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BE901602A - 1-UNSATURATED SIDE CHAIN HYDROXYVITAMINS. - Google Patents

1-UNSATURATED SIDE CHAIN HYDROXYVITAMINS.

Info

Publication number
BE901602A
BE901602A BE0/214413A BE214413A BE901602A BE 901602 A BE901602 A BE 901602A BE 0/214413 A BE0/214413 A BE 0/214413A BE 214413 A BE214413 A BE 214413A BE 901602 A BE901602 A BE 901602A
Authority
BE
Belgium
Prior art keywords
side chain
hydroxyvitamins
unsaturated side
osteomalacia
rickets
Prior art date
Application number
BE0/214413A
Other languages
French (fr)
Inventor
Luca H F De
H K Schnoes
R R Sicinski
Y Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE901602A publication Critical patent/BE901602A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Les vitamines D 1-hydroxylées contenant une double liaison en 22,23-cis dans la chaine latérale décrites (I, II) se distinguent par une aptitude extremement élevée à la fixation sur la protéine réceptrice. Ces composés sont donc préférés pour remplacer la vitamine D ou différents de ses métabolites dans le traitement de diverses affections métaboliques osseuses comme le rachitisme ou l'ostéomalacie.The vitamins D 1-hydroxylated containing a double bond in 22,23-cis in the side chain described (I, II) are distinguished by an extremely high aptitude for fixing on the receptor protein. These compounds are therefore preferred to replace vitamin D or different of its metabolites in the treatment of various bone metabolic conditions such as rickets or osteomalacia.

BE0/214413A 1984-01-30 1985-01-29 1-UNSATURATED SIDE CHAIN HYDROXYVITAMINS. BE901602A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57511684A 1984-01-30 1984-01-30

Publications (1)

Publication Number Publication Date
BE901602A true BE901602A (en) 1985-05-17

Family

ID=24299022

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214413A BE901602A (en) 1984-01-30 1985-01-29 1-UNSATURATED SIDE CHAIN HYDROXYVITAMINS.

Country Status (11)

Country Link
JP (1) JPS61501146A (en)
AU (1) AU589113B2 (en)
BE (1) BE901602A (en)
CH (1) CH667087A5 (en)
DE (2) DE3590020T1 (en)
DK (1) DK437585A (en)
FR (1) FR2558830B1 (en)
GB (1) GB2153359B (en)
IE (1) IE57947B1 (en)
NL (1) NL8520003A (en)
WO (1) WO1985003299A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6421A (en) * 1987-02-27 1989-01-05 Teijin Ltd Preventive for osteoporosis
CN1103755C (en) * 1993-07-09 2003-03-26 桑拉米克斯实验公司 Novel structural analogues of vitamin D

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697559A (en) * 1971-02-25 1972-10-10 Wisconsin Alumni Res Found 1,25-dihydroxycholecalciferol
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4264513A (en) * 1979-05-21 1981-04-28 Wisconsin Alumni Research Foundation 1α-hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same
AU1821383A (en) * 1982-07-26 1984-02-23 Wisconsin Alumni Research Foundation Novel vitamin d analogs
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
AU587174B2 (en) * 1984-01-30 1989-08-10 Wisconsin Alumni Research Foundation 1a, 25-dihydroxy-22z-dehydrovitamin d compound

Also Published As

Publication number Publication date
WO1985003299A1 (en) 1985-08-01
DE3590020C2 (en) 1995-03-09
DK437585D0 (en) 1985-09-27
GB2153359B (en) 1987-08-12
JPS61501146A (en) 1986-06-12
IE850212L (en) 1985-07-30
CH667087A5 (en) 1988-09-15
DE3590020T1 (en) 1986-01-23
FR2558830A1 (en) 1985-08-02
AU3831785A (en) 1985-08-09
IE57947B1 (en) 1993-05-19
DK437585A (en) 1985-09-27
FR2558830B1 (en) 1987-11-20
GB8502163D0 (en) 1985-02-27
NL8520003A (en) 1985-12-02
GB2153359A (en) 1985-08-21
JPH0455424B2 (en) 1992-09-03
AU589113B2 (en) 1989-10-05

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 19960131