BR112017000058A2 - dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usos - Google Patents
dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usosInfo
- Publication number
- BR112017000058A2 BR112017000058A2 BR112017000058A BR112017000058A BR112017000058A2 BR 112017000058 A2 BR112017000058 A2 BR 112017000058A2 BR 112017000058 A BR112017000058 A BR 112017000058A BR 112017000058 A BR112017000058 A BR 112017000058A BR 112017000058 A2 BR112017000058 A2 BR 112017000058A2
- Authority
- BR
- Brazil
- Prior art keywords
- scleral
- foams
- methods
- devices
- matrix
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 3
- 239000006260 foam Substances 0.000 title abstract 2
- 230000002792 vascular Effects 0.000 title 1
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 102000001554 Hemoglobins Human genes 0.000 abstract 2
- 108010054147 Hemoglobins Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- -1 polyethylene Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M2005/1401—Functional features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
a presente invenção relaciona-se particularmente a uma espuma de fármaco esclerosante injetável compreendendo: (i) uma matriz; (ii) pelo menos um fluido;(iii) pelo menos um fármaco esclerosante; (iv) uma mistura de gás medicinal ou gás medicinal aceitável para uso intravenoso,(v) na qual a referida matriz possui propriedades físicas, que são comparáveis ao sangue desnaturado, em que o sangue desnaturado é obtido a partir de uma amostra de sangue venoso integral de carne humana de 1 ml de volume, que foi aquecida em um container de polietileno de 3 mm de diâmetro interno e 3,4 mm de diâmetro externo por aproximadamente 0,5 a 10 min numa temperatura de cerca de 70°c a 100°c e/ou (vi) o referido nível de desnaturação é definido pela mudança na coloração vermelha da hemoglobina para marrom como indicador, em que o fe2+ é reduzido para fe3+ no complexo de hemoglobina em um grau de pelo menos 80%, preferivelmente 90% e ainda mais preferivelmente 95%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14175609.8A EP2962681A1 (en) | 2014-07-03 | 2014-07-03 | Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof |
| PCT/EP2015/065142 WO2016001378A1 (en) | 2014-07-03 | 2015-07-02 | Devices and methods for injectable vascular sclerofoams using a carrier matrix and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017000058A2 true BR112017000058A2 (pt) | 2017-11-07 |
Family
ID=51063316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017000058A BR112017000058A2 (pt) | 2014-07-03 | 2015-07-02 | dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usos |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10441539B2 (pt) |
| EP (2) | EP2962681A1 (pt) |
| JP (1) | JP6704356B2 (pt) |
| KR (2) | KR102710959B1 (pt) |
| CN (1) | CN106572973B (pt) |
| AU (1) | AU2015282889B2 (pt) |
| BR (1) | BR112017000058A2 (pt) |
| CA (1) | CA2954023C (pt) |
| IL (1) | IL249915B (pt) |
| NZ (1) | NZ728692A (pt) |
| RU (1) | RU2683033C2 (pt) |
| SG (2) | SG10202103272QA (pt) |
| WO (1) | WO2016001378A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2962681A1 (en) | 2014-07-03 | 2016-01-06 | Swiss VX Venentherapie und Forschung GmbH | Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof |
| JP7054525B2 (ja) * | 2016-09-06 | 2022-04-14 | セルメディシン株式会社 | 免疫刺激剤 |
| WO2018183214A1 (en) * | 2017-03-27 | 2018-10-04 | Dong Yonghua | Train-like pharmaceutical configuration, apparatus for preparation and storage device thereof |
| CN107837439B (zh) * | 2017-12-15 | 2023-10-17 | 广东省人民医院(广东省医学科学院) | 一体式可更换注射筒造影设备 |
| CN110123757B (zh) * | 2019-05-28 | 2020-09-01 | 山东大学齐鲁医院 | 一种应用于治疗脉管异常的乙醇泡沫硬化剂及制备方法 |
| CN110736789B (zh) * | 2019-11-28 | 2022-01-25 | 山东大学齐鲁医院 | 一种泡沫硬化剂制备终点的判断方法及应用 |
| CN111495222B (zh) * | 2020-04-28 | 2022-05-03 | 山东大学齐鲁医院 | 一种用于增强硬化剂泡沫稳定性的装置 |
| CN113143864B (zh) * | 2021-01-29 | 2022-10-18 | 山东大学 | 一种泡沫疗法用泡沫硬化剂及其制备方法与应用 |
| CN114903877B (zh) * | 2021-02-10 | 2024-04-19 | 上海交通大学医学院附属第九人民医院 | 脉管畸形栓塞硬化治疗用药物组合物及其制备方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3141641A1 (de) | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| ES2068151B1 (es) | 1993-06-23 | 1995-11-16 | Cabrera Garrido Juan | Microespuma inyectable para esclerosis. |
| US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| GB2369996B (en) * | 2000-12-18 | 2004-06-23 | S T D Pharmaceutical Products | Method and apparatus for producing an injectable foam |
| US6656107B1 (en) * | 2002-05-24 | 2003-12-02 | Mentor Corporation | Brachytherapy seed applicators |
| GB0212047D0 (en) * | 2002-05-24 | 2002-07-03 | Btg Int Ltd | Generation of therapeutic microfoam |
| GB0326768D0 (en) * | 2003-11-17 | 2003-12-24 | Btg Int Ltd | Generation of therapeutic microfoam |
| SI1694292T2 (sl) * | 2003-11-17 | 2017-04-26 | Btg International Limited | Terapevtska pena, ki obsega sklerozirajočo raztopino in majhno količino plinastega dušika |
| US8048439B2 (en) * | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| DE102004048749B4 (de) | 2004-10-05 | 2007-03-29 | Chemische Fabrik Kreussler & Co. Gmbh | Vorrichtung zur Erzeugung eines medizinischen Schaums |
| KR100730118B1 (ko) | 2004-10-28 | 2007-06-19 | 삼성에스디아이 주식회사 | 플라즈마 디스플레이 패널 |
| PT2125322E (pt) * | 2006-12-21 | 2013-06-04 | Btg Int Ltd | Dispositivo e processo para produzir espuma terapêutica |
| EP2656869B1 (en) * | 2012-04-24 | 2020-10-14 | angioclinic AG | Composition for treating venous insufficiency and varicose veins |
| CN103800278B (zh) * | 2014-02-25 | 2015-10-21 | 山东大学齐鲁医院 | 透明质酸联合聚桂醇在制备治疗静脉畸形泡沫硬化药物中的应用 |
| EP2962681A1 (en) | 2014-07-03 | 2016-01-06 | Swiss VX Venentherapie und Forschung GmbH | Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof |
-
2014
- 2014-07-03 EP EP14175609.8A patent/EP2962681A1/en not_active Withdrawn
-
2015
- 2015-07-02 SG SG10202103272QA patent/SG10202103272QA/en unknown
- 2015-07-02 KR KR1020227040893A patent/KR102710959B1/ko active IP Right Grant
- 2015-07-02 EP EP15732009.4A patent/EP3164109A1/en active Pending
- 2015-07-02 US US15/323,573 patent/US10441539B2/en active Active
- 2015-07-02 KR KR1020177002808A patent/KR102503994B1/ko active IP Right Grant
- 2015-07-02 AU AU2015282889A patent/AU2015282889B2/en active Active
- 2015-07-02 CA CA2954023A patent/CA2954023C/en active Active
- 2015-07-02 WO PCT/EP2015/065142 patent/WO2016001378A1/en active Application Filing
- 2015-07-02 NZ NZ728692A patent/NZ728692A/en unknown
- 2015-07-02 SG SG11201700018UA patent/SG11201700018UA/en unknown
- 2015-07-02 JP JP2016575771A patent/JP6704356B2/ja active Active
- 2015-07-02 BR BR112017000058A patent/BR112017000058A2/pt not_active Application Discontinuation
- 2015-07-02 RU RU2017103172A patent/RU2683033C2/ru active
- 2015-07-02 CN CN201580043311.9A patent/CN106572973B/zh active Active
-
2017
- 2017-01-03 IL IL249915A patent/IL249915B/en active IP Right Grant
-
2019
- 2019-05-21 US US16/417,963 patent/US11229601B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106572973B (zh) | 2020-11-24 |
| US10441539B2 (en) | 2019-10-15 |
| RU2683033C2 (ru) | 2019-03-26 |
| SG11201700018UA (en) | 2017-01-27 |
| US20170157047A1 (en) | 2017-06-08 |
| WO2016001378A1 (en) | 2016-01-07 |
| NZ728692A (en) | 2024-07-05 |
| EP2962681A1 (en) | 2016-01-06 |
| KR20220163501A (ko) | 2022-12-09 |
| RU2017103172A3 (pt) | 2018-09-06 |
| CA2954023A1 (en) | 2016-01-07 |
| CN106572973A (zh) | 2017-04-19 |
| JP2017524683A (ja) | 2017-08-31 |
| IL249915B (en) | 2020-07-30 |
| US11229601B2 (en) | 2022-01-25 |
| EP3164109A1 (en) | 2017-05-10 |
| AU2015282889A1 (en) | 2017-02-16 |
| CA2954023C (en) | 2024-01-09 |
| AU2015282889B2 (en) | 2020-09-24 |
| RU2017103172A (ru) | 2018-08-06 |
| KR20170039661A (ko) | 2017-04-11 |
| KR102503994B1 (ko) | 2023-02-28 |
| SG10202103272QA (en) | 2021-05-28 |
| KR102710959B1 (ko) | 2024-09-26 |
| IL249915A0 (en) | 2017-03-30 |
| JP6704356B2 (ja) | 2020-06-03 |
| US20190336445A1 (en) | 2019-11-07 |
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