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BR0215151A - Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 - Google Patents

Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6

Info

Publication number
BR0215151A
BR0215151A BR0215151-0A BR0215151A BR0215151A BR 0215151 A BR0215151 A BR 0215151A BR 0215151 A BR0215151 A BR 0215151A BR 0215151 A BR0215151 A BR 0215151A
Authority
BR
Brazil
Prior art keywords
ligands
hydroxytryptamine
azaindolylalkylamine
derivatives
azaindolylalkylamine derivatives
Prior art date
Application number
BR0215151-0A
Other languages
English (en)
Inventor
Ronald Charles Bernotas
Derek Cecil Cole
William Joseph Lennox
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0215151A publication Critical patent/BR0215151A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"DERIVADOS DE AZAINDOLILALQUILAMINA COMO LIGANDOS DE 5-HIDROXITRIPTAMINA-6". A presente invenção refere-se a um composto de fórmula (I) e o uso deste para o tratamento terapêutico de distúrbios relacionados a ou afetados pelo receptor de 5-HT6.
BR0215151-0A 2001-12-20 2002-12-17 Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 BR0215151A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34283801P 2001-12-20 2001-12-20
PCT/US2002/040220 WO2003053970A1 (en) 2001-12-20 2002-12-17 Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands

Publications (1)

Publication Number Publication Date
BR0215151A true BR0215151A (pt) 2004-10-19

Family

ID=23343489

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215151-0A BR0215151A (pt) 2001-12-20 2002-12-17 Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6

Country Status (22)

Country Link
US (3) US6800640B2 (pt)
EP (1) EP1456206B1 (pt)
JP (1) JP4339123B2 (pt)
KR (1) KR20040077861A (pt)
CN (1) CN1620455A (pt)
AR (1) AR037907A1 (pt)
AT (1) ATE396191T1 (pt)
AU (1) AU2002360618B2 (pt)
BR (1) BR0215151A (pt)
CA (1) CA2470832C (pt)
CO (1) CO5590960A2 (pt)
DE (1) DE60226775D1 (pt)
DK (1) DK1456206T3 (pt)
ES (1) ES2305338T3 (pt)
IL (1) IL162242A0 (pt)
MX (1) MXPA04005886A (pt)
NO (1) NO20043099L (pt)
PL (1) PL370890A1 (pt)
RU (1) RU2004122094A (pt)
TW (1) TW200301251A (pt)
WO (1) WO2003053970A1 (pt)
ZA (1) ZA200405733B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2222828B1 (es) 2003-07-30 2006-04-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
CN1902193B (zh) 2003-12-04 2011-07-13 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的喹喔啉
PT1753764E (pt) 2004-06-09 2009-01-28 Glaxo Group Ltd Derivados de pirrolopiridina
MX2007002324A (es) 2004-09-03 2007-05-11 Yuhan Corp Derivados de pirrolo[2-3-c]piridina y procesos para la preparacion de los mismos.
AU2005280739B2 (en) 2004-09-03 2010-11-11 Yuhan Corporation Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
KR101142363B1 (ko) 2005-06-27 2012-05-21 주식회사유한양행 피롤로피리딘 유도체를 포함하는 항암제 조성물
EP1947085A1 (en) * 2007-01-19 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted indole sulfonamide compounds, their preparation and use as medicaments
CN101678014B (zh) * 2007-05-21 2012-12-12 Sgx药品公司 杂环激酶调节剂
AU2008256859A1 (en) * 2007-05-24 2008-12-04 Memory Pharmaceuticals Corporation 4' substituted compounds having 5-HT6 receptor affinity
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
EP2356116A1 (en) * 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
WO2011019634A2 (en) * 2009-08-10 2011-02-17 Taipei Medical University Aryl substituted sulfonamide compounds and their use as anticancer agents
EP2569315A1 (en) 2010-05-14 2013-03-20 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
AR081039A1 (es) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc Inhibidores biciclicos fusionados de quinasa
JP2014515368A (ja) * 2011-05-26 2014-06-30 第一三共株式会社 プロテインキナーゼ阻害剤としての複素環化合物
US10112946B2 (en) 2011-07-22 2018-10-30 Glaxosmithkline Llc Composition
CN104755480B (zh) 2012-08-24 2017-04-12 葛兰素史克有限责任公司 吡唑并嘧啶化合物
ES2625023T3 (es) 2012-11-20 2017-07-18 Glaxosmithkline Llc Compuestos novedosos
RU2643371C2 (ru) 2012-11-20 2018-02-01 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Новые соединения
PL2922549T3 (pl) 2012-11-20 2017-11-30 Glaxosmithkline Llc Nowe związki
CN102977094A (zh) * 2012-11-30 2013-03-20 盛世泰科生物医药技术(苏州)有限公司 一种2-羟基-1,5-萘啶的合成方法
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
US9974785B2 (en) 2014-07-08 2018-05-22 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
EP3601235A4 (en) 2017-03-30 2020-11-18 XW Laboratories Inc. BICYCLIC HETERARYL DERIVATIVES, PREPARATION AND ASSOCIATED USES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977131A (en) 1997-04-09 1999-11-02 Pfizer Inc. Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
US6100291A (en) * 1998-03-16 2000-08-08 Allelix Biopharmaceuticals Inc. Pyrrolidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
DE69937372T2 (de) * 1999-04-21 2008-06-26 Nps Allelix Corp., Mississauga Piperidin-indol derivate mit 5-ht6 affinität
WO2001012629A1 (en) * 1999-08-12 2001-02-22 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
ES2269827T3 (es) * 2001-12-20 2007-04-01 Wyeth Derivados de indolilalquilamina como ligandos de 5-hidroxitriptamina-6.
JP2008523146A (ja) * 2004-12-14 2008-07-03 ワイス 神経変性障害の処置および予防のための５−ｈｔ６アゴニストの使用

Also Published As

Publication number Publication date
AU2002360618B2 (en) 2009-01-08
US6800640B2 (en) 2004-10-05
KR20040077861A (ko) 2004-09-07
DK1456206T3 (da) 2008-09-08
EP1456206A1 (en) 2004-09-15
PL370890A1 (en) 2005-05-30
JP4339123B2 (ja) 2009-10-07
CO5590960A2 (es) 2005-12-30
US20080114023A1 (en) 2008-05-15
CA2470832A1 (en) 2003-07-03
NO20043099L (no) 2004-08-17
AR037907A1 (es) 2004-12-22
US20050020598A1 (en) 2005-01-27
ZA200405733B (en) 2005-10-19
ATE396191T1 (de) 2008-06-15
EP1456206B1 (en) 2008-05-21
WO2003053970A1 (en) 2003-07-03
RU2004122094A (ru) 2005-03-27
DE60226775D1 (de) 2008-07-03
US7585876B2 (en) 2009-09-08
MXPA04005886A (es) 2004-09-13
IL162242A0 (en) 2005-11-20
CA2470832C (en) 2010-09-21
AU2002360618A1 (en) 2003-07-09
JP2005519046A (ja) 2005-06-30
US7297705B2 (en) 2007-11-20
ES2305338T3 (es) 2008-11-01
TW200301251A (en) 2003-07-01
CN1620455A (zh) 2005-05-25
US20030171395A1 (en) 2003-09-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.