BR112012029576B1 - MIXTURES, PESTICIDE COMPOSITION, METHOD FOR IMPROVING THE HEALTH OF PLANTS, METHOD FOR CONTROLLING PESTS IN PLANTS, METHOD FOR PROTECTING PLANT PROPAGATION MATERIALS AND USES OF A MIXTURE - Google Patents

Abstract

MIXTURES, PESTICIDE COMPOSITION, METHODS FOR IMPROVING PLANT HEALTH, METHOD FOR CONTROLLING PESTS AND METHOD FOR PROTECTING PLANT PROPAGATION MATERIALS AND USES OF A MIXTURE. It is a mixture comprising [(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a, 12b-trimethyl-11-oxo -9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro11H,12H-benzo[f]pyrano[4,3-b] chromen-4 -yl]methyl cyclopropanecarboxylate and a fungicidal compound II in synergistically effective amounts, to the use of this mixture to control pests and to improve plant health and to the plant propagation material comprising this mixture.

Description

DESCRIPTION OF THE INVENTION

[001] The present invention relates to synergistic mixtures comprising 1) the insecticidal compound of formula I and 2) one or more, for example, 1, 2, 3 or 4, specifically a fungicidal compound II selected A) from the group of strobilurin fungicides consisting of azoxystrobin, coumethoxystrobin, coumoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, kresoxim-methyl , metominostrobin, orisastrobin, picoxystrobin, pyraclostrobin, pyramethostrobin, pyroxystrobin, piribencarb, trifloxystrobin, 2-[2-(2,5-dimethyl-phenoxymethyl)-phenyl]-3-methoxy-acrylic acid methyl ester and 2-(2- (3-(2,6-dichlorophenyl)-1-methyl-allylideneaminooxymethyl)-phenyl)-2-methoxyimino-N-methyl-acetamide; or B) from the group of carboxanilides consisting of fluxapyroxad, bixafen, penflufen, penthiopyrad, isopyrazam, sedaxane, benalaxyl, benalaxyl-M, benodanil, boscalid, carboxin, fenfuram, fenexamid, flutolanil, furametpir, isotianil, kiralaxyl, mepronil, metalaxyl, ofurace, oxadixyl, oxycarboxin, teclophthalam, thifluzamide, thiadinyl, 2-amino-4-methyl-thiazol-5-carboxanilide, N-(4'-trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazole -4-carboxamide and N-(2-(1,3,3-trimethyl-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1H-pyrazol-4-carboxamide; or

[006]C) from the group of carboxylic morpholides consisting of dimetomorph, flumorph, pyrimorph; or

[007]Cc) from the group consisting of benzimidazoles or benzimidazole releasing precursors consisting of thiophanate, methyl thiophanate, debacarb and furophanate; or

[008]D) from the group of benzoic acid amides consisting of flumetover, fluopicolide, fluopyram, zoxamide; or

[009]E) of the carboxamides carpropamid, dicyclomet, mandiproamid, oxytetracycline, silthiofam and N-(6-methoxy-pyridin-3-yl) cyclopropanecarboxylic acid amide; or

[010]F) from the group of azole fungicides, wherein said group consists of the triazole fungicides azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole , metconazole, myclobutanil, oxpoconazole, paclobutrazol, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole; and in the imidazole fungicides ciazofamid, imazalil, pefurazoate, prochloraz, triflumizole; and in the azoles etaboxam, etridiazole, himexazole and 2-(4-chloro-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-ynyloxy-acetamide ; or

[011]G) from the group of pyridines consisting of fluazinam, pyrifenox, 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine, 3-[5-( 4-methyl-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine; or

[012]H) from the group of pyrimidines consisting of bupyrimate, cyprodinil, diflumetorim, fenarimol, ferimzone, mepanipyrim, nitrapyrin, nuarimol, pyrimethanil; or

[013] I) from the group of piperazines consisting of triporin; or

[014]J) from the group of pyrroles consisting of fenpiclonil, fludioxonil; or

[015]K) of the group and morpholines consisting of aldimorph, dodemorph, dodemorph-acetate, fenpropimorph, tridemorph; or

[016]L) from the group of piperidines consisting of fenpropidine; or

[017]M) from the group of dicarboximides consisting of fluoroimid, iprodione, procymidone, vinclozolin; or

[018]N) from the group of non-aromatic 5-membered heterocycles consisting of famoxadone, fenamidone, flutianil, octylinone, probenazole, S-allyl ester of 5-amino-2-isopropyl-3-oxo-4-ortho-acid tolyl-2,3-dihydro-pyrazol-1-carbothioic acid; or

[019] O) from the group consisting of the fungicides acibenzolar-S-methyl, ametoctradin, amisulbrom, anilazin, blasticidin-S, Captafol, Captan, Quinomethionat, Dazomet, Diclomezine, Diffenzoquat, Diphenzoquatmethylsulfate, Fenoxanil, Folpet, Oxolinic acid, Piperalin, proquinazid, piroquilon, quinoxyfen, triazoxide, tricyclazole, 2-butoxy-6-iodo-3-propylchromen-4-one, 5-chloro-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-methyl- 1H-benzoimidazole and 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine; or

[020]P) of the thio- and dithiocarbamates ferbam, mancozeb, maneb, metam, metasulfocarb, metiram, propineb, thiram, zineb and ziram; or

[021]Q) of the carbamates bentiavalicarb, diethofencarb, iprovalicarb, propamocarb, propamocarb hydrochloride, valifenalate and (4-fluorophenyl) N-(1-(1-(4-cyano-phenyl)ethanesulfonyl)-but-2 acid ester -il) carbamic; or

[022]R) guanidine fungicides consisting of guanidine, dodine, dodine free base, guazatine, guazatine-acetate, iminoctadine, iminoctadine-triacetate and iminoctadine-tris (albesylate); or

[023]S) antibiotic fungicides consisting of kasugamycin, kasugamycin hydrochloride, streptomycin, polyoxin and validamycin A; or

[024]T) of nitrophenyl derivatives consisting of binapacril, dichloran, dinobuton, dinocap, nitrotal-isopropyl and tecnazen, or

[025]U) of organometallic compounds consisting of fentin salts, such as fentin acetate, fentin chloride or fentin hydroxide; or

[026]V) sulfur-containing heterocyclyl compounds consisting of dithianon, isoprothiolane; or

[027] W) organophosphate compounds consisting of edifenphos, fosetyl, fosetyl-aluminum, iprobenphos, phosphorous acid and its salts, pyrazophos, tolclofos-methyl; or

[028] -4-methyl-benzenesulfonamide; or

[029]Y) inorganic active substances consisting of Bordeaux mixture, copper acetate, copper hydroxide, copper oxychloride, basic copper sulfate, sulfur; or

[030]Z) antifungal biocontrol agents, plant bioactivators consisting of Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus pumilus, Bacillus subtilis, Bacillus subtilis variant amyloliquefaciens FZB24, Candida oleophila I-82, Candida saitoana, Clonostachys rosea f. catenulata, also called Gliocladium catenulatum Coniothyrium minitans, Cryphonectria parasitica,Cryptococcus albidus, Fusarium oxysporum, Metschnikowia fructicola, Microdochium dimerum, Phlebiopsis gigantea, Pseudozyma flocculosa, Pytium oligandrum DV74, Reynoutria sachlinensis, Talaromyces flavus V117 b, Trichoderma asperellum SKT-1, T. atroviride LC52, T. harzianum T-22, T. harzianum TH 35, T. harzianum T-39, T. harzianum and T. viride, T. harzianum ICC012 and T. viride ICC080, T. polysporum and T. harzianum, T. stromaticum, T. virens GL-21, T. viride, T. viride TV1, Ulocladium oudemansii HRU3; or

[031]Ab) from the group consisting of the fungicides biphenyl, bronopol, ciflufenamid, cymoxanil, diphenilamin, metrafenone, pyriofenone, mildiomycin, copper-oxyx, prohexadione-calcium, spiroxamine, tebufloquin, tolylfluanid, N-(cyclopropylmethoxyimino-(6 -difluoro-methoxy-2,3-difluoro-phenyl)-methyl)-2-phenyl acetamide, N'-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N -ethyl-N-methyl formamidine, N'-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine, N'-(2- methyl-5-trifluoromethyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methyl formamidine, N'-(5-difluoromethyl-2-methyl-4-(3-trimethylsilanyl-propoxy)- phenyl)-N-ethyl-N-methyl formamidine, methyl-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amide 2-{1-[2-(5-methyl-3- trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-carboxylic acid, methyl-(R)-1,2,3,4-tetrahydro-naphthalen-1-yl-amide 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-carboxylic acid, 6-tert-butyl-8-fluoro- Methoxyacetic acid 2,3-dimethyl-quinolin-4-yl ester and N-Methyl-2-{1-[(5-methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-acetyl]-piperidin -4-yl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-thiazolcarboxamide;

[032]in synergistically effective amounts.

[033] Hereinafter in this document, the compound of formula I is named "compound I".

[034] The mixture according to the invention can be a physical mixture of compound I and at least one compound II. Accordingly, the invention also provides a physical mixture comprising compound I and at least one compound II. However, the mixture can also be any combination of compound I with at least one compound II, and it is not required that compounds I and II be present together in the same formulation.

[035] An example of a mixture according to the invention in which compound I and at least one compound II are not present together in the same formulation is a kit of parts. In a kit of parts, two or more components of a kit are packaged separately, that is, not pre-formulated. Additional details will be explained below.

[036] The present invention additionally relates to binary mixtures comprising compounds of formula I and a compound of formula II.

[037] The present invention also relates to ternary mixtures comprising the compound of formula I and two different compounds of formula II or the compound of formula I, a compound of formula II and an additional active compound III, where compound III is selected from insecticides other than compound I and fungicides other than compound II and, preferably, insecticides other than compound I, in synergistically effective amounts.

[038] Preferably, the present invention relates to ternary mixtures comprising the compound of formula I and two different compounds II, with compounds II being selected from thiophanate-methyl, metalaxyl, azoxystrobin, pyraclostrobin, trifloxystrobin, prochloraz, fludioxonil, dimetomorph, triticonazole, difenoconazole, cresoxim-methyl, boscalid, fluopyram, fluxapyroxad, penflufen, penthiopyrad, sedaxane and pyrimethanil in synergistically effective amounts.

[039] Alternatively, preferably, the present invention relates to ternary mixtures comprising the compound of formula I, a compound II and a compound III, wherein

[040]a) compound II is selected from azoxystrobin, pyraclostrobin, trifloxystrobin, cresoxim-methyl, fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane; It is

[041]b) compound III is selected from clothianidin, imidacloprid, thiamethoxam and fipronil;

[042]in synergistically effective amounts.

[043] The present invention also relates to quaternary mixtures comprising the compound of formula I and three different compounds of formula II, or the compound of formula I, two different compounds of formula II and an additional active compound III, or, of preferably, the compound of formula I, a compound of formula II and two additional active compounds III, where the compound III is as defined above, in synergistically effective amounts.

[044] Preferably, the present invention also relates to quaternary mixtures comprising the compound of formula I, one compound II and two compounds III, wherein

[045]a) compound II is selected from azoxystrobin, pyraclostrobin, trifloxystrobin, cresoxim-methyl, fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane; It is

[046] b) compound III (1) is selected from clothianidin, imidacloprid, thiamethoxam; It is;

[047]c) compound III (2) is selected from fipronil;

[048]in synergistically effective amounts.

[049] The present invention also relates to quinary mixtures comprising the compound of formula I and four different compounds of formula II, or the compound of formula I, three different compounds of formula II and an additional active compound III, or the compound of formula I, a compound of formula II and three additional active compounds III, or, preferably, the compound of formula I, two different compounds of formula II and two additional active compounds III, where the compound III is as defined above, in synergistically effective amounts.

[050] Preferably, the present invention also relates to quinary mixtures comprising the compound of formula I, two compounds II and two compounds III, wherein

[051]a) compound II (1) is selected from azoxystrobin, pyraclostrobin, trifloxystrobin and kresoxim-methyl; It is

[052] b) compound II (2) is selected from fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane; It is

[053]c) compound III (1) is selected from clothianidin, imidacloprid, thiamethoxam; It is;

[054]d) compound III (2) is fipronil;

[055]in synergistically effective amounts.

[056] The terms "binary", "ternary", "quaternary" and "five-fold" in the binary, ternary, quaternary and quinary mixtures defined above refer to the number of active ingredients present in the mixture. "Active ingredient" in this context refers to a compound with an agriculturally relevant action, for example, with a fungicidal, insecticidal, herbicidal or nematicidal activity.

[057] The mixtures referred to above are, hereinafter in this document, also referred to as “mixtures of the invention”.

[058] The present invention also relates to a pesticide composition (agricultural or veterinary), which comprises a liquid or solid carrier and a mixture as defined above.

[059] The present invention further relates to a method for increasing the health of plants, wherein the plant, the location where the plant is growing or is expected to grow, or the plant propagation material from from which the plant grows is treated with an effective amount of a compound of formula I.

[060] Furthermore, the invention relates to a method for controlling pests, wherein the pests, their habitat, breeding sites, their food supply, their location or the plants to be protected against pest attacks, the soil or the plant propagation material are treated with compound I in combination with at least one compound II in effective amounts, or, in other words, are treated with an effective amount of the mixture of the invention.

[061] Additionally, the present invention also relates to a method for protecting plant propagation material and/or plants growing therefrom against pests which comprises contacting the plant propagation material with the compound I in combination with at least one compound II in effective amounts, or, in other words, bringing the plant propagation material into contact with a mixture of the invention in an effective amount. The invention also comprises plant propagation material treated with the mixture of the invention.

[062] The "combined" use of at least one compound I with the at least one compound II or the treatment according to the invention with the at least one compound I "in combination with" the at least one compound II may, for a hand, be understood as the use of a physical mixture of compound I and at least one compound II. On the other hand, combined use may also consist of using compound I and at least one compound II separately, but within a sufficiently short time so that the desired effect can occur. More detailed illustrations of combined use can be found in the specifications below.

