BR9707056B1 - processos e composições para determinar a seqüência de moléculas de ácido nucleico. - Google Patents
processos e composições para determinar a seqüência de moléculas de ácido nucleico.Info
- Publication number
- BR9707056B1 BR9707056B1 BRPI9707056-4A BR9707056A BR9707056B1 BR 9707056 B1 BR9707056 B1 BR 9707056B1 BR 9707056 A BR9707056 A BR 9707056A BR 9707056 B1 BR9707056 B1 BR 9707056B1
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- sequence
- tags
- determining
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58926096A | 1996-01-23 | 1996-01-23 | |
| US1046296P | 1996-01-23 | 1996-01-23 | |
| PCT/US1997/001304 WO1997027331A2 (en) | 1996-01-23 | 1997-01-23 | Methods and compositions for determining the sequence of nucleic acid molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9707056A BR9707056A (pt) | 1999-12-28 |
| BR9707056B1 true BR9707056B1 (pt) | 2009-05-05 |
Family
ID=26681206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9707056-4A BR9707056B1 (pt) | 1996-01-23 | 1997-01-23 | processos e composições para determinar a seqüência de moléculas de ácido nucleico. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0868535B9 (pt) |
| JP (2) | JP2001501449A (pt) |
| KR (1) | KR100482917B1 (pt) |
| CN (1) | CN1163619C (pt) |
| AT (2) | ATE425175T1 (pt) |
| AU (1) | AU717435B2 (pt) |
| BR (1) | BR9707056B1 (pt) |
| CA (1) | CA2243560A1 (pt) |
| CZ (1) | CZ218498A3 (pt) |
| DE (2) | DE69739304D1 (pt) |
| ES (1) | ES2144846T5 (pt) |
| GR (1) | GR3033733T3 (pt) |
| HU (1) | HUP9901321A3 (pt) |
| NZ (1) | NZ331044A (pt) |
| PL (1) | PL328271A1 (pt) |
| PT (1) | PT868535E (pt) |
| WO (1) | WO1997027331A2 (pt) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6401267B1 (en) | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
| CN1202260C (zh) * | 1996-01-23 | 2005-05-18 | 佳根基因组学公司 | 利用大小分离技术分析核酸分子的方法和组合物 |
| PT850320E (pt) * | 1996-01-23 | 2000-05-31 | Rapigene Inc | Metodos para a deteccao da ligacao num par de ligantes com sensibilidade aumentada |
| US6060248A (en) * | 1997-02-24 | 2000-05-09 | Tm Technologies, Inc. | Process for selecting anti-sense oligonucleotides |
| AU734636B2 (en) * | 1997-07-11 | 2001-06-21 | Xzillion Gmbh & Co. Kg | Characterising nucleic acids |
| WO1999005319A2 (en) * | 1997-07-22 | 1999-02-04 | Rapigene, Inc. | Methods and compounds for analyzing nucleic acids by mass spectrometry |
| AU731110B2 (en) | 1997-07-22 | 2001-03-22 | Qiagen Genomics, Inc. | Computer method and system for correlating sequencing data by MS |
| GB9718921D0 (en) * | 1997-09-05 | 1997-11-12 | Brax Genomics Ltd | Catalytically generated mass labels |
| JP2001516591A (ja) * | 1997-09-15 | 2001-10-02 | ブラックス グループ リミテッド | 質量分析法による核酸の分析方法 |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| GB9815163D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds |
| GB2335035B (en) * | 1998-03-03 | 2003-05-28 | Brax Genomics Ltd | Screening for functional antisense agents |
| AU3199699A (en) * | 1998-03-23 | 1999-10-18 | Invitrogen Corporation | Modified nucleotides and methods useful for nucleic acid sequencing |
| DE69913509T2 (de) * | 1998-05-15 | 2004-09-23 | Oxford Gene Technology Ip Ltd., Kidlington | Bibliotheken von Oligomeren, die mit unterschiedlichen Markierungen (TAGS) markiert sind |
