BR112012027034A2 - inibidores da arginase e suas aplicações terapêuticas - Google Patents
inibidores da arginase e suas aplicações terapêuticasInfo
- Publication number
- BR112012027034A2 BR112012027034A2 BR112012027034A BR112012027034A BR112012027034A2 BR 112012027034 A2 BR112012027034 A2 BR 112012027034A2 BR 112012027034 A BR112012027034 A BR 112012027034A BR 112012027034 A BR112012027034 A BR 112012027034A BR 112012027034 A2 BR112012027034 A2 BR 112012027034A2
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic applications
- arginase inhibitors
- formula
- arginase
- inhibitors
- Prior art date
Links
- 102000004452 Arginase Human genes 0.000 title abstract 4
- 108700024123 Arginases Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract
inibidores da arginase e suas aplicações terapêuticas. os compostos de acordo com a fórmula i e fórmula ii são potentes inibidores da atividade de arginase i e ii: fórmula (i) e (ii) em que r^ 1^, r^ 2^, r^ 3^, r^ 4^, r^ 5^, r^ 6^, r^ 7^, r^ 8^, r^ 9^, d, m, x, e y são definidos como apresentado na especificação. a invenção também proporciona composições farmacêuticas dos compostos e métodos para a sua utilização para o tratamento ou prevenção de uma doença ou de uma condição associada com a atividade de arginase.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32689210P | 2010-04-22 | 2010-04-22 | |
| US61/326,892 | 2010-04-22 | ||
| US41320210P | 2010-11-12 | 2010-11-12 | |
| US61/413,202 | 2010-11-12 | ||
| PCT/US2011/033223 WO2011133653A1 (en) | 2010-04-22 | 2011-04-20 | Inhibitors of arginase and their therapeutic applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012027034A2 true BR112012027034A2 (pt) | 2016-07-19 |
| BR112012027034B1 BR112012027034B1 (pt) | 2020-10-13 |
Family
ID=44072631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012027034-6A BR112012027034B1 (pt) | 2010-04-22 | 2011-04-20 | compostos inibidores de arginase, composição farmacêutica compreendendo o referido composto, método in vitro para inibição de arginase i e ii e uso do referido composto |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9040703B2 (pt) |
| EP (1) | EP2560978B1 (pt) |
| JP (1) | JP5898177B2 (pt) |
| KR (1) | KR101931822B1 (pt) |
| CN (2) | CN103068830B (pt) |
| AU (1) | AU2011242794B2 (pt) |
| BR (1) | BR112012027034B1 (pt) |
| CA (1) | CA2796867C (pt) |
| ES (1) | ES2729936T3 (pt) |
| HK (1) | HK1213901A1 (pt) |
| IL (1) | IL222484A0 (pt) |
| MX (2) | MX338114B (pt) |
| MY (1) | MY162535A (pt) |
| NZ (1) | NZ603364A (pt) |
| RU (1) | RU2586219C2 (pt) |
| SG (2) | SG184956A1 (pt) |
| WO (1) | WO2011133653A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9040703B2 (en) | 2010-04-22 | 2015-05-26 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| JP5909239B2 (ja) * | 2010-10-26 | 2016-04-26 | マーズ インコーポレイテッド | アルギナーゼ阻害剤としてのボロネート |
| CN104857005B (zh) * | 2010-12-31 | 2019-04-26 | 阿斯利康公司 | 精氨酸酶抑制剂及其使用方法 |
| DK2707101T3 (da) * | 2011-05-12 | 2019-05-13 | Proteostasis Therapeutics Inc | Proteostaseregulatorer |
| EP2768491B1 (en) * | 2011-10-19 | 2016-12-21 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| MX355758B (es) * | 2012-04-18 | 2018-04-27 | Mars Inc | Analogos constreñidos en el anillo como inhibidores de arginasa. |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| WO2015164743A2 (en) * | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| MX2017003999A (es) | 2014-10-01 | 2018-02-09 | Merck Patent Gmbh | Derivados de acido boronico. |
| PL410665A1 (pl) * | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| KR20180021117A (ko) | 2015-06-23 | 2018-02-28 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 활성 억제를 위한 조성물 및 방법 |
| PT3368541T (pt) | 2015-10-30 | 2020-07-06 | Calithera Biosciences Inc | Composições e métodos para inibição da atividade da arginase |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| KR20190104521A (ko) | 2016-11-08 | 2019-09-10 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 억제제 병용 요법들 |
| KR102579849B1 (ko) | 2016-12-22 | 2023-09-18 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 활성을 억제시키기 위한 조성물 및 방법 |
| CN108794517B (zh) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | 一种精氨酸酶抑制剂及其制备方法与用途 |
| US10494339B2 (en) | 2017-05-12 | 2019-12-03 | Calithera Biosciences, Inc. | Method of preparing (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide |
| MA51837A (fr) * | 2018-02-17 | 2021-06-16 | Astrazeneca Ab | Inhibiteurs de l'arginase et leurs procédés d'utilisation |
| MX2020009290A (es) | 2018-03-05 | 2020-09-28 | Arcus Biosciences Inc | Inhibidores de la arginasa. |
| EP3765006A4 (en) * | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
| RU2684781C1 (ru) * | 2018-03-21 | 2019-04-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Анальгезирующее и противовирусное средство на основе замещенной 2-[1-(1Н-бензимидазол-2-ил)-3-фенил-1Н-1,2,4-триазол-5-ил]пропановой кислоты |
| CA3094939A1 (en) | 2018-03-29 | 2019-10-03 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
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