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BR9306619A - Glicosídeos esteroidais para o tratamento da hipercolesterolemia - Google Patents

Glicosídeos esteroidais para o tratamento da hipercolesterolemia

Info

Publication number
BR9306619A
BR9306619A BR9306619A BR9306619A BR9306619A BR 9306619 A BR9306619 A BR 9306619A BR 9306619 A BR9306619 A BR 9306619A BR 9306619 A BR9306619 A BR 9306619A BR 9306619 A BR9306619 A BR 9306619A
Authority
BR
Brazil
Prior art keywords
hypercholesterolemia
treatment
steroidal glycosides
glycosides
steroidal
Prior art date
Application number
BR9306619A
Other languages
English (en)
Inventor
Michael Paul Deninno
Peter Andrew Mccarthy
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9306619A publication Critical patent/BR9306619A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR9306619A 1992-06-26 1993-05-06 Glicosídeos esteroidais para o tratamento da hipercolesterolemia BR9306619A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90491492A 1992-06-26 1992-06-26
PCT/US1993/004092 WO1994000480A1 (en) 1992-06-26 1993-05-06 Steroidal glycosides for treating hypercholesterolemia

Publications (1)

Publication Number Publication Date
BR9306619A true BR9306619A (pt) 1998-12-08

Family

ID=25419965

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9306619A BR9306619A (pt) 1992-06-26 1993-05-06 Glicosídeos esteroidais para o tratamento da hipercolesterolemia

Country Status (19)

