BE2014C068I2 - - Google Patents
Info
- Publication number
- BE2014C068I2 BE2014C068I2 BE2014C068C BE2014C068C BE2014C068I2 BE 2014C068 I2 BE2014C068 I2 BE 2014C068I2 BE 2014C068 C BE2014C068 C BE 2014C068C BE 2014C068 C BE2014C068 C BE 2014C068C BE 2014C068 I2 BE2014C068 I2 BE 2014C068I2
- Authority
- BE
- Belgium
- Prior art keywords
- present
- immunoglobulin
- humanized
- human
- humanized immunoglobulin
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 abstract 8
- 102000018358 immunoglobulin Human genes 0.000 abstract 8
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 241001529936 Murinae Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 229940072221 immunoglobulins Drugs 0.000 abstract 2
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 1
- 241000282412 Homo Species 0.000 abstract 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 1
- 241000283984 Rodentia Species 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 230000007115 recruitment Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/700,737 US7147851B1 (en) | 1996-08-15 | 1996-08-15 | Humanized immunoglobulin reactive with α4β7 integrin |
Publications (1)
Publication Number | Publication Date |
---|---|
BE2014C068I2 true BE2014C068I2 (fr) | 2017-09-22 |
Family
ID=24814673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2014C068C BE2014C068I2 (fr) | 1996-08-15 | 2014-11-12 |
Country Status (19)
Country | Link |
---|---|
US (3) | US7147851B1 (fr) |
EP (2) | EP0918797B2 (fr) |
JP (3) | JP4171071B2 (fr) |
CN (1) | CN100406562C (fr) |
AT (1) | ATE321788T1 (fr) |
AU (1) | AU730326C (fr) |
BE (1) | BE2014C068I2 (fr) |
BR (1) | BRPI9711079B1 (fr) |
CA (1) | CA2263106C (fr) |
DE (1) | DE69735596T3 (fr) |
DK (1) | DK0918797T4 (fr) |
ES (1) | ES2262186T5 (fr) |
IL (3) | IL128052A0 (fr) |
LT (1) | LTC0918797I2 (fr) |
LU (1) | LU92596I2 (fr) |
NZ (1) | NZ334226A (fr) |
PT (1) | PT918797E (fr) |
SI (1) | SI0918797T2 (fr) |
WO (1) | WO1998006248A2 (fr) |
Families Citing this family (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
AU2011226857B2 (en) * | 1998-05-13 | 2013-09-19 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
US7090845B2 (en) * | 1998-05-13 | 2006-08-15 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
EP1133315B1 (fr) * | 1998-11-25 | 2006-02-01 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Antagonistes de l'integrine alpha e beta 7 utilises comme agents therapeutiques pour traiter les maladies inflammatoires |
EE05662B1 (et) * | 1999-04-22 | 2013-06-17 | Biogen, Inc. | Fibroosi ravimise kompositsioon, mis kasutab integriin alfa-4 subhiku antagonisti ja selle kompositsiooni kasutamine |
US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
AU2006220426B2 (en) * | 2000-04-14 | 2008-10-30 | Genentech Inc. | Method of administering an antibody |
US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
DE60235408D1 (de) * | 2001-12-17 | 2010-04-01 | Univ Cardiff | Enzymatische spaltbare reagenzien zum spezifischen targeting von krankheitsherden |
WO2003066662A2 (fr) | 2002-02-05 | 2003-08-14 | Genentech, Inc. | Purification de proteines |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US7323553B2 (en) | 2002-04-26 | 2008-01-29 | Genentech, Inc. | Non-affinity purification of proteins |
AU2003231293A1 (en) | 2002-05-02 | 2003-11-17 | Wyeth Holdings Corporation | Calicheamicin derivative-carrier conjugates |
GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
EP2368578A1 (fr) * | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification et ingénierie d'anticorps avec régions FC de variante et procédés d'utilisation associés |
