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BE876767A - Derives silyles de naphtacenones utilisables notamment dans la synthese d'agents antitumeurs - Google Patents

Derives silyles de naphtacenones utilisables notamment dans la synthese d'agents antitumeurs

Info

Publication number
BE876767A
BE876767A BE0/195566A BE195566A BE876767A BE 876767 A BE876767 A BE 876767A BE 0/195566 A BE0/195566 A BE 0/195566A BE 195566 A BE195566 A BE 195566A BE 876767 A BE876767 A BE 876767A
Authority
BE
Belgium
Prior art keywords
naphtacenones
antitumorous
synthesis
agents
silyl derivatives
Prior art date
Application number
BE0/195566A
Other languages
English (en)
Inventor
R Garland
R Pappo
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BE876767A publication Critical patent/BE876767A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE0/195566A 1978-06-05 1979-06-05 Derives silyles de naphtacenones utilisables notamment dans la synthese d'agents antitumeurs BE876767A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/912,671 US4161480A (en) 1978-06-05 1978-06-05 Intermediates for the synthesis of 4-demethoxydaunorubicin

Publications (1)

Publication Number Publication Date
BE876767A true BE876767A (fr) 1979-12-05

Family

ID=25432257

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/195566A BE876767A (fr) 1978-06-05 1979-06-05 Derives silyles de naphtacenones utilisables notamment dans la synthese d'agents antitumeurs

Country Status (10)

Country Link
US (1) US4161480A (fr)
JP (1) JPS554372A (fr)
BE (1) BE876767A (fr)
CA (1) CA1125284A (fr)
CH (1) CH640242A5 (fr)
DE (1) DE2922800A1 (fr)
FR (1) FR2428045A1 (fr)
GB (1) GB2022114B (fr)
IT (1) IT1116897B (fr)
NL (1) NL7904421A (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1130074B (it) * 1979-04-20 1986-06-11 Hoffmann La Roche Composti policiclici e procedimento per la loro preparazione
US4564674A (en) * 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
JPH0631266B2 (ja) * 1986-07-31 1994-04-27 史衛 佐藤 光学活性アルコール
GB8708927D0 (en) * 1987-04-14 1987-05-20 Erba Farmitalia Chiral synthesis of anthracyclines
JP2869650B2 (ja) * 1987-05-15 1999-03-10 チッソ株式会社 光学活性化合物およびその製造方法
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues

Also Published As

Publication number Publication date
IT1116897B (it) 1986-02-10
IT7949293A0 (it) 1979-06-04
FR2428045B1 (fr) 1984-01-06
DE2922800A1 (de) 1979-12-13
US4161480A (en) 1979-07-17
GB2022114A (en) 1979-12-12
FR2428045A1 (fr) 1980-01-04
JPS554372A (en) 1980-01-12
CA1125284A (fr) 1982-06-08
NL7904421A (nl) 1979-12-07
GB2022114B (en) 1982-10-27
CH640242A5 (de) 1983-12-30

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: G.D. SEARLE & CO.

Effective date: 19870630