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BR9106978A - Derivados de indol - Google Patents

Derivados de indol

Info

Publication number
BR9106978A
BR9106978A BR919106978A BR9106978A BR9106978A BR 9106978 A BR9106978 A BR 9106978A BR 919106978 A BR919106978 A BR 919106978A BR 9106978 A BR9106978 A BR 9106978A BR 9106978 A BR9106978 A BR 9106978A
Authority
BR
Brazil
Prior art keywords
aryl
alkyl
hydrogen
nr5r6
compounds
Prior art date
Application number
BR919106978A
Other languages
English (en)
Inventor
John Eugene Macor
Martin James Wyther
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24393510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9106978(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of BR9106978A publication Critical patent/BR9106978A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electroluminescent Light Sources (AREA)
  • Lasers (AREA)
BR919106978A 1990-10-15 1991-10-08 Derivados de indol BR9106978A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59792890A 1990-10-15 1990-10-15
PCT/US1991/007194 WO1992006973A1 (en) 1990-10-15 1991-10-08 Indole derivatives

Publications (1)

Publication Number Publication Date
BR9106978A true BR9106978A (pt) 1993-09-28

Family

ID=24393510

Family Applications (2)

Application Number Title Priority Date Filing Date
BR919106978A BR9106978A (pt) 1990-10-15 1991-10-08 Derivados de indol
BR1100080-5A BR1100080A (pt) 1990-10-15 1996-11-12 Compostos derivados de indol e composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR1100080-5A BR1100080A (pt) 1990-10-15 1996-11-12 Compostos derivados de indol e composição farmacêutica

Country Status (33)

Country Link
EP (1) EP0592438B1 (pt)
JP (2) JP2575272B2 (pt)
KR (1) KR0179053B1 (pt)
CN (1) CN1039322C (pt)
AT (1) ATE157361T1 (pt)
AU (1) AU651637B2 (pt)
BG (1) BG61975B1 (pt)
BR (2) BR9106978A (pt)
CA (1) CA2091562C (pt)
DE (3) DE69127468T2 (pt)
DK (1) DK0592438T5 (pt)
EG (1) EG20224A (pt)
ES (1) ES2104733T3 (pt)
FI (1) FI105812B (pt)
GR (1) GR3025087T3 (pt)
HU (2) HUT64326A (pt)
IE (1) IE913555A1 (pt)
IL (3) IL99701A (pt)
LU (1) LU90902I2 (pt)
MX (1) MX9101606A (pt)
MY (1) MY111683A (pt)
NL (1) NL300070I2 (pt)
NO (3) NO305121B1 (pt)
NZ (2) NZ270675A (pt)
OA (1) OA09874A (pt)
PL (3) PL169987B1 (pt)
PT (1) PT99218B (pt)
RO (1) RO111767B1 (pt)
RU (1) RU2095360C1 (pt)
SG (1) SG54270A1 (pt)
WO (1) WO1992006973A1 (pt)
YU (1) YU48088B (pt)
ZA (1) ZA918156B (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
WO1993011106A1 (en) * 1991-11-25 1993-06-10 Pfizer, Inc. Indole derivatives
TW288010B (pt) * 1992-03-05 1996-10-11 Pfizer
EP0635017A1 (en) * 1992-04-07 1995-01-25 Pfizer Inc. Indole derivatives as 5-ht1 agonists
EP0635015B1 (en) * 1992-04-10 1997-01-29 Pfizer Inc. Acylaminoindole derivatives as 5-ht1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (pt) * 1992-11-02 1995-07-11 Pfizer
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ATE144773T1 (de) * 1993-04-22 1996-11-15 Pfizer Res & Dev Indol-derivate als 5-ht1-ähnliche antagonisten zur behandlung von migräne
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
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GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
ATE224388T1 (de) * 1994-10-12 2002-10-15 Pfizer Res & Dev Indolderivate zur behandlung von migräne
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
GB9424471D0 (en) * 1994-12-03 1995-01-18 Pfizer Ltd Treatment of emesis
CZ288897A3 (cs) * 1995-03-20 1998-02-18 Eli Lilly And Company V poloze 5-substituovaný 3-(1,2,3,6-tetrahydropyridin-4-yl)indol a 3-(piperidin-4-yl)indol a farmaceutický prostředek, který je obsahuje
GB9510223D0 (en) * 1995-05-20 1995-07-19 Pfizer Ltd Therapeutic agent
US5945118A (en) * 1995-09-29 1999-08-31 Pfizer Inc Indole derivative for the treatment of migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
GB9825988D0 (en) 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP2000336074A (ja) 1999-03-24 2000-12-05 Sumitomo Chem Co Ltd [2−(アリールスルホニル)エテニル]ベンゼン誘導体の製造方法
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
KR20020035857A (ko) * 1999-08-26 2002-05-15 후지야마 아키라 인돌 유도체 또는 그의 염의 제조방법
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
CZ2004196A3 (cs) 2001-08-15 2005-01-12 Pharmacia & Upjohn Company Krystaly obsahující sůl N-[2-(diethylamino)ethyl]-5-[(5-fluor-2-oxo-3H-indol-3-yliden) methyl]-2,4-dimethyl-1H-pyrrol 3-karboxamidu s kyselinou jablečnou, způsob jejich výroby a kompozice na jejich bázi
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
GB0312478D0 (en) * 2003-05-30 2003-07-09 Pfizer Ltd Improved process
US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
JP4312256B2 (ja) 2005-06-15 2009-08-12 ファイザー・リミテッド 寄生生物に対して使用する置換アリールピラゾール
WO2006079999A2 (en) * 2006-04-09 2006-08-03 Barth Frederik H Induction of a novel state of mind with a 5-ht2a agonist and a nmda antagonist
US20090299077A1 (en) * 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan
EP2296652B1 (en) 2008-06-30 2017-11-08 Afgin Pharma, Llc Topical regional neuro-affective therapy
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IT1393700B1 (it) * 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (en) 2009-06-25 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of eletriptan and its salt thereof
WO2011024039A1 (en) * 2009-08-25 2011-03-03 Ramesh Babu Potluri Synthesis of novel 5-(2-(phenylsulfonyl)ethyl)-1h-indole derivatives
US8754239B2 (en) 2010-01-19 2014-06-17 Sms Pharmaceuticals Limited Process for preparing eletriptan hydrobromide having α-form
CN102606426B (zh) * 2012-03-02 2014-05-21 王仲彦 踏步健身发电装置
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
AU2016226267A1 (en) 2015-03-02 2017-09-28 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
JP2019502761A (ja) 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ ((r)−3−[(−1−メチルピロリジン−2−イル)メチル]−5−(2−フェニルスルホニルエチル)−1h−インドールを作製する方法
CN106065008B (zh) * 2016-06-16 2018-06-05 黑龙江中医药大学 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
TR201619983A2 (tr) 2016-12-29 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇klofenak ve eletri̇ptanin farmasöti̇k formülasyonlari
KR102129947B1 (ko) 2018-06-08 2020-07-03 김종창 콘크리트 타설을 위한 입체형 와이어 메쉬
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Also Published As

