BR0008552A - Células tronco e redes derivadas de tecido adiposo - Google Patents
Células tronco e redes derivadas de tecido adiposoInfo
- Publication number
- BR0008552A BR0008552A BR0008552-9A BR0008552A BR0008552A BR 0008552 A BR0008552 A BR 0008552A BR 0008552 A BR0008552 A BR 0008552A BR 0008552 A BR0008552 A BR 0008552A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- derived
- adipose tissue
- stem cells
- provides
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 5
- 210000000577 adipose tissue Anatomy 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 210000001789 adipocyte Anatomy 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000003636 conditioned culture medium Substances 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12N2501/30—Hormones
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1305—Adipocytes
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"CéLULAS TRONCO E REDES DERIVADAS DE TECIDO ADIPOSO". A presente invenção fornece células tronco e redes derivadas de tecido adiposo. Em um aspecto, a presente invenção fornece uma célula tronco lipo-derivada substancialmente livre de adipócitos e células vermelhas sang³íneas e populações clonais de células tronco de tecido conectivo. As células podem ser empregadas, isoladas ou em composições biologicamente compatíveis, para gerar tecidos e estruturas diferenciadas, tanto in vivo como in vitro. Adicionalmente, as células podem ser expandidas e cultivadas para produzir hormónios e para fornecer meios de cultura condicionados para suportar o crescimento e expansão de outras populações de células. Em um outro aspecto, a presente invenção fornece uma rede lipo-derivada substancialmente desprovida de células, que inclui material de matriz extracelular de tecido adiposo. A rede pode ser usada como um substrato para facilitar o crescimento e diferenciação de células, seja in vivo ou in vitro, em tecidos ou estruturas primordiais ou mesmo maduros.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12371199P | 1999-03-10 | 1999-03-10 | |
US16246299P | 1999-10-29 | 1999-10-29 | |
PCT/US2000/006232 WO2000053795A1 (en) | 1999-03-10 | 2000-03-10 | Adipose-derived stem cells and lattices |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0008552A true BR0008552A (pt) | 2002-05-07 |
Family
ID=26821819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0008552-9A BR0008552A (pt) | 1999-03-10 | 2000-03-10 | Células tronco e redes derivadas de tecido adiposo |
Country Status (11)
Country | Link |
---|---|
US (2) | US20020076400A1 (pt) |
EP (1) | EP1165830B1 (pt) |
JP (3) | JP2002537849A (pt) |
KR (4) | KR100968164B1 (pt) |
CN (1) | CN1352696A (pt) |
AU (1) | AU784580B2 (pt) |
BR (1) | BR0008552A (pt) |
CA (1) | CA2366078C (pt) |
IL (1) | IL145002A0 (pt) |
RU (2) | RU2306335C2 (pt) |
WO (1) | WO2000053795A1 (pt) |
Families Citing this family (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
CN100453530C (zh) | 1997-05-14 | 2009-01-21 | 阿特罗吉尼克斯公司 | 抑制vcam-1表达的化合物及其药物组合物 |
AU1615599A (en) | 1997-12-02 | 1999-06-16 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
US7001746B1 (en) | 1999-01-29 | 2006-02-21 | Artecel Sciences, Inc. | Methods and compositions for the differentiation of human preadipocytes into adipocytes |
US20050153442A1 (en) * | 1999-03-10 | 2005-07-14 | Adam Katz | Adipose-derived stem cells and lattices |
US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
US7078232B2 (en) | 1999-08-19 | 2006-07-18 | Artecel, Inc. | Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof |
US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
EP1918366A1 (en) | 2000-02-26 | 2008-05-07 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
US7582292B2 (en) | 2000-02-26 | 2009-09-01 | Artecel, Inc. | Adipose tissue derived stromal cells for the treatment of neurological disorders |
ES2300320T3 (es) | 2000-02-26 | 2008-06-16 | Artecel, Inc. | Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos. |
FR2819265B1 (fr) * | 2001-01-10 | 2004-01-02 | Centre Nat Rech Scient | Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques |
US7202080B2 (en) | 2001-03-29 | 2007-04-10 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway |
JPWO2003008592A1 (ja) * | 2001-07-19 | 2004-11-11 | 田畑 泰彦 | 脂肪組織由来多能性幹細胞 |
US20030054331A1 (en) * | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
CZ2004694A3 (cs) * | 2001-11-09 | 2005-03-16 | Artecel Sciences, Inc. | Buňky stromatu odvozené z adipózní tkáně pro opravu korneálních a intraorbitálních defektů a použití těchto buněk |
RU2351648C2 (ru) * | 2001-11-09 | 2009-04-10 | Артесел Сайенсиз, Инк. | Дифференцировка стромальных клеток, полученных из жировой ткани, в эндокринные клетки поджелудочной железы и их использование |
KR101083454B1 (ko) * | 2001-12-07 | 2011-11-16 | 사이토리 테라퓨틱스, 인크. | 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한 시스템 및 방법 |
US20050048035A1 (en) | 2001-12-07 | 2005-03-03 | Fraser John K. | Methods of using regenerative cells in the treatment of stroke and related diseases and disorders |
US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
EP1496978A4 (en) * | 2002-04-03 | 2006-11-29 | Artecel Sciences Inc | IMPROVEMENTS IN DIFFERENTIATED ADULT DIFFERENTIATED STEM CELLS DERIVED FROM ADIPOSE TISSUE AND USES THEREOF |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US7832566B2 (en) * | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
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2000
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- 2000-03-10 CN CN00807461A patent/CN1352696A/zh active Pending
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- 2000-03-10 RU RU2001127430/13A patent/RU2306335C2/ru not_active IP Right Cessation
- 2000-03-10 IL IL14500200A patent/IL145002A0/xx unknown
- 2000-03-10 KR KR1020017011443A patent/KR100870508B1/ko not_active IP Right Cessation
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- 2000-03-10 JP JP2000603416A patent/JP2002537849A/ja active Pending
- 2000-03-10 WO PCT/US2000/006232 patent/WO2000053795A1/en not_active Application Discontinuation
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2001
- 2001-09-06 US US09/947,985 patent/US20020076400A1/en not_active Abandoned
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2005
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KR20080063426A (ko) | 2008-07-03 |
IL145002A0 (en) | 2002-06-30 |
KR20090043612A (ko) | 2009-05-06 |
EP1165830A1 (en) | 2002-01-02 |
US20050282275A1 (en) | 2005-12-22 |
JP2011078416A (ja) | 2011-04-21 |
CA2366078C (en) | 2015-09-01 |
EP1165830A4 (en) | 2003-10-08 |
KR100968164B1 (ko) | 2010-07-06 |
CN1352696A (zh) | 2002-06-05 |
CA2366078A1 (en) | 2000-09-14 |
US20020076400A1 (en) | 2002-06-20 |
KR20070053359A (ko) | 2007-05-23 |
KR100870508B1 (ko) | 2008-11-25 |
JP2002537849A (ja) | 2002-11-12 |
KR20020013510A (ko) | 2002-02-20 |
KR100979664B1 (ko) | 2010-09-02 |
RU2306335C2 (ru) | 2007-09-20 |
RU2007114846A (ru) | 2008-11-27 |
AU784580B2 (en) | 2006-05-04 |
KR100968165B1 (ko) | 2010-07-06 |
JP2015109834A (ja) | 2015-06-18 |
WO2000053795A1 (en) | 2000-09-14 |
AU3522300A (en) | 2000-09-28 |
EP1165830B1 (en) | 2017-07-12 |
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