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BR112013007309A2 - conjugados anticorpo-fármaco (adc) que se ligam às proteínas 191p4d12 - Google Patents

conjugados anticorpo-fármaco (adc) que se ligam às proteínas 191p4d12

Info

Publication number
BR112013007309A2
BR112013007309A2 BR112013007309A BR112013007309A BR112013007309A2 BR 112013007309 A2 BR112013007309 A2 BR 112013007309A2 BR 112013007309 A BR112013007309 A BR 112013007309A BR 112013007309 A BR112013007309 A BR 112013007309A BR 112013007309 A2 BR112013007309 A2 BR 112013007309A2
Authority
BR
Brazil
Prior art keywords
adc
bind
antibody
conjugates
drug
Prior art date
Application number
BR112013007309A
Other languages
English (en)
Other versions
BR112013007309B1 (pt
Inventor
Aya Jakobovits
Daulet Satpaev
Jean Gudas
Karen Jane Meyrick Morrison
Michael Torgov
Robert Kendall Morrison
Zili An
Original Assignee
Agensys Inc
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013007309(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agensys Inc, Seattle Genetics Inc filed Critical Agensys Inc
Publication of BR112013007309A2 publication Critical patent/BR112013007309A2/pt
Publication of BR112013007309B1 publication Critical patent/BR112013007309B1/pt

Links

Classifications

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Abstract

conjugados anticorpo-fármaco (adc) que se ligam às proteínas 191p4d12. a presente invenção refere-se a conjugados anticorpo-fármaco (adc<39>s) que se ligam à proteína 191p4d12 e variantes dos mesmos. o 191p4d12 mostra expressão tecido-específica em tecido adulto normal e é expresso de forma aberrante nos cânceres mencionados na tabela i. consequentemente, os adc<39>s da invenção fornecem uma composição terapêutica para o tratamento do câncer.
BR112013007309-8A 2010-09-29 2011-09-29 conjugado anticorpo-fármaco que compreende um anticorpo anti-191p4d12 conjugado a monometil auristatina e (mmae), seu uso, e composição farmacêutica BR112013007309B1 (pt)

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