[063] The mixture of the invention has fungicidal activity as well as activity against animal pests, especially insecticidal activity. Accordingly, "pest" within the meaning of the present invention refers to phytopathogenic fungi and animal pests, for example, invertebrate pests such as insects, arachnids, mites or nematodes, in particular, arthropod pests such as insects, arachnids or mites, and especially , insects.

[064] Thus, in a preferred embodiment, the invention relates to a method for controlling harmful phytopathogenic fungi that comprises bringing into contact the harmful phytopathogenic fungi, their habitat, plants, soil, plant propagation material or materials to be protected against fungal attack with an effective amount of a mixture as defined above, or, in other words, treat the harmful phytopathogenic fungi, their habitat, the plants, the soil, plant propagation material or materials to be protected against fungal attack with compound I in combination with at least one compound II in amounts effective as a fungicide.

[065] In an alternatively preferred embodiment, the invention relates to a method for controlling invertebrate pests which method comprises treating the pests, their food supply, their habitat or their breeding ground or a plant, plant propagation material, soil, area , material or environment in which invertebrate pests grow or may grow, or the materials, plants, plant propagating material, soils, surfaces or spaces to be protected against invertebrate pest infestation or attack with compound I in combination with at least a compound II in effective amounts, or, in other words, with an effective amount of the mixture of the invention.

[066] In a preferred embodiment, the present invention also relates to a method for protecting plant propagation material and/or plants growing therefrom against harmful phytopathogenic fungi which comprises bringing plant propagation materials into contact with plant with a mixture of the invention in a fungicide-effective amount, or, in other words, with compound I in combination with at least one compound II in fungicide-effective amounts. The invention also comprises plant propagation material treated with the mixture of the invention.

[067] In an alternatively preferred embodiment, the present invention also relates to a method for protecting plant propagation material against attack or infestation by invertebrate pests which comprises contacting plant propagation materials with a mixture of the invention in an effective amount, or, in other words, with compound I in combination with at least one compound II in effective amounts.

[068] The present invention further provides a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises administering or applying, orally, topically or parenterally, to animals, a parasiticidally effective amount of the mixture of the invention , or, in other words, administering or applying compound I to animals in combination with compound II in parasiticidally effective amounts.

[069] Additionally, in a further embodiment, the present invention also comprises a method for increasing the health of plants, wherein said method comprises contacting plant propagation materials of such plants with a mixture of the invention in effective amounts. , or, in other words, with compound I in combination with at least one compound II in effective amounts. The invention also comprises plant propagation material treated with a mixture of the invention.

[070] The invention also relates to the use of the mixture of the invention to improve plant health.

[071] The invention further relates to the use of the mixture of the invention to control pests.

[072] The invention also relates to the use of a compound II to improve the pesticidal activity of compound I.

[073] The term "plant propagation material" should be understood to denote all generative parts of the plant such as seeds and vegetable plant material such as cuttings and bulbs (e.g. potatoes), which can be used for multiplication of the plant . This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, shoots and other parts of plants, including seedlings and young plants, which must be transplanted after germination or after emergence from the soil. These young plants can also be protected before transplanting by a full or partial soaking or pouring treatment. In a particularly preferred embodiment, the term propagation material denotes seeds.

[074] The present invention further relates to a plant protection active ingredient mixture that has a synergistically enhanced plant health-improving action and to a method for improving plant health and/or increasing yield, in which the plant, the location where the plant is growing or is expected to grow or the plant propagation material from which the plant grows is treated with an effective amount of a mixture of the invention.

[075] The compound of formula I, which has the IUPAC name [(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12b -trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro- 11H,12H-benzo[f]pyrano[4 ,3-b]chromen-4-yl]methyl cyclopropanecarboxylate as well as its pesticidal action has been described in documents WO2006/129714 and WO2009/081851, insecticidal mixtures thereof in documents WO2008/108491 and methods for producing the compound are, for example, disclosed in document WO2009/022702.

[076] Compounds II as well as their pesticide action and methods for producing them are, in general, known. For example, commercially available compounds can be found in The Pesticide Manual, 14th Edition, British Crop Protection Council (2006) among other publications. Fluxapyroxad, bixafen, penflufen, penthiopyrad, isopyrazam and sedaxane are known fungicides (compare, for example, EP-A 545 099, EP-A 589 301, EP-A 737682, EP-A 824099, WO 99/09013, WO 03 /010149, WO 03/070705, WO 03/074491, WO 2004/005242, WO 2004/035589, WO 2004/067515, WO 06/087343), or they can be prepared in the manner described therein.

[077] Metalaxyl is a fungicide that includes: metalaxyl; metalaxyl consisting of equal to or more than 50% by weight of the R-enantiomer and equal to or less than 50% of the S-enantiomer; metalaxyl consisting of more than 85% by weight of the R-enantiomer less than 15% of the S-enantiomer; metalaxyl consisting of more than 92% by weight of the R-enantiomer and less than 8% of the S-enantiomer; metalaxyl consisting of more than 97% by weight of the R-enantiomer less than 3% of the S-enantiomer; and mefenoxam (i.e., more than 97.5% R-metalaxyl or metalaxyl-M and less than 2.5% S-enantiomer). See, for example, The Pesticide Manual, 11th Edition (1997), The British Crop Protection Council, London, page 792; and The Pesticide Manual, 11th Edition (1997), The British Crop Protection Council, London, page 794.

[078] References for Group Z biological control agents) are presented below: Ampelomyces quisqualis (e.g. AQ 10® with Intrachem Bio GmbH & Co. KG, Germany), Aspergillus flavus (e.g. AFLAGUARD® with Singenta, CH), Aureobasidium pullulans (e.g. BOTECTOR® from bio-ferm GmbH, Germany), Bacillus pumilus (e.g. Accession No. NRRL B-30087 in SONATA® and BALLAD® Plus from AgraQuest Inc., USA), Bacillus subtilis (e.g. NRRL-Nr. B-21661 isolated in RHAPSODY®, SERENADE® MAX and SERENADE® ASO from AgraQuest Inc., USA), Bacillus subtilis variant amyloliquefaciens FZB24 (e.g. TAEGRO® from Novozyme Biologicals, Inc., USA), Candida oleophila I-82 (e.g. ASPIRE® from Ecogen Inc., USA), Candida saitoana (e.g. BIOCURE® (in mixture with lysozyme) and BIOCOAT® from Micro Flo Company, USA (BASF SE) and Arysta), Chitosan (e.g. ARMOUR-ZEN with BotriZen Ltd., NZ), Clonostachys rosea f. catenulata, also called Gliocladium catenulatum (e.g. J1446 isolated: PRESTOP® near Verdera, Finland), Coniothyrium minitans (e.g. CONTANS® near Prophita, Germany), Cryphonectria parasitica (e.g. Endotia parasitica near CNICM, France ), Cryptococcus albidus (e.g. YIELD PLUS® with Anchor Bio-Technologies, South Africa), Fusarium oxysporum (e.g. BIOFOX® with S.I.A.P.A., Italy, FEUACLEAN® with Natural Plant Protection, France), Metschnikowia fructicola (e.g. SHEMER® from Agrogreen, Israel), Microdochium dimerum (e.g. ANTIBOT® from Agrauxina, France), Phlebiopsis gigantea (e.g. ROTSOP® from Verdera, Finland), Pseudozyma flocculosa (e.g. SPORODEX ® with Plant Products Co. Ltd., Canada), Pytium oligandrum DV74 (e.g. POLYVERSUM® with Remeslo SSRO, Biopreparaty, Czech Rep.), Reynoutria sachlinensis (e.g. REGALIA® with Marrone BioInnovations, USA) , Talaromyces flavus V117b (e.g., PROTUS® from Prophita, Germany), Trichoderma asperellum SKT-1 (e.g., ECO-HOPE® from Kumiai Chemical Industry Co., Ltd., Japan), T. atroviride LC52 (by e.g. SENTINEL® from Agrimm Technologies Ltd, NZ), T. harzianum T-22 (e.g. PLANTSHIELD® from Firma BioWorks Inc., USA), T. harzianum TH 35 (e.g. ROOT PRO® from Mycontrol Ltd ., Israel), T. harzianum T-39 (e.g., TRICHODEX® and TRICHODERMA 2000® from Mycontrol Ltd., Israel and Makhteshim Ltd., Israel), T. harzianum and T. viride (e.g., TRICHOPEL from Agrimm Technologies Ltd, NZ), T. harzianum ICC012 and T. viride ICC080 (e.g. REMEDIER® WP with Isagro Ricerca, Italy), T. polysporum and T. harzianum (e.g. BINAB® with BINAB Bio-Innovation AB, Sweden), T. stromaticum (e.g. TRICOVAB® with C.E.P.L.A.C., Brazil), T. virens GL-21 (e.g. SOILGARD® with Certis LLC, USA), T. viride (e.g. TRIECO® together with Ecosense Labs. (India) Pvt. Ltd., Indien, BIOCURE® F with T. Stanes & Co. Ltd., Indien), T. viride TV1 (e.g. T. viride TV1 with Agribiotec srl, Italy), Ulocladium oudemansii HRU3 (e.g. BOTRY-ZEN® from Botry-Zen Ltd, NZ).

[079] A typical problem that arises in the field of pest control lies in the need to reduce dosage rates of the active ingredient in order to reduce or avoid unfavorable environmental or toxicological effects while still allowing effective pest control.

[080] The term "phytopathogenic harmful fungi" is, hereinafter in this document, also abbreviated as "harmful fungi".

[081] Another problem encountered is related to the need to have pest control agents available that are effective against a broad spectrum of harmful fungi.

[082] There is also a need for pest control agents that combine knock-down activity with prolonged control, that is, rapid action with long-lasting action.

[083] Another difficulty regarding the use of pesticides is that the repeated and exclusive application of an individual pesticide compound leads, in many cases, to a rapid selection of harmful fungi, which have developed natural or adapted resistance against the active compound in question. Therefore, there is a need for pest control agents that help prevent or overcome resistance.

[084] Another problem that underlies the present invention is the desire for compositions that improve plants, a process that is commonly and, hereinafter in this document, called “plant health”.

[085] The term “plant health” comprises various types of plant improvements that are not connected to pest control. For example, advantageous properties that may be mentioned are improved crop characteristics that include: emergence, crop yields, protein content, oil content, starch content, more developed root system (improved root growth), stress tolerance improved (e.g. against dryness, heat, salt, UV, water, cold), reduced ethylene (reduced production and/or inhibition of reception), increased tillering, increased plant height, increased leaf blade, fewer basal leaves deadheads, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less input needed (such as fertilizer or water), fewer seeds needed, more productive tillers, early flowering, early grain maturity, less plant backside ( lodging), increased shoot growth, enhanced plant vigor, increased plant support, and earlier, more satisfactory germination; or any other advantages familiar to one skilled in the art.

[086] If used in connection with the treatment of plant propagation material (preferably seeds), the term "plant health" is equivalent to "seed vitality". Seed vitality itself manifests itself in a variety of factors. Examples of factors that are manifestations of plant vitality are:

[087] (a) general visual appearance;

[088](b) root growth and/or root development;

[089](c) size of the leaf area;

[090](d) intensity of the green color of the leaves;

[091](e) number of dead leaves close to the ground;

[092](f) plant height;

[093](g) plant weight;

[094](h) growth rate;

[095] (i) plant support density;

[096](j) germination behavior;

[097](k) emergence behavior;

[098](l) number of shoots;

[099](m) type of sprout (quality and productivity)

[0100](n) plant resistance, for example, resistance to biotic or abiotic stress;

[0101] (o) presence of necrosis;

[0102](p) senescence behavior.

[0103] Preferably, the term "seed vitality" denotes plant bearing density, seed storage capacity and/or germination behavior.

[0104] An additional objective of various crop protection efforts is to increase plant yields. “Yield” should be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the appropriate sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of forestry plants) or even flowers (for example, in the case of garden, ornamental plants). Plant products can, in addition, be further used and/or processed after harvest.

[0105] According to the present invention, "increased yield" of a plant, in particular an agricultural plant, from forestry and/or horticulture, preferably an agricultural plant, means that the yield of a product from the respective plant is increased by a measurable amount above the yield of the same product from the plant produced under the same conditions, but without applying the mixture according to the invention.

[0106] The increased yield can be characterized, among others, by the following improved properties of the plant:

[0107]• increased plant weight

[0108]• increased plant height

[0109]• Increased biomass as higher overall fresh weight (FW)

[0110]• higher grain yield

[0111]• more tillers

[0112]• larger leaves

[0113]• increased bud growth

[0114]• increased protein content

[0115]• increased oil content

[0116]• increased starch content

[0117]• increased pigment content.

[0118] According to the present invention, the yield is increased by at least 2%, preferably by at least 4%, more preferably by at least 8%, even more preferably by at least 16%.

[0119] It should be emphasized that the above effects of the mixture of the invention or compound I when used alone, i.e. enhanced crop yield of the plant, are also present when the plant is not under biotic stress and, in particular, when The plant is not under pest pressure, such as fungal or insect stress. It is evident that a plant that suffers from a pest attack produces a lower biomass and a lower crop yield when compared to a plant that has undergone curative or preventive treatment against the pest and that can grow without the damage caused by the biotic stress factor. . However, the use and method according to the invention lead to an enhanced crop yield even in the absence of any biotic stress and, in particular, in the absence of any pest. This means that the positive effect of the mixture of the invention or compound I used alone on crop yield cannot be explained solely by the pesticide activities of the mixture, but is based on additional activity profiles. But, certainly, plants under biotic stress can also be treated according to the methods of the present invention.

[0120] Documents EP 2119361 and EP 2223599 disclose various pesticide mixtures that may, among other things, comprise the compound of formula I.

[0121] However, the excellent synergistic plant health and/or fungicidal action of the specific mixtures of the invention as defined at the outset are not disclosed in this, nor, what such combinations may have and, especially, their quality of being suitable for seed treatment purposes.

[0122] Therefore, it was an object of the present invention to provide pesticide mixtures that solve the problems of reducing the dose rate and/or accentuating the spectrum of activity and/or combining knock-down activity with prolonged control and /or for resistance management and/or plant health promotion.

[0123] It was also an object of the present invention to provide methods of increasing plant health.

[0124] It was found that this objective is, in part or as a whole, achieved by complex mixtures comprising the active compounds defined at the beginning.

[0125] In the present document, a method for increasing the health of plants has been found, in which the plant, the place where the plant is growing or is expected to grow, or the plant propagation material from which the The plant grows is treated with an effective amount of a compound of formula I, preferably the plant propagation material from which the plant grows is treated with an effective amount of a compound of formula I. Such said treatment Lastly of plant propagation material leads to increase in seed vitality.

[0126] It has been found that the mixtures as defined at the beginning show markedly enhanced action against harmful pests, such as harmful fungi or animal pests, preferably harmful fungi, compared to the control rates that are possible with the individual compounds and/or are suitable for improving plant health when applied to plants, plant parts, plant propagation materials (preferably seeds), or their place of growth.

[0127] It was found that the action of the mixtures of the invention goes far beyond the pesticide action, as a fungicide or insecticide, preferably fungicide, and/or improving the plant health of the active compounds present in the mixture alone (synergism).

[0128] In particular, it was found that the action of the mixtures of the invention goes far beyond the pesticide action, as a fungicide or insecticide, preferably fungicide, and/or improving plant health of the active compounds present in the mixture alone (synergism ) if applied as a seed treatment.

[0129] These mixtures are also suitable for improving the health of plants when applied to plants, parts of plants, seeds, or their place of growth, preferably on plants and plant propagation material, more preferably on seeds .

[0130] Furthermore, it was found that simultaneous application, i.e. united or separate, of compound I and compound II or the successive application of compound I and compound II allows accentuated control of harmful pests, such as harmful fungi or pests animals, preferably harmful fungi, compared to the control rates that are possible with individual compounds (synergistic mixtures).

[0131] Furthermore, it was found that simultaneous application, i.e. united or separate, of compound I and compound II or successive application of compound I and compound II provides enhanced plant health effects compared to the health effects of plant that are possible with the individual compounds (synergistic mixtures in which the synergism is plant health synergism).

[0132] In general, the general amounts by weight for respective mixtures comprising compound I and at least one compound II are from 1:500 to 1500:1, preferably from 1:100 to 1500:1, with more preferably, from 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200:1 or 20:1 to 1100:1.

[0133] In a preferred embodiment, the present invention relates to synergistic mixtures comprising,

[0134]1) the insecticidal compound of formula I It is

[0135]2) one or more, for example, 1, 2, 3 or 4, specifically a fungicidal compound II selected from compounds of the following groups A to Ab:

[0136] A) strobilurin fungicides selected from the group consisting of coumethoxystrobin, coumoxystrobin, dimoxystrobin, enestroburin, metominostrobin, pyraclostrobin, pyramethostrobin, pyraoxystrobin, 2-[2-(2,5-dimethyl-phenoxymethyl)-phenyl acid methyl ester ]-3-methoxy-acrylic and 2-(2-(3-(2,6-dichlorophenyl)-1-methyl-allylideneaminooxymethyl)-phenyl)-2-methoxyimino-N-methyl-acetamide;

[0137] B) carboxanilides selected from the group consisting of fluxapiroxad, bixafen, penflufen, sopirazam, sedaxane, benodanil, carboxin, fenfuram, fenhexamid, furametpyr, kiralaxyl, oxycarboxin, tecloftalam, thifluzamide, 2-amino-4-methyl- thiazol-5-carboxanilide, N-(4'-trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazol-4-carboxamide and N-(2-(1,3,3-trimethyl-butyl )-phenyl)-1,3-dimethyl-5-fluoro-1H-pyrazol-4-carboxamide;

[0138]C) carboxylic morpholides selected from the group consisting of flumorph, and pyrimorph;

[0139]Cc) benzimidazoles or benzimidazole releasing precursors selected from the group consisting of debacarb and furophanate;

[0140]D) benzoic acid amides selected from the group consisting of flumetover, fluopyram, zoxamide;

[0141]E) carboxamides selected from the group consisting of mandiproamid, oxytetracycline, silthiofam and N-(6-methoxy-pyridin-3-yl) cyclopropanecarboxylic acid amide;

[0142] F) azole fungicides, such group selected from the group consisting of the triazole fungicides azaconazole, bromuconazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, fenbuconazole, fluquinconazole, flutriafol, imibenconazole, ipconazole, metconazole, oxpoconazole, paclobutrazol, prothioconazole, tetraconazole, triadimenol, triticonazole, uniconazole; of the imidazole fungicides imazalil, pefurazoate; and of the azoles etaboxam, etridiazole, himexazole and 2-(4-chloro-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-ynyloxy-acetamide ;

[0143]G) pyridines selected from the group consisting of 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine, 3-[5-(4-methyl- phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine;

[0144]H) pyrimidines selected from the group consisting of bupirimate, diflumetorim, nitrapyrin, nuarimol;

[0145] K) morpholines selected from the group consisting of aldimorph, dodemorph, dodemorph-acetate, tridemorph; O

[0146]M) dicarboximides selected from the group consisting of fluoroimid;

[0147]N) non-aromatic 5-membered heterocycles selected from the group consisting of flutianyl, octilinone, S-allyl ester of 5-amino-2-isopropyl-3-oxo-4-ortho-tolyl-2,3-dihydro acid -pyrazole-1-carbothioic acid;

[0148] O) fungicides selected from the group consisting of ametoctradin, amisulbrom, anilazin, blasticidin-S, quinomethionat, dazomet, diclomezine, diphenzoquat, diphenzoquat-methylsulfate, oxolinic acid, piperalin, triazoxide, 2-butoxy-6-iodo-3 -propylchromen-4-one, 5-chloro-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-methyl-1H-benzoimidazole and 5-chloro-7-(4-methylpiperidin-1-yl) -6- (2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine;

[0149] P) thio- and dithiocarbamates selected from the group consisting of ferbam, metam, metasulfocarb, metiram, thiram and ziram;

[0150] Q) carbamates selected from the group consisting of propamocarb, propamocarb hydrochloride, valifenalate and (4-fluorophenyl) acid ester N-(1-(1-(4-cyano-phenyl)ethanesulfonyl)-but-2- il) carbamic;

[0151] R) guanidine fungicides selected from the group consisting of guanidine, dodine, dodine free base, guazatine, guazatine-acetate, iminoctadine, iminoctadine-triacetate and iminoctadine-tris (albesylate); or

[0152] S) antibiotic fungicides selected from the group consisting of streptomycin, polyoxin;

[0153]T) nitrophenyl derivatives selected from the group consisting of binapacril, dichloran, dinobuton, dinocap, nitrotal-isopropyl and tecnazen,

[0154]U) organometallic compounds selected from the group consisting of fentin salts, such as fentin acetate, fentin chloride or fentin hydroxide;

[0155] V) sulfur-containing heterocyclyl compounds consisting of dithianon, isoprothiolane;

[0156] W) organophosphate compounds selected from the group consisting of edifenphos, iprobenfos, phosphorous acid and its salts, pyrazophos;

[0157] ;

[0158]Y) inorganic active substances selected from the group consisting of Bordeaux mixture, copper acetate, copper oxychloride, basic copper sulfate, sulfur;

[0159]Z) antifungal biocontrol agents, plant bioactivators selected from the group consisting of Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus pumilus, Bacillus subtilis, Bacillus subtilis variant amyloliquefaciens FZB24, Candida oleophila I-82, Candida saitoana, Clonostachys rosea f. catenulata, also called Gliocladium catenulatum Coniothyrium minitans, Cryphonectria parasitica,Cryptococcus albidus, Fusarium oxysporum, Metschnikowia fructicola, Microdochium dimerum, Phlebiopsis gigantea, Pseudozyma flocculosa, Pytium oligandrum DV74, Reynoutria sachlinensis, Talaromyces flavus V117 b, Trichoderma asperellum SKT-1, T. atroviride LC52, T. harzianum T-22, T. harzianum TH 35, T. harzianum T-39, T. harzianum and T. viride, T. harzianum ICC012 and T. viride ICC080, T. polysporum and T. harzianum, T. stromaticum, T. virens GL-21, T. viride, T. viride TV1, Ulocladium oudemansii HRU3; It is

[0160]Ab) fungicides selected from the group consisting of biphenyl, bronopol, diphenylamine, metrafenone, pyriofenone, mildiomycin, oxycopper, prohexadione-calcium, spiroxamine, tebufloquin, tolylfluanid, N-(cyclopropylmethoxyimino-(6-difluoro- methoxy-2,3-difluoro-phenyl)-methyl)-2-phenyl acetamide, N'-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl- N-methyl formamidine, N'-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine, N'-(2-methyl-5 -trifluoromethyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methyl formamidine, N'-(5-difluoromethyl-2-methyl-4-(3-trimethylsilanyl-propoxy)-phenyl)- N-ethyl-N-methyl formamidine, 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazole) acid methyl-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amide -1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-carboxylic acid, methyl-(R)-1,2,3,4-tetrahydro-naphthalen-1-yl-amide 2-{ 1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-carboxylic acid, 6-tert-butyl-8-fluoro-2,3 -dimethyl-quinolin-4-yl ester of methoxy-acetic acid and N-Methyl-2- {1-[(5-methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-acetyl]-piperidin-4- yl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-thiazolcarboxamide;

[0161] in synergistically effective amounts.

[0162] Suitable and preferred weight ratios of compound I and compound(s) II are listed above.

[0163] Alternatively, preference is given to mixtures comprising the compound I and, like the fungicidal compound II, at least one fungicide selected from the group A strobilurins), and particularly selected from the strobilurins azoxystrobin, coumethoxystrobin, coumoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, cresoxim-methyl, metominostrobin, orisastrobin, picoxystrobin, pyraclostrobin, pyramethostrobin, pyraoxystrobin, piribencarb and trifloxystrobin, more preferably, azoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, cresoxim-methyl, metominostrobin, orisastrobin, picoxystrobin, pyraclostrobin, piribencarb and trifloxystrobin in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably 1:100 to 1000:1, more preferably 1:25 to 500:1 , even more preferably, from 1:10 to 100:1, and, in particular, from 1:1 to 100:1, for example, 1:10 to 100:1 or 1:20 to 100:1. Further preference is given to mixtures comprising the compound I and, like the fungicidal compound II, at least one fungicide selected from the group A strobilurins), which are in turn selected from the strobilurins dimoxystrobin, enestroburin, metominostrobin and pyraclostrobin. in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably 1:100 to 1500:1, more preferably 1:25 to 1000: 1, even more preferably, from 1:10 to 500:1, and, in particular, from 1:1 to 100:1, for example, 10:1 to 100:1 or 20:1 to 100:1. Specifically, the strobilurin fungicide is pyraclostrobin.

[0164] Alternatively, preference is given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group B carboxamides), and particularly selected from bixafen, boscalid, fluxapyroxad, isopyrazam, penflufen, penthiopyrad , sedaxane, metalaxyl and ofurace in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably of 1:100 to 1500:1, more preferably of 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200:1 or 20:1 at 1100:1. More preference is given to mixtures comprising the compound I and, like the fungicidal compound II, at least one fungicide selected from group B carboxamides), which are preferably selected from bixafen, fluxapyroxad, isopyrazam, penflufen and sedaxane in amounts synergistically effective, preferably in a weight ratio of compound I:II of 1:500 to 1500:1, preferably of 1:100 to 1500:1, more preferably of 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200:1 or 20:1 to 1100:1. Specifically, the carboxamide fungicide is fluxapyroxad.

[0165] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group C) or D), and particularly selected from dimetomorph, flumorph, fluopicolid (picobenzamid) and zoxamide in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25: 1 and most preferably, from 1:10 to 10:1. More preference is given to mixtures comprising the compound I and, like the fungicidal compound II, at least one fungicide selected from group C) or D), which are selected from flumorph and zoxamide in synergistically effective amounts, preferably in a ratio by weight of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0166] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group E), and particularly selected from carpropamid and mandipropamid in synergistically effective amounts, preferably in a weight ratio of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1. More preference is given to mixtures comprising the compound I and, as the fungicidal compound II, mandipropamid in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably, from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0167] More preference is also given to mixtures comprising a compound of formula I and, like the fungicidal compound II, at least one fungicide selected from the group of azoles F), and particularly selected from the azoles cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, himexazole, ipconazole, imazalil, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, triadimefon, triadimenol, tebuconazole, tetraconazole, triticonazole, prochloraz, cyazofamid, and etaboxam in synergistically effective amounts, preferably in a weight ratio of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1 . More preference is given to mixtures comprising a compound of formula I and, like the fungicidal compound II, at least one fungicide selected from the azoles group F), which are selected from the azoles difenoconazole, epoxiconazole, fluquinconazole, flutriafol, himexazole, ipconazole, imazalil, metconazole, prothioconazole, triadimenol, tetraconazole, triticonazole, cyazofamid, and etaboxam in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0168] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group G), and particularly selected from fluazinam in synergistically effective amounts, preferably in a ratio in weight of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10 :1.

[0169] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group H), and particularly selected from cyprodinil, fenarimol, mepanipyrim, pyrimethanil in synergistically effective amounts, of preferably, in a weight ratio of compound I:II of 1:500 to 500:1, preferably, of 1:100 to 100:1, more preferably, of 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0170] More preference is also given to mixtures comprising compound I and triporin in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1: 100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1:10 to 10:1.

[0171] More preference is also given to mixtures comprising compound I and fludioxonil in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1: 100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1:10 to 10:1.

[0172] More preference is also given to mixtures comprising compound I and at least one fungicidal compound II selected from the group of morpholines, in particular, dodemorph, fenpropimorph or tridemorph. More preference is also given to mixtures comprising compound I and at least one fungicidal compound II selected from the group of morpholines, which are selected from dodemorph and tridemorph.

[0173] More preference is also given to mixtures comprising compound I and silthiofam in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1: 100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1:10 to 10:1.

[0174] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group M), and particularly selected from iprodione and vinclozolin in synergistically effective amounts, preferably in a weight ratio of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0175] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group N), and particularly selected from famoxadone, fenamidone and probenazole in synergistically effective amounts, preferably, in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1 :10 to 10:1.

