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BR0317348A - EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac - Google Patents

EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac

Info

Publication number
BR0317348A
BR0317348A BR0317348-8A BR0317348A BR0317348A BR 0317348 A BR0317348 A BR 0317348A BR 0317348 A BR0317348 A BR 0317348A BR 0317348 A BR0317348 A BR 0317348A
Authority
BR
Brazil
Prior art keywords
acid derivatives
enantiomers
hdac inhibitors
hydroxamic acid
thiophene hydroxamic
Prior art date
Application number
BR0317348-8A
Other languages
English (en)
Inventor
Adelbert Grossmann
Frank Herting
Matthias Koerner
Klaus-Peter Kuenkele
Anja Limberg
Olaf Mundigl
Ulrich Tibes
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0317348A publication Critical patent/BR0317348A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

"ENANTIÈMEROS DE DERIVADOS DE áCIDO TIOFENO HIDROXâMICO E SEU USO COMO INIBIDORES DE HDAC". Compostos da fórmula (I) onde Ar, R1 e R2 possuem os significados definidos no relatório descritivo, processo para fabricação desses compostos e medicamentos com atividade inibidora de HDAC contendo tal composto.
BR0317348-8A 2002-12-16 2003-12-15 EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac BR0317348A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02028038 2002-12-16
PCT/EP2003/014235 WO2004054999A1 (en) 2002-12-16 2003-12-15 Enantiomers of thiophene hydroxamic acid derivatives and their use as hdac inhibitors

Publications (1)

Publication Number Publication Date
BR0317348A true BR0317348A (pt) 2005-11-16

Family

ID=32524005

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317348-8A BR0317348A (pt) 2002-12-16 2003-12-15 EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac

Country Status (18)

Country Link
US (1) US7098241B2 (pt)
EP (1) EP1575933A1 (pt)
JP (1) JP2006513181A (pt)
KR (1) KR100781929B1 (pt)
CN (1) CN100391954C (pt)
AR (1) AR042459A1 (pt)
AU (1) AU2003293882A1 (pt)
BR (1) BR0317348A (pt)
CA (1) CA2507629A1 (pt)
CL (1) CL2003002611A1 (pt)
GT (1) GT200300285A (pt)
PA (1) PA8592101A1 (pt)
PE (1) PE20040913A1 (pt)
PL (1) PL377696A1 (pt)
RU (1) RU2348625C2 (pt)
TW (1) TW200418825A (pt)
UY (1) UY28127A1 (pt)
WO (1) WO2004054999A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
ES2345438T3 (es) 2002-12-10 2010-09-23 Virochem Pharma Inc. Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
CA2566525A1 (en) * 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Thiophene derivatives, their manufacture and use as pharmaceutical agents
EP1758881A1 (en) * 2004-06-14 2007-03-07 F.Hoffmann-La Roche Ag Thiophene hydroxamic acid derivatives and their use as hdac inhibitors
JP2008502627A (ja) * 2004-06-14 2008-01-31 エフ．ホフマン−ラ　ロシュ　アーゲー ヒドロキサム酸塩、その製造、および薬剤としての使用
AP2007004245A0 (en) * 2005-05-13 2007-12-31 Virochem Pharma Inc Compounds and methods for the treatment or prevention of flavivirus infections
BRPI0613429A2 (pt) 2005-07-14 2009-02-10 Takeda San Diego Inc inibidores de histona desacetilase
GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0522130D0 (en) * 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0603041D0 (en) * 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
PL2104674T3 (pl) 2006-11-15 2013-12-31 Vertex Pharmaceuticals Canada Incorporated Analogi tiofenu do leczenia lub zapobiegania zakażeniom flawiwirusowym
AR074797A1 (es) 2008-10-10 2011-02-16 Japan Tobacco Inc Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial
US20110212969A1 (en) * 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2011106627A1 (en) * 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012019772A1 (en) * 2010-08-12 2012-02-16 Institut De Recherche Pour Le Developpement (I.R.D) Method for treating protozoan parasitic diseases
WO2012112447A2 (en) * 2011-02-14 2012-08-23 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors and methods of use thereof
CA2850757A1 (en) * 2011-10-03 2013-04-11 The Trustees Of Columbia University In The City Of New York Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
EP3348545A1 (en) 2013-03-15 2018-07-18 Japan Tobacco Inc. Pyrazole-amide compound and medicinal uses therefor
CN103159646B (zh) * 2013-03-19 2014-10-22 广东药学院 一种异羟肟酸类化合物及其制备方法和应用
US9890136B2 (en) 2013-12-23 2018-02-13 The Trustees Of Columbia University In The City Of New York Memorial Sloan-Kettering Cancer Center Selective HDAC6 inhibitors
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物
MX2019001228A (es) 2016-07-29 2019-06-03 Japan Tobacco Inc Metodo de produccion del compuesto de pirazol-amida.
CN116120300B (zh) * 2023-02-21 2024-10-15 贵州大学 一种含异羟肟酸片段的嘧啶类化合物其制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6406688A (pt) 1964-06-05 1965-12-06
BE661226A (fr) 1965-03-17 1965-09-17 Acides arylacethydroxamiques, amides correspondants et procedes de preparation.
GB1200886A (en) 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
US4173652A (en) 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
NL7614113A (nl) 1976-12-18 1978-06-20 Akzo Nv Hydroxamzuren.
JPS5436229A (en) 1977-08-25 1979-03-16 Hokuriku Pharmaceutical Substituted acetohydroxam derivative
JPS57145838A (en) 1981-03-05 1982-09-09 Hodogaya Chem Co Ltd P-benzyloxybenzoic acid derivative and herbicide containing the same
JPS57149254A (en) 1981-03-10 1982-09-14 Hodogaya Chem Co Ltd M-benzyloxybenzamide derivative and herbicide containing the same
GB8320702D0 (en) 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agents
US4769461A (en) 1986-09-16 1988-09-06 American Home Products Corporation Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
GB8728051D0 (en) 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
JPH01216961A (ja) 1988-02-25 1989-08-30 Takeda Chem Ind Ltd １２−リポキシゲネース阻害剤
DE3903989A1 (de) 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
US5091533A (en) 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
JPH04217950A (ja) 1990-03-28 1992-08-07 Asahi Chem Ind Co Ltd ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤
JPH03291264A (ja) 1990-04-06 1991-12-20 Japan Tobacco Inc ジメチルアニリン誘導体、その製造方法及びそれを有効成分として含有するガン細胞分化誘導検査試薬及び制癌剤
JPH04187666A (ja) 1990-11-20 1992-07-06 Asahi Chem Ind Co Ltd シクロヘキサンカルボン酸アミド誘導体及び酵素阻害剤ならびに抗潰瘍剤
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5700811A (en) 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
EP0544166A3 (en) 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
JPH07509269A (ja) 1992-07-16 1995-10-12 ザ・ダウ・ケミカル・カンパニー チオジフェノールコポリカーボネートおよびそれらの多層ポリマー反射性物体の構成成分としての使用
US5783593A (en) 1993-11-04 1998-07-21 Abbott Laboratories Inhibitors of squalene synthetase and protein farnesyltransferase
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US6008257A (en) 1994-01-28 1999-12-28 Bayer Aktiengesellschaft Hydroxamic-acid derivatives, method of preparing them and their use as fungicides
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
ES2175079T3 (es) 1995-04-10 2002-11-16 Fujisawa Pharmaceutical Co Derivados de indol utiles como inhibidores de cgmp-pde.
DE69618875D1 (de) 1995-09-08 2002-03-14 Univ Princeton Nicht-klassische Antifolate
AU7392696A (en) 1995-10-04 1997-04-28 Warner-Lambert Company Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins
FR2746098B1 (fr) 1996-03-14 1998-04-30 Composes propynyl biaromatiques
AUPO118896A0 (en) 1996-07-23 1996-08-15 Fujisawa Pharmaceutical Co., Ltd. New use
RU2171250C2 (ru) 1996-08-05 2001-07-27 Пролинкс, Инк. Производные 2,6-дигидрокси-4-аминометилбензоата
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JPH10114654A (ja) 1996-10-09 1998-05-06 Fujisawa Pharmaceut Co Ltd 新規用途
AU743901B2 (en) 1996-10-16 2002-02-07 Wyeth Holdings Corporation Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
US6392010B1 (en) 1996-12-19 2002-05-21 Aventis Pharmaceuticals Inc. Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
JPH10182583A (ja) 1996-12-25 1998-07-07 Mitsui Chem Inc 新規ヒドロキサム酸誘導体
EP1486486A3 (en) 1997-01-22 2009-06-10 Aventis Pharmaceuticals Inc. Substituted B-thiocarboxylic acids
YU40999A (sh) 1997-02-27 2002-06-19 American Cyanamid Company N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
JPH10259176A (ja) 1997-03-17 1998-09-29 Japan Tobacco Inc 血管新生阻害作用を有する新規アミド誘導体及びその用途
JPH10287634A (ja) 1997-04-11 1998-10-27 Otsuka Pharmaceut Co Ltd ベンゼン誘導体
ES2174450T3 (es) 1997-06-17 2002-11-01 Schering Corp Derivados de benzo(5,6)ciclohepta(1,2-b)piridina como inhibidores de la farnesil-protein-transferasa.
JP2001514245A (ja) 1997-08-28 2001-09-11 ファルマシア・アンド・アップジョン・カンパニー タンパク質チロシンホスファターゼ阻害剤
WO1999012884A1 (fr) 1997-09-09 1999-03-18 Shionogi & Co., Ltd. Derives d'acide benzoique a substitution en 4 et cancerostatiques renfermant ces derives comme ingredient actif
JP2003520183A (ja) 1997-10-06 2003-07-02 アメリカン・サイアナミド・カンパニー マトリクス金属プロテイナーゼおよびｔａｃｅ阻害薬としてのオルト−スルホンアミド二環式ヘテロアリールヒドロキサム酸の製造および使用
EE200000225A (et) 1997-10-15 2001-06-15 American Home Products Corporation Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon
PL342548A1 (en) 1998-02-19 2001-06-18 American Cyanamid Co N-hydroxy-2-(alkyl-, aryl- or heteroarylsulphanyl-, sulphinyl- or sulphonyl)-3-substituted alkyl-, aryl- or heteroarylamides as inhibitors of matrix metaloproteinases
EP0960882A1 (en) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
AU783504C (en) 1999-11-23 2006-08-03 Methylgene Inc. Inhibitors of histone deacetylase
ATE489360T1 (de) 2000-03-24 2010-12-15 Methylgene Inc Inhibitoren der histon-deacetylase
US6784173B2 (en) * 2001-06-15 2004-08-31 Hoffmann-La Roche Inc. Aromatic dicarboxylic acid derivatives
AU2002352443A1 (en) * 2001-12-21 2003-07-15 Consejo Superior De Investigaciones Cientificas Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3

Also Published As

Publication number Publication date
WO2004054999A1 (en) 2004-07-01
PA8592101A1 (es) 2004-11-02
RU2005122447A (ru) 2006-05-27
EP1575933A1 (en) 2005-09-21
UY28127A1 (es) 2004-06-30
KR100781929B1 (ko) 2007-12-04
AU2003293882A1 (en) 2004-07-09
TW200418825A (en) 2004-10-01
CA2507629A1 (en) 2004-07-01
JP2006513181A (ja) 2006-04-20
CN1726204A (zh) 2006-01-25
KR20050089157A (ko) 2005-09-07
CN100391954C (zh) 2008-06-04
AR042459A1 (es) 2005-06-22
GT200300285A (es) 2004-07-14
US7098241B2 (en) 2006-08-29
US20040122079A1 (en) 2004-06-24
PL377696A1 (pl) 2006-02-06
PE20040913A1 (es) 2005-01-18
CL2003002611A1 (es) 2005-01-14
RU2348625C2 (ru) 2009-03-10

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.