BR112012004851B8 - uso de um derivado de tiazol - Google Patents
uso de um derivado de tiazolInfo
- Publication number
- BR112012004851B8 BR112012004851B8 BR112012004851A BR112012004851A BR112012004851B8 BR 112012004851 B8 BR112012004851 B8 BR 112012004851B8 BR 112012004851 A BR112012004851 A BR 112012004851A BR 112012004851 A BR112012004851 A BR 112012004851A BR 112012004851 B8 BR112012004851 B8 BR 112012004851B8
- Authority
- BR
- Brazil
- Prior art keywords
- thiazole derivative
- agent
- thiazole
- prophylaxis
- therapeutic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
agente para o tratamento e/ou profilaxia de um distúrbio de humor, derivado de tiazol, e, uso do derivado de tiazol divulgado é um agente terapêutico e/ou profilático para distúrbios de humor compreendendo, que contém um derivado de tiazol representado pela fórmula (i) (em que r1 representa uma grupo arila ou semelhantes, e r2 representa um grupo piridila ou semelhantes) ou um sal farmaceuticamente aceitável do mesmo como um ingrediente ativo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009202893 | 2009-09-02 | ||
| JP2009-202893 | 2009-09-02 | ||
| PCT/JP2010/064988 WO2011027805A1 (ja) | 2009-09-02 | 2010-09-02 | 気分障害治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012004851A2 BR112012004851A2 (pt) | 2016-04-05 |
| BR112012004851B1 BR112012004851B1 (pt) | 2021-03-02 |
| BR112012004851B8 true BR112012004851B8 (pt) | 2021-05-25 |
Family
ID=43649339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012004851A BR112012004851B8 (pt) | 2009-09-02 | 2010-09-02 | uso de um derivado de tiazol |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9249135B2 (pt) |
| EP (1) | EP2474543B1 (pt) |
| JP (1) | JP5663484B2 (pt) |
| KR (1) | KR101762981B1 (pt) |
| CN (1) | CN102482272A (pt) |
| AU (1) | AU2010290423B2 (pt) |
| BR (1) | BR112012004851B8 (pt) |
| CA (1) | CA2772920C (pt) |
| CL (1) | CL2012000534A1 (pt) |
| CY (1) | CY1119118T1 (pt) |
| DK (1) | DK2474543T3 (pt) |
| DO (1) | DOP2012000058A (pt) |
| EA (1) | EA030333B1 (pt) |
| ES (1) | ES2633538T3 (pt) |
| GE (1) | GEP20156224B (pt) |
| HR (1) | HRP20171137T1 (pt) |
| HU (1) | HUE033690T2 (pt) |
| IL (1) | IL218321A (pt) |
| LT (1) | LT2474543T (pt) |
| MA (1) | MA33618B1 (pt) |
| ME (1) | ME02804B (pt) |
| MX (1) | MX2012002528A (pt) |
| NZ (1) | NZ598750A (pt) |
| PL (1) | PL2474543T3 (pt) |
| PT (1) | PT2474543T (pt) |
| RS (1) | RS56345B1 (pt) |
| SI (1) | SI2474543T1 (pt) |
| TN (1) | TN2012000092A1 (pt) |
| UA (1) | UA110097C2 (pt) |
| WO (1) | WO2011027805A1 (pt) |
| ZA (1) | ZA201202346B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3002283T (lt) * | 2003-12-26 | 2017-09-11 | Kyowa Hakko Kirin Co., Ltd. | Tiazolo dariniai |
| UA113383C2 (xx) * | 2009-09-02 | 2017-01-25 | Терапевтичний агент для лікування тривожних розладів | |
| MA41090A (fr) * | 2014-12-03 | 2017-10-10 | H Lundbeck As | Antagoniste de a2a faiblement dosé pour le traitement du tdah et de la maladie de parkinson |
| JOP20200093A1 (ar) | 2015-01-09 | 2017-06-16 | Kyowa Kirin Co Ltd | طريقة لإنتاج مشتق ثيازول |
| JO3544B1 (ar) * | 2015-03-19 | 2020-07-05 | Kyowa Kirin Co Ltd | عامل علاجي للاختلال الوظيفي في الفص الجبهي |
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| JP2021528398A (ja) | 2018-06-18 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγＴのモジュレーターとしての６−アミノピリジン−３−イルピラゾール |
| CA3103932A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Pyridinyl pyrazoles as modulators of roryt |
| CA3103770A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl and pyridinyl substituted imidazoles as modulators of roryt |
| WO2019243999A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl substituted pyrazoles as modulators of roryt |
| WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69331843T2 (de) | 1992-07-08 | 2002-09-26 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine-Derivate als Antidepressiva |
| ATE325610T1 (de) | 1997-09-05 | 2006-06-15 | Kyowa Hakko Kogyo Kk | Xanthinderivative zur behandlung von hirnischämie |
| US20030139395A1 (en) | 2001-09-13 | 2003-07-24 | Schering Corporation | Combination of an adenosine A2a receptor antagonist and an antidepressant or anxiolytic |
| US6620811B2 (en) | 2001-11-19 | 2003-09-16 | Hoffmann-La Roche Inc. | Isonicotin- and nicotinamide derivatives of benzothiazoles |
| CN1787821A (zh) | 2003-06-10 | 2006-06-14 | 协和发酵工业株式会社 | 一种治疗焦虑症的方法 |
| LT3002283T (lt) | 2003-12-26 | 2017-09-11 | Kyowa Hakko Kirin Co., Ltd. | Tiazolo dariniai |
| EP1730122A2 (en) | 2004-03-30 | 2006-12-13 | Taisho Pharmaceutical Co., Ltd | Pyrimidine derivatives and methods of treatment related to the use thereof |
| EP1894930A4 (en) * | 2005-06-23 | 2010-06-23 | Kyowa Hakko Kirin Co Ltd | THIAZOLE DERIVATIVE |
| TWI457125B (zh) | 2005-08-02 | 2014-10-21 | 睡眠障礙之治療劑 |
-
2010
- 2010-02-09 UA UAA201203928A patent/UA110097C2/uk unknown
- 2010-09-02 PT PT108137530T patent/PT2474543T/pt unknown
- 2010-09-02 EP EP10813753.0A patent/EP2474543B1/en active Active
- 2010-09-02 WO PCT/JP2010/064988 patent/WO2011027805A1/ja active Application Filing
- 2010-09-02 JP JP2011529926A patent/JP5663484B2/ja not_active Expired - Fee Related
- 2010-09-02 CN CN2010800392296A patent/CN102482272A/zh active Pending
- 2010-09-02 RS RS20170748A patent/RS56345B1/sr unknown
- 2010-09-02 AU AU2010290423A patent/AU2010290423B2/en not_active Ceased
- 2010-09-02 PL PL10813753T patent/PL2474543T3/pl unknown
- 2010-09-02 US US13/393,035 patent/US9249135B2/en not_active Expired - Fee Related
- 2010-09-02 ES ES10813753.0T patent/ES2633538T3/es active Active
- 2010-09-02 NZ NZ598750A patent/NZ598750A/en not_active IP Right Cessation
- 2010-09-02 ME MEP-2017-168A patent/ME02804B/me unknown
- 2010-09-02 MX MX2012002528A patent/MX2012002528A/es active IP Right Grant
- 2010-09-02 LT LTEP10813753.0T patent/LT2474543T/lt unknown
- 2010-09-02 KR KR1020127008307A patent/KR101762981B1/ko active IP Right Grant
- 2010-09-02 EA EA201270359A patent/EA030333B1/ru unknown
- 2010-09-02 CA CA2772920A patent/CA2772920C/en not_active Expired - Fee Related
- 2010-09-02 SI SI201031510T patent/SI2474543T1/sl unknown
- 2010-09-02 DK DK10813753.0T patent/DK2474543T3/en active
- 2010-09-02 HU HUE10813753A patent/HUE033690T2/hu unknown
- 2010-09-02 GE GEAP201012647A patent/GEP20156224B/en unknown
- 2010-09-02 BR BR112012004851A patent/BR112012004851B8/pt not_active IP Right Cessation
-
2012
- 2012-02-26 IL IL218321A patent/IL218321A/en active IP Right Grant
- 2012-02-27 TN TNP2012000092A patent/TN2012000092A1/en unknown
- 2012-02-29 CL CL2012000534A patent/CL2012000534A1/es unknown
- 2012-03-01 DO DO2012000058A patent/DOP2012000058A/es unknown
- 2012-03-30 MA MA34733A patent/MA33618B1/fr unknown
- 2012-03-30 ZA ZA2012/02346A patent/ZA201202346B/en unknown
-
2017
- 2017-07-21 HR HRP20171137TT patent/HRP20171137T1/hr unknown
- 2017-07-26 CY CY20171100798T patent/CY1119118T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: KYOWA KIRIN CO., LTD. (JP) |
|
| B25G | Requested change of headquarter approved |
Owner name: KYOWA KIRIN CO., LTD. (JP) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/03/2021, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/09/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B15V | Prolongation of time limit allowed | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 13A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2738 DE 27-06-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |