[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BR112018013911A2 - multivalent and multispecific ox40 binding fusion proteins - Google Patents

multivalent and multispecific ox40 binding fusion proteins

Info

Publication number
BR112018013911A2
BR112018013911A2 BR112018013911-4A BR112018013911A BR112018013911A2 BR 112018013911 A2 BR112018013911 A2 BR 112018013911A2 BR 112018013911 A BR112018013911 A BR 112018013911A BR 112018013911 A2 BR112018013911 A2 BR 112018013911A2
Authority
BR
Brazil
Prior art keywords
multivalent
multispecific
fusion proteins
binding fusion
bind
Prior art date
Application number
BR112018013911-4A
Other languages
Portuguese (pt)
Inventor
P. Eckelman Brendan
C. Timmer John
Hata Chelsie
S. Jones Kyle
Hussain Abrahim
S. Razai Amir
Becklund Bryan
Pandit Rajay
Kaplan Mike
Rason Lucas
Deveraux Quinn
Original Assignee
Inhibrx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx, Inc. filed Critical Inhibrx, Inc.
Publication of BR112018013911A2 publication Critical patent/BR112018013911A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

esta invenção refere-se geralmente a moléculas que se ligam especificamente a ox40, um membro da superfamília de receptores de tnf (tnfrsf). mais especificamente, esta invenção refere-se a moléculas multivalentes e multiespecíficas que se ligam a pelo menos ox40.This invention generally relates to molecules that specifically bind to ox40, a member of the tnf (tnfrsf) receptor superfamily. more specifically, this invention relates to multivalent and multispecific molecules that bind at least ox40.

BR112018013911-4A 2016-01-11 2017-01-11 multivalent and multispecific ox40 binding fusion proteins BR112018013911A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662277027P 2016-01-11 2016-01-11
US62/277,027 2016-01-11
PCT/US2017/013070 WO2017123673A2 (en) 2016-01-11 2017-01-11 Multivalent and multispecific ox40-binding fusion proteins

Publications (1)

Publication Number Publication Date
BR112018013911A2 true BR112018013911A2 (en) 2018-12-18

Family

ID=59275443

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018013911-4A BR112018013911A2 (en) 2016-01-11 2017-01-11 multivalent and multispecific ox40 binding fusion proteins

Country Status (13)

Country Link
US (3) US20170198051A1 (en)
EP (1) EP3402507A4 (en)
JP (2) JP7328761B2 (en)
KR (1) KR20180098671A (en)
CN (1) CN108883153A (en)
AU (2) AU2017207318B2 (en)
BR (1) BR112018013911A2 (en)
CA (1) CA3009075A1 (en)
IL (2) IL298686A (en)
MX (2) MX2018008310A (en)
RU (1) RU2022106508A (en)
SG (1) SG11201805422WA (en)
WO (1) WO2017123673A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2854843A4 (en) 2012-05-31 2016-06-01 Sorrento Therapeutics Inc Antigen binding proteins that bind pd-l1
JP6826055B2 (en) 2015-03-13 2021-02-03 サイトメックス セラピューティクス インコーポレイテッド Anti-PDL1 antibody, activating anti-PDL1 antibody, and how to use it
JP7328761B2 (en) * 2016-01-11 2023-08-17 インヒブルクス インコーポレイテッド Multivalent multispecific OX40 binding fusion proteins
WO2018017888A1 (en) * 2016-07-20 2018-01-25 Igm Biosciences, Inc. Multimeric ox40 binding molecules and uses thereof
JP2019530434A (en) 2016-08-05 2019-10-24 ジェネンテック， インコーポレイテッド Multivalent and multi-epitope antibodies with agonist activity and methods of use
WO2018056821A1 (en) * 2016-09-23 2018-03-29 Merus N.V. Binding molecules that modulate a biological activity expressed by a cell
EA201991207A1 (en) 2016-12-19 2019-12-30 Гленмарк Фармасьютикалс С.А. NEW TNFR AGONISTS AND THEIR APPLICATION
AU2018250641A1 (en) 2017-04-11 2019-10-31 Inhibrx Biosciences, Inc. Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same
EP3609921A2 (en) 2017-04-13 2020-02-19 Agenus Inc. Anti-cd137 antibodies and methods of use thereof
WO2018222949A1 (en) 2017-06-01 2018-12-06 Cytomx Therapeutics, Inc. Activatable anti-pdl1 antibodies, and methods of use thereof
AU2018394939B2 (en) * 2017-12-29 2022-02-24 Ap Biosciences, Inc. Monospecific and bispecific proteins with immune checkpoint regulation for cancer therapy
CN110305210B (en) 2018-03-27 2023-02-28 信达生物制药(苏州)有限公司 Novel antibody molecules, methods of making and uses thereof
WO2020023553A1 (en) 2018-07-24 2020-01-30 Inhibrx, Inc. Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
CN112601761A (en) 2018-08-13 2021-04-02 印希比股份有限公司 Polypeptides that bind OX40 and uses thereof
WO2020076992A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. 5t4 single domain antibodies and therapeutic compositions thereof
CN113166261A (en) 2018-10-11 2021-07-23 印希比股份有限公司 B7H3 single domain antibodies and therapeutic compositions thereof
JP2022504822A (en) 2018-10-11 2022-01-13 インヒブルクス インコーポレイテッド DLL3 single domain antibody and therapeutic composition thereof
AU2019356573A1 (en) 2018-10-11 2021-05-27 Inhibrx Biosciences, Inc. PD-1 single domain antibodies and therapeutic compositions thereof
WO2020102647A1 (en) * 2018-11-15 2020-05-22 Invenra Inc. Multivalent receptor-clustering agonist antibody constructs and antigen binding proteins
WO2020144164A1 (en) * 2019-01-07 2020-07-16 Bactolife Aps Pathogen binding proteins
TWI793395B (en) * 2019-01-25 2023-02-21 大陸商信達生物製藥（蘇州）有限公司 Bispecific antibodies that bind to pd-l1 and ox40
US20240141070A1 (en) * 2019-10-17 2024-05-02 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Ox40/pd-l1 bispecific antibody
WO2021084104A1 (en) * 2019-10-30 2021-05-06 Bioinvent International Ab Tetravalent antibody molecules
CA3171363A1 (en) * 2019-12-20 2021-06-24 Kisoji Biotechnology Inc. Polypeptides, protein complexes and method for making same
WO2022002009A1 (en) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 Ox40-targeted antibody, and preparation method therefor and application thereof
EP3940931A1 (en) 2020-07-14 2022-01-19 Siemens Aktiengesellschaft Method for producing a rotor of an asynchronous engine
WO2022243341A1 (en) * 2021-05-18 2022-11-24 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding affinity for ox40
TW202334203A (en) * 2021-11-19 2023-09-01 德商皮里斯製藥有限公司 Novel fusion protein specific for ox40 and pd-l1
KR20240122784A (en) * 2021-12-17 2024-08-13 상하이 헨리우스 바이오테크, 인크. Anti-OX40 antibodies and methods of use
WO2024006831A2 (en) * 2022-06-28 2024-01-04 Beijing Starmab Biomed Technology Ltd Monospecific and multi-specific antibodies
CN118515763B (en) * 2024-07-23 2024-11-01 北京百普赛斯生物科技股份有限公司 Antibody of IL-6, detection kit and application thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20030157108A1 (en) * 2001-10-25 2003-08-21 Genentech, Inc. Glycoprotein compositions
WO2004041865A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Stabilized single domain antibodies
US20060280728A1 (en) * 2005-05-06 2006-12-14 Providence Health System Trimeric OX40-immunoglobulin fusion protein and methods of use
KR20140053410A (en) 2005-08-19 2014-05-07 아보트 러보러터리즈 Dual variable domain immunoglobulin and uses thereof
EP2889309B1 (en) 2006-03-03 2017-12-27 Ono Pharmaceutical Co., Ltd. Multimer of extracellular domain of pd-1 or pd-l1
US20130332133A1 (en) * 2006-05-11 2013-12-12 Ramot At Tel Aviv University Ltd. Classification of Protein Sequences and Uses of Classified Proteins
KR20180089573A (en) 2008-12-09 2018-08-08 제넨테크, 인크. Anti-pd-l1 antibodies and their use to enhance t-cell function
JP5844159B2 (en) 2009-02-09 2016-01-13 ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ PD-1 antibody and PD-L1 antibody and use thereof
PT2398498T (en) 2009-02-17 2018-12-03 Ucb Biopharma Sprl Antibody molecules having specificity for human ox40
EP3309176A1 (en) * 2009-12-14 2018-04-18 Ablynx N.V. Immunoglobulin single variable domain antibodies against ox40l, constructs and therapeutic use
WO2011119484A1 (en) * 2010-03-23 2011-09-29 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
ES2537207T3 (en) 2010-08-16 2015-06-03 Novimmune S.A. Methods for the generation of multispecific and multivalent antibodies
KR20130139884A (en) 2010-08-26 2013-12-23 애브비 인코포레이티드 Dual variable domain immunoglobulins and uses thereof
UA115781C2 (en) * 2012-02-27 2017-12-26 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cx3cr1-binding polypeptides
ES2746103T3 (en) 2012-04-30 2020-03-04 Medimmune Llc Molecules with reduced effector function and long half-lives, compositions and uses thereof
US9540442B2 (en) * 2012-08-02 2017-01-10 Jn Biosciences Llc Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece
WO2014028776A1 (en) 2012-08-15 2014-02-20 Zyngenia, Inc. Monovalent and multivalent multispecific complexes and uses thereof
AR093984A1 (en) * 2012-12-21 2015-07-01 Merck Sharp & Dohme ANTIBODIES THAT JOIN LEGEND 1 OF SCHEDULED DEATH (PD-L1) HUMAN
EP2951209A4 (en) * 2013-01-31 2016-06-22 Univ Jefferson Agonist fusion protein for cd40 ox40 and uses thereof
AU2014227638A1 (en) * 2013-03-15 2015-09-17 Merck Patent Gmbh Tetravalent bispecific antibodies
MD20180107A2 (en) 2013-03-18 2019-06-30 Biocerox Products B.V. Humanized anti-CD134 (OX40) antibodies and uses thereof
WO2014209804A1 (en) 2013-06-24 2014-12-31 Biomed Valley Discoveries, Inc. Bispecific antibodies
MX2016007965A (en) * 2013-12-17 2016-10-28 Genentech Inc Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists.
JP2017537090A (en) * 2014-11-17 2017-12-14 ジェネンテック， インコーポレイテッド Combination therapy comprising OX40 binding agonist and PD-1 axis binding antagonist
JP6826055B2 (en) 2015-03-13 2021-02-03 サイトメックス セラピューティクス インコーポレイテッド Anti-PDL1 antibody, activating anti-PDL1 antibody, and how to use it
JP7328761B2 (en) * 2016-01-11 2023-08-17 インヒブルクス インコーポレイテッド Multivalent multispecific OX40 binding fusion proteins
EA201991207A1 (en) * 2016-12-19 2019-12-30 Гленмарк Фармасьютикалс С.А. NEW TNFR AGONISTS AND THEIR APPLICATION

Also Published As

Publication number Publication date
US20170198051A1 (en) 2017-07-13
WO2017123673A3 (en) 2017-08-24
RU2022106508A (en) 2022-04-05
US11117972B2 (en) 2021-09-14
CA3009075A1 (en) 2017-07-20
JP7328761B2 (en) 2023-08-17
CN108883153A (en) 2018-11-23
AU2017207318B2 (en) 2023-12-07
IL260531B2 (en) 2023-05-01
JP2022185021A (en) 2022-12-13
SG11201805422WA (en) 2018-07-30
MX2018008310A (en) 2019-01-28
AU2017207318A1 (en) 2018-07-12
IL260531A (en) 2018-08-30
KR20180098671A (en) 2018-09-04
EP3402507A2 (en) 2018-11-21
MX2024004017A (en) 2024-05-08
WO2017123673A2 (en) 2017-07-20
IL298686A (en) 2023-01-01
EP3402507A4 (en) 2019-08-07
RU2018128629A3 (en) 2020-06-16
AU2024200551A1 (en) 2024-02-22
US20220106397A1 (en) 2022-04-07
US20190263916A1 (en) 2019-08-29
JP2019504062A (en) 2019-02-14
IL260531B1 (en) 2023-01-01
RU2018128629A (en) 2020-02-13

Similar Documents

Publication Publication Date Title
BR112018013911A2 (en) multivalent and multispecific ox40 binding fusion proteins
BR112018013677A2 (en) multivalent and multispecific 41bb binding fusion proteins
BR112018001161A2 (en) multispecific and multivalent gitr-binding fusion proteins
BR112018000584A2 (en) multivalent and multispecific dr5-binding fusion proteins
CL2020000938A1 (en) Anti-tigit antibodies, their compositions and use. (divisional request 201800744)
CL2018000042A1 (en) Tau binding antibodies
CL2018000920A1 (en) Antibody conjugates comprising similar receptor agonists
BR112016021083A2 (en) ANTIBODY-FYNOMER CONJUGATES
EA201891066A1 (en) ANTIBODIES TO ROR1
BR112018014150A2 (en) immunostimulating humanized monoclonal antibodies to human interleukin-2, and fusion proteins thereof
BR112016001782A2 (en) THERAPEUTIC FUSION PROTEIN
DK3337824T3 (en) ANTI-BCMA ANTIBODIES, BISPECIFIC ANTIGEN-BINDING MOLECULES, WHICH BIND BCMA AND CD3, AND THEIR USE
CU24533B1 (en) ANTIBODIES OR FRAGMENTS THEREOF THAT BIND THYMIC STROMAL LYMPHOPOYETIN (TSLP) AND PHARMACEUTICAL COMPOSITIONS THEREOF
CL2018000883A1 (en) Farnesoid x receiver modulators
CU24498B1 (en) FACTOR XI ANTIBODIES
CR20150664A (en) MODULATORS OF ESTROGEN RECEIVERS AND THEIR USES
CL2018000043A1 (en) Tau binding antibodies
EA201792662A1 (en) SPECIFIC ANTIBODIES TO T-CELL RECEPTOR
IL280002A (en) Antibody molecules that bind cd137 and ox40
EA201892440A1 (en) ANTIBODIES TO TL1A AND THEIR APPLICATIONS
EA201890078A1 (en) ANTIBODY
CO2020006453A2 (en) Anti-cxcr5 antibodies and compositions and uses thereof
EA201791691A1 (en) SINGLE-DOMAIN ANTIBODIES DIRECTED TO CD1d
EA201792312A1 (en) CONSTRUCTIONS BASED ON KALIHEAMICIN AND METHODS OF THEIR APPLICATION
BR112015028082A2 (en) taste receptor internalization test

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: INHIBRX, INC. (US)

B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]