CN1745175A (zh) * | 2003-02-01 | 2006-03-08 | 神经实验室有限公司 | 自动免疫产生针对可溶性A-β的抗体 |
EP3095793B1 (fr) | 2003-07-28 | 2020-03-25 | Genentech, Inc. | Réduction de protéine a pendant une chromatographie d'affinité sur protéine a |
CA2536918A1 (fr) | 2003-08-26 | 2005-03-03 | Leland Shapiro | Compositions et procedes pour molecules de fusion fc de l'alpha-1 antitrypsine |
JP2007521248A (ja) | 2003-12-10 | 2007-08-02 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | ヒト化抗ccr2抗体および該抗体を使用する方法 |
DK2177537T3 (da) | 2004-01-09 | 2011-12-12 | Pfizer | Antistoffer til MAdCAM |
US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
PL3530673T3 (pl) * | 2004-09-03 | 2022-08-01 | Genentech, Inc. | Humanizowani antagoniści anty-beta7 i ich zastosowania |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
MY146381A (en) * | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
WO2007007151A2 (fr) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Utilisation d'anticorps anti mad-cam dans le traitement de l'emphyseme |
WO2007007160A2 (fr) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anticorps anti-madcam servant a traiter la fievre |
WO2007061679A1 (fr) * | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | IMMUNOGLOBULINE HUMANISEE REACTIVE AVEC L’INTEGRINE α4β7 |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
WO2008079302A2 (fr) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification de protéines |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
US7947813B2 (en) | 2007-01-22 | 2011-05-24 | Genentech, Inc. | Polyelectrolyte precipitation and purification of proteins |
AU2008223541B2 (en) * | 2007-03-02 | 2012-04-05 | Amgen Inc. | Methods and compositions for treating tumor diseases |
EP2125892A2 (fr) * | 2007-03-20 | 2009-12-02 | Millennium Pharmaceuticals, Inc. | Acides nucléiques codant une immunoglobuline humanisée qui se lie à l'intégrine a4b7 |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
CN106366192B (zh) | 2007-06-25 | 2020-03-27 | 艾斯巴技术-诺华有限责任公司 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
PT3597659T (pt) | 2007-07-09 | 2023-04-04 | Genentech Inc | Prevenção da redução de ligações de dissulfureto durante a produção recombinante de polipéptidos |
EP2182983B1 (fr) * | 2007-07-27 | 2014-05-21 | Janssen Alzheimer Immunotherapy | Traitement de maladies amyloïdogéniques avec anti-abeta anticorps humanise |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US20090148435A1 (en) | 2007-10-30 | 2009-06-11 | Genentech, Inc. | Antibody purification by cation exchange chromatography |
RU2503720C2 (ru) * | 2008-01-11 | 2014-01-10 | Астеллас Фарма Инк. | УЛУЧШЕННОЕ ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К ЧЕЛОВЕЧЕСКОМУ α9-ИНТЕГРИНУ |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
US8999702B2 (en) | 2008-06-11 | 2015-04-07 | Emd Millipore Corporation | Stirred tank bioreactor |
EP2321337B2 (fr) | 2008-08-14 | 2018-10-10 | Genentech, Inc. | Procédés d'élimination d'un contaminant au moyen de la chromatographie à membrane échangeuse d'ions à déplacement de protéines |
EP2334323A2 (fr) | 2008-09-10 | 2011-06-22 | F. Hoffmann-La Roche AG | Compositions et procédés permettant d éviter la dégradation oxydative des protéines |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
ES2749232T3 (es) | 2008-12-16 | 2020-03-19 | Emd Millipore Corp | Reactor de tanque agitado y procedimiento |
EP2358734A1 (fr) | 2008-12-16 | 2011-08-24 | Millipore Corporation | Purification de protéines |
ES2547712T3 (es) | 2009-02-27 | 2015-10-08 | Genentech, Inc. | Métodos y composiciones para el marcado de proteínas |
TWI466681B (zh) | 2009-03-20 | 2015-01-01 | Amgen Inc | α4β7雜二聚體專一性拮抗抗體 |
AU2016208453B2 (en) * | 2009-03-20 | 2018-02-22 | Amgen Inc. | Alpha-4-beta-7 heterodimer specific antagonist antibody |
AU2013205341B2 (en) * | 2009-03-20 | 2016-05-05 | Amgen Inc. | Alpha-4-beta-7 heterodimer specific antagonist antibody |
CN102459628A (zh) | 2009-05-13 | 2012-05-16 | 基酶有限公司 | 抗人cd52 免疫球蛋白 |
MX355650B (es) | 2009-08-11 | 2018-04-26 | Genentech Inc | Produccion de proteinas en medios de cultivo de celulas libres de glutamina. |
CA2772653C (fr) | 2009-09-01 | 2019-06-25 | Genentech, Inc. | Purification amelioree d'une proteine grace a une elution modifiee de la proteine a |
PL2493922T3 (pl) | 2009-10-26 | 2017-07-31 | F.Hoffmann-La Roche Ag | Sposób wytwarzania glikozylowanych immunoglobulin |
CN106983862A (zh) | 2010-03-22 | 2017-07-28 | 弗·哈夫曼-拉罗切有限公司 | 对于稳定含有蛋白质的制剂有用的组合物和方法 |
CA2794864A1 (fr) | 2010-05-03 | 2011-11-10 | Genentech, Inc. | Compositions et procedes utiles pour la reduction de la viscosite de formulations contenant des proteines |
EP2571903B1 (fr) | 2010-05-17 | 2019-09-04 | EMD Millipore Corporation | Polymères répondant à des stimuli pour la purification de biomolécules |
ES2599412T3 (es) | 2010-05-28 | 2017-02-01 | F. Hoffmann-La Roche Ag | Disminución del nivel de lactato y aumento de la producción de polipéptidos regulando por disminución la expresión de la lactato deshidrogenasa y de la piruvato deshidrogenasa quinasa |
CA2802756C (fr) | 2010-06-24 | 2021-05-04 | Genentech, Inc. | Compositions et methodes pour stabiliser des preparations contenant des proteines |
KR20130100125A (ko) | 2010-08-13 | 2013-09-09 | 제넨테크, 인크. | 질환의 치료를 위한, IL-1β 및 IL-18에 대한 항체 |
WO2012030512A1 (fr) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Procédé de purification de protéine en flux |
UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
KR102308938B1 (ko) | 2011-05-02 | 2021-10-01 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
EP3628327A1 (fr) | 2011-06-24 | 2020-04-01 | The Regents of the University of Colorado, A Body Corporate | Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine |
US10745468B2 (en) | 2011-12-22 | 2020-08-18 | Kota Biotherapeutics, Llc | Compositions and methods for modified B cells expressing reassigned biological agents |
SG11201403437TA (en) | 2011-12-22 | 2014-07-30 | Genentech Inc | Ion exchange membrane chromatography |
KR20140137347A (ko) * | 2012-01-10 | 2014-12-02 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
EA201992881A3 (ru) * | 2012-01-12 | 2020-12-30 | Милленниум Фармасьютикалз, Инк. | Композиция анти-47 антитела |
JP6225162B2 (ja) | 2012-03-27 | 2017-11-01 | ジェネンテック, インコーポレイテッド | 組換えタンパク質の改良された収集操作 |
CN103374073A (zh) * | 2012-04-26 | 2013-10-30 | 中国科学院上海生命科学研究院 | 识别活化形式整合素α4β7的人源化单克隆抗体 |
HRP20250525T1 (hr) | 2012-05-18 | 2025-06-20 | Genentech, Inc. | Visokokoncentrirane formulacije monoklonskog protutijela |
CN104994885B (zh) | 2012-12-19 | 2017-09-29 | 基因泰克公司 | 用于放射性卤素蛋白质标记的方法和组合物 |
AR095199A1 (es) | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
AU2015287760B2 (en) | 2014-07-09 | 2019-06-20 | Genentech, Inc. | pH adjustment to improve thaw recovery of cell banks |
KR20240033093A (ko) | 2014-10-06 | 2024-03-12 | 케모센트릭스, 인크. | C-c 케모카인 수용체 타입 9 (ccr9)의 억제제 및 항-알파4베타7 인테그린 차단 항체의 조합 요법 |
JP2017537105A (ja) | 2014-11-26 | 2017-12-14 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 瘻孔を伴うクローン病の治療用ベドリズマブ |
US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
MA41636A (fr) | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
MX2018001668A (es) | 2015-08-11 | 2018-05-07 | Univ Osaka | Anticuerpo. |