[0176] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group O), and particularly selected from acibenzolar-S-methyl, capitafol, folpet, fenoxanil, quinoxifen and ametoctradin in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25:1 and most preferably, from 1:10 to 10:1. More preference is given to mixtures comprising the compound I and, as the fungicidal compound II, ametoctradin in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably, from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0177] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group P), and particularly selected from mancozeb, metiram, propineb and thiram in synergistically effective amounts, of preferably, in a weight ratio of compound I:II of 1:500 to 500:1, preferably, of 1:100 to 100:1, more preferably, of 1:25 to 25:1 and most preferably, from 1:10 to 10:1. More preference is given to mixtures comprising the compound I and, like the fungicidal compound II, at least one fungicide selected from group P), which is selected from metiram, and thiram in synergistically effective amounts, preferably in a weight ratio of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10: 1.

[0178] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group Q), and particularly selected from iprovalicarb, bentiavalicarb and propamocarb in synergistically effective amounts, preferably, in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1 :10 to 10:1. More preference is given to mixtures comprising the compound I and, as the fungicidal compound II, propamocarb in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0179] More preference is also given to mixtures comprising compound I and dithianon in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1: 100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1:10 to 10:1.

[0180] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group U), and particularly selected from salts of fentin, such as fentin acetate in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25:1 and most preferably , from 1:10 to 10:1.

[0181] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group W), and particularly selected from fosetyl, fosetyl aluminum, phosphorous acid and salts thereof in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25:1 and most preferably, from 1:10 to 10:1. More preference is given to mixtures comprising the compound I and, as the fungicidal compound II, phosphorous acid and salts thereof in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500: 1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0182] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group weight ratio of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0183] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group Y), and particularly selected from copper acetate, copper hydroxide, copper oxychloride, sulfate of copper and sulfur in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably of 1: 25 to 25:1 and most preferably, from 1:10 to 10:1. More preference is given to mixtures comprising the compound I and, like the fungicidal compound II, at least one fungicide selected from group Y), and particularly selected from copper acetate, copper oxychloride, copper sulfate and sulfur in synergistically effective amounts. , preferably, in a weight ratio of compound I:II of 1:500 to 500:1, preferably, of 1:100 to 100:1, more preferably, of 1:25 to 25:1 and with maximum preferably from 1:10 to 10:1.

[0184] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group Ab), and particularly selected from cymoxanil, metrafenone, spiroxamine and N-methyl-2-{ 1-[(5-methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1- yl]-4-thiazolecarboxamide in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably of 1:25 to 25:1 and most preferably, from 1:10 to 10:1. More preference is given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group Ab), which is selected from metrafenone, spiroxamine and N-methyl-2-{1-[(5- methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-thiazolcarboxamide in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25: 1 and most preferably, from 1:10 to 10:1.

[0185] More preference is also given to mixtures comprising compound I and at least one active substance selected from the antifungal biocontrol agents given in group Z) and particularly selected from Bacillus subtilis strain NRRL No. B-21661, Bacillus strain pumilus NRRL N° B-30087 and Ulocladium oudemansii in synergistically effective amounts.

[0186] More preference is also given to mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from group Cc), and particularly selected from thiophanate-methyl, benomyl, carbendazim and thiabendazole in synergistically effective amounts. , preferably, in a weight ratio of compound I:II of 1:500 to 500:1, preferably, of 1:100 to 100:1, more preferably, of 1:25 to 25:1 and with maximum preferably from 1:10 to 10:1.

[0187] As mentioned at the beginning, the mixtures of the invention are in a preferred embodiment used as a seed treatment. For the purpose of seed treatment, the following mixtures are preferred:

[0188] Mixtures comprising compound I and, like fungicidal compound II, at least one fungicide selected from the strobilurins azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, orisastrobin, picoxystrobin, pyraclostrobin, and trifloxystrobin, more preferably dimoxystrobin and pyraclostrobin, in particular pyraclostrobin, in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably of 1:100 to 1000:1, more preferably, from 1:25 to 500:1, even more preferably, from 1:10 to 100:1, and, in particular, from 1:1 to 100:1, for example, 10:1 to 100:1 or 20: 1 to 100:1.

[0189] Mixtures comprising compound I and, like fungicidal compound II, at least one carboxamide fungicide selected from bixafen, boscalid, fluopyram, fluxapiroxad, isopyrazam, penflufen, penthiopyrad and sedaxane, more preferably from bixafen, fluxapiroxad, isopyrazam, penflufen and sedaxane, in particular fluxapyroxad, in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably of 1:100 to 1500:1, more preferably, from 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200: 1 or 20:1 to 1100:1.

[0190] Mixtures comprising a compound of formula I and at least one azole fungicide selected from the azoles cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flutriafol, himexazole, ipconazole, imazalil, metconazole, prothioconazole, tebuconazole, triticonazole, prochloraz and pyrimethanil, of preferably, difenoconazole, epoxiconazole, fluquinconazole, flutriafol, himexazole, ipconazole, imazalil, metconazole, prothioconazole and triticonazole, in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0191] Mixtures comprising a compound of formula I and at least one fungicide selected from fludioxonil, silthiofam, iprodione, metiram and tiram in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0192] Mixtures comprising compound I and at least one active substance selected from antifungal biocontrol agents Bacillus subtilis strain NRRL No. B-21661, Bacillus pumilus strain NRRL No. B-30087 and Ulocladium oudemansii in synergistically effective amounts.

[0193] Mixtures comprising compound I and, like fungicidal compound II, at least one banzimidazole fungicide or benzimidazole-releasing precursor selected from thiophanate-methyl, benomyl, carbendazim, and thiabendazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably 1:25 to 25:1 and most preferably 1: 10 to 10:1.

[0194] For the purpose of seed treatment, the following mixtures are most preferred:

[0195] Mixtures comprising compound I and, as fungicidal compound II, a fungicide selected from the strobilurins azoxystrobin, cresoxim-methyl, orisastrobin, picoxystrobin, pyraclostrobin, and trifloxystrobin, more preferably, dimoxystrobin and pyraclostrobin, in particular, pyraclostrobin , in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably 1:100 to 1000:1, more preferably 1:25 to 500 :1, even more preferably, from 1:10 to 100:1, and, in particular, from 1:1 to 100:1, for example, 10:1 to 100:1 or 20:1 to 100:1.

[0196] Mixtures comprising compound I and, as fungicidal compound II, a carboxamide fungicide selected from boscalid, fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane, more preferably from bixafen, fluxapiroxad, isopyrazam, penflufen and sedaxane, in particular, fluxapyroxad, in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably 1:100 to 1500:1, more preferably 1 :25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200:1 or 20:1 to 1100:1.

[0197] Mixtures comprising a compound of formula I and an azole fungicide selected from the azoles cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flutriafol, himexazole, ipconazole, imazalil, metconazole, prothioconazole, tebuconazole, triticonazole, prochloraz and pyrimethanil, preferably, of difenoconazole, epoxiconazole, fluquinconazole, flutriafol, himexazole, ipconazole, imazalil, metconazole, prothioconazole and triticonazole, in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably , from 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0198] Mixtures comprising a compound of formula I and a fungicide selected from fludioxonil, silthiofam, iprodione, metiram and tiram in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500: 1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0199] Mixtures comprising compound I and at least one active substance selected from antifungal biocontrol agents, Bacillus subtilis strain NRRL No. B-21661, Bacillus pumilus strain NRRL No. B-30087 and Ulocladium oudemansii in synergistically effective amounts .

[0200] Mixtures comprising compound I and, like fungicidal compound II, a benzimidazole or benzimidazole releasing precursor fungicide selected from thiophanate-methyl, benomyl, carbendazim, and thiabendazole in synergistically effective amounts, preferably in a ratio by weight of compound I:II from 1:500 to 500:1, preferably from 1:100 to 100:1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0201] For the purpose of seed treatment, the following mixtures are highly preferred:

[0202] Mixtures comprising compound I and azoxystrobin in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0203] Mixtures comprising compound I and pyraclostrobin in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 100:1, even more preferably, from 1:10 to 100:1, and, in particular, from 1:1 to 100:1, for example, 10:1 to 100: 1 or 20:1 to 100:1.

[0204] Mixtures comprising compound I and trifloxystrobin in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0205] Mixtures comprising compound I and kresoxim-methyl in synergistically effective amounts, preferably, in a weight ratio of compound I:II of 1:500 to 500:1, preferably, of 1:100 to 100: 1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0206] Mixtures comprising compound I and boscalid in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0207] Mixtures comprising compound I and fluopyram in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0208] Mixtures comprising compound I and fluxapyroxad in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably from 1:100 to 1500:1, more preferably, from 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200: 1 or 20:1 to 1100:1.

[0209] Mixtures comprising compound I and penflufen in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0210] Mixtures comprising compound I and penthiopyrad in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0211] Mixtures comprising compound I and sedaxane in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0212] Mixtures comprising compound I and fluquinconazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0213] Mixtures comprising compound I and ipconazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0214] Mixtures comprising compound I and prothioconazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0215] Mixtures comprising compound I and tebuconazole in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0216] Mixtures comprising compound I and triticonazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0217] Mixtures comprising compound I and prochloraz in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0218] Mixtures comprising compound I and fludioxonil in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0219] Mixtures comprising compound I and silthiofam in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0220] Mixtures comprising compound I and iprodione in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0221] Mixtures comprising compound I and extract in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0222] Mixtures comprising compound I and thiophanate-methyl in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100: 1, more preferably from 1:25 to 25:1 and most preferably from 1:10 to 10:1.

[0223] Mixtures comprising compound I and carbendazim in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0224] Mixtures comprising compound I and metalaxyl in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0225] Mixtures comprising compound I and dimethomorph in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0226] Mixtures comprising compound I and difenoconazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0227] Extreme preference is given, for the purpose of seed treatment, to the following mixtures:

[0228] Mixtures comprising compound I and pyraclostrobin in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably from 1:25 to 100:1, further preferably from 1:10 to 100:1, and in particular from 1:1 to 100:1, for example 10:1 to 100: 1 or 20:1 to 100:1.

[0229] Mixtures comprising compound I and fluopyram in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0230] Mixtures comprising compound I and fluxapyroxad in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 1500:1, preferably 1:100 to 1500:1, more preferably, from 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200: 1 or 20:1 to 1100:1.

[0231] Mixtures comprising compound I and penflufen in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0232] Mixtures comprising compound I and sedaxane in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0233] Mixtures comprising compound I and fluquinconazole in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0234] Mixtures comprising compound I and ipconazole in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0235] Mixtures comprising compound I and prothioconazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0236] Mixtures comprising compound I and tebuconazole in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0237] Mixtures comprising compound I and triticonazole in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0238] Mixtures comprising compound I and silthiofam in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0239] Mixtures comprising compound I and extract in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0240] Mixtures comprising compound I and carbendazim in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0241] Mixtures comprising compound I and metalaxyl in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0242] Mixtures comprising compound I and dimethomorph in synergistically effective amounts, preferably in a weight ratio of compound I:II of 1:500 to 500:1, preferably of 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0243] Mixtures comprising compound I and difenoconazole in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably, from 1:25 to 25:1 and most preferably, from 1:10 to 10:1.

[0244] Among the above mixture, specific preference is given to the following mixtures:

[0245] Mixtures comprising compound I and pyraclostrobin in synergistically effective amounts, preferably in a compound I:II weight ratio of 1:500 to 500:1, preferably 1:100 to 100:1, more preferably from 1:25 to 100:1, further preferably from 1:10 to 100:1, and in particular from 1:1 to 100:1, for example 10:1 to 100: 1 or 20:1 to 100:1;

[0246]e

[0247] mixtures comprising compound I and fluxapyroxad in synergistically effective amounts, preferably, in a compound I:II weight ratio of 1:500 to 1500:1, preferably, of 1:100 to 1500:1, more preferably, from 1:25 to 1500:1, even more preferably, from 1:10 to 1500:1, and, in particular, from 1:1 to 1500:1, for example, 10:1 to 1200: 1 or 20:1 to 1100:1.

[0248] In a preferred embodiment, the present invention also relates to ternary mixtures comprising the compound of formula I and two compounds II, wherein compounds II are selected from thiophanate-methyl, metalaxyl, azoxystrobin, pyraclostrobin, trifloxystrobin, prochloraz , fludioxonil, dimetomorph, triticonazole, difenoconazole, cresoxim-methyl, boscalid, fluopyram, fluxapyroxad, penflufen, penthiopyrad, sedaxane and pyrimethanil in synergistically effective amounts.

[0249] In relation to its intended use as a seed treatment, the following ternary mixtures of compound I and two fungicidal compounds II presented in table 1 are preferred.

[0250] The weight ratios for the respective tertiary mixtures of compound I, and first compound II and second compound II are preferably 1:100:100 to 100:1:1, more preferably 50:1 :1 to 1:50:50, even more preferably, from 1:20:20 to 20:1:1.

[0251] In table 1, the following abbreviations are used in this document: TABLE 1

[0252] In a preferred embodiment, the present invention also relates to ternary mixtures comprising the compound of formula I, compound II and compound III, wherein

[0253]a) compound II is selected from azoxystrobin, pyraclostrobin, trifloxystrobin, cresoxim-methyl, fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane; It is

[0254] b) compound III is selected from clothianidin, imidacloprid, thiamethoxam and fipronil;

[0255]in synergistically effective amounts.

[0256] In a preferred embodiment, the present invention also relates to quaternary mixtures comprising the compound of formula I, compound II and two compounds III, wherein

[0257]a) compound II is selected from azoxystrobin, pyraclostrobin, trifloxystrobin, cresoxim-methyl, fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane; It is

[0258] b) compound III (1) is selected from clothianidin, imidacloprid, thiamethoxam; It is;

[0259]c) compound III (2) is fipronil;

[0260]in synergistically effective amounts.

[0261] In a preferred embodiment, the present invention also relates to quinary mixtures comprising the compound of formula I, two compounds II and two compounds III, wherein

[0262]a) compound II (1) is selected from azoxystrobin, pyraclostrobin, trifloxystrobin and kresoxim-methyl; It is

[0263] b) compound II (2) is selected from fluopyram, fluxapyroxad, penflufen, penthiopyrad and sedaxane; It is

[0264]c) compound III (1) is selected from clothianidin, imidacloprid, thiamethoxam; It is;

[0265]d) compound III (2) is selected from fipronil;

[0266]in synergistically effective amounts.