| US6074831A (en) * | 1998-07-09 | 2000-06-13 | Agilent Technologies, Inc. | Partitioning of polymorphic DNAs |
| US6270976B1 (en) * | 1998-09-15 | 2001-08-07 | Brax Group Limited | Characterizing nucleic acid by mass spectrometry |
| US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| MXPA02002265A (es) * | 1999-08-31 | 2003-04-10 | Qiagen Genomics Inc | Compuestos enatiomericamente enriquecidos que tienen enlace (s) fotodesdoblable (s) y metodos relacionados a los mismos. |
| GB0006141D0 (en) | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| DE10036743A1 (de) * | 2000-07-27 | 2002-02-07 | Max Planck Gesellschaft | Verfahren zur Bestimmung einer partiellen Nukleotidsequenz eines Nukleinsäuremoleküls |
| US6706162B1 (en) * | 2000-09-25 | 2004-03-16 | Applera Corporation | High speed, high resolution compositions, methods, and kits for capillary electrophoresis |
| EP1950305A1 (en) | 2001-05-09 | 2008-07-30 | Monsanto Technology, LLC | Tyr a genes and uses thereof |
| US6613523B2 (en) | 2001-06-29 | 2003-09-02 | Agilent Technologies, Inc. | Method of DNA sequencing using cleavable tags |
| AU2002327236A1 (en) | 2001-07-12 | 2003-01-29 | Illumina, Inc. | Multiplex nucleic acid reactions |
| DE60223696T2 (de) * | 2001-09-14 | 2009-01-29 | Electrophoretics Ltd., Cobham | Massenmarker |
| CN100360722C (zh) * | 2001-11-21 | 2008-01-09 | 艾普勒拉公司 | 数字化分析 |
| IL160869A0 (en) | 2004-03-15 | 2004-08-31 | Dnr Imaging System Ltd | Integrated system for real time gel electrophoresis running and documenting |
| EP2246417B1 (en) | 2004-04-22 | 2015-01-21 | Grifols Therapeutics Inc. | Recombinantly modified plasmin |
| US20070054345A1 (en) | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
| EP1776588A1 (en) * | 2004-07-12 | 2007-04-25 | Applera Corporation | Mass tags for quantitative analyses |
| US20070048752A1 (en) | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
| US20060183238A1 (en) | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
| US7396676B2 (en) | 2005-05-31 | 2008-07-08 | Agilent Technologies, Inc. | Evanescent wave sensor with attached ligand |
| GB0515323D0 (en) | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| GB0518585D0 (en) | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
| US7501254B2 (en) | 2006-07-20 | 2009-03-10 | Ghc Technologies, Inc. | Methods and compositions for amplification and capture of nucleic acid sequences |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| US8017403B2 (en) * | 2007-06-14 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Mass spectrometry method for measuring vitamin B6 in body fluid |
| AU2008331545B2 (en) | 2007-11-29 | 2014-01-16 | Grifols Therapeutics Inc. | Recombinantly modified plasmin |
| GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| JP2011522538A (ja) | 2008-06-04 | 2011-08-04 | タレクリス・バイオセラピユーテイクス・インコーポレーテツド | プラスミン製造のための組成物、方法およびキット |
| HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
| RU2579977C2 (ru) | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ |
| GB0921665D0 (en) | 2009-12-10 | 2010-01-27 | Trillion Genomics Ltd | Phobes |
| US9291597B2 (en) | 2010-07-02 | 2016-03-22 | Ventana Medical Systems, Inc. | Detecting targets using mass tags and mass spectrometry |
