BR9714632A - Preparado de combinação farmacêutica, processo para a produção de preparados de combinações farmacêuticas, utilização de preparados de eritropoietina, e de ferro, e unidade de acondicionamento farmacêutica - Google Patents
Preparado de combinação farmacêutica, processo para a produção de preparados de combinações farmacêuticas, utilização de preparados de eritropoietina, e de ferro, e unidade de acondicionamento farmacêuticaInfo
- Publication number
- BR9714632A BR9714632A BR9714632-3A BR9714632A BR9714632A BR 9714632 A BR9714632 A BR 9714632A BR 9714632 A BR9714632 A BR 9714632A BR 9714632 A BR9714632 A BR 9714632A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical
- preparations
- pharmaceutical combination
- preparation
- erythropoietin
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 7
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 4
- 102000003951 Erythropoietin Human genes 0.000 title abstract 2
- 108090000394 Erythropoietin Proteins 0.000 title abstract 2
- 229940105423 erythropoietin Drugs 0.000 title abstract 2
- 229940082629 iron antianemic preparations Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000009512 pharmaceutical packaging Methods 0.000 title abstract 2
- 102100031939 Erythropoietin Human genes 0.000 abstract 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract 2
- 208000007502 anemia Diseases 0.000 abstract 1
- 238000001631 haemodialysis Methods 0.000 abstract 1
- 230000000322 hemodialysis Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Clamps And Clips (AREA)
- Medicinal Preparation (AREA)
Abstract
<MU><B>PREPARADO DE COMBINAçãO FARMACêUTICA, PROCESSO PARA A PRODUçãO DE PREPARADOS DE COMBINAçõES FARMACêUTICAS, UTILIZAçãO DE PREPARADOS DE ERITROPOIETINA, E DE FERRO, E UNIDADE DE ACONDICIONAMENTO FARMACêUTICA<MV><D> A presente invenção relaciona-se com um preparado de combinação farmacêutica que compreende 250 - 20.000 U de um preparado EPO em formas de administração individuais e 5 - 20 mg de um complexo de Fe (III), em que o preparado EPO e o complexo de Fe (III) podem estar presentes em formas de administração separadas ou em uma forma de administração uniforme. O preparado farmacêutico é utilizado para tratar anemias ou pacientes de hemodiálise.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1997/001343 WO1998041226A1 (de) | 1997-03-18 | 1997-03-18 | Pharmazeutische kombinationspräparate enthaltend erythropoietin und eisenpräparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9714632A true BR9714632A (pt) | 2000-05-23 |
Family
ID=8166555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9714632-3A BR9714632A (pt) | 1997-03-18 | 1997-03-18 | Preparado de combinação farmacêutica, processo para a produção de preparados de combinações farmacêuticas, utilização de preparados de eritropoietina, e de ferro, e unidade de acondicionamento farmacêutica |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6710028B2 (pt) |
| EP (1) | EP0977582B1 (pt) |
| JP (1) | JP2000514092A (pt) |
| AT (1) | ATE222118T1 (pt) |
| AU (1) | AU726801B2 (pt) |
| BR (1) | BR9714632A (pt) |
| CA (1) | CA2284910C (pt) |
| CZ (1) | CZ296960B6 (pt) |
| DE (1) | DE59707988D1 (pt) |
| DK (1) | DK0977582T3 (pt) |
| ES (1) | ES2180958T3 (pt) |
| HU (1) | HU226204B1 (pt) |
| IL (2) | IL131959A0 (pt) |
| NO (1) | NO324661B1 (pt) |
| NZ (1) | NZ337465A (pt) |
| PL (1) | PL187479B1 (pt) |
| PT (1) | PT977582E (pt) |
| SI (1) | SI0977582T1 (pt) |
| WO (1) | WO1998041226A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
| US7459435B2 (en) | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US7459436B2 (en) | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
| US20040198663A1 (en) * | 2003-04-04 | 2004-10-07 | Baker John E. | Method of treating cardiac ischemia by using erythropoietin |
| WO2005000340A1 (en) * | 2003-06-27 | 2005-01-06 | Pomytkin Igor A | Synergistic compositions comprising erythropoietin and succinic acid (salt) |
| EP1696947B1 (en) * | 2003-12-19 | 2014-02-26 | F.Hoffmann-La Roche Ag | Use of erythropoietin in the treatment of disturbances of iron distribution in chronic inflammatory intestinal diseases |
| US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
