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BR112015028278A2 - processo para a preparação de eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico e eritrócitos assim obtidos - Google Patents

processo para a preparação de eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico e eritrócitos assim obtidos

Info

Publication number
BR112015028278A2
BR112015028278A2 BR112015028278A BR112015028278A BR112015028278A2 BR 112015028278 A2 BR112015028278 A2 BR 112015028278A2 BR 112015028278 A BR112015028278 A BR 112015028278A BR 112015028278 A BR112015028278 A BR 112015028278A BR 112015028278 A2 BR112015028278 A2 BR 112015028278A2
Authority
BR
Brazil
Prior art keywords
erythrocytes
loaded
substances
preparation
pharmaceutical interest
Prior art date
Application number
BR112015028278A
Other languages
English (en)
Other versions
BR112015028278B1 (pt
Inventor
Capogrossi Giovanni
Mambrini Giovanni
Benatti Luca
Mandolini Marco
Original Assignee
Erydel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT000280A external-priority patent/ITRM20130280A1/it
Priority claimed from IT000610A external-priority patent/ITRM20130610A1/it
Application filed by Erydel Spa filed Critical Erydel Spa
Publication of BR112015028278A2 publication Critical patent/BR112015028278A2/pt
Publication of BR112015028278B1 publication Critical patent/BR112015028278B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01001—Hexokinase (2.7.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

resumo "processo para a preparação de eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico e eritrócitos assim obtidos” a presente invenção refere-se a um processo para preparação de eritrócitos carregados com uma ou mais substância de interesse farmacêutico. a presente in-venção também é dirigida a eritrócitos carregados, desse modo obtido e composi-ções farmacêuticas compreendendo a população de eritrócitos carregados bem co-mo aplicação terapêutica dos mesmos, em particular no tratamento de ataxia telan-giectasia.
BR112015028278-4A 2013-05-10 2014-05-09 Processo para a preparação de eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico, eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico, composição farmacêutica e uso terapêutico dos ditos eritrócitos BR112015028278B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT000280A ITRM20130280A1 (it) 2013-05-10 2013-05-10 Procedimento per la preparazione di eritrociti caricati con una o più sostanze di interesse farmaceutico.
ITRM2013A000280 2013-05-10
ITRM2013A000610 2013-11-05
IT000610A ITRM20130610A1 (it) 2013-11-05 2013-11-05 Eritrociti caricati con una o più sostanze di interesse farmaceutico
PCT/IB2014/061338 WO2014181309A1 (en) 2013-05-10 2014-05-09 Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes

Publications (2)

Publication Number Publication Date
BR112015028278A2 true BR112015028278A2 (pt) 2017-07-25
BR112015028278B1 BR112015028278B1 (pt) 2022-12-20

Family

ID=50981593

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028278-4A BR112015028278B1 (pt) 2013-05-10 2014-05-09 Processo para a preparação de eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico, eritrócitos carregados com uma ou mais substâncias de interesse farmacêutico, composição farmacêutica e uso terapêutico dos ditos eritrócitos

Country Status (19)

Country Link
US (2) US10849858B2 (pt)
EP (2) EP4338803A3 (pt)
JP (1) JP6367314B2 (pt)
KR (1) KR102223080B1 (pt)
CN (1) CN105228596B (pt)
AU (1) AU2014264205B2 (pt)
BR (1) BR112015028278B1 (pt)
CA (1) CA2911976C (pt)
CR (1) CR20150604A (pt)
ES (1) ES2950419T3 (pt)
IL (1) IL242503B (pt)
MX (1) MX2015015409A (pt)
PH (1) PH12015502535B1 (pt)
PL (1) PL2994117T3 (pt)
PT (1) PT2994117T (pt)
RU (1) RU2670070C2 (pt)
SA (1) SA515370122B1 (pt)
SG (1) SG11201509252QA (pt)
WO (1) WO2014181309A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3071515A2 (en) 2013-11-18 2016-09-28 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
MX2020000621A (es) 2014-04-01 2020-11-12 Rubius Therapeutics Inc Composiciones para usarse en inmunomodulacion.
US11243218B2 (en) 2015-10-07 2022-02-08 Sangui Bio Pty Ltd. Blood preparation and profiling
US11564948B2 (en) 2015-12-22 2023-01-31 Sangui Bio Pty Ltd Therapeutic methods using erythrocytes
KR101671361B1 (ko) * 2016-08-08 2016-11-01 에스씨엠생명과학 주식회사 TYMP(thymidine phosphorylase) 단백질을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물
CA3047607A1 (en) 2016-12-20 2018-06-28 Sangui Bio Pty. Ltd Blood profiling with protease inhibitors
US20210403571A1 (en) 2018-11-15 2021-12-30 Erytech Pharma Synergistic combinations of methionine depletion agents and immune checkpoint modulators
CN109453137A (zh) * 2018-12-07 2019-03-12 上海交通大学 一种活红细胞载倍他米松磷酸钠的缓释制剂及其制备方法与应用
CN113008653A (zh) * 2019-12-20 2021-06-22 深圳市帝迈生物技术有限公司 稀释液、血细胞分析仪、血细胞分析仪用试剂以及试剂盒
EP4149440A1 (en) 2020-05-11 2023-03-22 Erytech Pharma Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof
CN111658772B (zh) * 2020-07-22 2022-06-03 南通大学 一种自然光诱导控释药物及其制备方法与应用
CA3219808A1 (en) 2021-05-27 2022-12-01 Erydel S.P.A. Engineering new metabolic pathways in isolated cells for the degradation of guanidinoacetic acid and simultaneous production of creatine
WO2023027613A1 (ru) * 2021-08-27 2023-03-02 Общество С Ограниченной Ответственностью "Рбк-Фармэко" Устройство и способ для включения биологически активных компонентов в эритроциты способом проточного диализа
CN114469865B (zh) * 2022-03-17 2023-09-22 中国医学科学院输血研究所 一种与血细胞膜结合的脂质体药物载体及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327710A (en) * 1980-06-18 1982-05-04 The United States Of America As Represented By The Secretary Of Agriculture Process for encapsulating additives in resealed erythrocytes for disseminating chemicals via the circulatory system
SU1807595A1 (ru) * 1989-10-16 1996-08-10 Целиноградский государственный медицинский институт Минздрава КазССР Средство для лечения отравлений ртутью
JPH08511680A (ja) * 1993-03-23 1996-12-10 シービーアール・ラボラトリーズ・インコーポレーテツド 細胞内への生物学的活性物質の封入のための方法および装置
EP0882448B1 (en) * 1997-05-05 2005-01-12 DIDECO S.r.l. Method of encapsulating biologically active agents within erythrocytes and apparatus therefor
GB0002856D0 (en) 2000-02-08 2000-03-29 Gendel Limited Ultrasound sensitisation
KR100478791B1 (ko) * 2002-07-11 2005-03-24 오유경 유전자 수송체로서의 생체 적합성 혈구 세포
FR2873925B1 (fr) * 2004-08-05 2006-10-13 Erytech Pharma Soc Par Actions Procede et dispositif de lyse-rescellement pour l'incorporation de principe actif notamment asparaginase ou inositol hexaphosphate, dans des erythrocytes
ITBO20100256A1 (it) 2010-04-26 2011-10-27 Erydel Spa Metodo per incapsulare almeno un composto ad uso terapeutico e/o diagnostico all'interno di eritrociti
IT1399590B1 (it) 2010-04-26 2013-04-26 Erydel Spa Apparato e kit per incapsulare almeno un composto ad uso terapeutico e/o diagnostico all'interno di eritrociti

Also Published As

Publication number Publication date
WO2014181309A1 (en) 2014-11-13
AU2014264205B2 (en) 2018-08-30
KR20160005781A (ko) 2016-01-15
US20160051482A1 (en) 2016-02-25
EP2994117B1 (en) 2023-06-07
ES2950419T3 (es) 2023-10-09
US10849858B2 (en) 2020-12-01
PH12015502535A1 (en) 2016-02-22
EP2994117A1 (en) 2016-03-16
EP4338803A2 (en) 2024-03-20
CN105228596A (zh) 2016-01-06
MX2015015409A (es) 2016-06-02
BR112015028278B1 (pt) 2022-12-20
US20210283063A1 (en) 2021-09-16
CR20150604A (es) 2016-03-09
PH12015502535B1 (en) 2020-01-29
RU2670070C2 (ru) 2018-10-17
IL242503B (en) 2020-08-31
EP4338803A3 (en) 2024-10-09
RU2015152801A (ru) 2017-06-16
JP6367314B2 (ja) 2018-08-01
JP2016518402A (ja) 2016-06-23
KR102223080B1 (ko) 2021-03-04
SA515370122B1 (ar) 2016-11-08
CN105228596B (zh) 2018-08-24
AU2014264205A1 (en) 2015-11-12
CA2911976A1 (en) 2014-11-13
CA2911976C (en) 2021-01-19
SG11201509252QA (en) 2015-12-30
PL2994117T3 (pl) 2023-10-16
PT2994117T (pt) 2023-07-14

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/05/2014, OBSERVADAS AS CONDICOES LEGAIS