| CN103551212B (zh) | 2010-07-23 | 2016-01-20 | 贝克曼考尔特公司 | 试剂盒 |
| KR101207742B1 (ko) | 2010-10-14 | 2012-12-03 | 포항공과대학교 산학협력단 | 라벨링제 및 이를 이용한 아미노산 서열 및 단백질 다중 정량 동시 분석방법 |
| US8809012B2 (en) | 2010-08-23 | 2014-08-19 | Postach Academy-Industry Foundation | Labeling agent and methods for simultaneous sequencing and quantification of multiple peptides and proteins using the same |
| CN102140524A (zh) * | 2011-03-23 | 2011-08-03 | 山东农业大学 | 多微卫星位点检测试剂盒及检测方法 |
| EP2776843B1 (en) | 2011-11-07 | 2019-03-27 | Beckman Coulter, Inc. | Centrifuge system and workflow |
| CN103975245A (zh) | 2011-11-07 | 2014-08-06 | 贝克曼考尔特公司 | 用于试样输送系统的磁阻尼 |
| US9046506B2 (en) | 2011-11-07 | 2015-06-02 | Beckman Coulter, Inc. | Specimen container detection |
| KR20140092378A (ko) | 2011-11-07 | 2014-07-23 | 베크만 컬터, 인코포레이티드 | 샘플을 처리하기 위한 시스템 및 방법 |
| BR112014011035A2 (pt) | 2011-11-07 | 2017-06-13 | Beckman Coulter, Inc. | sistema de aliquotagem e fluxo de trabalho |
| CN104040352B (zh) | 2011-11-07 | 2016-09-07 | 贝克曼考尔特公司 | 机械臂 |
| AU2012340501A1 (en) | 2011-12-19 | 2013-07-11 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| WO2013130487A2 (en) | 2012-02-29 | 2013-09-06 | Duke University | Novel oxidoreductases for enantioselective reactions |
| CN103849617A (zh) * | 2013-12-16 | 2014-06-11 | 复旦大学 | 用于基因组dna永久保存的接头及方法 |
| GB201322567D0 (en) | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| CN103966210B (zh) * | 2014-05-29 | 2016-06-29 | 江苏省农业科学院 | 桃ssap分子标记引物组合、分子标记组合及其在桃品种遗传多样性分析上的应用 |
| EP3197269A1 (en) | 2014-09-26 | 2017-08-02 | Purecircle Usa Inc. | Single nucleotide polymorphism (snp) markers for stevia |
| JP7138050B2 (ja) | 2015-12-22 | 2022-09-15 | キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド | ブリルアン光散乱に基づくラベルフリーサイトメトリーのシステム及び方法 |
| US10732092B2 (en) | 2015-12-22 | 2020-08-04 | University Of Maryland, College Park | Analysis of single cell mechanical phenotyping for metastatic detection |
| US10598594B2 (en) | 2015-12-22 | 2020-03-24 | University Of Maryland | Cell classification based on mechanical signature of nucleus |
| US20180265887A1 (en) | 2017-03-16 | 2018-09-20 | Jacobs Farm Del Cabo | Basil Plants With High Tolerance to Downy Mildew |
| CN106905399B (zh) * | 2017-03-27 | 2019-07-09 | 武汉大学 | 一种双链dna b-z构象相互转换的光控方法 |
| JP7396902B2 (ja) * | 2017-06-06 | 2023-12-12 | ユニバーシティ オブ メリーランド，カレッジ パーク | 転移検出のために単一細胞の機械的フェノタイピングを行う分析 |
| US12091706B2 (en) * | 2018-01-30 | 2024-09-17 | Rush University Medical Center | Sequential staining for multiplex analyses of tissues and cells |
| KR20240096817A (ko) | 2020-05-19 | 2024-06-26 | 사이빈 아이알엘 리미티드 | 중수소화된 트립타민 유도체 및 사용 방법 |
| CN112229892B (zh) * | 2020-10-22 | 2021-09-28 | 中国科学院化学研究所 | 一种酚醛树脂组成测试和定量分析方法及应用 |
| CN114984032B (zh) * | 2022-06-27 | 2023-07-07 | 四川大学 | Dna四面体框架核酸-绿原酸复合物及其在制备治疗肝纤维化的药物中的用途 |
| CN115337916B (zh) * | 2022-07-29 | 2023-10-24 | 福建卫生职业技术学院 | 一种水凝胶型细胞膜半制备色谱柱及其制备方法与应用 |
| CN117269287A (zh) * | 2023-11-20 | 2023-12-22 | 中国计量科学研究院 | 一种喷墨进样-毛细管电泳-质谱联用装置及工作方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5346670A (en) * | 1986-12-24 | 1994-09-13 | British Technology Group U.S.A. Inc. | Phthalocyanine and tetrabenztriazaporphyrin reagents |
| US5003059A (en) † | 1988-06-20 | 1991-03-26 | Genomyx, Inc. | Determining DNA sequences by mass spectrometry |
