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BE896572A - Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique - Google Patents

Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique

Info

Publication number
BE896572A
BE896572A BE0/210633A BE210633A BE896572A BE 896572 A BE896572 A BE 896572A BE 0/210633 A BE0/210633 A BE 0/210633A BE 210633 A BE210633 A BE 210633A BE 896572 A BE896572 A BE 896572A
Authority
BE
Belgium
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
therapeutics
preparation
Prior art date
Application number
BE0/210633A
Other languages
English (en)
Inventor
C Malen
J-L Peglion
J Duhault
M Boulanger
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BE896572A publication Critical patent/BE896572A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE0/210633A 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique BE896572A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (fr) 1982-04-27 1982-04-27 Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BE896572A true BE896572A (fr) 1983-10-26

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/210633A BE896572A (fr) 1982-04-27 1983-04-26 Benzoazacycloalkyl-spiro-imidazolidines leur preparation et leur application en therapeutique

Country Status (22)

Country Link
JP (1) JPS5910584A (fr)
KR (1) KR840004428A (fr)
AT (1) ATA125383A (fr)
AU (1) AU1395383A (fr)
BE (1) BE896572A (fr)
DD (1) DD209833A5 (fr)
DE (1) DE3315106A1 (fr)
DK (1) DK183583A (fr)
ES (1) ES521895A0 (fr)
FR (1) FR2525603A1 (fr)
GB (1) GB2133401B (fr)
GR (1) GR78481B (fr)
IL (1) IL68497A0 (fr)
IT (1) IT1167123B (fr)
LU (1) LU84770A1 (fr)
MA (1) MA19783A1 (fr)
NL (1) NL8301476A (fr)
NO (1) NO831473L (fr)
OA (1) OA07412A (fr)
PT (1) PT76595B (fr)
SE (1) SE8302347L (fr)
ZA (1) ZA832927B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
DK2332921T3 (en) 2003-06-17 2016-05-09 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3benzazepine hydrochloride
BRPI0411470A (pt) 2003-06-17 2006-07-11 Arena Pharm Inc derivados de benzazepina úteis para o tratamento de doenças associadas com o receptor de 5ht2c
WO2006069363A2 (fr) 2004-12-21 2006-06-29 Arena Pharmaceuticals, Inc. Formes cristallines d'hydrochlorure de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
PL1833473T3 (pl) 2004-12-23 2010-02-26 Arena Pharm Inc Kompozycje modulatora receptora 5HT2C i sposoby zastosowania
EP2001852A2 (fr) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Procédés de préparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermédiaires associés
CA2670285A1 (fr) 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Procedes de preparation de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et intermediaires de celle-ci
WO2009111004A1 (fr) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Procédés de préparation d'intermédiaires se rapportant à l'agoniste 5-ht<sb>2c</sb> (r)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1h-3-benzazepine
WO2010148207A2 (fr) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Procédés pour la préparation d'agonistes du récepteur 5-ht2c
WO2011153206A1 (fr) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Procédés pour la préparation d'agonistes du récepteur 5-ht2c
WO2012030927A2 (fr) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Formes galéniques à libération modifiée d'agonistes de 5-ht2c, utiles pour la gestion du poids
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
KR20130101524A (ko) 2010-09-01 2013-09-13 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
AU2011296015B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
RU2674670C1 (ru) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Способ коррекции массы тела

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
LU84770A1 (fr) 1984-11-28
GB2133401A (en) 1984-07-25
ZA832927B (en) 1984-06-27
AU1395383A (en) 1983-11-03
IT8348155A0 (it) 1983-04-26
OA07412A (fr) 1984-11-30
FR2525603B1 (fr) 1984-09-14
DE3315106A1 (de) 1983-11-03
GR78481B (fr) 1984-09-27
IL68497A0 (en) 1983-07-31
KR840004428A (ko) 1984-10-15
MA19783A1 (fr) 1983-12-31
FR2525603A1 (fr) 1983-10-28
SE8302347L (sv) 1983-10-28
DK183583D0 (da) 1983-04-26
NO831473L (no) 1983-10-28
JPS5910584A (ja) 1984-01-20
ES8405796A1 (es) 1984-06-16
ES521895A0 (es) 1984-06-16
PT76595B (fr) 1986-01-21
ATA125383A (de) 1986-05-15
NL8301476A (nl) 1983-11-16
PT76595A (fr) 1983-05-01
SE8302347D0 (sv) 1983-04-26
GB8311508D0 (en) 1983-06-02
DK183583A (da) 1983-10-28
GB2133401B (en) 1985-10-23
IT1167123B (it) 1987-05-13
DD209833A5 (de) 1984-05-23

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ADIR

Effective date: 19860430