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BR0201234A - Métodos para purificação de nucleosìdeos de 2-desoxipurina 5'-protegida - Google Patents

Métodos para purificação de nucleosìdeos de 2-desoxipurina 5'-protegida

Info

Publication number
BR0201234A
BR0201234A BR0201234-0A BR0201234A BR0201234A BR 0201234 A BR0201234 A BR 0201234A BR 0201234 A BR0201234 A BR 0201234A BR 0201234 A BR0201234 A BR 0201234A
Authority
BR
Brazil
Prior art keywords
protected
nucleosides
deoxypurine
deoxipurin
purification
Prior art date
Application number
BR0201234-0A
Other languages
English (en)
Inventor
Hironori Komatsu
Toshiyuki Kouno
Katsutoshi Tsuchiya
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Publication of BR0201234A publication Critical patent/BR0201234A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MéTODOS PARA PURIFICAçãO DE NUCLEOSìDEOS DE 2'-DESOXIPURINA 5'-PROTEGIDA". Um método para eficientemente purificação de nucleosídeos de 2'-desoxipurina 5' protegida, produção eficiente dos quais era anteriormente difícil. As impurezas podem ser separadas obtendo-se o nucleosídeo de 2'-desoxipurina 5' protegida como um cristal de inclusão incluindo um solvente tal como aquele tendo uma estrutura de nitrila a fim de purificar o nucleosídeo 2'-desoxipurina 5' protegida em uma pureza elevada. Esta invenção permite a síntese de nucleosídeos de desoxipurina protegida altamente purificados facilmente em uma grande escala, que era anteriormente realizada pelo método de cromatografia de coluna.
BR0201234-0A 2001-04-12 2002-04-12 Métodos para purificação de nucleosìdeos de 2-desoxipurina 5'-protegida BR0201234A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001113835 2001-04-12

Publications (1)

Publication Number Publication Date
BR0201234A true BR0201234A (pt) 2003-02-25

Family

ID=18965005

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0201234-0A BR0201234A (pt) 2001-04-12 2002-04-12 Métodos para purificação de nucleosìdeos de 2-desoxipurina 5'-protegida

Country Status (8)

Country Link
US (2) US6958391B2 (pt)
EP (1) EP1253154B1 (pt)
KR (1) KR100461709B1 (pt)
CN (1) CN1176097C (pt)
AT (1) ATE441658T1 (pt)
BR (1) BR0201234A (pt)
CA (1) CA2381367A1 (pt)
DE (1) DE60233541D1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10586282B2 (en) * 1996-03-25 2020-03-10 Cfph, Llc System and method for trading based on tournament-style events
CN101098970B (zh) * 2004-12-10 2010-05-12 V.B.医疗保险私人有限公司 通过在6-乙酰基-4,1',6'三氯半乳蔗糖和4,1',6'三氯半乳蔗糖的有机溶剂提取物的浓缩过程中直接加入碳酸盐和碳酸氢盐来调节pH的方法
WO2011113476A2 (en) * 2010-03-16 2011-09-22 Cilag Ag Method for producing 2'-deoxyadenosine compounds
CN102288692A (zh) * 2011-06-16 2011-12-21 深圳市华测检测技术股份有限公司 一种用高效液相色谱仪检测n6-苯甲酰基-5′-o-(4，4′-二甲氧基三苯基)-2′-脱氧腺苷的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (en) 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
JPS60152495A (ja) 1984-01-18 1985-08-10 Nippon Zeon Co Ltd 保護化ヌクレオシドの製造法
US5034518A (en) * 1989-05-23 1991-07-23 Southern Research Institute 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
US5672697A (en) 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5719273A (en) * 1993-06-14 1998-02-17 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide
DE19529599A1 (de) * 1995-08-11 1997-02-13 Basf Ag Verfahren zur Herstellung einer wäßrigen Polymerisatdispersion
US6414137B1 (en) 1998-12-23 2002-07-02 Alliedsignal Inc. Selective solvent extraction for the purification of protected nucleosides
AU5460700A (en) 1999-06-04 2000-12-28 Allied-Signal Inc. Protected nucleosides

Also Published As

Publication number Publication date
EP1253154B1 (en) 2009-09-02
ATE441658T1 (de) 2009-09-15
CA2381367A1 (en) 2002-10-12
KR20030022672A (ko) 2003-03-17
US7074917B2 (en) 2006-07-11
US20030009028A1 (en) 2003-01-09
DE60233541D1 (de) 2009-10-15
CN1380299A (zh) 2002-11-20
US6958391B2 (en) 2005-10-25
US20060009635A1 (en) 2006-01-12
CN1176097C (zh) 2004-11-17
KR100461709B1 (ko) 2004-12-14
EP1253154A1 (en) 2002-10-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A, 4A,5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1980 DE 16/12/2008.