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BR112012024401A2 - processo de preparo de derivados de 3-ceto-benzofurano - Google Patents

processo de preparo de derivados de 3-ceto-benzofurano

Info

Publication number
BR112012024401A2
BR112012024401A2 BR112012024401A BR112012024401A BR112012024401A2 BR 112012024401 A2 BR112012024401 A2 BR 112012024401A2 BR 112012024401 A BR112012024401 A BR 112012024401A BR 112012024401 A BR112012024401 A BR 112012024401A BR 112012024401 A2 BR112012024401 A2 BR 112012024401A2
Authority
BR
Brazil
Prior art keywords
keto
preparing
formula
group
alkyl
Prior art date
Application number
BR112012024401A
Other languages
English (en)
Inventor
Bailly Frédéric
Vayron Philippe
Priem Thomas
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012024401A2 publication Critical patent/BR112012024401A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B45/00Formation or introduction of functional groups containing sulfur
    • C07B45/04Formation or introduction of functional groups containing sulfur of sulfonyl or sulfinyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo de preparo de derivados de 3-ceto-benzofurano. a presente invenção refere-se a um processo de preparo de derivados de 3-ceto-benzo furano de fórmula geral: fórmula (i), na qual r representa um grupo alquila ou arila, r~ 1~ representa o hidrogênio ou um grupo alquila ou arila e r~ 2~ representa um grupo aquila ou fenila substituído, por acoplamento de um derivado de benzo furano de fórmula iii, na qual x representa cloro, bromo ou iodo ou um grupamento sulfonato de fórmula (iii) com um derivado de sulfonamida de fórmula r-so~ 2~-nh~ 2~, em presença de um agente básico e de um sistema catalítico formado de um complexo entre um composto de paládio e um ligante.
BR112012024401A 2010-03-30 2011-03-30 processo de preparo de derivados de 3-ceto-benzofurano BR112012024401A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1052332A FR2958289B1 (fr) 2010-03-30 2010-03-30 Procede de preparation de derives de 3-ceto-benzofurane
PCT/FR2011/050706 WO2011131881A1 (fr) 2010-03-30 2011-03-30 Procede de preparation de derives de 3-ceto-benzofurane

Publications (1)

Publication Number Publication Date
BR112012024401A2 true BR112012024401A2 (pt) 2019-09-24

Family

ID=43430822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012024401A BR112012024401A2 (pt) 2010-03-30 2011-03-30 processo de preparo de derivados de 3-ceto-benzofurano

Country Status (13)

Country Link
US (1) US8871956B2 (pt)
EP (1) EP2552898A1 (pt)
JP (1) JP2013523698A (pt)
KR (1) KR20130040181A (pt)
CN (1) CN102822160A (pt)
AU (1) AU2011244175A1 (pt)
BR (1) BR112012024401A2 (pt)
CA (1) CA2794576A1 (pt)
FR (1) FR2958289B1 (pt)
MX (1) MX2012011327A (pt)
RU (1) RU2012146189A (pt)
SG (1) SG184334A1 (pt)
WO (1) WO2011131881A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) * 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
EP2593226B1 (en) 2010-07-16 2018-11-14 AbbVie Ireland Unlimited Company Phosphine ligands for catalytic reactions
JP5819959B2 (ja) 2010-07-16 2015-11-24 アッヴィ・バハマズ・リミテッド 抗ウイルス性化合物を調製するための方法
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
TW201536763A (zh) * 2013-08-27 2015-10-01 Gilead Sciences Inc 製備決奈達隆或其鹽類之製程
CN108329285B (zh) * 2018-04-04 2019-12-10 武汉大学 一种合成2,3-二氢苯并呋喃类化合物的方法
CN114539193B (zh) * 2022-01-20 2024-08-06 安徽普利药业有限公司 一种盐酸胺碘酮中间体的制备方法
CN114456135B (zh) * 2022-03-18 2024-09-10 江苏慧聚药业股份有限公司 决奈达隆的制备

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2817864B1 (fr) * 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
CA2651871A1 (en) * 2006-05-10 2007-11-22 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Also Published As

Publication number Publication date
US8871956B2 (en) 2014-10-28
FR2958289A1 (fr) 2011-10-07
KR20130040181A (ko) 2013-04-23
AU2011244175A1 (en) 2012-10-25
MX2012011327A (es) 2012-11-16
CN102822160A (zh) 2012-12-12
RU2012146189A (ru) 2014-05-10
CA2794576A1 (fr) 2011-10-27
JP2013523698A (ja) 2013-06-17
WO2011131881A1 (fr) 2011-10-27
EP2552898A1 (fr) 2013-02-06
SG184334A1 (en) 2012-11-29
US20130165673A1 (en) 2013-06-27
FR2958289B1 (fr) 2012-06-15

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.