KR20180039726A (ko) * | 2015-09-04 | 2018-04-18 | 더 캘리포니아 인스티튜트 포 바이오메디칼 리써치 | 인슐린 면역글로불린 융합 단백질 |
EP3397274A1 (fr) | 2015-12-31 | 2018-11-07 | The Regents of the University of Colorado, a body corporate | Méthodes et utilisations de l'alpha-1 anti-trypsine, ou de ses formes recombinées, sur une maladie du greffon contre l'hôte, réfractaire aux stéroïdes, impliquant des complications gastro-intestinales |
WO2017160699A2 (fr) * | 2016-03-14 | 2017-09-21 | Millennium Pharmaceuticals, Inc. | Méthode de traitement de la réaction du greffon contre l'hôte (gvd) |
CN109153721A (zh) * | 2016-03-14 | 2019-01-04 | 千禧制药公司 | 治疗或预防移植物抗宿主疾病的方法 |
WO2017165742A1 (fr) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Procédés de traitement d'événements indésirables liés à l'immunité gastro-intestinale dans des polythérapies anti-ctla4 et anti-pd-1 |
MA44483A (fr) | 2016-03-24 | 2019-01-30 | Millennium Pharm Inc | Procédés pour traiter des événements indésirables gastro-intestinaux d'origine immunitaire dans des traitements oncologiques immunitaires |
CA3019373A1 (fr) | 2016-03-29 | 2017-10-05 | Geltor, Inc. | Expression de proteines dans des bacteries gram negatif, avec un rapport du volume periplasmique au volume cytoplasmique compris entre 0,5:1 et 10:1 |
MA44864A (fr) | 2016-05-04 | 2019-03-13 | Icahn School Med Mount Sinai | Trithérapie pour le traitement d'une maladie intestinale inflammatoire |
WO2017214376A1 (fr) * | 2016-06-10 | 2017-12-14 | Elwha Llc | Compositions et procédés comprenant une lignée cellulaire de lymphocytes b exprimant une immunoglobuline membranaire différente d'une immunoglobuline sécrétée et fonction cytolytique |
MA45245A (fr) | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
WO2018104893A1 (fr) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | Anticorps anti-alpha4-beta7 présentant une liaison à fcrn et/ou une demi-vie augmentées |
AU2017382281B2 (en) | 2016-12-22 | 2024-07-11 | Genentech, Inc. | Methods and formulations for reducing reconstitution time of lyophilized polypeptides |
US20200179486A1 (en) | 2017-04-28 | 2020-06-11 | Millennium Pharmaceuticals, Inc. | Method of treating pediatric disorders |
WO2019014572A1 (fr) | 2017-07-14 | 2019-01-17 | Pfizer, Inc. | Anticorps dirigés contre madcam |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
KR20210027427A (ko) | 2018-07-03 | 2021-03-10 | 브리스톨-마이어스 스큅 컴퍼니 | 재조합 단백질 생산 방법 |
KR20210074341A (ko) | 2018-10-10 | 2021-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 고밀도 생물 반응기 배양에서 막 기체 전달을 위한 방법 |
US20220098329A1 (en) * | 2018-11-30 | 2022-03-31 | Memorial Sloan Kettering Cancer Center | Heterodimeric tetravalency and specificity antibody compositions and uses thereof |
CN113660953A (zh) | 2019-04-01 | 2021-11-16 | 豪夫迈·罗氏有限公司 | 用于稳定含蛋白质制剂的组合物和方法 |
GB2597416A (en) | 2019-04-12 | 2022-01-26 | Geltor Inc | Recombinant elastin and production thereof |
MA55735A (fr) * | 2019-04-17 | 2022-02-23 | Millennium Pharm Inc | Polythérapie à base d'inhibiteur d'alpha4bêta7 et d'inhibiteur d'il-23 |
MX2021015301A (es) * | 2019-06-10 | 2022-02-03 | Takeda Pharmaceuticals Co | Métodos de cultivo celular y composiciones para la producción de anticuerpos. |
CN114025843A (zh) * | 2019-06-10 | 2022-02-08 | 武田药品工业株式会社 | 抗体纯化方法及其组合物 |
CN114514311A (zh) | 2019-08-01 | 2022-05-17 | 百时美施贵宝公司 | 改进补料分批细胞培养物中蛋白质产量的方法 |
KR20230073270A (ko) | 2020-09-22 | 2023-05-25 | 브리스톨-마이어스 스큅 컴퍼니 | 치료 단백질의 생산 방법 |
US20250115666A1 (en) | 2021-08-05 | 2025-04-10 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
US20240390869A1 (en) | 2021-09-21 | 2024-11-28 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
