BR9710264A - Aplicações terapéuticas da tecnologia do t-bam (cd40l) para tratar de doenças envolvendo as células do músculo liso - Google Patents

Aplicações terapéuticas da tecnologia do t-bam (cd40l) para tratar de doenças envolvendo as células do músculo liso

Info

Publication number: BR9710264A
Authority: BR; Brazil
Prior art keywords: cd40l; bam; technology; smooth muscle; muscle cells
Prior art date: 1996-07-08

Application number

BR9710264A

Other languages

English (en)

Inventor

Michael J Yellin

Seth Lederman

Leonard Chess

Mihail N Karpusas

David W Thomas

Original Assignee

Univ Columbia

Biogen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-08

Filing date

1997-07-03

Publication date

1999-08-10

1997-07-03 Application filed by Univ Columbia, Biogen Inc filed Critical Univ Columbia

1999-08-10 Publication of BR9710264A publication Critical patent/BR9710264A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Zoology (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
Analytical Chemistry (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)

BR9710264A 1996-07-08 1997-07-03 Aplicações terapéuticas da tecnologia do t-bam (cd40l) para tratar de doenças envolvendo as células do músculo liso BR9710264A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67773096A	1996-07-08	1996-07-08
PCT/US1997/012925 WO1998001145A1 (en)	1996-07-08	1997-07-03	Therapeutic applications of t-bam (cd40l) technology to treat diseases involving smooth muscle cells

Publications (1)

Publication Number	Publication Date
BR9710264A true BR9710264A (pt)	1999-08-10

Family

ID=24719894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9710264A BR9710264A (pt)	1996-07-08	1997-07-03	Aplicações terapéuticas da tecnologia do t-bam (cd40l) para tratar de doenças envolvendo as células do músculo liso

Country Status (20)

Country	Link
US (2)	US20030219437A1 (pt)
EP (1)	EP0956030A4 (pt)
JP (1)	JP2000515507A (pt)
CN (1)	CN1242809C (pt)
AU (1)	AU731299B2 (pt)
BG (1)	BG63489B1 (pt)
BR (1)	BR9710264A (pt)
CA (1)	CA2259962C (pt)
CZ (1)	CZ297300B6 (pt)
EA (1)	EA004401B1 (pt)
EE (1)	EE9900010A (pt)
HU (1)	HUP9904669A3 (pt)
IL (1)	IL127884A0 (pt)
IS (1)	IS4935A (pt)
NO (1)	NO990019L (pt)
NZ (1)	NZ333602A (pt)
PL (1)	PL188408B1 (pt)
SK (1)	SK499A3 (pt)
TR (1)	TR199900029T2 (pt)
WO (1)	WO1998001145A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1284747A2 (en)	2000-05-12	2003-02-26	Beth Israel Deaconess Medical Center, Inc.	Compositions and methods for achieving immune suppression
US20020173053A1 (en) *	2001-04-27	2002-11-21	Bassam Damaj	Multiple simultaneous antigen detection by immunohistochemistry
DK1517921T3 (da) *	2002-06-28	2006-10-09	Domantis Ltd	Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf
US7563443B2 (en) *	2004-09-17	2009-07-21	Domantis Limited	Monovalent anti-CD40L antibody polypeptides and compositions thereof
UY32802A (es) *	2009-07-23	2011-01-31	Provimi Holding B V	Composiciones para reducir la metanogénesis gastrointestinal en rumiantes
MX2018013762A (es) *	2016-05-13	2019-03-28	Medimmune Llc	Polipeptidos de fusion de ligando de cumulo de diferenciacion 40 y fragmento cristalizable (cd40l-fc) y sus metodos de uso.
CN110546164B (zh) *	2016-11-11	2023-10-20	锦湖Ht株式会社	特异性结合cd40的抗体及其用途
US11793854B2 (en)	2019-03-21	2023-10-24	Op-T Llc	Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction
US12048734B2 (en)	2020-04-17	2024-07-30	Op-T Llc	Bioactive peptides and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5474771A (en) *	1991-11-15	1995-12-12	The Trustees Of Columbia University In The City Of New York	Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
IL104684A0 (en) *	1992-02-14	1993-06-10	Bristol Myers Squibb Co	The cd40cr receptor and ligands therefor
US6001358A (en) *	1995-11-07	1999-12-14	Idec Pharmaceuticals Corporation	Humanized antibodies to human gp39, compositions containing thereof
US6340459B1 (en) *	1995-12-01	2002-01-22	The Trustees Of Columbia University In The City Of New York	Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients
US6822070B2 (en) *	1996-03-11	2004-11-23	David Baltimore	Truncated CRAF1 inhibits CD40 signaling