Publication number Publication date
EP0592438B1 (en) 1997-08-27
NZ270675A (en) 1997-07-27
IL99701A (en) 1996-10-31
SG54270A1 (en) 1998-11-16
ZA918156B (en) 1993-04-14
NO2001019I1 (no) 2001-12-03
FI931667A0 (fi) 1993-04-14
GR3025087T3 (en) 1998-01-30
NO985607D0 (no) 1998-12-01
JP2677777B2 (ja) 1997-11-17
CN1039322C (zh) 1998-07-29
NO985607L (no) 1998-12-01
PL168919B1 (pl) 1996-05-31
JP2575272B2 (ja) 1997-01-22
HU225055B1 (en) 2006-05-29
PT99218B (pt) 1999-04-30
IL115117A (en) 1996-11-14
YU48088B (sh) 1997-01-08
FI105812B (fi) 2000-10-13
KR0179053B1 (ko) 1999-03-20
DE10299004I2 (de) 2006-03-16
PT99218A (pt) 1992-09-30
RU2095360C1 (ru) 1997-11-10
DK0592438T5 (da) 1999-12-06
DE9190141U1 (de) 1993-07-15
MY111683A (en) 2000-11-30
IL99701A0 (en) 1992-08-18
NO931378L (no) 1993-04-14
PL169987B1 (en) 1996-09-30
PL170330B1 (pl) 1996-11-29
NZ240217A (en) 1995-05-26
CA2091562A1 (en) 1992-04-16
NO305121B1 (no) 1999-04-06
BG97632A (bg) 1994-03-31
LU90902I2 (fr) 2002-06-26
NO931378D0 (no) 1993-04-14
WO1992006973A1 (en) 1992-04-30
ATE157361T1 (de) 1997-09-15
MX9101606A (es) 1992-06-05
RO111767B1 (ro) 1997-01-30
DK0592438T3 (da) 1997-09-29
CN1062529A (zh) 1992-07-08
BG61975B1 (bg) 1998-11-30
EG20224A (en) 1997-12-31
DE69127468T2 (de) 1998-01-02
HU9301098D0 (en) 1993-07-28
EP0592438A1 (en) 1994-04-20
NL300070I2 (nl) 2002-03-01
FI931667A (fi) 1993-04-14
YU165391A (sh) 1994-01-20
JPH05507288A (ja) 1993-10-21
DE10299004I1 (de) 2002-05-08
BR1100080A (pt) 2000-06-06
HUT64326A (en) 1993-12-28
JPH093063A (ja) 1997-01-07
DE69127468D1 (de) 1997-10-02
CA2091562C (en) 2001-03-27
OA09874A (en) 1994-09-15
IE913555A1 (en) 1992-04-22
AU8950491A (en) 1992-05-20
ES2104733T3 (es) 1997-10-16
IL115117A0 (en) 1995-12-08
AU651637B2 (en) 1994-07-28
NL300070I1 (nl) 2002-02-01

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