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BG105256A - Muscarinic agonists and antagonists - Google Patents

Muscarinic agonists and antagonists

Info

Publication number
BG105256A
BG105256A BG105256A BG10525601A BG105256A BG 105256 A BG105256 A BG 105256A BG 105256 A BG105256 A BG 105256A BG 10525601 A BG10525601 A BG 10525601A BG 105256 A BG105256 A BG 105256A
Authority
BG
Bulgaria
Prior art keywords
antagonists
muscarinic agonists
present
compounds
muscarinic
Prior art date
Application number
BG105256A
Other languages
Bulgarian (bg)
English (en)
Inventor
Gurmit Grewal
Anna Toy-Palmer
Xiong CAY
George Latham
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of BG105256A publication Critical patent/BG105256A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
BG105256A 1998-08-18 2001-02-14 Muscarinic agonists and antagonists BG105256A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9697798P 1998-08-18 1998-08-18
PCT/US1999/018570 WO2000011001A1 (en) 1998-08-18 1999-08-16 Muscarinic agonists and antagonists

Publications (1)

Publication Number Publication Date
BG105256A true BG105256A (en) 2001-11-30

Family

ID=22260061

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105256A BG105256A (en) 1998-08-18 2001-02-14 Muscarinic agonists and antagonists

Country Status (30)

Country Link
US (5) US6093724A (ru)
EP (1) EP1112272B1 (ru)
JP (1) JP2002523416A (ru)
KR (1) KR20010072784A (ru)
CN (1) CN1312812A (ru)
AR (1) AR020199A1 (ru)
AT (1) ATE227724T1 (ru)
AU (1) AU750566B2 (ru)
BG (1) BG105256A (ru)
BR (1) BR9913072A (ru)
CA (1) CA2340946A1 (ru)
CO (1) CO5130018A1 (ru)
DE (1) DE69903961T2 (ru)
EE (1) EE200100096A (ru)
ES (1) ES2191455T3 (ru)
HK (1) HK1038918A1 (ru)
HU (1) HUP0103203A3 (ru)
ID (1) ID27544A (ru)
IL (1) IL141050A0 (ru)
IS (1) IS5827A (ru)
NO (1) NO20010804L (ru)
NZ (1) NZ509762A (ru)
PE (1) PE20000988A1 (ru)
PL (1) PL346247A1 (ru)
RU (1) RU2219179C2 (ru)
SK (1) SK1892001A3 (ru)
TR (1) TR200100462T2 (ru)
WO (1) WO2000011001A1 (ru)
YU (1) YU13301A (ru)
ZA (1) ZA200100978B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1471534A (zh) * 2000-10-19 2004-01-28 �Ʒ� 桥(连)哌嗪衍生物
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20030064979A1 (en) * 2001-06-29 2003-04-03 Hansen Thomas Kruse Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
US6828328B1 (en) * 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
US7897766B2 (en) * 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8076350B2 (en) 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
ES2378116T3 (es) * 2007-03-23 2012-04-09 Abbott Laboratories Derivados acetamida y carboxamida de azaadamantano y métodos de uso de los mismos
EP2139891B1 (en) * 2007-03-23 2012-09-05 Abbott Laboratories 4-substituted azaadamantane derivatives and methods of use thereof
BRPI1015043A2 (pt) * 2009-06-19 2019-07-09 Abbott Lab derivados de diazahomoadamantano e métodos de uso dos mesmos
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
PT3061821T (pt) 2009-07-22 2019-09-05 PureTech Health LLC Composições para tratamento de distúrbios melhorados por ativação de recetores muscarínicos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
RU2579121C2 (ru) 2010-09-23 2016-03-27 Эббви Бахамаз Лтд. Моногидрат производного азаадамантана
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
EP3732163A4 (en) * 2017-12-20 2021-07-14 Vanderbilt University MUSCARIN M4 ACETYLCHOLIN RECEPTOR ANTAGONISTS
SG11202102349PA (en) 2018-09-28 2021-04-29 Karuna Therapeutics Inc Compositions and methods for treating disorders ameliorated by muscarnic receptor activation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739074A (en) * 1986-01-22 1988-04-19 Pennwalt Corporation Adamantane spiro-pyrrolidine derivatives
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
EP0563036A1 (en) * 1990-12-21 1993-10-06 Merck Sharp & Dohme Ltd. 4-azatricyclo 2.2.1.0?2,6 ]heptanes and pharmaceutical compositions
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
BR9611300A (pt) * 1995-11-02 1999-06-15 Neurosearch As Derivados de tropano em fusão suas preparações e uso
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use

Also Published As

Publication number Publication date
HUP0103203A2 (hu) 2002-01-28
US6555550B1 (en) 2003-04-29
US6423842B1 (en) 2002-07-23
IL141050A0 (en) 2002-02-10
NO20010804L (no) 2001-04-11
ID27544A (id) 2001-04-12
AU5775899A (en) 2000-03-14
US6323194B1 (en) 2001-11-27
US6251916B1 (en) 2001-06-26
NZ509762A (en) 2002-12-20
ES2191455T3 (es) 2003-09-01
DE69903961T2 (de) 2003-07-03
EP1112272B1 (en) 2002-11-13
AU750566B2 (en) 2002-07-25
US20020045617A1 (en) 2002-04-18
ATE227724T1 (de) 2002-11-15
HK1038918A1 (zh) 2002-04-04
ZA200100978B (en) 2002-02-05
RU2219179C2 (ru) 2003-12-20
WO2000011001A1 (en) 2000-03-02
DE69903961D1 (de) 2002-12-19
EP1112272A1 (en) 2001-07-04
TR200100462T2 (tr) 2001-09-21
US6093724A (en) 2000-07-25
CA2340946A1 (en) 2000-03-02
IS5827A (is) 2001-01-26
BR9913072A (pt) 2001-05-15
YU13301A (sh) 2005-06-10
JP2002523416A (ja) 2002-07-30
PL346247A1 (en) 2002-01-28
HUP0103203A3 (en) 2002-10-28
CO5130018A1 (es) 2002-02-27
PE20000988A1 (es) 2000-09-30
NO20010804D0 (no) 2001-02-16
CN1312812A (zh) 2001-09-12
SK1892001A3 (en) 2001-11-06
KR20010072784A (ko) 2001-07-31
EE200100096A (et) 2002-06-17
AR020199A1 (es) 2002-05-02

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