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BR0214373A - Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase - Google Patents

Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase

Info

Publication number
BR0214373A
BR0214373A BR0214373-9A BR0214373A BR0214373A BR 0214373 A BR0214373 A BR 0214373A BR 0214373 A BR0214373 A BR 0214373A BR 0214373 A BR0214373 A BR 0214373A
Authority
BR
Brazil
Prior art keywords
aromatase inhibitors
triazole derivatives
derivatives containing
group
sulfamate group
Prior art date
Application number
BR0214373-9A
Other languages
English (en)
Inventor
Barry Victor Lloyd Potter
Lok Wai Lawrence Woo
Atul Purohit
Michael John Reed
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0127923.1A external-priority patent/GB0127923D0/en
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of BR0214373A publication Critical patent/BR0214373A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
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  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • AIDS & HIV (AREA)
  • Otolaryngology (AREA)

Abstract

"DERIVADOS DE 1,2,4-TRIAZOL CONTENDO UM GRUPO SULFAMATO COMO INIBIDORES DE AROMATASE". Proporciona-se um composto de Fórmula (I) , no qual cada T é selecionado independentemente de H, hidrocarbila, -F-R, e uma ligação com um de D, E, P ou Q, ou forma um anel juntamente com um de P e Q; Z é um átomo adequado cuja valência é m; D, E e F são independentemente entre eles um grupo de agente de ligação opcional, em que quando Z é um nitrogênio, E é um grupo à exceção de CH~ 2~ e C=O; P, Q e R são independentemente entre eles um sistema de anel; e pelo menos Q compreende um grupo sulfamato.
BR0214373-9A 2001-11-21 2002-11-20 Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase BR0214373A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0127923.1A GB0127923D0 (en) 2001-11-21 2001-11-21 Compound
US34648302P 2002-01-07 2002-01-07
PCT/GB2002/005214 WO2003045925A1 (en) 2001-11-21 2002-11-20 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors

Publications (1)

Publication Number Publication Date
BR0214373A true BR0214373A (pt) 2004-10-13

Family

ID=26246791

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214373-9A BR0214373A (pt) 2001-11-21 2002-11-20 Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase

Country Status (9)

Country Link
EP (1) EP1446388B1 (pt)
JP (2) JP5582604B2 (pt)
CN (1) CN100473648C (pt)
AU (1) AU2002339192A1 (pt)
BR (1) BR0214373A (pt)
CA (1) CA2464770C (pt)
HK (1) HK1066219A1 (pt)
MX (1) MXPA04004802A (pt)
WO (1) WO2003045925A1 (pt)

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GB0317743D0 (en) 2003-07-30 2003-09-03 Amersham Biosciences Uk Ltd Method for measuring aromatase activity
KR20060123186A (ko) * 2003-12-15 2006-12-01 라보라뚜와르 떼라멕스 1-엔-페닐-아미노-1에이치-이미다졸 유도체 및 이들을포함하는 약학적 조성물
GB0411562D0 (en) * 2004-05-24 2004-06-23 Sterix Ltd Compound
GB0412492D0 (en) * 2004-06-04 2004-07-07 Sterix Ltd Compound
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
JPWO2007129745A1 (ja) 2006-05-09 2009-09-17 第一三共株式会社 ヘテロアリールアミド低級カルボン酸誘導体
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
CA2698814A1 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
GB0914767D0 (en) * 2009-08-24 2009-09-30 Sterix Ltd Compound
CN103157110B (zh) * 2011-12-14 2014-12-17 上海市肿瘤研究所 芳香化酶抑制剂在制备抗肝硬化或抗肝纤维化的药物中的应用
CN103333257A (zh) * 2013-07-09 2013-10-02 许颖 对大剂量辐射具有高效防护效果的融合蛋白及其制备方法
CN103816534A (zh) * 2014-03-25 2014-05-28 王斌 一种防治胃肠溃疡的纤连蛋白口服剂

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GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
FR2653119B1 (fr) * 1989-10-18 1994-08-05 Lipha Nouveaux aryloxy alcoyl benzenes, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
AU665569B2 (en) * 1991-09-02 1996-01-11 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated tertiary amine compound or salt thereof
WO1999047529A1 (en) * 1998-03-18 1999-09-23 Ariad Pharmaceuticals, Inc. Heterocyclic signal transduction inhibitors, compositions containing them
JP4320089B2 (ja) * 1999-07-06 2009-08-26 あすか製薬株式会社 フェニルスルファメート誘導体
ATE308556T1 (de) * 1999-12-13 2005-11-15 Sterix Ltd Halogenierte sulphamat-, phosphonat-, thiophosphonat-, sulphonat- und sulphonamid- verbindungen als inhibitoren von steroidsulfatase
WO2001081364A1 (fr) * 2000-04-24 2001-11-01 Kyowa Hakko Kogyo Co., Ltd. Derives d'estra-1,3,5(10)-triene
GB0025788D0 (en) * 2000-10-20 2000-12-06 Sterix Ltd Use
GB0127923D0 (en) * 2001-11-21 2002-01-16 Sterix Ltd Compound

Also Published As

Publication number Publication date
AU2002339192A1 (en) 2003-06-10
CN100473648C (zh) 2009-04-01
EP1446388A1 (en) 2004-08-18
CN1599728A (zh) 2005-03-23
CA2464770C (en) 2011-08-16
WO2003045925A1 (en) 2003-06-05
JP5582604B2 (ja) 2014-09-03
EP1446388B1 (en) 2013-01-09
CA2464770A1 (en) 2003-06-05
JP2010195819A (ja) 2010-09-09
MXPA04004802A (es) 2004-08-11
JP2014040488A (ja) 2014-03-06
HK1066219A1 (en) 2005-03-18

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