1997
- 1997-07-03 BR BR9710264A patent/BR9710264A/pt not_active Application Discontinuation
- 1997-07-03 HU HU9904669A patent/HUP9904669A3/hu not_active Application Discontinuation
- 1997-07-03 EE EEP199900010A patent/EE9900010A/xx unknown
- 1997-07-03 IL IL12788497A patent/IL127884A0/xx unknown
- 1997-07-03 CN CNB971971749A patent/CN1242809C/zh not_active Expired - Fee Related
- 1997-07-03 NZ NZ333602A patent/NZ333602A/en unknown
- 1997-07-03 CA CA002259962A patent/CA2259962C/en not_active Expired - Fee Related
- 1997-07-03 WO PCT/US1997/012925 patent/WO1998001145A1/en active IP Right Grant
- 1997-07-03 CZ CZ0002699A patent/CZ297300B6/cs not_active IP Right Cessation
- 1997-07-03 EP EP97940539A patent/EP0956030A4/en not_active Withdrawn
- 1997-07-03 PL PL97331104A patent/PL188408B1/pl not_active IP Right Cessation
- 1997-07-03 TR TR1999/00029T patent/TR199900029T2/xx unknown
- 1997-07-03 EA EA199900091A patent/EA004401B1/ru not_active IP Right Cessation
- 1997-07-03 AU AU42292/97A patent/AU731299B2/en not_active Ceased
- 1997-07-03 JP JP10505404A patent/JP2000515507A/ja active Pending
- 1997-07-03 SK SK4-99A patent/SK499A3/sk unknown
1998
- 1998-12-23 IS IS4935A patent/IS4935A/is unknown
1999
- 1999-01-04 NO NO990019A patent/NO990019L/no not_active Application Discontinuation
- 1999-02-04 BG BG103148A patent/BG63489B1/bg unknown
2002
- 2002-11-15 US US10/298,508 patent/US20030219437A1/en not_active Abandoned
2007
- 2007-01-25 US US11/698,692 patent/US20080050369A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1227494A (zh)	1999-09-01
CZ2699A3 (cs)	1999-05-12
WO1998001145A1 (en)	1998-01-15
EP0956030A1 (en)	1999-11-17
PL188408B1 (pl)	2005-01-31
NO990019L (no)	1999-03-08
JP2000515507A (ja)	2000-11-21
NZ333602A (en)	2000-06-23
EA004401B1 (ru)	2004-04-29
HUP9904669A2 (hu)	2000-05-28
EP0956030A4 (en)	2001-11-28
IL127884A0 (en)	1999-10-28
EE9900010A (et)	1999-06-15
AU731299B2 (en)	2001-03-29
NO990019D0 (no)	1999-01-04
CZ297300B6 (cs)	2006-11-15
PL331104A1 (en)	1999-06-21
CA2259962C (en)	2002-01-22
AU4229297A (en)	1998-02-02
HUP9904669A3 (en)	2001-06-28
SK499A3 (en)	1999-08-06
BG103148A (en)	1999-10-29
BG63489B1 (bg)	2002-03-29
US20080050369A1 (en)	2008-02-28
IS4935A (is)	1998-12-23
US20030219437A1 (en)	2003-11-27
CN1242809C (zh)	2006-02-22
CA2259962A1 (en)	1998-01-15
TR199900029T2 (xx)	1999-04-21
EA199900091A1 (ru)	1999-08-26

