BG106079A - Cyclocarbamate derivatives as progesterone receptor modulators - Google Patents
Cyclocarbamate derivatives as progesterone receptor modulatorsInfo
- Publication number
- BG106079A BG106079A BG106079A BG10607901A BG106079A BG 106079 A BG106079 A BG 106079A BG 106079 A BG106079 A BG 106079A BG 10607901 A BG10607901 A BG 10607901A BG 106079 A BG106079 A BG 106079A
- Authority
- BG
- Bulgaria
- Prior art keywords
- substituted
- alkyl
- alkoxy
- aminoalkyl
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides compounds of formula wherein R1 and R2 may be single substituents or fused to form spirocycle or heterospirocycle ring; R3 is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, CORC; RC is H, C1 to C3 alkyl, substituted C 1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R4 is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2 or 3 heteroatoms from the group including O, S, SO2 or NR6 and containing one or two independent substituents from the group including H, halogen, CN, NO2, amino, and C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C33 aminoalkyl, CORF, or NRGCORF; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions using the compounds as antagonists of the progesterone receptor. 22 claims
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18301299P | 1999-05-04 | 1999-05-04 | |
| US09/552,633 US6509334B1 (en) | 1999-05-04 | 2000-04-19 | Cyclocarbamate derivatives as progesterone receptor modulators |
| PCT/US2000/011822 WO2000066571A1 (en) | 1999-05-04 | 2000-05-01 | Cyclocarbamate derivatives as progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG106079A true BG106079A (en) | 2002-05-31 |
Family
ID=26878647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106079A BG106079A (en) | 1999-05-04 | 2001-11-02 | Cyclocarbamate derivatives as progesterone receptor modulators |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1173426A1 (en) |
| JP (1) | JP2002543193A (en) |
| KR (1) | KR20010114250A (en) |
| CN (1) | CN1145618C (en) |
| AU (1) | AU766428B2 (en) |
| BG (1) | BG106079A (en) |
| BR (1) | BR0010213A (en) |
| CA (1) | CA2371726A1 (en) |
| CZ (1) | CZ20013951A3 (en) |
| EA (1) | EA004512B1 (en) |
| HU (1) | HUP0201609A3 (en) |
| IL (1) | IL146280A0 (en) |
| MX (1) | MXPA01011286A (en) |
| NO (1) | NO321361B1 (en) |
| NZ (1) | NZ515355A (en) |
| PL (1) | PL351127A1 (en) |
| SG (1) | SG114650A1 (en) |
| SK (1) | SK15912001A3 (en) |
| TR (1) | TR200103286T2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1756095T3 (en) * | 2004-04-27 | 2008-10-31 | Wyeth Corp | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| EP1844768A1 (en) * | 2005-01-19 | 2007-10-17 | Dainippon Sumitomo Pharma Co., Ltd. | Aromatic sulfone compound as aldosterone receptor modulator |
| JP5470043B2 (en) * | 2007-10-05 | 2014-04-16 | Ｍｓｄ株式会社 | Benzoxazinone derivatives |
| CN111925353B (en) * | 2020-08-31 | 2022-04-08 | 苏州大学附属第二医院 | Preparation method of 2-thiophenecarbonitrile |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
| AU1694295A (en) * | 1994-01-28 | 1995-08-15 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
| EP0800519B1 (en) * | 1994-12-22 | 2003-10-22 | Ligand Pharmaceuticals, Inc. | Steroid receptor modulator compounds and methods |
| WO1998014436A1 (en) * | 1996-10-02 | 1998-04-09 | Dupont Pharmaceuticals Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same |
-
2000
- 2000-05-01 AU AU46886/00A patent/AU766428B2/en not_active Ceased
- 2000-05-01 NZ NZ515355A patent/NZ515355A/en unknown
- 2000-05-01 SK SK1591-2001A patent/SK15912001A3/en unknown
- 2000-05-01 HU HU0201609A patent/HUP0201609A3/en unknown
- 2000-05-01 JP JP2000615601A patent/JP2002543193A/en active Pending
- 2000-05-01 MX MXPA01011286A patent/MXPA01011286A/en unknown
- 2000-05-01 KR KR1020017013970A patent/KR20010114250A/en not_active Application Discontinuation
- 2000-05-01 IL IL14628000A patent/IL146280A0/en unknown
- 2000-05-01 SG SG200400080A patent/SG114650A1/en unknown
- 2000-05-01 CA CA002371726A patent/CA2371726A1/en not_active Abandoned
- 2000-05-01 BR BR0010213-0A patent/BR0010213A/en not_active Application Discontinuation
- 2000-05-01 EP EP00928689A patent/EP1173426A1/en not_active Withdrawn
- 2000-05-01 PL PL00351127A patent/PL351127A1/en not_active Application Discontinuation
- 2000-05-01 CZ CZ20013951A patent/CZ20013951A3/en unknown
- 2000-05-01 CN CNB008071004A patent/CN1145618C/en not_active Expired - Fee Related
- 2000-05-01 TR TR2001/03286T patent/TR200103286T2/en unknown
- 2000-05-01 EA EA200101176A patent/EA004512B1/en not_active IP Right Cessation
-
2001
- 2001-11-02 NO NO20015378A patent/NO321361B1/en not_active Application Discontinuation
- 2001-11-02 BG BG106079A patent/BG106079A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0201609A3 (en) | 2002-12-28 |
| NO20015378D0 (en) | 2001-11-02 |
| BR0010213A (en) | 2002-02-19 |
| SK15912001A3 (en) | 2002-06-04 |
| CA2371726A1 (en) | 2000-11-09 |
| EA200101176A1 (en) | 2002-04-25 |
| JP2002543193A (en) | 2002-12-17 |
| NO20015378L (en) | 2002-01-03 |
| TR200103286T2 (en) | 2002-07-22 |
| KR20010114250A (en) | 2001-12-31 |
| CZ20013951A3 (en) | 2002-05-15 |
| PL351127A1 (en) | 2003-03-24 |
| NZ515355A (en) | 2004-02-27 |
| EA004512B1 (en) | 2004-04-29 |
| EP1173426A1 (en) | 2002-01-23 |
| AU4688600A (en) | 2000-11-17 |
| HUP0201609A2 (en) | 2002-08-28 |
| AU766428B2 (en) | 2003-10-16 |
| NO321361B1 (en) | 2006-05-02 |
| CN1145618C (en) | 2004-04-14 |
| MXPA01011286A (en) | 2003-07-14 |
| CN1349517A (en) | 2002-05-15 |
| SG114650A1 (en) | 2005-09-28 |
| IL146280A0 (en) | 2002-07-25 |
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