BR9802915A - Procedimento para formar composições farmaceuticas em pilulas ou granulos substancialmente esfericos, de ação controlada e continuada, contendo como agente ativo o (7-bromo-1,3-diidro-5-(2-piridninilo)-2h-1,4-benzodiazep ina-2(1h)-um) - Google Patents
Procedimento para formar composições farmaceuticas em pilulas ou granulos substancialmente esfericos, de ação controlada e continuada, contendo como agente ativo o (7-bromo-1,3-diidro-5-(2-piridninilo)-2h-1,4-benzodiazep ina-2(1h)-um)Info
- Publication number
- BR9802915A BR9802915A BR9802915A BR9802915A BR9802915A BR 9802915 A BR9802915 A BR 9802915A BR 9802915 A BR9802915 A BR 9802915A BR 9802915 A BR9802915 A BR 9802915A BR 9802915 A BR9802915 A BR 9802915A
- Authority
- BR
- Brazil
- Prior art keywords
- nodules
- release
- bromazepan
- coating
- forming
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCEDIMENTO PARA FORMAR COMPOSIçõES FARMACêUTICAS EM PìLULAS OU GRâNULOS SUBSTANCIALMENTE ESFéRICOS, DE AçãO CONTROLADA E CONTINUADA, CONTENDO COMO AGENTE ATIVO O (7-BROMO-1,3-DIIDRO-5-(2-PIRIDINILO)-2H-1,4-BENZODIAZEPI NA-2(1H)-UM)", incluindo as seguintes etapas: A) revestimento de nódulos ou núcleos formados por partículas de açúcar consolidado com amido, numa operação de mistura de ditos nódulos com Bromazepan micronizado e um polímero de ligação em solução, para formar um revestimento biodegradável sobre ditos nódulos, que retém o material micronizado, o grupo de nódulos revestidos formando uma primeira formulação, de rápida liberação de Bromazepan; B) formação de, no mínimo, uma fração separada dos nódulos de liberação provenientes da etapa A de um segundo revestimento, numa operação de mistura de dita fração com um polímero eutérico formador de filme em solução, a dita fração deste revestimento eutérico em solução formando uma segunda formulação de lenta liberação; C) combinação de quantidades suficientes de formulações de Bromazepan, de rápida e lenta ou ininterrupta liberação, formadas nas etapas A) e B), para produzir composições contendo doses predeterminadas e de liberação programada de Bromazepan.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AR9704185 | 1997-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9802915A true BR9802915A (pt) | 2000-01-11 |
Family
ID=3461035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9802915A BR9802915A (pt) | 1997-09-12 | 1998-05-28 | Procedimento para formar composições farmaceuticas em pilulas ou granulos substancialmente esfericos, de ação controlada e continuada, contendo como agente ativo o (7-bromo-1,3-diidro-5-(2-piridninilo)-2h-1,4-benzodiazep ina-2(1h)-um) |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0908177B1 (pt) |
| BR (1) | BR9802915A (pt) |
| DE (1) | DE69823299T2 (pt) |
| ES (1) | ES2221140T3 (pt) |
| PT (1) | PT908177E (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1064937A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
| BG65576B1 (bg) * | 2002-04-17 | 2009-01-30 | ПИРИМОВА Румяна | Състав на болкоуспокояващо средство, по-специалнопри главоболие и мигрена |
| US20050038042A1 (en) * | 2002-11-15 | 2005-02-17 | Jenet Codd | Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA735524B (en) * | 1972-09-21 | 1974-07-31 | Hoffmann La Roche | Therapeutic compositions |
| DE3430389A1 (de) * | 1984-08-17 | 1986-02-27 | Roland 7831 Malterdingen Kopf | Arzneimittel fuer die gewichtsreduktion |
| FI101344B (fi) * | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta |
-
1998
- 1998-05-28 BR BR9802915A patent/BR9802915A/pt not_active Application Discontinuation
- 1998-09-11 EP EP19980500202 patent/EP0908177B1/en not_active Expired - Lifetime
- 1998-09-11 ES ES98500202T patent/ES2221140T3/es not_active Expired - Lifetime
- 1998-09-11 DE DE69823299T patent/DE69823299T2/de not_active Expired - Fee Related
- 1998-09-11 PT PT98500202T patent/PT908177E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0908177B1 (en) | 2004-04-21 |
| PT908177E (pt) | 2004-09-30 |
| DE69823299T2 (de) | 2005-02-24 |
| DE69823299D1 (de) | 2004-05-27 |
| ES2221140T3 (es) | 2004-12-16 |
| EP0908177A1 (en) | 1999-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCP | Transfer pending | ||
| PC | Transfer |
Owner name: BINDECOR SOCIEDAD ANONIMA (UY) |
|
| B07A | Technical examination (opinion): publication of technical examination (opinion) | ||
| B09B | Decision: refusal |
Free format text: INDEFERO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI. |
|
| B12B | Appeal: appeal against refusal |