Publication	Publication Date	Title
AU6649996A (en)	1997-02-26	Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
ID25824A (id)	2000-11-09	Formulasi terapeutik untuk memberikan tolterodin dengan pelepasan yang terkendali
AU2003248691A1 (en)	2003-12-31	Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
EP0379161A3 (de)	1991-07-31	Verwendung alkylierter Polyethylenimine als gallensäureadsorbierende Arzneimittel sowie pharmazeutische Präparate
IL132758A0 (en)	2001-03-19	Methods for treating inflammation and inflammatory diseases using padprt
ID23554A (id)	2000-05-04	Formulasi-formulasi intranasal untuk pengobatan penyakit-penyakit seksual
ID23496A (id)	2000-04-27	Ekstrak tanaman untuk mengobati peningkatan resorpsi tulang
TR200000755T2 (tr)	2000-09-21	Karşıt olma-karşı gelme bozukluğunun tedavisi.
NO20020779L (no)	2002-04-15	Fremgangsmåter, preparater og sett for å fremme helbredelse ved skader på sentralnervesystemet
BR9710264A (pt)	1999-08-10	Aplicações terapéuticas da tecnologia do t-bam (cd40l) para tratar de doenças envolvendo as células do músculo liso
AU7138601A (en)	2002-01-08	Methods of treating neutrophil-related diseases with topical anesthetics
AU4224600A (en)	2000-10-23	Composition and method for treatment of inflammation and pain in mammals
ID26861A (id)	2001-02-15	Terapi gabungan untuk pengobatan depresi refaktori
NO985066D0 (no)	1998-10-30	Terapeutisk behandling for VEGF-relaterte sykdommer
DK1011733T3 (da)	2009-09-28	Sammensætninger og fremgangsmåder til at forbedre levering af terapeutiske midler til celler
HRPK20010442B1 (en)	2003-10-31	Utilization of inhibitors of the kqt1 channel in order to produce a medicament for treating diseases which are caused by parasitic helminths and ectoparasites
AU8038998A (en)	1999-01-04	Prophylactic or therapeutic agent for diseases attributable to infection with helicobacters
DK0817646T3 (da)	2003-04-22	Fremgangsmåder til behandling af inflammation og præparater derfor
AR002119A1 (es)	1998-01-07	Procedimiento para preparar n-fosfonome-tilglicinaa partir de ácido n-fosfonometili-minodiacetico
BR9609153A (pt)	1999-05-04	Derivados de estiril-benzimidazol como inibidores da proliferação de celula de musculo liso
BR9708081A (pt)	1999-07-27	Formulações tópicas para tratamento de psóriase de unhas
DK0951294T3 (da)	2003-11-17	Sårhelende formuleringer indeholdende humanplasmafibronectin
EP1150669A4 (en)	2005-06-22	FORMULATIONS ON L-ARGININE BASE FOR DISEASE TREATMENT AND USE THEREOF
AU2002221013A1 (en)	2002-06-11	Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease
NO20012569L (no)	2001-07-25	Anvendelse av aryl-substituerte syklobutylalkylaminer for behandling av urininkontinens

Legal Events

Date	Code	Title	Description
2007-04-17	B25D	Requested change of name of applicant approved	Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF Free format text: ALTERADO DE: BIOGEN IDEC MA, INC.
2007-10-09	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2008-03-04	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: DE ACORDO COM O ART. 37 DA LEI 9.279/96, OPINO PELO INDEFERIMENTO DO PRESENTE PEDIDO, COM BASE NOSARTS. 8O, 10 (VIII), 13 E 24 DA LEI 9.279/96.

Date

Code

Title

Description

2007-04-17

B25D

Requested change of name of applicant approved

Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF

Free format text: ALTERADO DE: BIOGEN IDEC MA, INC.

2007-10-09

B07A

Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]

2008-03-04

B09B

Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 37 DA LEI 9.279/96, OPINO PELO INDEFERIMENTO DO PRESENTE PEDIDO, COM BASE NOSARTS. 8O, 10 (VIII), 13 E 24 DA LEI 9.279/96.