| GB8910880D0 (en) * | 1989-05-11 | 1989-06-28 | Amersham Int Plc | Sequencing method |
| GB9208733D0 (en) * | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
| US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| EP1262564A3 (en) * | 1993-01-07 | 2004-03-31 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| EP0765401B1 (en) * | 1993-11-17 | 2001-02-21 | Amersham Pharmacia Biotech UK Limited | Primer extension mass spectroscopy nucleic acid sequencing method |
| DK0751950T3 (da) * | 1994-03-23 | 2001-01-29 | Penn State Res Found | Fremgangsmåde til identifikation af elementer af kombinatoriske biblioteker |
-
1997
- 1997-01-23 DE DE69739304T patent/DE69739304D1/de not_active Expired - Lifetime
- 1997-01-23 PL PL97328271A patent/PL328271A1/xx unknown
- 1997-01-23 CZ CZ982184A patent/CZ218498A3/cs unknown
- 1997-01-23 WO PCT/US1997/001304 patent/WO1997027331A2/en active IP Right Grant
- 1997-01-23 ES ES97905634T patent/ES2144846T5/es not_active Expired - Lifetime
- 1997-01-23 AT AT99113790T patent/ATE425175T1/de not_active IP Right Cessation
- 1997-01-23 CN CNB971925577A patent/CN1163619C/zh not_active Expired - Fee Related
- 1997-01-23 JP JP09527085A patent/JP2001501449A/ja not_active Withdrawn
- 1997-01-23 NZ NZ331044A patent/NZ331044A/xx unknown
- 1997-01-23 DE DE69701671T patent/DE69701671T3/de not_active Expired - Lifetime
- 1997-01-23 AU AU22473/97A patent/AU717435B2/en not_active Ceased
- 1997-01-23 KR KR10-1998-0705638A patent/KR100482917B1/ko not_active IP Right Cessation
- 1997-01-23 HU HU9901321A patent/HUP9901321A3/hu unknown
- 1997-01-23 AT AT97905634T patent/ATE191750T1/de not_active IP Right Cessation
- 1997-01-23 PT PT97905634T patent/PT868535E/pt unknown
- 1997-01-23 CA CA002243560A patent/CA2243560A1/en not_active Abandoned
- 1997-01-23 EP EP97905634A patent/EP0868535B9/en not_active Expired - Lifetime
- 1997-01-23 BR BRPI9707056-4A patent/BR9707056B1/pt not_active IP Right Cessation
-
2000
- 2000-06-20 GR GR20000401427T patent/GR3033733T3/el not_active IP Right Cessation
-
2008
- 2008-03-04 JP JP2008054176A patent/JP2008183012A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT868535E (pt) | 2000-12-29 |
| EP0868535B1 (en) | 2000-04-12 |
| PL328271A1 (en) | 1999-01-18 |
| EP0868535B2 (en) | 2006-01-04 |
| NZ331044A (en) | 1999-02-25 |
| WO1997027331A2 (en) | 1997-07-31 |
| ATE191750T1 (de) | 2000-04-15 |
| BR9707056A (pt) | 1999-12-28 |
| DE69701671T3 (de) | 2006-08-17 |
| HUP9901321A3 (en) | 2001-10-29 |
| ATE425175T1 (de) | 2009-03-15 |
| CN1212021A (zh) | 1999-03-24 |
| DE69739304D1 (de) | 2009-04-23 |
| DE69701671D1 (de) | 2000-05-18 |
| ES2144846T3 (es) | 2000-06-16 |
| KR19990081925A (ko) | 1999-11-15 |
| AU717435B2 (en) | 2000-03-23 |
| CZ218498A3 (cs) | 1998-12-16 |
| DE69701671T2 (de) | 2000-08-10 |
| GR3033733T3 (en) | 2000-10-31 |
| ES2144846T5 (es) | 2006-07-16 |
| EP0868535A2 (en) | 1998-10-07 |
| CN1163619C (zh) | 2004-08-25 |
| JP2001501449A (ja) | 2001-02-06 |
| CA2243560A1 (en) | 1997-07-31 |
| KR100482917B1 (ko) | 2005-11-11 |
| JP2008183012A (ja) | 2008-08-14 |
| EP0868535B9 (en) | 2007-05-09 |
| WO1997027331A3 (en) | 1998-04-02 |
| HUP9901321A2 (hu) | 1999-07-28 |
| AU2247397A (en) | 1997-08-20 |
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