AU9536198A - Furopyrrolidine derivatives and their use as serine protease inhibitors - Google Patents

Furopyrrolidine derivatives and their use as serine protease inhibitors

Info

Publication number: AU9536198A
Authority: AU; Australia
Prior art keywords: furopyrrolidine; derivatives; protease inhibitors; serine protease; serine
Prior art date: 1997-09-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU95361/98A

Inventor

Steven John Coote

Michael Dennis Dowle

Harry Finch

Michael Menteith Hann

Henry Anderson Kelly

Simon John Fawcett Macdonald

Neil Anthony Pegg

Nigel Grahame Ramsden

Nigel Stephen Watson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-07

Publication date

1999-03-29

1998-09-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1999-03-29 Publication of AU9536198A publication Critical patent/AU9536198A/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Biotechnology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Diabetes (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AU95361/98A 1997-09-09 1998-09-07 Furopyrrolidine derivatives and their use as serine protease inhibitors Abandoned AU9536198A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9719176		1997-09-09
GBGB9719176.1A GB9719176D0 (en)	1997-09-09	1997-09-09	New therapeutic method
PCT/EP1998/005606 WO1999012936A1 (en)	1997-09-09	1998-09-07	Furopyrrolidine derivatives and their use as serine protease inhibitors

Publications (1)

Publication Number	Publication Date
AU9536198A true AU9536198A (en)	1999-03-29

Family

ID=10818813

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU95361/98A Abandoned AU9536198A (en)	1997-09-09	1998-09-07	Furopyrrolidine derivatives and their use as serine protease inhibitors

Country Status (5)

Country	Link
EP (1)	EP1015458A1 (en)
JP (1)	JP2001515907A (en)
AU (1)	AU9536198A (en)
GB (1)	GB9719176D0 (en)
WO (1)	WO1999012936A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5255841B2 (en) *	2004-10-15	2013-08-07	ジェネンコー・インターナショナル・インク	Competitive differential screening

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU690656B2 (en) *	1994-03-11	1998-04-30	Pharmacopeia Drug Discovery, Inc.	Sulfonamide derivatives and their use

1997
- 1997-09-09 GB GBGB9719176.1A patent/GB9719176D0/en not_active Ceased
1998
- 1998-09-07 JP JP2000510743A patent/JP2001515907A/en active Pending
- 1998-09-07 WO PCT/EP1998/005606 patent/WO1999012936A1/en not_active Application Discontinuation
- 1998-09-07 AU AU95361/98A patent/AU9536198A/en not_active Abandoned
- 1998-09-07 EP EP98948906A patent/EP1015458A1/en not_active Withdrawn

Also Published As

Publication number	Publication date
GB9719176D0 (en)	1997-11-12
WO1999012936A1 (en)	1999-03-18
EP1015458A1 (en)	2000-07-05
JP2001515907A (en)	2001-09-25

Publication	Publication Date	Title
AU8875398A (en)	1999-03-22	1-amino-7-isoquinoline derivatives as serine protease inhibitors
AU7127298A (en)	1998-11-11	Serine protease inhibitors
AU5481498A (en)	1998-06-22	Benzamidoaldehydes and their use as cysteine protease inhibitors
AU4236796A (en)	1996-05-31	Cysteine protease and serine protease inhibitors
AU3972697A (en)	1998-02-25	Inhibitors of cysteine protease
AU4135697A (en)	1998-03-26	Novel acetamide derivatives and protease inhibitors
AU8140898A (en)	1998-12-30	Inhibitors of beta-lactamases and uses therefor
ZA983629B (en)	1998-11-04	Serine protease inhibitors
AU3102397A (en)	1998-01-07	Metalloprotease inhibitors
HUP9901187A3 (en)	1999-11-29	Serine protease inhibitors
AU1795697A (en)	1997-09-16	Serine protease inhibitors
AU4723799A (en)	2000-01-10	Protease inhibitors
AU1877597A (en)	1997-09-16	Serine protease inhibitors
AU7139598A (en)	1998-11-24	Protease inhibitors
AU3124300A (en)	2000-07-03	Inhibitors of beta-lactamases and uses therefor
AU7179598A (en)	1998-06-03	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
AU9059798A (en)	2000-04-10	Urokinase inhibitors
AU2190400A (en)	2000-07-03	Inhibitors of beta-lactamases and uses therefor
AU6536200A (en)	2001-03-05	Proteases and protease inhibitors
AU4092799A (en)	1999-12-06	Protease inhibitors
AU9624398A (en)	1999-03-29	Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors
AU1393900A (en)	2000-06-05	Morpholino-ethoxybenzofuran protease inhibitors
AU9110298A (en)	1999-12-06	Protease inhibitors
AU1588901A (en)	2001-06-06	Protease inhibitors
AU9300298A (en)	1999-03-22	Protease inhibitors

Legal Events

Date	Code	Title	Description
2000-06-01	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase