B1 (pt) 2013-10-29
BRPI9807312B8 BRPI9807312B8 (pt) 2016-09-13

Family

ID=25169927

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9807312A BRPI9807312B8 (pt) 1997-02-07 1998-01-20 derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos, composição farmacêutica e processo para a preparação dos referidos derivados

Country Status (22)

Country Link
EP (1) EP1015446B1 (pt)
JP (1) JP4177461B2 (pt)
KR (1) KR100509878B1 (pt)
CN (1) CN1092653C (pt)
AR (1) AR011614A1 (pt)
AT (1) ATE236150T1 (pt)
AU (1) AU725301B2 (pt)
BR (1) BRPI9807312B8 (pt)
CA (1) CA2281702C (pt)
CY (1) CY2324B1 (pt)
DE (1) DE69812980T2 (pt)
DK (1) DK1015446T3 (pt)
ES (1) ES2194303T3 (pt)
HK (1) HK1027812A1 (pt)
HU (1) HUP0001308A3 (pt)
IL (1) IL131243A (pt)
NO (1) NO318936B1 (pt)
NZ (1) NZ336719A (pt)
PT (1) PT1015446E (pt)
TW (1) TW518333B (pt)
WO (1) WO1998034933A1 (pt)
ZA (1) ZA98831B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749001B1 (en) * 2004-04-29 2010-03-03 Aventis Pharmaceuticals, Inc. 3-piperidinylisochroman-5-ols as dopamine agonists
CN102210663B (zh) 2004-05-28 2013-07-31 尤尼根公司 作为双核酶强效抑制剂的二芳基烷烃
EP2183245B1 (en) 2007-07-26 2014-07-09 F. Hoffmann-La Roche AG Dual modulators of 5-ht2a and d3 receptors
PL3542780T3 (pl) 2008-07-21 2022-05-02 Unigen, Inc. Szereg związków wybielających (rozjaśniających)
US8877778B2 (en) 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
CN102079720B (zh) * 2011-01-20 2013-02-06 蚌埠丰原医药科技发展有限公司 一种制备1-苄基-4-哌啶甲醛的方法
KR101976642B1 (ko) 2011-03-24 2019-05-09 유니젠, 인크. 디아릴프로판의 제조를 위한 화합물 및 방법
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives
US4963568A (en) * 1989-05-31 1990-10-16 Abbott Laboratories Dopamine agonists

Also Published As

Publication number Publication date
KR100509878B1 (ko) 2005-08-25
TW518333B (en) 2003-01-21
HUP0001308A2 (hu) 2001-06-28
ZA98831B (en) 1998-08-07
EP1015446B1 (en) 2003-04-02
PT1015446E (pt) 2003-08-29
NO318936B1 (no) 2005-05-30
WO1998034933A1 (en) 1998-08-13
IL131243A (en) 2004-02-19
AU5923798A (en) 1998-08-26
CN1092653C (zh) 2002-10-16
NO993812L (no) 1999-10-05
ES2194303T3 (es) 2003-11-16
IL131243A0 (en) 2001-01-28
AU725301B2 (en) 2000-10-12
CA2281702A1 (en) 1998-08-13
CA2281702C (en) 2006-04-11
BRPI9807312B8 (pt) 2016-09-13
AR011614A1 (es) 2000-08-30
KR20000070862A (ko) 2000-11-25
EP1015446A1 (en) 2000-07-05
HK1027812A1 (en) 2001-01-23
HUP0001308A3 (en) 2001-07-30
BR9807312A (pt) 2000-05-02
NO993812D0 (no) 1999-08-06
DE69812980T2 (de) 2003-11-13
CY2324B1 (en) 2003-11-14
JP4177461B2 (ja) 2008-11-05
NZ336719A (en) 2000-10-27
DE69812980D1 (de) 2003-05-08
DK1015446T3 (da) 2003-07-14
CN1246859A (zh) 2000-03-08
ATE236150T1 (de) 2003-04-15
JP2001512436A (ja) 2001-08-21

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

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B25D Requested change of name of applicant approved

Owner name: AVENTIS PHARMACEUTICALS INC. (US)

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B25G Requested change of headquarter approved

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B12B Appeal against refusal [chapter 12.2 patent gazette]
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B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 405/04, C07D 405/14, C07D 409/14, C07D 413/14, C07D 417/14, C07D 493/04, C07D 493/10, A61K 31/453, A61K 31/4535, A61K 31/4523, A61P 25/18

Ipc: C07D 405/04 (2011.01), C07D 405/14 (2011.01), C07D

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B25A Requested transfer of rights approved
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B25D Requested change of name of applicant approved
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