Country Link
US (2) US5629295A (pt)
EP (4) EP0796863A2 (pt)
JP (2) JPH07504921A (pt)
KR (1) KR950702203A (pt)
CN (1) CN1085561A (pt)
AP (1) AP489A (pt)
AU (1) AU4226593A (pt)
BG (1) BG99261A (pt)
BR (1) BR9306619A (pt)
CA (1) CA2139104A1 (pt)
CZ (1) CZ331094A3 (pt)
HR (1) HRP930994A2 (pt)
IL (1) IL106055A0 (pt)
MX (1) MX9303826A (pt)
OA (1) OA10121A (pt)
RU (1) RU94046294A (pt)
SK (1) SK158394A3 (pt)
WO (1) WO1994000480A1 (pt)
YU (1) YU44793A (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2138016A1 (en) * 1992-06-26 1994-01-06 Kathleen D. Goggin Steroidal beta-o-cellobioside heptaalkanoate process
WO1994025479A1 (en) * 1993-04-28 1994-11-10 Pfizer Inc. Spirostanyl glycosidal crystalline monohydrate
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
FI96243C (fi) * 1993-10-26 1996-05-27 Ilmari Paakkinen Menetelmä ja laite rakeisten maamassojen ominaisuuksien mittaamiseksi
US5698526A (en) * 1993-12-28 1997-12-16 Pfizer Inc. Steroidal glycosides
WO1995018143A1 (en) * 1993-12-28 1995-07-06 Pfizer Inc. Hypocholesterolemic agents
FR2722690B1 (fr) * 1994-07-21 1996-10-25 Univ Montpellier Ii Compositions de saponines et/ou de leurs formes aglycones et leurs applications comme medicaments
SI9520092A (en) * 1994-08-30 1997-12-31 Pfizer Spirostanyl glycosidal crystals
AU2453295A (en) * 1994-09-20 1996-04-19 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
WO1996038466A1 (en) * 1995-05-29 1996-12-05 Pfizer Inc. Steroidal glycosides
US5698527A (en) * 1995-08-08 1997-12-16 Merck & Co., Inc. Steroidal glycosides as antihyperlipidemic agents
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
DE69929177T2 (de) * 1998-03-26 2006-08-24 Phytopharm Plc, Godmanchester Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
JP3370610B2 (ja) * 1998-08-21 2003-01-27 武田薬品工業株式会社 害虫防除剤
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US6343258B1 (en) 1999-08-13 2002-01-29 ALEXIS Brian Method for testing for readiness for harvesting of tribulus terrestris l. having high steroidal saponin content
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
CA2389670A1 (en) * 1999-11-01 2001-05-10 Forbes Medi-Tech Inc. Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
AU2002232575A1 (en) 2000-12-15 2002-06-24 Pacifichealth Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US6703530B2 (en) * 2002-02-28 2004-03-09 General Electric Company Chemical reactor system and process
CN102727501A (zh) * 2002-03-27 2012-10-17 菲特法姆股份有限公司 皂角苷配基及其衍生物的用途
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
PL210114B1 (pl) * 2002-10-28 2011-12-30 Phytopharm Plc Sposób stereospecyficznego wytwarzania 3β-hydroksy-5β-H-steroidowych sapogenin
AP2007003979A0 (en) 2004-11-23 2007-06-30 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
US8258329B2 (en) * 2008-04-18 2012-09-04 Reata Pharmaceuticals, Inc. Dehydroandrosterone analogs including an anti-inflammatory pharmacore and methods of use
CA2731650A1 (en) * 2008-07-22 2010-01-28 Tadashi Honda Monocyclic cyanoenones and methods of use thereof
CA2799708A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
WO2012120414A2 (en) 2011-03-04 2012-09-13 Pfizer Inc. Edn3-like peptides and uses thereof
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178418A (en) 1963-02-26 1965-04-13 Glaxo Lab Ltd Monobromination at the 11-position of hecogenin and 3-lower alkanoyl esters thereof
DE2926463A1 (de) * 1978-07-05 1980-01-24 Roecar Holdings Nv Spiroketaline und ihre verwendung
US4260603A (en) * 1979-01-02 1981-04-07 Pegel Karl H Sterol glycoside with activity as prostaglandin synthetase inhibitor
NZ193564A (en) * 1979-05-02 1985-01-31 Aruba Pty Ltd Steroid alkaloids from solanum sodomeum and pharmaceutical compositions
US4602003A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
ES8404693A1 (es) * 1982-08-12 1984-05-01 Nativelle Sa Ets Procedimiento de preparacion de nuevos amino-14 esteroides.
ES524796A0 (es) * 1982-08-20 1984-05-01 Nativelle Sa Ets Procedimiento de preparacion de nuevos derivos de amino-14 esteroides
IT1188184B (it) 1985-08-14 1988-01-07 Texcontor Ets Sali ammonici quaternari di polisaccaridi ad attivita' ipocolesterolemizzante
US5017562A (en) * 1987-02-11 1991-05-21 Regents Of The University Of Minnesota Crystalline saponin-containing complex
FR2621316B1 (fr) * 1987-10-02 1991-06-21 Nativelle Sa Ets Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant
US5010185A (en) * 1989-06-13 1991-04-23 Pfizer Inc. Processes for tigogenin beta-cellobioside
EP0596015B1 (en) * 1991-07-23 1997-10-01 Schering Corporation Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
AU2675092A (en) * 1991-09-27 1993-04-27 Procter & Gamble Pharmaceuticals, Inc. Use of 14-aminosteroids for the manufacture of a medicament to slow the rate of progression of myocardial structural damages characteristic of congestive heart failure
EP0607245B1 (en) * 1991-10-04 1998-04-22 The Procter & Gamble Company Cholesterol lowering compounds and process for making them
JPH0826064B2 (ja) * 1991-11-25 1996-03-13 ファイザー インク． ステロイドペルアシルグリコシド類の製法
US5530107A (en) * 1992-10-15 1996-06-25 Pfizer Inc. Method for making steroidal peracyl glycosides
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents

Also Published As

Publication number Publication date
RU94046294A (ru) 1996-10-10
CN1085561A (zh) 1994-04-20
EP0796864A2 (en) 1997-09-24
EP0647234A1 (en) 1995-04-12
MX9303826A (es) 1994-02-28
OA10121A (en) 1996-12-18
IL106055A0 (en) 1993-10-20
CZ331094A3 (en) 1995-09-13
BG99261A (en) 1995-06-30
CA2139104A1 (en) 1994-01-06
SK158394A3 (en) 1995-05-10
JPH07504921A (ja) 1995-06-01
US5703052A (en) 1997-12-30
EP0796863A2 (en) 1997-09-24
EP0796862A2 (en) 1997-09-24
KR950702203A (ko) 1995-06-19
HRP930994A2 (en) 1996-08-31
AU4226593A (en) 1994-01-24
YU44793A (sh) 1996-10-09
AP489A (en) 1996-05-02
US5629295A (en) 1997-05-13
WO1994000480A1 (en) 1994-01-06
AP9300539A0 (en) 1993-07-31
JPH09309897A (ja) 1997-12-02

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal