BR0212772A - Processo para a preparação de repaglinida - Google Patents
Processo para a preparação de repaglinidaInfo
- Publication number
- BR0212772A BR0212772A BR0212772-5A BR0212772A BR0212772A BR 0212772 A BR0212772 A BR 0212772A BR 0212772 A BR0212772 A BR 0212772A BR 0212772 A BR0212772 A BR 0212772A
- Authority
- BR
- Brazil
- Prior art keywords
- repaglinide
- preparation
- economically
- relates
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE REPAGLINIDA". A presente invenção se relaciona com um processo de preparação de repaglinida, eficiente sob o ponto de vista económico e industrialmente vantajoso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN983DE2001 IN192527B (pt) | 2001-09-25 | 2001-09-25 | |
PCT/IB2002/003943 WO2003027072A1 (en) | 2001-09-25 | 2002-09-24 | Process for the preparation of repaglinide |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212772A true BR0212772A (pt) | 2004-10-13 |
Family
ID=11097115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212772-5A BR0212772A (pt) | 2001-09-25 | 2002-09-24 | Processo para a preparação de repaglinida |
Country Status (13)
Country | Link |
---|---|
US (1) | US7148355B2 (pt) |
EP (1) | EP1432682B1 (pt) |
JP (1) | JP2005521634A (pt) |
CN (1) | CN1571769A (pt) |
AR (1) | AR036623A1 (pt) |
AT (1) | ATE296287T1 (pt) |
BR (1) | BR0212772A (pt) |
CA (1) | CA2461087A1 (pt) |
DE (1) | DE60204334T2 (pt) |
ES (1) | ES2242068T3 (pt) |
IN (1) | IN192527B (pt) |
PT (1) | PT1432682E (pt) |
WO (1) | WO2003027072A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004018442A1 (en) * | 2002-08-23 | 2004-03-04 | Dr. Reddy's Laboratories Limited | Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof |
US7915421B2 (en) * | 2003-05-14 | 2011-03-29 | Cilag Ltd. | Method for preparing phenyl acetic acid derivatives |
WO2004103983A1 (en) * | 2003-05-26 | 2004-12-02 | Biocon Limited | Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives |
CN100445275C (zh) * | 2006-06-21 | 2008-12-24 | 浙江大学 | 一种合成瑞格列奈的工艺 |
US8101769B2 (en) * | 2007-02-15 | 2012-01-24 | Actavis Group Ptc Ehf | Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide |
WO2009004485A2 (en) * | 2007-06-06 | 2009-01-08 | Actavis Group Ptc Ehf | Repaglinide substantially free of dimer impurity |
CN101481363B (zh) * | 2008-01-10 | 2011-05-04 | 江苏豪森药业股份有限公司 | 一种制备瑞格列奈的方法 |
CN101220007B (zh) * | 2008-01-16 | 2010-09-15 | 浙江耐司康药业有限公司 | 一种制备瑞格列奈的方法 |
CN102267959B (zh) * | 2011-07-06 | 2013-05-01 | 海南锦瑞制药股份有限公司 | 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂 |
CN103012319B (zh) * | 2011-09-20 | 2015-06-10 | 浙江九洲药业股份有限公司 | 瑞格列奈中间体的合成工艺改进 |
CN102633750A (zh) * | 2012-03-26 | 2012-08-15 | 浙江昂利康制药有限公司 | 一锅法合成治疗糖尿病的药物瑞格列奈 |
CN102731436A (zh) * | 2012-04-09 | 2012-10-17 | 海南中化联合制药工业股份有限公司 | 一种瑞格列奈的制备及精制方法 |
CN104557778A (zh) * | 2015-01-09 | 2015-04-29 | 蔡伦 | 一种瑞格列奈的制备方法及其应用 |
CN105198838A (zh) * | 2015-10-21 | 2015-12-30 | 河南普瑞制药有限公司 | 一种瑞格列奈的制备方法 |
CN105906583B (zh) * | 2015-12-23 | 2018-03-09 | 嘉实(湖南)医药科技有限公司 | 一种瑞格列奈中间体的制备工艺 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5965094A (ja) * | 1982-10-06 | 1984-04-13 | Sumitomo Chem Co Ltd | セフアロスポリン化合物の製造法 |
US5312924A (en) * | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
-
2001
- 2001-09-25 IN IN983DE2001 patent/IN192527B/en unknown
-
2002
- 2002-09-24 US US10/490,275 patent/US7148355B2/en not_active Expired - Fee Related
- 2002-09-24 EP EP02775017A patent/EP1432682B1/en not_active Expired - Lifetime
- 2002-09-24 DE DE60204334T patent/DE60204334T2/de not_active Expired - Fee Related
- 2002-09-24 CN CNA028204492A patent/CN1571769A/zh active Pending
- 2002-09-24 AT AT02775017T patent/ATE296287T1/de not_active IP Right Cessation
- 2002-09-24 JP JP2003530663A patent/JP2005521634A/ja active Pending
- 2002-09-24 BR BR0212772-5A patent/BR0212772A/pt not_active Application Discontinuation
- 2002-09-24 ES ES02775017T patent/ES2242068T3/es not_active Expired - Lifetime
- 2002-09-24 WO PCT/IB2002/003943 patent/WO2003027072A1/en active IP Right Grant
- 2002-09-24 CA CA002461087A patent/CA2461087A1/en not_active Abandoned
- 2002-09-24 PT PT02775017T patent/PT1432682E/pt unknown
- 2002-09-25 AR ARP020103594A patent/AR036623A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20050107614A1 (en) | 2005-05-19 |
DE60204334D1 (de) | 2005-06-30 |
ATE296287T1 (de) | 2005-06-15 |
IN192527B (pt) | 2004-04-24 |
DE60204334T2 (de) | 2006-03-23 |
JP2005521634A (ja) | 2005-07-21 |
AR036623A1 (es) | 2004-09-22 |
EP1432682B1 (en) | 2005-05-25 |
PT1432682E (pt) | 2005-09-30 |
CA2461087A1 (en) | 2003-04-03 |
US7148355B2 (en) | 2006-12-12 |
ES2242068T3 (es) | 2005-11-01 |
WO2003027072A1 (en) | 2003-04-03 |
CN1571769A (zh) | 2005-01-26 |
EP1432682A1 (en) | 2004-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |