BR112015026841A8 - sal de l-tartarato de [(s)-2-[metil-3-(2-oxo-pirrolidin-1-il)- benzenossulfonilamino]-3-(4-metil-piperazin-1-il)-3-oxopropril] amida de ácido 5-cloro-tiofeno-2-carboxílico, processo de preparação do mesmo, seu uso, medicamento e composição farmacêutica - Google Patents
sal de l-tartarato de [(s)-2-[metil-3-(2-oxo-pirrolidin-1-il)- benzenossulfonilamino]-3-(4-metil-piperazin-1-il)-3-oxopropril] amida de ácido 5-cloro-tiofeno-2-carboxílico, processo de preparação do mesmo, seu uso, medicamento e composição farmacêutica Download PDFInfo
- Publication number
- BR112015026841A8 BR112015026841A8 BR112015026841A BR112015026841A BR112015026841A8 BR 112015026841 A8 BR112015026841 A8 BR 112015026841A8 BR 112015026841 A BR112015026841 A BR 112015026841A BR 112015026841 A BR112015026841 A BR 112015026841A BR 112015026841 A8 BR112015026841 A8 BR 112015026841A8
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- oxo
- benzenesulfonylamino
- piperazin
- pyrrolidin
- Prior art date
Links
- -1 2-oxo-pyrrolidin-1-yl Chemical group 0.000 title abstract 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 title abstract 2
- OMOBWMBJNNCUFO-UHFFFAOYSA-N 5-chlorothiophene-2-carboxamide Chemical compound NC(=O)C1=CC=C(Cl)S1 OMOBWMBJNNCUFO-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- QZLSBOVWPHXCLT-UHFFFAOYSA-N 5-chlorothiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=C(Cl)S1 QZLSBOVWPHXCLT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
resumo patente de invenção: "sal de tartarato do ácido 5-cloro-tiofeno-2-carboxílico [(s)-2-[metil-3-(2-oxo-pirrolidin-1-il)-benzenossulfonilamino]-3-(4-metil-piperazin-1-il)-3-oxo propil) amida". a invenção se refere ao sal de l-tartarato do ácido 5-cloro-tiofeno-2-carboxílico [(s)-2-[metil-3-(2-oxo-pírrolidin-1-il)-benzenossulfonilamino] -3-(4-metil-piperazin-1-il)-3-oxo-propril] amida, à forma cristalina do mesmo, à preparação do mesmo e ao uso terapêutico do mesmo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305556 | 2013-04-26 | ||
| PCT/EP2014/058513 WO2014174102A1 (en) | 2013-04-26 | 2014-04-25 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(s)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl piperazin-1 -yl)-3-oxo-propryl]amide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015026841A2 BR112015026841A2 (pt) | 2017-07-25 |
| BR112015026841A8 true BR112015026841A8 (pt) | 2019-12-24 |
Family
ID=48428407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015026841A BR112015026841A8 (pt) | 2013-04-26 | 2014-04-25 | sal de l-tartarato de [(s)-2-[metil-3-(2-oxo-pirrolidin-1-il)- benzenossulfonilamino]-3-(4-metil-piperazin-1-il)-3-oxopropril] amida de ácido 5-cloro-tiofeno-2-carboxílico, processo de preparação do mesmo, seu uso, medicamento e composição farmacêutica |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9637479B2 (pt) |
| EP (1) | EP2989095B1 (pt) |
| JP (1) | JP6393310B2 (pt) |
| KR (1) | KR102388926B1 (pt) |
| CN (1) | CN105143213B (pt) |
| AU (1) | AU2014259378B2 (pt) |
| BR (1) | BR112015026841A8 (pt) |
| CA (1) | CA2910085C (pt) |
| CY (1) | CY1123536T1 (pt) |
| DK (1) | DK2989095T3 (pt) |
| ES (1) | ES2711144T3 (pt) |
| HR (1) | HRP20190245T1 (pt) |
| HU (1) | HUE042250T2 (pt) |
| IL (1) | IL242081B (pt) |
| LT (1) | LT2989095T (pt) |
| MX (1) | MX360896B (pt) |
| PL (1) | PL2989095T3 (pt) |
| PT (1) | PT2989095T (pt) |
| RU (1) | RU2664538C2 (pt) |
| SG (1) | SG11201508515WA (pt) |
| SI (1) | SI2989095T1 (pt) |
| TR (1) | TR201901931T4 (pt) |
| TW (1) | TWI615390B (pt) |
| WO (1) | WO2014174102A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250002483A1 (en) | 2021-09-03 | 2025-01-02 | Bayer Aktiengesellschaft | Substituted s-alaninate derivatives |
| WO2024175450A1 (en) | 2023-02-21 | 2024-08-29 | Bayer Aktiengesellschaft | Substituted s-alaninate derivatives |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071753C (zh) * | 1994-08-25 | 2001-09-26 | 弗吉尼亚大学 | 作为胆碱能受体配体的7－氮杂双环[2,2,1]－庚烷和庚烯衍生物 |
| ATE200479T1 (de) * | 1996-05-31 | 2001-04-15 | Sigma Tau Ind Farmaceuti | Stabile nichthygroskopische salze von l(- )carnitin und alkanoyl-l(-)carnitinen, verfahren zu ihrer herstellung und feste, oral verabreichbare zusammensetzungen,die sie enthalten |
| SE510305C2 (sv) * | 1997-05-30 | 1999-05-10 | Astra Ab | Nytt salt |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0114005D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0127568D0 (en) * | 2001-11-16 | 2002-01-09 | Glaxo Group Ltd | Chemical compounds |
| GB0228552D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Chemical compounds |
| CN101703467A (zh) * | 2003-08-28 | 2010-05-12 | 梅恩医药有限公司 | 含有酸的奥沙利铂制剂 |
| US7371743B2 (en) * | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| JP5422570B2 (ja) * | 2008-02-21 | 2014-02-19 | サノフイ | 凝固第Ｘａ因子及びトロンビンの阻害剤としてのクロロチオフェン−アミド類 |
| KR100953535B1 (ko) * | 2008-07-17 | 2010-04-21 | 재단법인 포항산업과학연구원 | 염소계 화합물을 이용한 배가스 내 수은 제거 방법 |
-
2014
- 2014-04-25 RU RU2015150388A patent/RU2664538C2/ru active
- 2014-04-25 LT LTEP14719340.3T patent/LT2989095T/lt unknown
- 2014-04-25 ES ES14719340T patent/ES2711144T3/es active Active
- 2014-04-25 SI SI201431086T patent/SI2989095T1/sl unknown
- 2014-04-25 BR BR112015026841A patent/BR112015026841A8/pt not_active Application Discontinuation
- 2014-04-25 WO PCT/EP2014/058513 patent/WO2014174102A1/en active Application Filing
- 2014-04-25 SG SG11201508515WA patent/SG11201508515WA/en unknown
- 2014-04-25 CN CN201480023265.1A patent/CN105143213B/zh active Active
- 2014-04-25 TR TR2019/01931T patent/TR201901931T4/tr unknown
- 2014-04-25 TW TW103115126A patent/TWI615390B/zh active
- 2014-04-25 HU HUE14719340A patent/HUE042250T2/hu unknown
- 2014-04-25 MX MX2015014986A patent/MX360896B/es active IP Right Grant
- 2014-04-25 JP JP2016509496A patent/JP6393310B2/ja active Active
- 2014-04-25 KR KR1020157032913A patent/KR102388926B1/ko active IP Right Grant
- 2014-04-25 AU AU2014259378A patent/AU2014259378B2/en active Active
- 2014-04-25 EP EP14719340.3A patent/EP2989095B1/en active Active
- 2014-04-25 US US14/786,953 patent/US9637479B2/en active Active
- 2014-04-25 CA CA2910085A patent/CA2910085C/en active Active
- 2014-04-25 PL PL14719340T patent/PL2989095T3/pl unknown
- 2014-04-25 PT PT14719340T patent/PT2989095T/pt unknown
- 2014-04-25 DK DK14719340.3T patent/DK2989095T3/en active
-
2015
- 2015-10-14 IL IL242081A patent/IL242081B/en active IP Right Grant
-
2019
- 2019-02-06 HR HRP20190245TT patent/HRP20190245T1/hr unknown
- 2019-02-20 CY CY20191100216T patent/CY1123536T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 409/12 Ipc: C07D 409/12 (2006.01), C07D 409/14 (2006.01), A61K |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: BEIJING COLLAB PHARM CO., LTD. (CN) |
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| B25A | Requested transfer of rights approved |
Owner name: BEIJING LIANXIN PHARMACEUTICAL CO., LTD. (CN) |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |