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BR112014028813A2 - 5-amino[1,4]tiazinas como inibidores bace1 - Google Patents

5-amino[1,4]tiazinas como inibidores bace1

Info

Publication number
BR112014028813A2
BR112014028813A2 BR112014028813A BR112014028813A BR112014028813A2 BR 112014028813 A2 BR112014028813 A2 BR 112014028813A2 BR 112014028813 A BR112014028813 A BR 112014028813A BR 112014028813 A BR112014028813 A BR 112014028813A BR 112014028813 A2 BR112014028813 A2 BR 112014028813A2
Authority
BR
Brazil
Prior art keywords
thiazines
amino
bace1 inhibitors
bace1
present
Prior art date
Application number
BR112014028813A
Other languages
English (en)
Inventor
Hilpert Hans
Woltering Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014028813A2 publication Critical patent/BR112014028813A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo patente de invenção: "5-amino[1,4]tiazinas como inibidores bace1". a presente invenção refere-se a um composto de fórmula i tendo atividade inibitória bace1, sua fabricação, composições farmacêuticas contendo o mesmo e seus usos como substâncias terapeuticamente ativas. os compostos ativos da presente invenção são úteis no tratamento terapêutico e/ou profilático de, por exemplo, doença de alzheimer.
BR112014028813A 2012-05-24 2013-05-21 5-amino[1,4]tiazinas como inibidores bace1 BR112014028813A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12169353 2012-05-24
PCT/EP2013/060352 WO2013174781A1 (en) 2012-05-24 2013-05-21 5-amino[1,4]thiazines as bace 1 inhibitors

Publications (1)

Publication Number Publication Date
BR112014028813A2 true BR112014028813A2 (pt) 2017-06-27

Family

ID=48534350

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014028813A BR112014028813A2 (pt) 2012-05-24 2013-05-21 5-amino[1,4]tiazinas como inibidores bace1

Country Status (22)

Country Link
US (1) US9273042B2 (pt)
EP (1) EP2855469B1 (pt)
JP (1) JP6251249B2 (pt)
KR (1) KR20150014934A (pt)
CN (1) CN104334554B (pt)
AU (1) AU2013265376B2 (pt)
BR (1) BR112014028813A2 (pt)
CA (1) CA2872179A1 (pt)
CL (1) CL2014003123A1 (pt)
CO (1) CO7131369A2 (pt)
CR (1) CR20140495A (pt)
EA (1) EA026004B1 (pt)
HK (1) HK1201261A1 (pt)
IL (1) IL235681A (pt)
MA (1) MA37691B1 (pt)
MX (1) MX2014013839A (pt)
NZ (1) NZ702254A (pt)
PE (1) PE20150021A1 (pt)
PH (1) PH12014502541A1 (pt)
SG (1) SG11201407575PA (pt)
UA (1) UA113438C2 (pt)
WO (1) WO2013174781A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524472A (ja) * 2011-08-22 2014-09-22 メルク・シャープ・アンド・ドーム・コーポレーション Ｂａｃｅ阻害剤としての２−スピロ置換イミノチアジンならびにそのモノオキシドおよびジオキシド、組成物、ならびにそれらの使用
WO2014059185A1 (en) 2012-10-12 2014-04-17 Amgen Inc. Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
US9096615B2 (en) 2013-07-30 2015-08-04 Amgen Inc. Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
WO2015038446A1 (en) * 2013-09-13 2015-03-19 Merck Sharp & Dohme Corp. C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use
CN107108652B (zh) * 2014-11-03 2019-06-18 豪夫迈·罗氏有限公司 Bace1抑制剂
US10047081B2 (en) 2015-03-20 2018-08-14 Hoffman-La Roche Inc. BACE1 inhibitors
CN107683283B (zh) * 2015-08-12 2021-05-18 豪夫迈·罗氏有限公司 Bace1抑制剂
US11629154B2 (en) 2018-04-27 2023-04-18 Shionogi & Co., Ltd. Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
CN110467611B (zh) * 2018-05-11 2022-09-27 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008516945A (ja) * 2004-10-15 2008-05-22 アストラゼネカ・アクチエボラーグ 置換されたアミノ化合物およびそれらの使用
US8461160B2 (en) * 2009-05-08 2013-06-11 Hoffmann-La Roche, Inc. Dihydropyrimidinones
US8188079B2 (en) * 2009-08-19 2012-05-29 Hoffman-La Roche Inc. 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
UA103272C2 (uk) 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
RU2013150349A (ru) * 2011-04-13 2015-05-20 Мерк Шарп И Доум Корп. 5-замещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов васе, содержащие их композиции и их применение
JP2014524472A (ja) * 2011-08-22 2014-09-22 メルク・シャープ・アンド・ドーム・コーポレーション Ｂａｃｅ阻害剤としての２−スピロ置換イミノチアジンならびにそのモノオキシドおよびジオキシド、組成物、ならびにそれらの使用

Also Published As

Publication number Publication date
WO2013174781A1 (en) 2013-11-28
AU2013265376A1 (en) 2014-11-13
SG11201407575PA (en) 2014-12-30
EP2855469A1 (en) 2015-04-08
PH12014502541B1 (en) 2015-01-21
US20150141413A1 (en) 2015-05-21
CN104334554B (zh) 2017-10-31
NZ702254A (en) 2016-08-26
EP2855469B1 (en) 2019-06-19
PH12014502541A1 (en) 2015-01-21
IL235681A (en) 2017-10-31
CA2872179A1 (en) 2013-11-28
CO7131369A2 (es) 2014-12-01
MA37691B1 (fr) 2016-11-30
JP6251249B2 (ja) 2017-12-20
MA37691A1 (fr) 2016-03-31
EA026004B1 (ru) 2017-02-28
CR20140495A (es) 2014-12-01
US9273042B2 (en) 2016-03-01
UA113438C2 (xx) 2017-01-25
HK1201261A1 (en) 2015-08-28
AU2013265376B2 (en) 2017-07-20
EA201492097A1 (ru) 2015-04-30
JP2015517548A (ja) 2015-06-22
CL2014003123A1 (es) 2015-02-27
IL235681A0 (en) 2015-02-01
KR20150014934A (ko) 2015-02-09
CN104334554A (zh) 2015-02-04
MX2014013839A (es) 2015-02-04
PE20150021A1 (es) 2015-01-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2516 DE 26-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.