EP4540289A2 (fr) | 2022-06-16 | 2025-04-23 | Cephalon LLC | Immunoconjugués anticorps anti-pd1-il2 atténuée et leurs utilisations |
WO2024249568A1 (fr) | 2023-05-30 | 2024-12-05 | Paragon Therapeutics, Inc. | Compositions d'anticorps anti-intégrine alpha4beta7 et procédés d'utilisation |
WO2024252368A2 (fr) | 2023-06-09 | 2024-12-12 | Takeda Pharmaceutical Company Limited | Procédés et compositions pour le traitement de la rectocolite hémorragique |
US20250195677A1 (en) | 2023-12-19 | 2025-06-19 | Cephalon Llc | Uses for attenuated il-2 immunoconjugates |
CN117777292B (zh) * | 2023-12-28 | 2024-10-18 | 天津大学 | 抗整合素α4β7纳米抗体及其用途 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3220049A1 (de) | 1982-05-27 | 1983-12-01 | Universal Maschinenfabrik Dr. Rudolf Schieber GmbH & Co KG, 7081 Westhausen | Strick- und umhaengeschlosskombination fuer v-bett-flachstrickmaschinen mit schiebernadeln |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4699880A (en) * | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5403919A (en) | 1987-08-11 | 1995-04-04 | Board Of Trustees Of The Leland Stanford Junior University Stanford University | Method to control leukocyte extravasation |
ATE114478T1 (de) | 1987-08-11 | 1994-12-15 | Univ Leland Stanford Junior | Verfahren zur kontrolle der leukozyten- extravasation. |
US5538724A (en) | 1987-08-11 | 1996-07-23 | The Board Of Trustees For The Leland Stanford Junior Univ. | Method of control leukocyte extravasation |
US5223392A (en) * | 1988-01-25 | 1993-06-29 | Exocell, Inc. | Monoclonal antibodies against glycated albumin, hybrid cell lines producing these antibodies, and use therefore |
WO1989007142A1 (fr) | 1988-02-05 | 1989-08-10 | Morrison Sherie L | Anticorps a region constante a modification de domaine |
EP0462111A4 (en) | 1988-12-23 | 1992-07-08 | The Board Of Trustees Of The Leland Stanford Junior University | Homing sequences and their uses |
IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
IL113261A (en) | 1989-09-01 | 1996-10-16 | Hutchinson Fred Cancer Res | Inhibition by peptides of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction and pharmaceutical compositions containing said peptides |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5558864A (en) | 1991-03-06 | 1996-09-24 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies |
US5665595A (en) * | 1991-06-07 | 1997-09-09 | Dowelanco | Immunoglobulins against insect tissue |
EP0590058B1 (fr) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | ANTICORP HUMANISE specifique pour heregulin |
GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
US5871734A (en) | 1992-01-13 | 1999-02-16 | Biogen, Inc. | Treatment for asthma with VLA-4 blocking agents |
US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
AU674302B2 (en) | 1992-02-12 | 1996-12-19 | Biogen Idec Ma Inc. | Treatment for inflammatory bowel disease |
WO1994012214A1 (fr) | 1992-12-01 | 1994-06-09 | Protein Design Labs, Inc. | Anticorps humanises reagissant avec la cd-18 |
AU5675794A (en) | 1992-12-15 | 1994-07-04 | Board Of Trustees Of The Leland Stanford Junior University | Mucosal vascular addressin, dna and expression |
ES2137354T3 (es) | 1993-01-12 | 1999-12-16 | Biogen Inc | Moleculas de anticuerpo anti-vla4 recombinante. |
ATE161730T1 (de) | 1993-02-09 | 1998-01-15 | Biogen Inc | Antikörper zur behandlung von insulinabhängigen diabetes |
JPH06303990A (ja) | 1993-04-24 | 1994-11-01 | Kanebo Ltd | モノクローナル抗体、それを産生するハイブリドーマおよび該抗体の製造方法 |
JPH08511420A (ja) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | 抗 体 |
US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
DE122006000043I1 (de) | 1994-01-25 | 2007-02-15 | Elan Pharm Inc | Humanisierte Antik¦rper gegen das Leukozytenadh{sionsmolek}l vla-4 |
US6551593B1 (en) * | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
-
1996
- 1996-08-15 US US08/700,737 patent/US7147851B1/en not_active Expired - Lifetime
-
1997
- 1997-08-06 EP EP97937148.1A patent/EP0918797B2/fr not_active Expired - Lifetime
- 1997-08-06 ES ES97937148.1T patent/ES2262186T5/es not_active Expired - Lifetime
- 1997-08-06 DK DK97937148.1T patent/DK0918797T4/en active
- 1997-08-06 WO PCT/US1997/013884 patent/WO1998006248A2/fr active IP Right Grant
- 1997-08-06 AU AU39728/97A patent/AU730326C/en not_active Expired
- 1997-08-06 CA CA2263106A patent/CA2263106C/fr not_active Expired - Lifetime
- 1997-08-06 EP EP06006108A patent/EP1710314A1/fr not_active Withdrawn
- 1997-08-06 BR BRPI9711079-5A patent/BRPI9711079B1/pt not_active IP Right Cessation
- 1997-08-06 CN CNB971972214A patent/CN100406562C/zh not_active Expired - Lifetime
- 1997-08-06 NZ NZ334226A patent/NZ334226A/xx not_active IP Right Cessation
- 1997-08-06 SI SI9730738T patent/SI0918797T2/sl unknown
- 1997-08-06 PT PT97937148T patent/PT918797E/pt unknown
- 1997-08-06 DE DE69735596.9T patent/DE69735596T3/de not_active Expired - Lifetime
- 1997-08-06 JP JP50985398A patent/JP4171071B2/ja not_active Expired - Lifetime
- 1997-08-06 AT AT97937148T patent/ATE321788T1/de active
- 1997-08-06 IL IL12805297A patent/IL128052A0/xx unknown
-
1999
- 1999-01-14 IL IL175570A patent/IL175570A0/en unknown
- 1999-01-14 IL IL128052A patent/IL128052A/en active Protection Beyond IP Right Term
-
2006
- 2006-08-28 US US11/511,164 patent/US7402410B2/en not_active Expired - Fee Related
-
2008
- 2008-05-02 JP JP2008120608A patent/JP4578536B2/ja not_active Expired - Lifetime
- 2008-06-18 US US12/214,304 patent/US20090011464A1/en not_active Abandoned
-
2010
- 2010-05-24 JP JP2010118596A patent/JP5166483B2/ja not_active Expired - Lifetime
-
2014
- 2014-10-13 LT LTPA2014037C patent/LTC0918797I2/lt unknown
- 2014-11-12 LU LU92596C patent/LU92596I2/fr unknown
- 2014-11-12 BE BE2014C068C patent/BE2014C068I2/fr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE2014C068I2 (fr) | ||
PT699755E (pt) | Metodo para obtencao de imunoglobulinas modificadas com imunogenicidade reduzida de dominios variaveis de anticorpos de murideo composicoes que as contem | |
CY1107708T1 (el) | Ανθρωπινα μονοκλωνικα αντισωματα για υποδοχεα παραγοντα επιδερμικης αναπτυξης | |
BR9507594B8 (pt) | Anticorpo monoclonal com scfv humanizado, molécula de ácido nucleico recombinante e proteína recombinante. | |
WO1999037681A3 (fr) | Procede servant a preparer des fragments d'anticorps | |
ATE504601T1 (de) | Anti-cd3-antikörper zur verwendung zur induzierung von immunsuppression | |
EP1362868A3 (fr) | Anticorps monoclonaux humanisés et chimériques se liant au récepteur du facteur de croissance épidermique (EGF-R) | |
DE69000338D1 (de) | Expressionssystem zur herstellung von chimaeren monoklonalen antikoerpern. | |
WO1998033919A3 (fr) | Anticorps anti-alpha-v beta-3 humanises de recombinaison, acides nucleiques codant lesdits anticorps et leurs procedes d'utilisation | |
GR3020610T3 (en) | Monoclonal antibodies against tumor associated antigen, their preparation and use | |
CA2068222A1 (fr) | Anticorps monoclonaux | |
AU1971295A (en) | Humanized monoclonal antibodies against human interleukin-4 | |
WO1998012334A3 (fr) | Anticorps chimeres humanises a chaine unique contre l'alpha-2-antiplasmine | |
RU94045907A (ru) | Вич-антитела человека или их фрагменты, экспрессионные кассеты, клетки-хозяева, фармацевтические композиции, способ защиты |