| EP3381445B1 (en) | 2007-11-15 | 2023-10-25 | Amgen Inc. | Aqueous formulation of antibody stablised by antioxidants for parenteral administration |
| EP2067752A1 (en) * | 2007-12-06 | 2009-06-10 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Construction material |
| US8536106B2 (en) | 2010-04-14 | 2013-09-17 | Ecolab Usa Inc. | Ferric hydroxycarboxylate as a builder |
| WO2011149962A1 (en) | 2010-05-24 | 2011-12-01 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
| WO2014081980A2 (en) | 2012-11-21 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
| US4745099A (en) | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
| KR880012235A (ko) * | 1987-04-10 | 1988-11-26 | 벤자민 에프.람버트 | 정상 포유동물의 헤마토크릿을 증가시키는 방법 |
| GB9001987D0 (en) * | 1990-01-29 | 1990-03-28 | Janssen Pharmaceutica Nv | Improved cyclodextrin based erythropietin formulation |
| DE19535571A1 (de) * | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| EP0885613A1 (de) * | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
| DE19734293A1 (de) * | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
| US20020065214A1 (en) * | 2000-11-29 | 2002-05-30 | Adrian Iaina | Method of treating congestive heart failure |
| AU2002233230B2 (en) * | 2000-12-20 | 2007-02-01 | F. Hoffmann-La Roche Ag | Erythropoietin conjugates |
-
1997
- 1997-03-18 DK DK97914258T patent/DK0977582T3/da active
- 1997-03-18 AT AT97914258T patent/ATE222118T1/de active
- 1997-03-18 CA CA002284910A patent/CA2284910C/en not_active Expired - Lifetime
- 1997-03-18 BR BR9714632-3A patent/BR9714632A/pt not_active Application Discontinuation
- 1997-03-18 EP EP97914258A patent/EP0977582B1/de not_active Expired - Lifetime
- 1997-03-18 IL IL13195997A patent/IL131959A0/xx active IP Right Grant
- 1997-03-18 SI SI9730390T patent/SI0977582T1/xx unknown
- 1997-03-18 ES ES97914258T patent/ES2180958T3/es not_active Expired - Lifetime
- 1997-03-18 CZ CZ0330099A patent/CZ296960B6/cs not_active IP Right Cessation
- 1997-03-18 NZ NZ337465A patent/NZ337465A/en not_active IP Right Cessation
- 1997-03-18 AU AU21572/97A patent/AU726801B2/en not_active Expired
- 1997-03-18 JP JP10540046A patent/JP2000514092A/ja active Pending
- 1997-03-18 PL PL97335858A patent/PL187479B1/pl unknown
- 1997-03-18 DE DE59707988T patent/DE59707988D1/de not_active Expired - Lifetime
- 1997-03-18 PT PT97914258T patent/PT977582E/pt unknown
- 1997-03-18 WO PCT/EP1997/001343 patent/WO1998041226A1/de active IP Right Grant
- 1997-03-18 HU HU0001409A patent/HU226204B1/hu unknown
-
1999
- 1999-09-16 IL IL131959A patent/IL131959A/en not_active IP Right Cessation
- 1999-09-17 NO NO19994511A patent/NO324661B1/no not_active IP Right Cessation
-
2001
- 2001-10-23 US US10/047,749 patent/US6710028B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL131959A0 (en) | 2001-03-19 |
| NO324661B1 (no) | 2007-11-26 |
| WO1998041226A1 (de) | 1998-09-24 |
| DE59707988D1 (de) | 2002-09-19 |
| IL131959A (en) | 2006-12-31 |
| HUP0001409A2 (en) | 2001-03-28 |
| CZ296960B6 (cs) | 2006-08-16 |
| HU226204B1 (en) | 2008-06-30 |
| US20020094948A1 (en) | 2002-07-18 |
| NO994511L (no) | 1999-09-17 |
| ES2180958T3 (es) | 2003-02-16 |
| ATE222118T1 (de) | 2002-08-15 |
| SI0977582T1 (en) | 2002-12-31 |
| PL335858A1 (en) | 2000-05-22 |
| JP2000514092A (ja) | 2000-10-24 |
| PL187479B1 (pl) | 2004-07-30 |
| EP0977582A1 (de) | 2000-02-09 |
| NO994511D0 (no) | 1999-09-17 |
| US6710028B2 (en) | 2004-03-23 |
| PT977582E (pt) | 2002-12-31 |
| CA2284910C (en) | 2003-01-28 |
| EP0977582B1 (de) | 2002-08-14 |
| CA2284910A1 (en) | 1998-09-24 |
| AU2157297A (en) | 1998-10-12 |
| AU726801B2 (en) | 2000-11-23 |
| HUP0001409A3 (en) | 2003-08-28 |
| DK0977582T3 (da) | 2002-12-16 |
| NZ337465A (en) | 2002-04-26 |
| CZ9903300A3 (cs) | 2001-03-14 |
| WO1998041226A9 (de) | 1999-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37, INDEFIRO O PRESENTE PEDIDO UMA VEZ QUE: - INCIDE NO ARTIGO 229 DA LEI 9279/96 SEGUNDO REDACAO DADA PELO ARTIGO 229-A DA LEI 10196/01; - NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA (ART. 8O COMBINADO COM ART. 13 DA LPI); - NAO E CONSIDERADO INVENCAO, UMA VEZ QUE INCIDE NO ART. 10 DA LPI. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |