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BR112014005522A2 - métodos para redução dos níveis de lipoproteína(a) pela administração de um inibidor da proproteína subtilisina quexina-9 convertase (pcsk9) - Google Patents

métodos para redução dos níveis de lipoproteína(a) pela administração de um inibidor da proproteína subtilisina quexina-9 convertase (pcsk9)

Info

Publication number
BR112014005522A2
BR112014005522A2 BR112014005522A BR112014005522A BR112014005522A2 BR 112014005522 A2 BR112014005522 A2 BR 112014005522A2 BR 112014005522 A BR112014005522 A BR 112014005522A BR 112014005522 A BR112014005522 A BR 112014005522A BR 112014005522 A2 BR112014005522 A2 BR 112014005522A2
Authority
BR
Brazil
Prior art keywords
pcsk9
inhibitor
administering
methods
proprotein
Prior art date
Application number
BR112014005522A
Other languages
English (en)
Inventor
Swergold Gary
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46881178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014005522(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112014005522A2 publication Critical patent/BR112014005522A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo patente de invenção: "métodos para redução dos níveis de lipoproteína(a) pela administração de um inibidor da proproteína subtilisina quexina-9 convertase (pcsk9)". a presente invenção refere-se a métodos para reduzir a lipoproteína (a) (lp(a)) em pacientes. os métodos da presente invenção compreendem a seleção de um paciente que exibe lp(a) sérica elevada, e administração ao paciente de uma composição farmacêutica compreendendo um inibidor da pcsk9. em certas modalidades, o inibidor da pcsk9 é um anticorpo anti-pcsk9 tal como o exemplo de anticorpo mencionado aqui como mab316p.
BR112014005522A 2011-09-16 2012-09-12 métodos para redução dos níveis de lipoproteína(a) pela administração de um inibidor da proproteína subtilisina quexina-9 convertase (pcsk9) BR112014005522A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161535392P 2011-09-16 2011-09-16
US201161559162P 2011-11-14 2011-11-14
US201261641321P 2012-05-02 2012-05-02
PCT/US2012/054756 WO2013039969A1 (en) 2011-09-16 2012-09-12 METHODS FOR REDUCING LIPOPROTEIN(a) LEVELS BY ADMINISTERING AN INHIBITOR OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN-9 (PCSK9)

Publications (1)

Publication Number Publication Date
BR112014005522A2 true BR112014005522A2 (pt) 2017-03-21

Family

ID=46881178

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014005522A BR112014005522A2 (pt) 2011-09-16 2012-09-12 métodos para redução dos níveis de lipoproteína(a) pela administração de um inibidor da proproteína subtilisina quexina-9 convertase (pcsk9)

Country Status (21)

Country Link
US (2) US10076571B2 (pt)
EP (4) EP3536712B1 (pt)
JP (2) JP6158813B2 (pt)
KR (1) KR101964031B1 (pt)
CN (2) CN103930444B (pt)
AR (1) AR087881A1 (pt)
AU (1) AU2012308797B2 (pt)
BR (1) BR112014005522A2 (pt)
CA (1) CA2848201C (pt)
CL (1) CL2014000605A1 (pt)
CO (1) CO6910163A2 (pt)
EA (1) EA028278B1 (pt)
ES (2) ES2953713T3 (pt)
IL (1) IL231011B (pt)
MA (1) MA35430B1 (pt)
MX (1) MX363642B (pt)
MY (1) MY170089A (pt)
SG (1) SG2014010524A (pt)
TW (1) TWI601740B (pt)
WO (1) WO2013039969A1 (pt)
ZA (1) ZA201401114B (pt)

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