[0267] The weight ratios for the respective tertiary mixtures of compound I, and a compound II and an additional compound III are preferably 1:100:100 to 100:1:1, more preferably 50: 1:1 to 1:50:50, even more preferably, from 1:20:20 to 20:1:1.

[0268] The weight ratios for the respective quaternary mixtures comprising compound I, and one compound II and two additional compounds III are preferably from 1:100:100:100 to 100:1:1:1, with more preferably, from 50:1:1:1 to 1:50:50:50, even more preferably, from 1:20:20:20 to 20:1:1:1.

[0269] The weight ratios for the respective quaternary mixtures comprising compound I, and two compounds II and one additional compound III are preferably from 1:100:100:100 to 100:1:1:1, with more preferably, from 50:1:1:1 to 1:50:50:50, even more preferably, from 1:20:20:20 to 20:1:1:1.

[0270] The weight ratios for the respective quinary mixtures comprising compound I, two compounds II and two compounds III and an insecticide IV (I:II:II:III:III) are preferably 1:100: 100:100:100 to 100:1:1:1:1, more preferably, 50:1:1:1:1 to 1:50:50:50:50, even more preferably, 1:20:20 :20:20 to 20:1:1:1:1.

[0271] In relation to its intended use as a seed treatment, the following mixtures presented below in table 2 are preferred.

[0272] In table 2, the following abbreviations are used in this document: TABLE 2

[0273] In relation to its intended use as a seed treatment, the following ternary mixtures of compound I and two fungicidal compounds IIA presented below in table 1 are preferred.

[0274] In relation to its intended use as a seed treatment, the following ternary mixtures of compound I and two fungicidal compounds IIA presented below in table 1 are preferred.

[0275] Each of the mixtures mentioned above of the invention may additionally comprise one or more insecticides, fungicides, herbicides.

[0276] For use in accordance with the present invention, mixtures according to the invention can be converted into customary formulations, for example, solutions, emulsions, suspensions, dusts, powders, pastes and granules. The form of use depends on the particular intended purpose; in each case, it should ensure a fine and uniform distribution of the mixtures of the invention. The formulations are prepared in a known manner (compare U.S. 3,060,084, EP-A 707,445 (for liquid concentrates), Browning: ”Agglomeration”, Chemical Engineering, December 4, 1967, 147 to 48, Perry's Chemical Engineer's Handbook, 4th Edition, McGraw-Hill, New York, 1963, S. 8-57 and then WO 91/13546, U.S. 4,172,714, U.S. 4,144,050, U.S. 3,920,442, U.S. 5,180,587, U.S. 5,232 701, U.S. 5,208,030, G.B. 2,095,558, U.S. 3,299,566, Klingman: Weed Control as a Science (J. Wiley & Sons, New York, 1961), Hance et al.: Weed Control Handbook (8th Edition, Blackwell Scientific, Oxford, 1989) and Mollet, H. and Grubemann, A.: Formulation technology (Wiley VCH Verlag, Weinheim, 2001).

[0277] Agrochemical formulations may also comprise auxiliaries that are common in agrochemical formulations. The auxiliaries used depend on the particular application form and the active substance, respectively.

[0278] Examples of suitable auxiliaries are solvents, solid carriers, dispersants or emulsifiers (such as solubilizers, protective colloids, surfactants and additional adhesion agents), organic and inorganic thickeners, bactericides, anti-freezing agents, anti-foam agents, if appropriate, colorants and tackifying agents or binders (e.g. for seed treatment formulations).

[0279] Suitable solvents are water, organic solvents such as mineral oil fractions of medium to high boiling point, such as kerosene or diesel oil, in addition, coal tar oils and oils of vegetable or animal origin, aliphatic hydrocarbons, cyclic and aromatic substances, for example, toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes or their derivatives, alcohols such as methanol, ethanol, propanol, butanol and cyclohexanol, glycols, ketones such as cyclohexanone and gamma-butyrolactone, fatty acid dimethylamides, fatty acids and fatty acid esters and strongly polar solvents, for example, amines such as N-methylpyrrolidone.

[0280] Solid vehicles are mineral earths such as silicates, silica gels, talc, kaolins, limestone, lime, chalk, bole, sediments, clays, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, materials crushed synthetics, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and products of plant origin such as cereal flour, bark flour, wood flour and walnut shell flour, cellulose powders and other solid carriers.

[0281] Suitable surfactants (adjuvants, wetting agents, tackifying agents, dispersants or emulsifiers) are alkali metals, alkaline earth metal and ammonium salts of aromatic sulfonic acids, such as lignosulfonic acid (types Borresperse®, Borregard, Norway) acid phenolsulfonic acid, naphthalenesulfonic acid (types Morwet®, Akzo Nobel, U.S.A.), dibutylnaphthalenesulfonic acid (types Nekal®, BASF, Germany), and fatty acids, alkylsulfonates, alkylarylsulfonates, alkyl sulfates, laurylether sulfates, fatty alcohol sulfates, and sulfated hexa-, hepta- and octadecanolates, sulfated glycol fatty alcohol ethers, in addition, condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, alkylphenyl polyglycol ethers, tributylphenyl polyglycol ether, Trisarylphenyl polyglycol ether, alkylaryl polyether alcohols, ethylene oxide/fatty alcohol condensates and alcohol, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol acetal ether, sorbitol esters, sulfite waste liquor proteins lignin, denatured proteins, polysaccharide (e.g. methylcellulose), hydrophically modified starches, polyvinyl alcohols (types Mowiol®, Clariant, Switzerland), polycarboxylates (types Sokolan®, BASF, Germany), polyalkoxylates, polyvinyl amines (type Lupasol® , BASF, Germany), polyvinylpyrrolidone and copolymers thereof.

[0282] Examples of thickeners (i.e., compounds that impart a modified fluidity to formulations, i.e., high viscosity under static conditions and low viscosity during stirring) are polysaccharides and organic and inorganic clays such as Xanthan gum (Kelzan®, CP Kelco , USA), Rhodopol® 23 (Rhodia, France), Veegum® (R.T. Vanderbilt, USA) or Attaclay® (Engelhard Corp., NJ, USA).

[0283] Bactericides can be added to preserve and stabilize the formulation. Examples of suitable bactericides are those based on dichlorophene and hemi-formal benzyl alcohol (Proxel® from ICI or Acticide® RS from Thor Chemie and Kathon® MK from Rohm & Haas) and isothiazolinone derivatives such as alkylisothiazolinones and benzisothiazolinones (Acticide® MBS with Thor Chemie).

[0284] Examples of suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin.

[0285] Examples of antifoam agents are silicone emulsions (such as Silikon® SRE, Wacker, Germany or Rhodorsil®, Rhodia, France), long-chain alcohols, fatty acids, fatty acid salts, organic fluoro compounds and mixtures of the same.

[0286] Suitable colorants are pigments with low water solubility and water-soluble dyes. Examples to be mentioned and the designations rhodamine B, C. I. red pigment 112, C. I. red solvent 1, blue pigment 15:4, blue pigment 15:3, blue pigment 15:2, blue pigment 15:1, blue pigment 80, yellow pigment 1, yellow pigment 13, red pigment 112, red pigment 48:2, red pigment 48:1, red pigment 57:1, red pigment 53:1, orange pigment 43, orange pigment 34, orange pigment 5, green pigment 36, green pigment 7, white pigment 6, brown pigment 25, basic violet 10, basic violet 49, acid red 51, acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108.

[0287] Examples of tackifiers or binders are polyvinylpyrrolidones, polyvinylacetates, polyvinyl alcohols and cellulose ethers (Tylose®, Shin-Etsu, Japan).

[0288] Powders, dispersion materials and dusts can be prepared by concomitantly mixing or grinding the compounds and the respective active compounds present in the mixtures of the invention and, if appropriate, additional active substances, with at least one solid carrier.

[0289] Granules, for example, coated granules, impregnated granules and homogeneous granules, can be prepared by binding the active substances to solid carriers. Examples of solid carriers are mineral earths such as silica gels, silicates, talc, kaolin, attaclay, limestone, lime, chalk, bole, sediment, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, crushed synthetic materials, fertilizers, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and products of plant origin, such as cereal flour, bark flour, wood flour and walnut shell flour , cellulose powders and other solid vehicles.

[0290] Examples of formulation types are:

[0291]1. Types of composition for dilution in water

[0292]i) Water-soluble concentrates (SL, LS)

[0293] 10 parts by weight of compounds from the mixtures of the invention are dissolved in 90 parts by weight of water or in a water-soluble solvent. As an alternative, wetting agents or other auxiliaries are added. The active substance dissolves upon dilution in water. In this way, a formulation having a content of 10% by weight and active substance is obtained.

[0294]ii) Dispersible concentrates (DC)

[0295] 20 parts by weight of compounds from the mixtures of the invention are dissolved in 70 parts by weight of cyclohexanone with the addition of 10 parts by weight of a dispersant, for example, polyvinylpyrrolidone. Dilution in water provides dispersion. The active substance content is 20% by weight.

[0296]iii) Emulsifiable concentrates (EC)

[0297] 15 parts by weight of compounds from the mixtures of the invention are dissolved in 75 parts by weight of xylene with the addition of calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight). Dilution in water provides an emulsion. The composition had an active substance content of 15% by weight.

[0298]iv) Emulsions (EW, EO, ES)

[0299] 25 parts by weight of compounds from the mixtures of the invention are dissolved in 35 parts by weight of xylene with the addition of calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight). This mixture is introduced in 30 parts by weight of water through an emulsifying machine (Ultraturrax) and transformed into a homogeneous emulsion. Dilution in water provides an emulsion. The composition had an active substance content of 25% by weight.

[0300]v) Suspensions (SC, OD, FS)

[0301] In an agitated ball mill, 20 parts by weight of compounds from the mixtures of the invention are pulverized with the addition of 10 parts by weight of dispersants and wetting agents and 70 parts by weight of water or an organic solvent to provide a suspension of fine active substance. Dilution in water provides a stable suspension of the active substance. The active substance content in the composition is 20% by weight.

[0302]vi) Water-dispersible granules and water-soluble granules (WG, SG)

[0303] 50 parts by weight of compounds from the mixtures of the invention are finely crushed with the addition of 50 parts by weight of dispersants and wetting agents and prepared as water-dispersible or water-soluble granules by means of technical tools (for example, extrusion , sprinkler tower, fluidized bed). Dilution in water provides a stable dispersion or solution of the active substance. The composition had an active substance content of 50% by weight.

[0304]vii) Water-dispersible powders and water-soluble powders (WP, SP, SS, WS)

[0305] 75 parts by weight of compounds from the mixtures of the invention are crushed in a rotor-stator mill with the addition of 25 parts by weight of dispersants, wetting agents and silica gel. Dilution in water provides a stable dispersion or solution of the active substance. The active substance content of the composition is 75% by weight.

[0306]viii) Gel (GF)

[0307] In an agitated ball mill, 20 parts by weight of compounds from the mixtures of the invention are pulverized with the addition of 10 parts by weight of dispersants, 1 part by weight of a gelling agent, wetting agents and 70 parts by weight of water or an organic solvent to provide a fine suspension of the active substance. Dilution in water provides a stable suspension of the active substance, whereby a composition with 20% (w/w) of the active substance is obtained.

[0308]2. Types of composition to be applied in undiluted form

[0309]ix) Sprayable powders (DP, DS)

[0310] 5 parts by weight of compounds from the mixtures of the invention are finely crushed and closely mixed with 95 parts by weight of finely divided kaolin. This provides a sprayable composition having an active substance content of 5% by weight.

[0311]x) Granules (GR, FG, GG, MG)

[0312] 0.5 part by weight of compounds from the mixtures of the invention is finely crushed and associated with 99.5 parts by weight of vehicles. Current methods are extrusion, spray drying or fluidized bed. This provides granules to be applied in undiluted form that have an active substance content of 0.5% by weight.

[0313]xi) ULV (UL) solutions

[0314] 10 parts by weight of compounds from the mixtures of the invention are dissolved in 90 parts by weight of an organic solvent, for example, xylene. This provides a composition to be applied in undiluted form that has an active substance content of 10% by weight.

[0315] Agrochemical formulations generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, most preferably between 0.5 and 90%, by weight of active substances. The compounds of the mixtures of the invention are used in a purity of 90% to 100%, preferably 95% to 100% (according to NMR spectrum).

[0316] The compounds of the mixtures of the invention can be used as such or in the form of their compositions, for example, in the form of solutions, powders, suspensions, dispersions, emulsions, oily dispersions, pastes, sprayable products, dispersion materials , or directly sprayable granules, by means of sprinkling, atomization, spraying, dispersion, brushing, immersion or pouring. The forms of application depend entirely on the intended purposes; this is intended to ensure, in each case, the finest possible distribution of the compounds present in the mixtures of the invention.

[0317] Aqueous application forms can be prepared from emulsion concentrates, pastes or wettable powders (sprayable powders, oily dispersions) by adding water. To prepare oily emulsions, pastes or dispersions, the substances, as such or dissolved in an oil or solvent, can be homogenized in water by means of a wetting agent, tackifier, dispersant or emulsifier. Alternatively, it is possible to prepare concentrates composed of active substance, wetting agent, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil, and such concentrates are suitable for dilution in water.

[0318] Active substance concentrations in ready-to-use preparations can vary within relatively wide ranges. In general, they are from 0.0001 to 10%, preferably from 0.001 to 1% by weight of compounds from the mixtures of the invention.

[0319] The compounds of the mixtures of the invention can also be used successfully in the ultra-low volume (ULV) process, making it possible to apply compositions that comprise more than 95% by weight of active substance, or even apply the active substance without additives.

[0320] Various types of oils, wetting agents, adjuvants, herbicides, fungicides, other pesticides, or bactericides can be added to the active compounds, if appropriate, not immediately before use (tank mixing). These agents can be mixed by adding to the compounds of the mixtures of the invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.

[0321] The compositions of this invention may also contain fertilizers such as ammonium nitrate, urea, potash, and superphosphate, phytotoxicants and plant growth protectors and regulators. They can be used sequentially or in combination with the compositions described above, if appropriate, also added only immediately before use (tank mixing). For example, the plant(s) may be sprayed with a composition of this invention before or after being treated with fertilizers.

[0322] As already explained above, the mixture of the invention is not restricted to a physical mixture, therefore, compounds I and II can be applied as a physical mixture or separately. The compounds contained in the mixtures as defined above can be applied simultaneously, i.e. together or separately, or in succession, the sequence, in the case of separate application, has, in general, no effect on the result of the control measures.

[0323] According to this invention, compound I and compound II should be understood to denote, that at least compound I and compound II occur simultaneously at the site of action (that is, pests, such as harmful fungi and pests animals such as insects, arachnids or nematodes to be controlled or their habitats such as plants, plant propagating materials, particularly infected seeds, surfaces, materials or soil as well as plants, plant propagating materials, particularly seeds, soil, surfaces, materials or environments to be protected against fungal or animal attack) in an effective quantity.

[0324] This can be achieved by applying compound I and compound II simultaneously, or together (for example, as a tank mix) or separately, or in succession, with the time interval between individual applications being selected to ensure that the applied active substance still occurs first at the site of action in a sufficient quantity at the time of application of the additional active substance(s). The order of application is not essential to the operation of the present invention.

[0325] In the mixtures of the present invention, the weight ratio of the compounds depends, in general, on the properties of the compounds in the mixtures of the invention.

[0326] The compounds of the mixtures of the invention can be used individually or partially or completely mixed together to prepare the composition according to the invention. It is also possible for them to be additionally packaged and used as a combination composition as a kit of parts.

[0327] In one embodiment of the invention, kits may include one or more, including all, components that can be used to prepare an agrochemical composition in question. For example, kits may include compound I and compound II and/or an adjuvant component and/or an additional pesticidal compound (e.g., insecticide or herbicide) and/or a growth regulatory component). One or more of the components can already be combined together or pre-formulated. In those embodiments where more than two components are provided in a kit, the components can already be combined together and, as such, are packaged in a simple container such as a vial, bottle, can, box, pouch or ampoule. In other embodiments, two or more components of a kit may be packaged separately, i.e., not pre-formulated. As such, kits may include one or more separate containers such as vials, cans, bottles, boxes, pouches or ampoules, each container containing a separate component for an agrochemical composition. In both forms, a component of the kit can be applied separately or together with additional components or as a component of a combination composition according to the invention to prepare the composition according to the invention.

[0328] The user applies the composition according to the invention usually from a pre-dosing device, a backpack sprinkler, a spray tank or a spray plane. In the present document, the agrochemical composition is constituted with water and/or buffer at a desired application concentration, it being possible, if appropriate, to add additional auxiliaries, and the ready-to-use spray liquor or the agrochemical composition according to the invention is obtained in this way. Usually, 50 to 500 liters of ready-to-use spray liquor are applied per hectare of useful agricultural area, preferably 100 to 400 liters.

[0329] According to one embodiment, the individual compounds of the mixtures of the invention formulated as a composition (or formulation) as part of a kit or part of the mixture of the invention can be mixed by the user himself in a spray tank and additional auxiliaries can be added if appropriate (tank mix).

[0330] In a further embodiment, the individual compounds of the mixtures of the invention formulated as partially pre-mixed composition or components, for example, components comprising compound I and compound II can be mixed by the user in a spray tank and auxiliaries Additional supplements and additives can be added if appropriate (tank mix).

[0331] In a further embodiment, individual components of the composition according to the invention or partially pre-mixed components, for example, components comprising compound I and compound II, can be applied together (e.g. after mixing tank ) or consecutively.

[0332] As stated above, the present invention comprises a method for controlling harmful fungi, wherein the harmful fungi, their habitat, breeding sites, their location or the plants to be protected against pest attacks, the soil or the pest propagation material plant (preferably seed) are treated with a pesticide-effective amount of a mixture of the invention.

[0333] Advantageously, the mixtures of the invention are suitable for controlling the following harmful fungi:

[0334]Albugo spp. (white mold) on ornamentals, vegetables (e.g. A. candida) and sunflowers (e.g. A. tragopogonis); Alternaria spp. (Alternaria leaf spot) on vegetables, rapeseed (A. brassicola or brassicae), sugar beet (A. tenuis), fruit, rice, soya beans, potatoes (e.g. A. solani or A. alternata), tomatoes (e.g. A. solani or A. alternata) and wheat; Afanomices spp. in sugar beets and vegetables; Ascochita spp. in cereals and vegetables, for example, A. tritici (anthracnose) in wheat and A. hordei in barley; Bipolaris and Drechslera spp. (telemorph: Cocliobolus spp.), e.g. Southern leaf wilt (D. maydis) or Northern leaf wilt (B. zeicola) in maize, e.g. leaf spot (B. sorokiniana) in cereals and e.g. oryzae in rice and grams; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e.g. on wheat or barley); Botrytis cinerea (telemorph: Botryotinia fuckeliana: gray mold) on fruits and berries (e.g. strawberries), vegetables (e.g. lettuce, carrots, celery and cabbages), rapeseed, flowers, vines, forest plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (wilt or rot) on broad-leaved and evergreen trees, e.g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spot) on corn (e.g. Gray leaf spot: C. zeae-maydis), rice, sugar beet (e.g. C. beticola), sugar cane, vegetables, coffee, soybeans (e.g. , C. sojina or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e.g. C. fulvum: leaf mold) and cereals, e.g. C. herbarum (black ear) on wheat; Claviceps purpureia (grass rust) on cereals; Cocliobolus (anamorph: Bipolaris Helminthosporium) spp. (leaf spots) in maize (C. carbonum), cereals (e.g. C. sativus, anamorph: B. sorokiniana) and rice (e.g. C. miyabeanus, anamorph: H. orizae); Colletotrichum (telemorph: Glomerella) spp. (anthracnose) on cotton (e.g. C. gossypii), corn (e.g. C. graminicola: anthracnose stem rot), soft fruit, potatoes (e.g. C. coccodes: black spot), beans (e.g. e.g., C. lindemuthianum) and soybeans (e.g., C. truncatum or C. gloeosporioides); Corticium spp., e.g. C. sasakii (sheath rust) on rice; Corinespora cassiicola (leaf spots) on soybeans and ornamentals; Cycloconium spp., e.g. C. oleaginum on olive trees; Cilindrocarpon spp. (e.g. fruit tree canker or vine blackfoot, telemorph: Nectria or Neonectria spp.) on fruit trees, vineyards (e.g. C. liriodendri, telemorph: Neonectria liriodendri: Blackfoot Disease) and ornamentals; Dematophora (telemorph: Rosellinia) necatrix (root and stem rot) in soybeans; Diaporte spp., e.g. D.phasaolorum (etiolation) in soybeans; Drechslera (syn. Helminthosporium, telemorph: Pirenophora) spp. in maize, cereals such as barley (e.g. D. teres, reticular spot) and wheat (e.g. D. tritici-repentis: yellow spot), rice and grass; Esca (sudden death, apoplexy) in vineyards, caused by Formitiporia (syn. Phellinus) punctata, F. mediterranea, Phaeomoniella clamidospora (formerly Phaeoacremonium clamidosporum), Phaeoacremonium aleophilum and/or Botryosfaeria obtusa; Elsinoe spp. in orchard fruits (E. piri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entiloma orizae (leaf sooty mold) on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp. (powdery mildew) on sugar beet (E. betae), vegetables (e.g. E. pisi) such as cucurbits (e.g. E. cichoracearum), cabbages, rapeseed (e.g. E. cruciferarum); Eutypa lata (cancer or sudden death caused by Eutypa, anamorph: Cytosporina lata, syn. Libertella blefaris) on fruit trees, vineyards and ornamental plants; Exserohilum (syn. Helminthosporium) spp. in maize (e.g. E. turcicum); Fusarium (telemorph: Gibberella) spp. (wilt, root or stem rot) in various plants, such as F. graminaarum or F. culmorum (root rot, stone rot or fusariosis) in cereals (e.g. wheat or barley), F. oxysporum in tomatoes, F. solani in soybeans and F. verticillioides in corn; Gaeumannomices graminis (foot disease) on cereals (e.g. wheat or barley) and maize; Gibberella spp. in cereals (e.g. G. zeae) and rice (e.g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, orchard fruits and other plants and G. gossypii on cotton; Rice grain staining complex; Guignardia bidwellii (black mold) in vineyards; Gymnosporangium spp. on rosaceous plants and junipers, e.g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, telemorph: Cocliobolus) in corn, cereals and rice; Hemileia spp., e.g. H. uvatrix (coffee leaf rust) in coffee; Isariopsis clavispora (syn. Cladosporium vitis) in vineyards; Macrophomina phaseolina (syn. faleoli) (root and stem rot) in soybeans and cotton; Microdochium (syn. Fusarium) nivale (pink snow disease) in cereals (e.g. wheat or barley); Microsfaera diffusa (powdery mildew) on soybeans; Monilinia spp., e.g. M. laxa, M. fructicola and M. fructigena (downy mildew on flowering and twigs, poor wilting) on stone fruit and other rosaceous plants; Mycosfaerella spp. in cereals, bananas, soft fruits and crushed nuts, such as M. graminicola (anamorph: Septoria tritici, Septoriosis) in wheat or M. fijiensis (black Sigatoka disease) in bananas; Peronospora spp. (downy mildew) on cabbage (e.g. P. brassicae), rapeseed (e.g. P. parasitica), onions (e.g. P. destructor), tobacco (P. tabacina) and soybeans (e.g. P. manshurica); Phakopsora pachirhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp., e.g. in vines (e.g. P. tracheiphila and P. tetraspora) and soybeans (e.g. P. gregata: stem rot); Phoma lingam (root and stem rot) on rapeseed and cabbage and P. betae (root rot, leaf spot and etiolation) on sugar beet; Phomopsis spp. in sunflowers, vines (e.g. P. viticola: leaf spot) and soybeans (e.g. stem rot: P. casooli, telemorph: Diaporte phaseolorum); Phisoderma maydis (brown spots) on corn; Phitofthora spp. (wilt, root, leaf and stem rot) in various plants such as paprika and cucurbits (e.g. P. capsici), soybeans (e.g. P. megasperma, syn. P.syiae), potatoes and tomatoes ( e.g. P. infestans: late blight) and broad-leaved trees (e.g. P. ramorum: sudden oak death); Plasmodiophora brassicae (cruciferous gall) on cabbage, rapeseed, radish and other plants; Plasmopara spp., e.g. P. viticola (vine downy mildew) on vineyards and P. halstedii on sunflowers; Podosfaera spp. (powdery mildew) on rosaceous plants, hops, orchard fruits and soft fruits, e.g. P. leucotricha on apples; Polymixa spp., for example, in cereals such as barley and wheat (P. graminis) and sugar beet (P. betae) and viral diseases transmitted by them; Pseudocercosporella herpotrichoides (cama, telemorph: Tapesia yallundae) on cereals, e.g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e.g. P. cubensis on cucurbits or P. humili on hops; Pseudopezicula tracheiphila (red fire disease or ‘rotbrenner’, anamorph: Phialophora) in vineyards; Puccinia spp. (rusts) on various plants, e.g. P. triticina (brown or leaf rust), P. striiformis (striped or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as wheat, barley or rye, P. kuehnii (orange rust) on sugar cane and P. asparagi on asparagus; Pirenophora (anamorph: Drechslera) tritici-repentis (yellow spot) on wheat or P. teres (reticular spot) on barley; Piricularia spp., e.g. P. orizae (telemorph: Magnaporte grisea, rice blast) in rice and P. grisea in grass and cereals; Pytium spp. (etiolation) in grass, rice, corn, wheat, cotton, rapeseed, sunflowers, soybeans, sugar beet, vegetables and various other plants (e.g. P. ultimum or P. afanidermatum); Ramularia spp., for example, R. collo-cigni (Ramularia leaf spot, physiological leaf spot) on barley and R. beticola on sugar beet; Rhizoctonia spp. on cotton, rice, potatoes, grass, corn, rapeseed, potatoes, sugar beet, vegetables and various other plants, e.g. R. solani (root and stem rot) on soybeans, R. solani (sheath rust ) in rice or R. cerealis (spring leaf blight in Rhizoctonia) in wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhinchosporium secalis (scald) on barley, rye and triticale; Sarocladium orizae and S. attenuatum (rubellosis) in rice; Sclerotinia spp. (stem rot or white mold) on vegetables and field crops such as rapeseed, sunflowers (e.g. S. sclerotiorum) and soybeans (e.g. S. rolfsii or S. sclerotiorum); Septoria spp. on several plants, for example, S. glycines (septoriosis) on soybeans, S. tritici (speckled spot) on wheat, and S. (syn. Stagonospora) nodorum (gum spot) on cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf blight) on corn (e.g., S. turcicum, syn. Helminthosporium turcicum) and grass; Sfacelotheca spp. (soot) on corn, (e.g. S. reiliana: soot on head), sorghum and sugar cane; Sfaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora subterranea (powdery mildew) on potatoes and viral diseases transmitted by them; Stagonospora spp. in cereals, for example, S. nodorum (gum spot, telemorph: Leptosfaeria [syn. Phaeosfaeria] nodorum) in wheat; Sinchitrium endobioticum on potatoes (potato black scab); Taphrina spp., e.g., T. deformans (blight blight) on peaches and T. pruni (plum bag blight) on plums; Thielaviopsis spp. (black root rot) on tobacco, orchard fruits, vegetables, soya beans and cotton, e.g. T. basicola (syn. Chalara elegans); Tilletia spp. (common caries or smelly soot) in cereals, e.g. T. tritici (syn. T. caries, wheat caries) and T. controversial (dwarf caries) in wheat; Typhula incarnata (gray snow disease) on barley or wheat; Urocystis spp., e.g. U. occulta (stem sooty mold) on rye; Uromices spp. (rust) on vegetables such as beans (e.g. U. appendiculatus, syn. U. faleoli) and sugar beet (e.g. U. betae); Ustilago spp. (coal) in cereals (e.g. U. nuda and U. avaenae), corn (e.g. U. maydis: corn soot) and sugar cane; Venturia spp. (scab) on apples (e.g. V. inaequalis) and pears; and Verticillium spp. (wilt) in various plants such as fruit and ornamentals, vines, soft fruits, vegetables and field crops, e.g. V. dahliae in strawberries, rapeseed, potatoes and tomatoes.

[0335] The mixtures of the invention are also suitable for controlling fungal diseases that occur in the protection of materials (for example, wood, paper, paint dispersions, fiber or fabrics) and in the protection of stored products. The term "materials protection" should be understood to denote the protection of technical and lifeless materials such as adhesives, glues, wood, paper and cardboard, textile products, leather, paint dispersions, plastics, cooling lubricants, fiber or fabrics , against infestation and destruction by harmful microorganisms, such as fungi and bacteria. For the protection of wood and other materials, particular attention is paid to the following harmful fungi: Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp. .; Basidiomycetes such as Coniophora spp., Coriolus spp., Gloeophillum spp., Lentinus spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromices spp., Deuteromycetes such as Aspergillus spp., Cladosporium spp., Penicillium spp., Trichorma spp., Alternaria spp., Paecilomices spp. and Zygomycetes such as Mucor spp., and, in addition, in the protection of stored products and harvesting the following yeast fungi are worthy of note: Candida spp. and Saccharomices cerevisae.

[0336] They are particularly important for controlling a plurality of harmful fungi on various cultivated plants, such as bananas, cotton, plant species (e.g. cucumbers, beans and cucurbits), barley, grass, oak, coffee, potatoes, corn, species fruit trees, rice, barley, soybeans, tomatoes, vines, wheat, ornamental plants, sugar cane and also a large number of plant propagation materials (preferably seeds).

[0337] "Site" means a plant, plant propagation material (preferably seed), soil, area, material or environment in which a pest grows or may grow.

[0338] In general, "pesticide-effective amount" means the amount of mixtures of the invention or compositions comprising mixtures necessary to achieve an observable effect of necrosis, killing, delaying, preventing, and removing, destroying, or decreasing the occurrence and activity of the target organism. The amount effective as a pesticide may vary for the various mixtures/compositions used in the invention. A pesticide-effective amount of the mixtures/compositions will also vary according to conditions prevailing such as desired pesticide effect and duration, climate, target species, location, mode of application, and the like.

[0339] As discussed above, the present invention comprises a method for improving the health of plants, wherein the plant, the location where the plant is growing or is expected to grow, or plant propagation material, from which the plant grows, it is treated with a plant health effective amount of a mixture of the invention.

[0340] The term "plant health effective amount" denotes an amount of the mixtures of the invention, which is sufficient to achieve plant health effects as defined herein. More exemplary information on quantities, forms of application and suitable reasons for use are given below. In any case, the skilled person is well aware of the fact that such quantity can vary over a wide range and depends on various factors, for example, on the treated cultivated plant or material and on climatic conditions.

[0341] The term “effective amount” comprises the terms “plant health effective amount” and/or “pesticide effective amount” as the case may be.

[0342] When preparing the mixtures, it is preferable to employ the pure active compounds, to which additional active compounds against pests, such as insecticides, herbicides, fungicides or other herbicidal or growth regulating active compounds or fertilizers can be added as additional active components according to the necessity.

[0343] The mixtures of the invention are employed by treating fungi or plants, plant propagation materials (preferably seeds), materials or soil to be protected against fungal attack with a pesticide-effective amount of the active compounds I and II. Application can be carried out before and after infection of the materials, plants or plant propagation materials (preferably seeds) by the harmful fungi.

[0344] Preferably, the mixtures of the invention are employed by treating the fungi and plants or soil to be protected against pesticide attack through foliar application with a pesticide-effective amount of the active compounds. Also in this document, application can be carried out before and after infection of plants by harmful fungi.

[0345] In the method of combating harmful fungi that depends on the type of compound and the desired effect, the application rates of the mixtures according to the invention are from 0.1 g/ha to 10,000 g/ha, preferably 2 g/ha to 2500 g/ha, more preferably from 5 to 1000 g/ha, most preferably from 10 to 750 g/ha, in particular from 20 to 500 g/ha.

[0346] The plants as well as the propagation material of said plants, which can be treated with the mixtures of the invention include all genetically modified plants or transgenic plants, for example, crops that tolerate the action of herbicides or fungicides or insecticides due to reproduction, including genetic modification methods, or plants that have had modified characteristics compared to existing plants, which can be generated, for example, through traditional breeding methods and/or the generation of mutants, or through recombinant procedures.

[0347] For example, the mixtures according to the present invention can be applied (as seed treatment, spray treatment, on the plow or by any other means) also to plants that have been modified by reproduction, mutagenesis or genetic modification including, but not limited to agricultural biotechnology products on the market or in development (compare http://www.bio.org/speeches/pubs/er/agri_products.asp). Genetically modified plants are plants whose genetic material has been so modified by the use of recombinant DNA techniques that, under natural circumstances, they cannot be readily obtained through cross-breeding, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant. Such genetic modifications also include, but are not limited to, targeted post-transitional modification of protein(s), oligo- or polypeptides, for example, through glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties.

[0348] Plants that have been modified by reproduction, mutagenesis or genetic modification, for example, have become tolerant to applications of specific classes of herbicides, such as hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors; acetolactate synthase (ALS) inhibitors such as sulfonyl ureas (see, e.g., U.S. 6,222,100, WO 01/82685, WO 00/26390, WO 97/41218, WO 98/02526, WO 98/02527, WO 04/ 106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/14356, WO 04/16073) or imidazolinones (see, e.g., U.S. 6,222,100, WO 01/82685, WO 00/026390, WO 97/41218, WO 98/002526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/014357, WO 03/13225, WO 03/14356, WO 04/16073); enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitors such as glyphosate (see, for example, WO 92/00377); glutamine synthetase (GS) inhibitors such as glufosinate (see, e.g., EP-A 242,236, EP-A 242,246) or oxynyl herbicides (see, e.g., U.S. 5,559,024) as a result of conventional methods of reproduction or genetic modification. Several cultivated plants have become tolerant to herbicides by conventional breeding methods (mutagenesis), e.g. Clearfield® summer rapeseed (Canola, BASF SE, Germany) tolerant to imidazolinones, e.g. imazamox. Genetic modification methods are used to make crop plants such as soybeans, cotton, corn, beets and rapeseed tolerant to herbicides such as glyphosate and glufosinate, some of which are commercially available under the trade name RoundupReady® (glyphosate tolerant, Monsanto, USA) and LibertyLink® (glufosinate tolerant, Bayer CropScience, Germany).

[0349] Furthermore, plants that have, through the use of recombinant DNA techniques, the ability to synthesize one or more insecticidal proteins, especially those known from the bacterial genus Bacillus, particularly Bacillus thuringiensis, such as endotoxins, for example, are also covered. example, CryIA(b), CryIA(c), CryIF, CryIF(a2), CryIIA(b), CryIIIA, CryIIIB(b1) or Cry9c; plant insecticidal proteins (VIP), for example, VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins from bacteria colonizing nematodes, e.g. Photorhabdus spp. or Xenorhabdus spp.; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, such as Streptomycete toxins; plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome inactivation proteins (RIP), such as ricin, maize-RIP, abren, lufin, saporin or bryodin; steroid metabolism enzymes such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyltransferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such as sodium or calcium channel blockers; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilbene synthase, bibenzyl synthase, chitinases or glucanases. In the context of the present invention, these insecticidal proteins or toxins must also be expressly understood as pre-toxins, hybrid proteins, truncated or modified proteins. Hybrid proteins are characterized by a novel combination of protein domains, (see, for example, WO 02/015701). Additional examples of such toxins or genetically modified plants that have the ability to synthesize such toxins are disclosed, for example, in EP-A374753, WO 93/007278, WO 95/34656, EP-A427529, EP-A451878, WO 03/18810 d WO 03/52073. Methods for producing such genetically modified plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above. These insecticidal proteins contained in genetically modified plants confer, on the plants that produce these proteins, tolerance to harmful pests of all taxonomic groups of arthropods, especially beetles Coeloptera), two-winged insects (Diptera), and moths (Lepidoptera) and the nematodes (Nematode). Genetically modified plants that have the ability to synthesize one or more insecticidal proteins are, for example, described in the publications mentioned above, and some are commercially available such as YieldGard® (corn cultivars that produce the Cry1Ab toxin), YieldGard® Plus (cultivars of corn that produce Cry1Ab and Cry3Bb1 toxins), Starlink® (corn cultivars that produce the Cry9c toxin), Herculex® RW (corn cultivars that produce Cry34Ab1, Cry35Ab1 and the enzyme Phosphinotricin-N-Acetyltransferase [PAT]); NuCOTN® 33B (cotton cultivars that produce Cry1Ac toxin), Bollgard® I (cotton cultivars that produce Cry1Ac toxin), Bollgard® II (cotton cultivars that produce Cry1Ac and Cry2Ab2 toxins); VIPCOT® (cotton cultivars that produce a VIP toxin); NewLeaf® (potato cultivars that produce the Cry3A toxin); Bt-Xtra®, NatureGard®, KnockOut®, BiteGard®, Protecta®, Bt11 (e.g. Agrisure® CB) and Bt176 from Singenta Seeds SAS, France, (corn cultivars that produce the Cry1Ab toxin and PAT enzyme), MIR604 with Singenta Seeds SAS, France (corn cultivars that produce a modified version of the Cry3A toxin, see WO 03/018810), MON863 with Monsanto Europe S.A., Belgium (corn cultivars that produce the Cry3Bb1 toxin), IPC 531 with to Monsanto Europe S.A., Belgium (cotton cultivars that produce a modified version of the Cry1Ac toxin) and 1507 with Pioneer Overseas Corporation, Belgium (corn cultivars that produce the Cry1F toxin and PAT enzyme).

[0350] Furthermore, plants that have, through the use of recombinant DNA techniques, the ability to synthesize one or more proteins to increase the resistance or tolerance of those plants to bacterial, viral or fungal pathogens are also covered. Examples of such proteins are so-called “pathogenesis-related proteins” (PR proteins, see e.g. EP-A392225), plant disease resistance genes (e.g. potato cultivars, which express resistance genes that act against Phitofthora infestans derived from Mexican wild potato Solanum bulbocastanum) or T4-lysozyme (e.g. potato cultivars that have the ability to synthesize these proteins with increased resistance against bacteria such as Erwinia amilvora). Methods for producing such genetically modified plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above.

[0351] Furthermore, plants that have, through the use of recombinant DNA techniques, the ability to synthesize one or more proteins to increase productivity (e.g., biomass production, grain yield, starch content, oil content or protein content), tolerance to dryness, salinity or other growth-limiting environmental factors or tolerance to pests and fungal, bacterial or viral pathogens of those plants.

[0352] Furthermore, plants are also covered that contain, through the use of recombinant DNA techniques, a modified amount of content substances or new content substances, specifically to improve human or animal nutrition, for example, oily groups that produce health-promoting long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids (e.g., rapeseed Nexera®, DOW Agro Sciences, Canada).

[0353] In addition, plants that contain, through the use of recombinant DNA techniques, a modified amount of high-grade substances or new low-grade substances, specifically to improve raw material production, for example, potatoes that produce high amounts of increased amylopectin (e.g. Amflora® potato, BASF SE, Germany).

[0354] As mentioned at the beginning, in a preferred embodiment of the invention, the mixtures of the invention are used to protect the seed and the roots and shoots of seedlings, preferably the seeds.

[0355] Seed treatment can be done in the seed box before planting in the field.

[0356] For seed treatment purposes, the weight ratio in the mixtures of the invention depends, in general, on the properties of the compounds in the mixtures of the invention.

[0357] The usual formulations, which are especially useful for seed treatment are, for example:

[0358] Soluble concentrates (SL, LS)

[0359] DEmulsions (EW, EO, ES)

[0360] ESsuspensions (SC, OD, FS)

[0361] Water-dispersible granules and water-soluble granules (WG, SG)

[0362] GWater dispersible powders and water soluble powders (WP, SP, WS)

[0363]HGel formulations (GF)

[0364] Sprayable powders (DP, DS)

[0365] These compositions can be applied to plant propagation materials, particularly seeds, in diluted or undiluted form. These compositions can be applied to plant propagation materials, particularly seeds, in diluted or undiluted form. The compositions in question provide, after dilution two to ten times, active substance concentrations of 0.01 to 60% by weight, preferably 0.1 to 40% by weight, in ready-to-use preparations. Application can be carried out before or during sowing.

[0366] Methods for applying the mixture of the invention and compositions thereof, respectively, onto plant propagation material, especially seeds, are known in the art, and include, but are not limited to seed filming, seed coating, spraying seed coating, seed soaking, seed film coating, multilayer seed coating, seed encrustation, seed dripping, and seed pelleting.

[0367] In a preferred embodiment, the compounds or compositions thereof, respectively, are applied to the plant propagation material by a method such that germination is not induced, for example, through seed filming, pelletization , coating and spraying.

[0368] When treating plant propagation material (preferably seed), the application rates of the mixture of the invention are, in general, for the formulated product (which usually comprises from 10 to 750 g/l of the active)).

[0369] The invention also relates to plant propagation products, and especially, the seed comprising, that is, coated with and/or containing, a mixture as defined above or a composition (usual formulation) comprising the mixture of invention of two or more active ingredients or a mixture of two or more compositions each providing one of the active ingredients. The plant propagation material (preferably seed) comprises the mixtures of the invention in an amount of 0.1 g to 10 kg per 100 kg of plant propagation material (preferably seed), preferably 0.1 g to 1 kg per 100 kg of plant propagation material (preferably seed).

[0370] The separate or united application of the compounds of the mixtures of the invention is carried out by sprinkling or spraying the seeds, seedlings, plants or soil before or after sowing the plants or before or after emerging the plants.

[0371] According to a variant of soil application, an additional subject of the invention is furrow treatment, which comprises adding a solid or liquid formulation comprising the mixtures of the invention to the open furrow, in which seeds have been sown or, alternatively , apply seeds and formulation simultaneously to the open furrow.

[0372] The mixture of the invention is also suitable for combating animal pests, preferably invertebrate pests.

[0373] The term "invertebrate pest" for use herein encompasses animal populations, such as insects, arachnids and nematodes, that can attack plants, thereby causing substantial damage to the attacked plants, as well as ectoparasites that can infest animals, in particular, warm-blooded animals such as mammals or birds, or other larger animals such as reptiles, amphibians or fish, thus causing substantial harm to infested animals.

[0374] Invertebrate pests controlled by the mixture of the invention include, for example:

[0375] insects of the order Lepidopterans (Lepidoptera), for example Agrotis ypsilon, Agrotis segetum, Alabama argillacea, Anticarsia gemmatalis, Argyrestia conjugella, Autografa gama, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheima-tobia brumata, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diafania nitidalis, Diatraea grandiosella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Grapholita funebrana, Grapholita molesta, Heliotis armigera, Heliotis virescens, Heliotis zea, Hello cosoma neustria, Mamestra brassicae, Orgyia pseu-dotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucefala, Phthorimaea operculella, Phillocnistis citrella, Pieris bras-sicae, Plathipena scabra, Plutella xilostella, Pseudoplusia includens, Rhiacion ia fferrugemrana, Scrobipalpula absolute , Sitotroga cerealella, Sparganotis pilleriana, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni and Zeiraphera canadensis;

[0376] beetles (Coleoptera), for example, Agrilus sinuatus, Agriotes lineatus, Agriotes obscu-rus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Atomaria linearis, Blastofagus piniperda, Blitofaga undata, Bruchus rufi-manus, Bruchus pisorum , Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cero-toma trifurcata, Ceuthorrhinchus assimilis, Ceuthorrhinchus napi, Chaetocnema tibi-alis, Conoderus vespertinus, Crioceris asparagi, Diabrotica longicornis, Diabrotica 12 punctata, Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, Eu tinobothrus brasiliensis , Hilobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata, Limonius californicus, Lissorhoptrus orizophilus, Melanotus communis, Meligetes aeneus, Melolonta hip-pocastani, Melolonta melolonta, Oulema orizae, Ortiorrhinchus sulcatus, Otiorrh in- chus ovatus, Phaedon cocleariae, Phillotreta crysocephala, Phillofaga sp., Phil-loperta horticola, Phillotreta nemorum, Phillotreta striolata, Popillia japonica, Sitona lineatus and Sitophilus granaria;

[0377]dipterans (Diptera), for example, Aedes aegypti, Aedes vexans, Anastrefa ludens, Anopheles maculipennis, Ceratitis capitata, Chrysomia bezziana, Chrysomia homi-nivorax, Chrysomia macellaria, Contarinia sorghicola, Cordilobia anthropofaga, Culex pipiens, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Fannia canicularis, Gasterophilus intestinalis, Glossina morsitans, Haematobia irritans, Haplodiplosis equestris, Hilemiia platura, Hypoderma lineata, Liriomiza sativae, Liriomiza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mayetiola destruc-tor, Musca domestica, Muscina stabulans, Oestrus ovis, Oscinella frit, Pegomia hiso-ciami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Rhagoletis cerasi, Rhagoletis pomonella, Tabanus bovinus, Tipula oleracea and Tipula paludosa;

[0378] aphids (Thisanoptera), for example, Dicromothrips corbetti, Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Thrips orizae, Thrips palmi and Thrips tabaci;

[0379] hymenopterans (Hymenoptera), for example, Atalia rosae, Atta cephalotes, Atta sexdens, Atta texana, Hoplocampa minuta, Hoplocampa testudinea, Monomorium faraonis, So-lenopsis geminata and Solenopsis invicta;

[0380] heteropterans (Heteroptera), for example, Acrosternum hilare, Blissus leucopterus, Cyrtopeltis Notatus, Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phillopus, Lygus lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubea ins ularis and Thianta perditor;

[0381] homopterans (Homoptera), for example, Acirthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Acirthosiphon pisum, Aulacortum solani, Bemisia argentifolii, Brachicaudus cardui, Brachicaudus helicrysi, Brachi-caudus persicae, Brachicaudus prunicola, Brevicorine brassicae, Capitophorus horni, Cerosifa gossypii, Chaetosiphon fragaefolii, Cryptomizus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis radicola, Dysaulacortum pseudosolani, Dysaphis plantaginea, Dysaphis piri, Empoasca fabae, Hyalopterus pruni, Hyperomizus lactu-cae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pirarius, Metopolophium dirhodum, Myzodes persicae, Myzus as-calonicus, Myzus cerasi, Myzus persicae, Myzus varians, Nasonovia ribis -nigri, Nila-parvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psilla mali, Psilla piri, Rhopalomizus ascalonicus, Rhopalosiphum maidis, Rhopalosi-phum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Sogatella furcifera Trialeurodes vaporariorum, Toxoptera aurantiiand, and Viteus vitifolii;

[0382] termites (Isoptera), for example, Calotermes flavicollis, Leucotermes flavipes, Reticulitermes flavipes, Reticulitermes lucifugus und Termes natalensis;

[0383] orthopterans (Orthoptera), for example, Acheta domestica, Blatta orientalis, Blattella germanica, Forficula auricularia, Grillotalpa grillotalpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femur-rubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melano-plus spretus, Nomadacris septemfasciata , Periplaneta americana, Schistocerca americacana, Schistocerca peregrina, Stauronotus maroccanus and Tachicines asinamorus;

[0384] Arachnoidea, such as arachnids (Acarina), for example, from the families Argasidae, Ixodidae and Sarcoptidae, such as Amblyomma americanum, Amblyomma variegatum, Argas persi-cus, Boophilus annulatus, Boophilus decoloratus, Boophilus microplus, Dermacentor silvarum, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ornithodorus mou-bata, Otobius megnini, Dermanyssus gallinae, Psoroptes ovis, Rhipicefalus appendi-culatus, Rhipicefalus evertsi, Sarcoptes scabiei, and Eriophiidae spp. such as Aculus sclechtendali, Phillocoptrata oleivora and Eriophies sheldoni; Tarsonemidae spp. such as Phitonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae spp. as Brevipalpus phoenicis; Tetranychidae spp. such as Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius and Tetranychus urticae, Panonychus ulmi, Panonychus citri, and oligonychus pratensis;

[0385] Siphonatera, for example, Xenopsilla cheopsis, Ceratophillus spp.

[0386] The mixture of the invention is useful for controlling nematodes, especially plant parasitic nematodes such as root knot nematodes, Meloidogine hapla, Meloidogine incognita, Meloidogine javanica, and other species of Meloidogine;

[0387] cyst-forming nematodes, Globodera grossochiensis and other species of Globodera; Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other species of Heterodera; Seed scouring nematodes, Anguina species; foliar and stem nematodes, Aphelenchoides species; Sting nematodes, Belonolaimus longicaudatus and other species of Belonolaimus; Pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; Ring nematodes, Criconema species, Criconemella species, Criconemoides species, Mesocriconema species; Stem and bulb nematodes, Ditilenchus destructor, Ditilenchus dipsaci and other species of Ditilenchus; Piercing nematodes, Dolichodorus species; Spiral nematodes, Heliocotilenchus multicinctus and other species of Helicotilenchus; Nematodes with and without sheath, Hemiciciliophora species and Hemicriconemoides species; Hirshmanniella species; Spear nematodes, Hoploaimus species; False root knot nematodes, Nacobbus species; Needle nematodes, Longidorus elongatus and other species of Longidorus; Pine nematodes, Paratilenchus species; Wound nematodes, Pratilenchus neglectus, Pratilenchus penetrans, Pratilenchus curvitatus, Pratilenchus goodeyi and other species of Pratilenchus; Burrowing nematodes, Radopholus similis and other Radopholus species; Reniform nematodes, Rotilenchus robustus and other species of Rotilenchus; Scutellonema species; Short and thick root nematodes, Trichodorus primitivus and other species of Trichodorus, Paratrichodorus species; Stunting nematodes, Tilenchorhinchus claytoni, Tilenchorhinchus dubius and other Tilenchorhinchus species; Citrus nematodes, Tilenchulus species; Dagger nematodes, Xiphinema species; other species of plant parasitic nematode.

[0388] In a preferred embodiment of the invention, the mixture of the invention is used to control insects or arachnids, in particular, insects of the orders Lepidoptera, Coleoptera, Thisanoptera and Homoptera and arachnids of the order Acarina. The mixture of the invention is particularly useful for controlling insects of the order Thisanoptera and Homoptera.

[0389] The mixtures of the present invention show synergistic action against the pests to be controlled. Synergism can be described as an interaction where the combined effect of a mixture of two or more compounds is greater than the sum of the individual effects of each of the compounds. The presence of a synergistic effect, in terms of percentage control, between two mixing partners (X and Y) can be calculated using the Colby equation (Colby, SR, 1967, Calculating Synergistic and Antagonistic Responses in Herbicide Combinations, Weeds , 15, 20 to 22):

[0390] In Colby's formula, X and Y are the % control observed for individual compounds at a given concentration. And a combined control effect is expected, which would be expected in the absence of synergism, if the compounds are applied together at the same concentrations as a single application. When the observed control effect for the mixture (i.e., observed combined control effect) is greater than the expected combined control effect (E) as calculated from Colby's formula, then the observed effect is synergistic.

EXAMPLES

[0391] The expected efficacies of active compound mixtures were determined using the Colby formula [R.S. Colby, “Calculating synergistic and antagonistic responses of herbicide combinations”, Weeds 15, 20 to 22 (1967)] and compared to the observed efficacies.

MICROTESTS

[0392] The active compounds were formulated separately as a stock solution having a concentration of 10000 ppm in dimethyl sulfoxide.

[0393] The compound of formula I was used as a commercial finished formulation and diluted in water to the reported concentration of the active compound.

EXAMPLE 1ACTIVITY AGAINST THE LATE WILTING PATHOGEN PHITOFTHORA INFESTANS IN THE MICROTITER TEST (PHYTIN)

[0394] The stock solutions were mixed according to the ratio, pipetted into a microtiter plate (MTP) and diluted in water to the established concentrations. A Phitoftora infestans spore suspension containing an aqueous pea juice-based nutrient medium was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18°C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation. The measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free and active compound-free blank value to determine the relative growth in % of pathogens on the respective active compounds. These percentages were converted into efficacies. An efficacy of 0 means that the growth level of the pathogens matches that of the untreated control; an efficacy of 100 means pathogens are not growing. The test results are shown in Table 1. TABLE 1

EXAMPLE 2ACTIVITY AGAINST LEAF SPOT IN WHEAT CAUSED BY SEPTORIA TRITICI (SEPTTR)

[0395] The stock solutions were mixed according to the ratio, pipetted into a microtiter plate (MTP) and diluted in water to the established concentrations. A suspension of Septoria tritici spores in an aqueous biomalt solution was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18°C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation. The measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free and active compound-free blank value to determine the relative growth in % of pathogens on the respective active compounds. These percentages were converted into efficacies. An efficacy of 0 means that the growth level of the pathogens matches that of the untreated control; an efficacy of 100 means pathogens are not growing. The test results are shown in Table 2. TABLE 2

EXAMPLE 3ACTIVITY AGAINST ALTERNARIA SOLANI (ALTESO)

[0396] The stock solutions were mixed according to the ratio, pipetted into a microtiter plate (MTP) and diluted in water to the established concentrations. A suspension of Alternaria solani spores in an aqueous biomalt solution was then added. The plates were placed in a chamber saturated with water vapor at a temperature of 18°C. Using an absorption photometer, MTPs were measured at 405 nm 7 days after inoculation. The measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free and active compound-free blank value to determine the relative growth in % of pathogens on the respective active compounds. These percentages were converted into efficacies. An efficacy of 0 means that the growth level of the pathogens matches that of the untreated control; an efficacy of 100 means pathogens are not growing. The test results are shown in Table 3. TABLE 3

[0397] The test results show that, due to the strong synergism, the activity of the mixtures according to the invention is considerably higher than what was predicted using the Colby formula.

Claims (15)

1. MIXTURES, characterized by the fact that they comprise 1) the insecticidal compound of formula I and 2) a fungicidal compound II selected from compounds in the following groups A to B: A) strobilurin fungicide, which is pyraclostrobin; B) carboxanilides, which is fluxapyroxad, in synergistically effective amounts. 2. MIXTURE, according to claim 1, characterized by the fact that the fungicidal compound II is pyraclostrobin. 3. MIXTURE, according to claim 1, characterized by the fact that the fungicidal compound II is fluxapyroxad. 4. MIXTURE according to one of claims 1 to 3, characterized in that the weight ratio of compound I:II is 1:500 to 1500:1, preferably 1:1 to 1500:1. 5. PESTICIDAL COMPOSITION, characterized by the fact that it comprises a liquid or solid carrier and a mixture, as defined in one of claims 1 to 4. 6. METHOD FOR IMPROVING PLANT HEALTH and/or increasing yield, characterized by the fact that the plant, the location where the plant is growing or is expected to grow, or plant propagation material from which the plant grows is treated with an effective amount of a mixture as defined in one of claims 1 to 4. 7. METHOD FOR CONTROLLING PESTS ON PLANTS, characterized by the fact that the pests, their habitat, food supply, breeding sites, their location or the plants to be protected against pest attacks, the soil or plant propagation material are treated with an effective amount of a mixture as defined in one of claims 1 to 4. 8. METHOD FOR PROTECTING PLANT PROPAGATION MATERIALS, and/or plants growing from them, against pests, characterized by the fact that it comprises bringing the plant propagation materials into contact with a mixture, as defined in a of claims 1 to 4, in pesticide-effective amounts. 9. METHOD, according to one of claims 6 to 8, characterized by the fact that the compounds, as defined in one of claims 1 to 4, are applied simultaneously, that is, together. 10. METHOD, according to one of claims 7 to 9, characterized by the fact that the pest is selected from phytopathogenic fungi and invertebrate pests. 11. METHOD, according to claim 10, characterized by the fact that the invertebrate pests are arthropod pests, preferably insects. 12. USE OF A MIXTURE, as defined in one of claims 1 to 4, characterized by the fact that it is to improve the health of plants. 13. USE OF A MIXTURE, as defined in one of claims 1 to 4, characterized by the fact that it is to control pests in plants. 14. USE, according to claim 13, characterized by the fact that the pest is selected from phytopathogenic fungi and invertebrate pests. 15. USE, according to claim 14, characterized by the fact that the invertebrate pests are arthropod pests, preferably insects.