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BG104902A - Полусинтетични ектеинасцидини - Google Patents

Полусинтетични ектеинасцидини

Info

Publication number
BG104902A
BG104902A BG104902A BG10490200A BG104902A BG 104902 A BG104902 A BG 104902A BG 104902 A BG104902 A BG 104902A BG 10490200 A BG10490200 A BG 10490200A BG 104902 A BG104902 A BG 104902A
Authority
BG
Bulgaria
Prior art keywords
semi
synthetic
ecteinascidins
synthetic ecteinascidins
ecteinascedins
Prior art date
Application number
BG104902A
Other languages
English (en)
Other versions
BG65088B1 (bg
Inventor
Kenneth Rinehart
Jose Morales
Original Assignee
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Illinois filed Critical The Board Of Trustees Of The University Of Illinois
Publication of BG104902A publication Critical patent/BG104902A/bg
Publication of BG65088B1 publication Critical patent/BG65088B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Dental Preparations (AREA)

Abstract

Изобретението се отнася до новополучени полусинтетични ектеинасцидини (Et), означени с формули, посочени в описанието, например Et 757, Boc-Et 729, Iso-Et 743, Et 875 и Et 1560. Изобретението се отнася също до физичните свойства на тези съединения, до тяхното получаване и до биоактивността им.
BG104902A 1998-04-06 2000-11-02 Полусинтетични ектеинасцидини BG65088B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8080298P 1998-04-06 1998-04-06
PCT/US1999/007471 WO1999051238A1 (en) 1998-04-06 1999-04-05 Semi-synthetic ecteinascidins

Publications (2)

Publication Number Publication Date
BG104902A true BG104902A (bg) 2001-07-31
BG65088B1 BG65088B1 (bg) 2007-02-28

Family

ID=22159716

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104902A BG65088B1 (bg) 1998-04-06 2000-11-02 Полусинтетични ектеинасцидини

Country Status (28)

Country Link
US (1) US6124293A (bg)
EP (2) EP1067933B1 (bg)
JP (1) JP4443043B2 (bg)
KR (1) KR100603219B1 (bg)
CN (1) CN1157189C (bg)
AT (1) ATE370148T1 (bg)
AU (1) AU758100B2 (bg)
BG (1) BG65088B1 (bg)
BR (1) BR9909488B1 (bg)
CA (1) CA2327468C (bg)
CY (1) CY1106988T1 (bg)
CZ (1) CZ301083B6 (bg)
DE (1) DE69936845T2 (bg)
DK (1) DK1067933T3 (bg)
ES (1) ES2292237T3 (bg)
HK (1) HK1033651A1 (bg)
HU (1) HUP0104273A3 (bg)
IL (2) IL138856A0 (bg)
MX (1) MXPA00009840A (bg)
NO (1) NO328147B1 (bg)
NZ (1) NZ507350A (bg)
PL (1) PL196809B1 (bg)
PT (1) PT1067933E (bg)
RU (1) RU2217432C2 (bg)
SK (1) SK285669B6 (bg)
TR (1) TR200002921T2 (bg)
UA (1) UA59439C2 (bg)
WO (1) WO1999051238A1 (bg)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
WO1999058125A1 (en) * 1998-05-11 1999-11-18 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
JP2003520801A (ja) * 2000-01-19 2003-07-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2447553A1 (en) * 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
EP1365808B1 (en) * 2000-11-06 2011-01-19 Pharma Mar, S.A. Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
EP1689404B9 (en) * 2003-11-13 2009-04-22 Pharma Mar, S.A.U. Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et－743和紫杉醇来治疗癌症的联合疗法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1768671A2 (en) * 2004-07-09 2007-04-04 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
EP1812114A2 (en) * 2004-09-29 2007-08-01 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti-inflammatory agents
BRPI0518250A2 (pt) * 2004-10-26 2008-11-11 Pharma Mar Sa tratamentos anticÂncer
EP1658848B1 (en) 2004-10-29 2007-08-01 Pharma Mar S.A., Sociedad Unipersonal Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN100355775C (zh) * 2006-01-20 2007-12-19 南方医科大学 一种海鞘多肽及其制备方法
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
LT2786753T (lt) 2010-11-12 2019-04-10 Pharma Mar S.A. Derinių terapija su antinavikiniu antibiotiku
KR20180103965A (ko) * 2016-02-04 2018-09-19 지앙수 헨그루이 메디슨 컴퍼니 리미티드 위장관 외용을 위한 트라벡테딘-함유 주사가능한 약학적 조성물 및 그의 제조 방법
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
US6124293A (en) 2000-09-26
DE69936845D1 (de) 2007-09-27
NO20004978L (no) 2000-12-05
WO1999051238A9 (en) 2000-01-27
ATE370148T1 (de) 2007-09-15
CN1157189C (zh) 2004-07-14
NZ507350A (en) 2003-03-28
CA2327468C (en) 2008-05-06
BG65088B1 (bg) 2007-02-28
IL138856A (en) 2007-07-24
BR9909488B1 (pt) 2011-02-08
DE69936845T2 (de) 2008-05-08
AU3471399A (en) 1999-10-25
MXPA00009840A (es) 2002-04-24
RU2217432C2 (ru) 2003-11-27
ES2292237T3 (es) 2008-03-01
PL196809B1 (pl) 2008-02-29
NO20004978D0 (no) 2000-10-03
NO328147B1 (no) 2009-12-21
EP1067933A4 (en) 2002-12-18
RU2000128058A (ru) 2004-02-20
DK1067933T3 (da) 2007-12-27
TR200002921T2 (tr) 2001-02-21
UA59439C2 (uk) 2003-09-15
HUP0104273A3 (en) 2003-12-29
EP1876180A3 (en) 2009-12-16
JP4443043B2 (ja) 2010-03-31
KR20010074474A (ko) 2001-08-04
PL343439A1 (en) 2001-08-13
PT1067933E (pt) 2007-11-15
SK285669B6 (sk) 2007-06-07
JP2002510633A (ja) 2002-04-09
HK1033651A1 (en) 2001-09-14
CZ301083B6 (cs) 2009-11-04
IL138856A0 (en) 2001-10-31
CN1304309A (zh) 2001-07-18
WO1999051238A1 (en) 1999-10-14
KR100603219B1 (ko) 2006-07-20
CZ20003650A3 (en) 2001-06-13
HUP0104273A2 (hu) 2002-03-28
SK15012000A3 (sk) 2001-08-06
EP1067933A1 (en) 2001-01-17
BR9909488A (pt) 2000-12-26
AU758100B2 (en) 2003-03-13
EP1876180A2 (en) 2008-01-09
EP1067933B1 (en) 2007-08-15
CY1106988T1 (el) 2012-09-26
CA2327468A1 (en) 1999-10-14

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