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BR112017022936A2 - inibidores da pde10 e composições e métodos relacionados - Google Patents

inibidores da pde10 e composições e métodos relacionados

Info

Publication number
BR112017022936A2
BR112017022936A2 BR112017022936A BR112017022936A BR112017022936A2 BR 112017022936 A2 BR112017022936 A2 BR 112017022936A2 BR 112017022936 A BR112017022936 A BR 112017022936A BR 112017022936 A BR112017022936 A BR 112017022936A BR 112017022936 A2 BR112017022936 A2 BR 112017022936A2
Authority
BR
Brazil
Prior art keywords
disorders
disease
isolated
pharmaceutically acceptable
pde10
Prior art date
Application number
BR112017022936A
Other languages
English (en)
Inventor
Varaprasad Botla Durga
Lynn Gage Jennifer
L Harbol Kevin
Reddy Karnati Laxma
Bommagani Raghuram
Narayanan Satyamurthi
Original Assignee
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp filed Critical Omeros Corp
Publication of BR112017022936A2 publication Critical patent/BR112017022936A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

divulgam-se compostos isolados ou puros que inibem a pde10, que têm utilidade no tratamento de uma variedade de condições, incluindo, porém não limitadas aos, distúrbios psicóticos, de ansiedade, de movimento e/ou distúrbios neurológicos, tais como a doença de parkinson, a doença de huntington, a doença de alzheimer, a encefalite, as fobias, a epilepsia, a afasia, a paralisia de bell, a paralisia cerebral, os distúrbios do sono, a dor, a síndrome de tourette, a esquizofrenia, os distúrbios de delírios, a psicose induzida por drogas e os distúrbios de pânico e obsessivo-compulsivos. os sais farmaceuticamente aceitáveis, os estereoisômeros, os solvatos e os pró-medicamentos dos compostos também são proporcionados. também são divulgadas as composições contendo um composto isolado ou puro em combinação com um veículo farmaceuticamente aceitável, assim como os métodos relacionados ao seu uso para inibir a pde10 em um animal de sangue quente que necessita dos mesmos.
BR112017022936A 2015-04-24 2016-04-22 inibidores da pde10 e composições e métodos relacionados BR112017022936A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562152736P 2015-04-24 2015-04-24
PCT/US2016/028973 WO2016172573A1 (en) 2015-04-24 2016-04-22 Pde10 inhibitors and related compositions and methods

Publications (1)

Publication Number Publication Date
BR112017022936A2 true BR112017022936A2 (pt) 2018-07-17

Family

ID=57144316

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017022936A BR112017022936A2 (pt) 2015-04-24 2016-04-22 inibidores da pde10 e composições e métodos relacionados

Country Status (11)

Country Link
US (1) US9879002B2 (pt)
EP (1) EP3285760A4 (pt)
JP (1) JP2018513153A (pt)
KR (1) KR20170139074A (pt)
CN (1) CN107530313A (pt)
AU (1) AU2016250843A1 (pt)
BR (1) BR112017022936A2 (pt)
CA (1) CA2980801A1 (pt)
IL (1) IL255219A0 (pt)
RU (1) RU2017134509A (pt)
WO (1) WO2016172573A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8343970B2 (en) * 2010-03-12 2013-01-01 Omeros Corporation PDE10 inhibitors and related compositions and methods
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態
KR102451200B1 (ko) 2020-05-29 2022-10-07 성이바이오(주) 향청란 추출물을 유효성분으로 포함하는 인지기능 장애 또는 정신질환 예방 또는 치료용 조성물
CN114524806B (zh) * 2022-02-22 2024-09-03 深圳市儿童医院 一种三氮唑衍生物及其作为pde10抑制剂的用途

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Also Published As

Publication number Publication date
RU2017134509A (ru) 2019-04-04
JP2018513153A (ja) 2018-05-24
CA2980801A1 (en) 2016-10-27
US9879002B2 (en) 2018-01-30
KR20170139074A (ko) 2017-12-18
WO2016172573A1 (en) 2016-10-27
EP3285760A4 (en) 2018-09-26
US20170022190A1 (en) 2017-01-26
AU2016250843A1 (en) 2017-10-12
CN107530313A (zh) 2018-01-02
IL255219A0 (en) 2017-12-31
EP3285760A1 (en) 2018-02-28

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